메뉴 건너뛰기




Volumn 15, Issue 1, 2015, Pages 41-46

Phase I/II study of clofarabine, etoposide, and mitoxantrone in patients with refractory or relapsed acute leukemia

Author keywords

Acute myeloid leukemia; Adult; Clofarabine; Refractory; Relapse

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CLOFARABINE; ETOPOSIDE; METHYLPREDNISOLONE; MITOXANTRONE; ADENINE NUCLEOTIDE; ANTINEOPLASTIC AGENT; ARABINONUCLEOSIDE;

EID: 84934438248     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.1016/j.clml.2014.06.005     Document Type: Article
Times cited : (11)

References (31)
  • 1
    • 0028801482 scopus 로고
    • Timed sequential chemotherapy for previously treated patients with acute myeloid leukemia: Long-term follow-up of the etoposide, mitoxantrone, and cytarabine-86 trial
    • Archimbaud E, Thomas X, Leblond V, et al. Timed sequential chemotherapy for previously treated patients with acute myeloid leukemia: Long-term follow-up of the etoposide, mitoxantrone, and cytarabine-86 trial. J Clin Oncol 1995; 13: 11-8.
    • (1995) J Clin Oncol , vol.13 , pp. 11-18
    • Archimbaud, E.1    Thomas, X.2    Leblond, V.3
  • 2
    • 0018627307 scopus 로고
    • Successful re-induction therapy for acute myelogenous leukemia with cytosine arabinoside and daunorubicin
    • Stein RS, Flexner JM. Successful re-induction therapy for acute myelogenous leukemia with cytosine arabinoside and daunorubicin. Cancer Treat Rep 1979; 63: 2123-4.
    • (1979) Cancer Treat Rep , vol.63 , pp. 2123-2124
    • Stein, R.S.1    Flexner, J.M.2
  • 3
    • 0033975925 scopus 로고    scopus 로고
    • Multivariate analysis of prognostic factors in patients with refractory and relapsed acute myeloid leukemia undergoing sequential high-dose cytosine arabinoside and mitoxantrone (S-HAM) salvage therapy: Relevance of cytogenetic abnormalities
    • Kern W, Schoch C, Haferlach T, et al. Multivariate analysis of prognostic factors in patients with refractory and relapsed acute myeloid leukemia undergoing sequential high-dose cytosine arabinoside and mitoxantrone (S-HAM) salvage therapy: Relevance of cytogenetic abnormalities. Leukemia 2000; 14: 226-31.
    • (2000) Leukemia , vol.14 , pp. 226-2231
    • Kern, W.1    Schoch, C.2    Haferlach, T.3
  • 4
    • 0032942270 scopus 로고    scopus 로고
    • Mitoxantrone, etoposide, and cytarabine plus cyclosporine for patients with relapsed or refractory acute myeloid leukemia: An Eastern Cooperative Oncology Group pilot study
    • Tallman MS, Lee S, Sikic BI, et al. Mitoxantrone, etoposide, and cytarabine plus cyclosporine for patients with relapsed or refractory acute myeloid leukemia: An Eastern Cooperative Oncology Group pilot study. Cancer 1999; 85: 358-67.
    • (1999) Cancer , vol.85 , pp. 358-367
    • Tallman, M.S.1    Lee, S.2    Sikic, B.I.3
  • 5
    • 0034351866 scopus 로고    scopus 로고
    • Mitoxantrone, etoposide, carboplatinum and ara-C combination therapy (MECA) in refractory and relapsed acute leukemia
    • Ferra C, Berlanga JJ, Gallardo D, et al. Mitoxantrone, etoposide, carboplatinum and ara-C combination therapy (MECA) in refractory and relapsed acute leukemia. Leuk Lymphoma 2000; 39: 583-90.
    • (2000) Leuk Lymphoma , vol.39 , pp. 583-590
    • Ferra, C.1    Berlanga, J.J.2    Gallardo, D.3
  • 6
    • 55749096752 scopus 로고    scopus 로고
    • Clofarabine combinations as acute myeloid leukemia salvage therapy
    • Faderl S, Ferrajoli A, Wierda W, et al. Clofarabine combinations as acute myeloid leukemia salvage therapy. Cancer 2008; 113: 2090-6.
    • (2008) Cancer , vol.113 , pp. 2090-2096
    • Faderl, S.1    Ferrajoli, A.2    Wierda, W.3
  • 7
    • 77449159668 scopus 로고    scopus 로고
    • Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors
    • Kantarjian HM, Erba HP, Claxton D, et al. Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol 2010; 28: 549-55.
    • (2010) J Clin Oncol , vol.28 , pp. 549-555
    • Kantarjian, H.M.1    Erba, H.P.2    Claxton, D.3
  • 8
    • 33745586575 scopus 로고    scopus 로고
    • Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older
    • Faderl S, Verstovsek S, Cortes J, et al. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older. Blood 2006; 108: 45-51.
    • (2006) Blood , vol.108 , pp. 45-51
    • Faderl, S.1    Verstovsek, S.2    Cortes, J.3
  • 9
    • 19944433802 scopus 로고    scopus 로고
    • Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
    • Faderl S, Gandhi V, O'Brien S, et al. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Blood 2005; 105: 940-7.
    • (2005) Blood , vol.105 , pp. 940-947
    • Faderl, S.1    Gandhi, V.2    O'Brien, S.3
  • 10
    • 0346963139 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias
    • Gandhi V, Kantarjian H, Faderl S, et al. Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias. Clin Cancer Res 2003; 9: 6335-42.
    • (2003) Clin Cancer Res , vol.9 , pp. 6335-6342
    • Gandhi, V.1    Kantarjian, H.2    Faderl, S.3
  • 11
    • 0346665773 scopus 로고    scopus 로고
    • Comparison of cytotoxicity of 2-chloro- 2'-arabino-fluoro-2'-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia
    • Lindemalm S, Liliemark J, Gruber A, et al. Comparison of cytotoxicity of 2-chloro- 2'-arabino-fluoro-2'-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia. Haematologica 2003; 88: 324-32.
    • (2003) Haematologica , vol.88 , pp. 324-332
    • Lindemalm, S.1    Liliemark, J.2    Gruber, A.3
  • 12
    • 34548851697 scopus 로고    scopus 로고
    • A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias
    • Karp JE, Ricklis RM, Balakrishnan K, et al. A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias. Blood 2007; 110: 1762-9.
    • (2007) Blood , vol.110 , pp. 1762-1769
    • Karp, J.E.1    Ricklis, R.M.2    Balakrishnan, K.3
  • 13
    • 33847347400 scopus 로고    scopus 로고
    • End points to establish the efficacy of new agents in the treatment of acute leukemia
    • Appelbaum FR, Rosenblum D, Arceci RJ, et al. End points to establish the efficacy of new agents in the treatment of acute leukemia. Blood 2007; 109: 1810-6.
    • (2007) Blood , vol.109 , pp. 1810-1816
    • Appelbaum, F.R.1    Rosenblum, D.2    Arceci, R.J.3
  • 14
    • 0035001004 scopus 로고    scopus 로고
    • Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poorprognosis acute myeloid leukemia
    • Visani G, Milligan D, Leoni F, et al. Combined action of PSC 833 (Valspodar), a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine in poorprognosis acute myeloid leukemia. Leukemia 2001; 15: