Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-κB activation

Advances in Experimental Medicine and Biology

Volumn 584, Issue , 2006, Pages 89-106

  Moreno García, Miguel E ^a   Sommer, Karen M ^b   Bandaranayake, Ashok D ^a   Rawlings, David J ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84934439146     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/0-387-34132-3_7     Document Type: Conference Paper

References (70)

1. J. Ruland, and T. W. Mak, Transducing signals from antigen receptors to nuclear factor kappaB, Immunol Rev 193, 93-100 (2003).
2. M. Karin, and Y. Ben-Neriah, Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity, Annu Rev Immunol 18, 621-663 (2000).
3. J. L. Pomerantz, and D. Baltimore, Two pathways to NF-kappaB, Mol Cell 10 (4), 693-695 (2002).
4. S. Miyamoto, M. J. Schmitt, and I. M. Verma, Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation, Proc Natl Acad Sci U S A 91 (11), 5056-5060 (1994).
5. H. Flaswinkel, and M. Reth, Dual role of the tyrosine activation motif of the Igalpha protein during signal transduction via the B cell antigen receptor, Embo J 13 (1), 83-89 (1994).
6. M. Reth, Antigen receptor tail clue, Nature 338 (6214), 383-384 (1989).
7. T. Kurosaki, Genetic analysis of B cell antigen receptor signaling, Annu Rev Immunol 17, 555-592 (1999).
8. P. C. Cheng, A. Cherukuri, M. Dykstra, S. Malapati, T. Sproul, M. R. Chen, and S. K. Pierce, Floating the raft hypothesis: the roles of lipid rafts in B cell antigen receptor function, Semin Immunol 13 (2), 107-114 (2001).
9. A. Veillette, S. Latour, and D. Davidson, Negative regulation of immunoreceptor signaling, Annu Rev Immunol 20, 669-707 (2002).
10. L. B. Justement, The role of the protein tyrosine phosphatase CD45 in regulation of B lymphocyte activation, Int Rev Immunol 20 (6), 713-738 (2001).
11. R. B. Rowley, A. L. Burkhardt, H. G. Chao, G. R. Matsueda, and J. B. Bolen, Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation, J Biol Chem 270 (19), 11590-11594 (1995).
12. T. Kurosaki, Molecular mechanisms in B cell antigen receptor signaling, Curr Opin Immunol 9 (3), 309-318 (1997).
13. D. J. Rawlings, and O. N. Witte, The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function, Semin Immunol 7 (4), 237-246 (1995).
14. A. M. Scharenberg, O. El-Hillal, D. A. Fruman, L. O. Beitz, Z. Li, S. Lin, I. Gout, L. C. Cantley, D. J. Rawlings, and J. P. Kinet, Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals, Embo J 17 (7), 1961-1972 (1998).
15. M. Takata, and T. Kurosaki, A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2, J Exp Med 184 (1), 31-40 (1996).
16. D. J. Rawlings, D. C. Saffran, S. Tsukada, D. A. Largaespada, J. C. Grimaldi, L. Cohen, R. N. Mohr, J. F. Bazan, M. Howard, N. G. Copeland, and et al., Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice, Science 261 (5119), 358-361 (1993).
17. D. A. Tuveson, R. H. Carter, S. P. Soltoff, and D. T. Fearon, CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase, Science 260 (5110), 986-989 (1993).
18. M. Fujimoto, Y. Fujimoto, J. C. Poe, P. J. Jansen, C. A. Lowell, A. L. DeFranco, and T. F. Tedder, CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification, Immunity 13 (1), 47-57 (2000).
19. D. J. Rawlings, A. M. Scharenberg, H. Park, M. I. Wahl, S. Lin, R. M. Kato, A. C. Fluckiger, O. N. Witte, and J. P. Kinet, Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases, Science 271 (5250), 822-825 (1996).
20. T. Kurosaki, and M. Kurosaki, Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function, J Biol Chem 272 (25), 15595-15598 (1997).
21. C. Fu, C. W. Turck, T. Kurosaki, and A. C. Chan, BLNK: a central linker protein in B cell activation, Immunity 9 (1), 93-103 (1998).
22. J. Wienands, J. Schweikert, B. Wollscheid, H. Jumaa, P. J. Nielsen, and M. Reth, SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation, J Exp Med 188 (4), 791-795 (1998).
23. N. Engels, B. Wollscheid, and J. Wienands, Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha, Eur J Immunol 31 (7), 2126-2134 (2001).
24. F. Kohler, B. Storch, Y. Kulathu, S. Herzog, S. Kuppig, M. Reth, and H. Jumaa, A leucine zipper in the N terminus confers membrane association to SLP-65, Nat Immunol 6 (2), 204-210 (2005).
25. J. N. Wu, and G. A. Koretzky, The SLP-76 family of adapter proteins, Semin Immunol 16 (6), 379-393 (2004).
26. M. Ishiai, H. Sugawara, M. Kurosaki, and T. Kurosaki, Cutting edge: association of phospholipase C-gamma 2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling, J Immunol 163 (4), 1746-1749 (1999).
27. M. Ishiai, M. Kurosaki, R. Pappu, K. Okawa, I. Ronko, C. Fu, M. Shibata, A. Iwamatsu, A. C. Chan, and T. Kurosaki, BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells, Immunity 10 (1), 117-125 (1999).
28. L. A. Humphries, C. Dangelmaier, K. Sommer, K. Kipp, R. M. Kato, N. Griffith, I. Bakman, C. W. Turk, J. L. Daniel, and D. J. Rawlings, Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker, J Biol Chem 279 (36), 37651-37661 (2004).
29. K. Saito, K. F. Tolias, A. Saci, H. B. Koon, L. A. Humphries, A. Scharenberg, D. J. Rawlings, J. P. Kinet, and C. L. Carpenter, BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity, Immunity 19 (5), 669-678 (2003).
30. D. J. Rawlings, Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function, Clin Immunol 91 (3), 243-253 (1999).
31. C. Dong, R. J. Davis, and R. A. Flavell, MAP kinases in the immune response, Annu Rev Immunol 20, 55-72 (2002).
32. J. C. Cambier, and J. T. Ransom, Molecular mechanisms of transmembrane signaling in B lymphocytes, Annu Rev Immunol 5, 175-199 (1987).
33. A. C. Newton, Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions, Chem Rev 101 (8), 2353-2364 (2001).
34. I. Mecklenbrauker, K. Saijo, N. Y. Zheng, M. Leitges, and A. Tarakhovsky, Protein kinase Cdelta controls self-antigen-induced B-cell tolerance, Nature 416 (6883), 860-865 (2002).
35. A. Miyamoto, K. Nakayama, H. Imaki, S. Hirose, Y. Jiang, M. Abe, T. Tsukiyama, H. Nagahama, S. Ohno, S. Hatakeyama, and K. I. Nakayama, Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta, Nature 416 (6883), 865-869 (2002).
36. P. Martin, A. Duran, S. Minguet, M. L. Gaspar, M. T. Diaz-Meco, P. Rennert, M. Leitges, and J. Moscat, Role of zeta PKC in B-cell signaling and function, Embo J 21 (15), 4049-4057 (2002).
37. M. Leitges, L. Sanz, P. Martin, A. Duran, U. Braun, J. F. Garcia, F. Camacho, M. T. Diaz-Meco, P. D. Rennert, and J. Moscat, Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway, Mol Cell 8 (4), 771-780 (2001).
38. M. Leitges, C. Schmedt, R. Guinamard, J. Davoust, S. Schaal, S. Stabel, and A. Tarakhovsky, Immunodeficiency in protein kinase cbeta-deficient mice, Science 273 (5276), 788-791 (1996).
39. T. T. Su, B. Guo, Y. Kawakami, K. Sommer, K. Chae, L. A. Humphries, R. M. Kato, S. Kang, L. Patrone, R. Wall, M. Teitell, M. Leitges, T. Kawakami, and D. J. Rawlings, PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling, Nat Immunol 3 (8), 780-786 (2002).
40. K. Saijo, I. Mecklenbrauker, A. Santana, M. Leitger, C. Schmedt, and A. Tarakhovsky, Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha, J Exp Med 195 (12), 1647-1652 (2002).
41. M. Thome, CARMA1, BCL-10 and MALT1 in lymphocyte development and activation, Nat Rev Immunol 4 (5), 348-359 (2004).
42. T. G. Willis, D. M. Jadayel, M. Q. Du, H. Peng, A. R. Perry, M. Abdul-Rauf, H. Price, L. Karran, O. Majekodunmi, I. Wlodarska, L. Pan, T. Crook, R. Hamoudi, P. G. Isaacson, and M. J. Dyer, Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types, Cell 96 (1), 35-45 (1999).
43. J. Dierlamm, M. Baens, I. Wlodarska, M. Stefanova-Ouzounova, J. M. Hernandez, D. K. Hossfeld, C. De Wolf-Peeters, A. Hagemeijer, H. Van den Berghe, and P. Marynen, The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21)p6ssociated with mucosa-associated lymphoid tissue lymphomas, Blood 93 (11), 3601-3609 (1999).
44. P. C. Lucas, M. Yonezumi, N. Inohara, L. M. McAllister-Lucas, M. E. Abazeed, F. F. Chen, S. Yamaoka, M. Seto, and G. Nunez, Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NFkappa B signaling pathway, J Biol Chem 276 (22), 19012-19019 (2001).
45. O. Gaide, F. Martinon, O. Micheau, D. Bonnet, M. Thome, and J. Tschopp, Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation, FEBS Lett 496 (2-3), 121-127 (2001).
46. J. Bertin, L. Wang, Y. Guo, M. D. Jacobson, J. L. Poyet, S. M. Srinivasula, S. Merriam, P. S. DiStefano, and E. S. Alnemri, CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B, J Biol Chem 276 (15), 11877-11882 (2001).
47. J. E. Jun, L. E. Wilson, C. G. Vinuesa, S. Lesage, M. Blery, L. A. Miosge, M. C. Cook, E. M. Kucharska, H. Hara, J. M. Penninger, H. Domashenz, N. A. Hong, R. J. Glynne, K. A. Nelms, and C. C. Goodnow, Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis, Immunity 18 (6), 751-762 (2003).
48. H. Hara, T. Wada, C. Bakal, I. Kozieradzki, S. Suzuki, N. Suzuki, M. Nghiem, E. K. Griffiths, C. Krawczyk, B. Bauer, F. D'Acquisto, S. Ghosh, W. C. Yeh, G. Baier, R. Rottapel, and J. M. Penninger, The MAGUK family protein CARD11 is essential for lymphocyte activation, Immunity 18 (6), 763-775 (2003).
49. K. Newton, and V. M. Dixit, Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes, Curr Biol 13 (14), 1247-1251 (2003).
50. T. Egawa, B. Albrecht, B. Favier, M. J. Sunshine, K. Mirchandani, W. O'Brien, M. Thome, and D. R. Littman, Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation, Curr Biol 13 (14), 1252-1258 (2003).
51. J. Ruland, G. S. Duncan, A. Elia, I. del Barco Barrantes, L. Nguyen, S. Plyte, D. G. Millar, D. Bouchard, A. Wakeham, P. S. Ohashi, and T. W. Mak, Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure, Cell 104 (1), 33-42 (2001).
52. L. Xue, S. W. Morris, C. Orihuela, E. Tuomanen, X. Cui, R. Wen, and D. Wang, Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells, Nat Immunol 4 (9), 857-865 (2003).
53. A. A. Ruefli-Brasse, D. M. French, and V. M. Dixit, Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase, Science 302 (5650), 1581-1584 (2003).
54. J. Ruland, G. S. Duncan, A. Wakeham, and T. W. Mak, Differential requirement for Malt1 in T and B cell antigen receptor signaling, Immunity 19 (5), 749-758 (2003).
55. D. Wang, Y. You, S. M. Case, L. M. McAllister-Lucas, L. Wang, P. S. DiStefano, G. Nunez, J. Bertin, and X. Lin, A requirement for CARMA1 in TCR-induced NFkappa B activation, Nat Immunol 3 (9), 830-835 (2002).
56. O. Gaide, B. Favier, D. F. Legler, D. Bonnet, B. Brissoni, S. Valitutti, C. Bron, J. Tschopp, and M. Thome, CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation, Nat Immunol 3 (9), 836-843 (2002).
57. H. Hara, C. Bakal, T. Wada, D. Bouchard, R. Rottapel, T. Saito, and J. M. Penninger, The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse, J Exp Med 200 (9), 1167-1177 (2004).
58. K. Sommer, B. Gou, J. L. Pomerantz, A. D. Bandaranayake, M. E. Moreno-Garcia, Y. L. Ovechkina, and D. J. Rawlings, Phosphorylation of the CARMA1 linker controls NF-êB activation, Immunity 23(6), 561-574 (2005).
59. D. Wang, R. Matsumoto, Y. You, T. Che, X. Y. Lin, S. L. Gaffen, and X. Lin, CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1, Mol Cell Biol 24 (1), 164-171 (2004).
60. J. L. Pomerantz, E. M. Denny, and D. Baltimore, CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex, Embo J 21 (19), 5184-5194 (2002).
61. S. D. Dimitratos, D. F. Woods, D. G. Stathakis, and P. J. Bryant, Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family, Bioessays 21 (11), 912-921 (1999).
62. J. Liu, and B. Rost, NORSp: Predictions of long regions without regular secondary structure, Nucleic Acids Res 31 (13), 3833-3835 (2003).
63. T. Che, Y. You, D. Wang, M. J. Tanner, V. M. Dixit, and X. Lin, MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation, J Biol Chem 279 (16), 15870-15876 (2004).
64. R. Stilo, D. Liguoro, B. Di Jeso, S. Formisano, E. Consiglio, A. Leonardi, and P. Vito, Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator, J Biol Chem 279 (33), 34323-34331 (2004).
65. L. Sun, L. Deng, C. K. Ea, Z. P. Xia, and Z. J. Chen, The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes, Mol Cell 14 (3), 289-301 (2004).
66. H. Zhou, I. Wertz, K. O'Rourke, M. Ultsch, S. Seshagiri, M. Eby, W. Xiao, and V. M. Dixit, Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO, Nature 427 (6970), 167-171 (2004).
67. H. Su, N. Bidere, L. Zheng, A. Cubre, K. Sakai, J. Dale, L. Salmena, R. Hakem, S. Straus, and M. Lenardo, Requirement for caspase-8 in NF-kappaB activation by antigen receptor, Science 307 (5714), 1465-1468 (2005).
68. D. R. Beisner, I. L. Ch'en, R. V. Kolla, A. Hoffmann, and S. M. Hedrick, Cutting edge: innate immunity conferred by B cells is regulated by caspase-8, J Immunol 175 (6), 3469-3473 (2005).
69. E. Scharschmidt, E. Wegener, V. Heissmeyer, A. Rao, and D. Krappmann, Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling, Mol Cell Biol 24 (9), 3860-3873 (2004).
70. C. Guiet, and P. Vito, Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation, J Cell Biol 148 (6), 1131-1140 (2000).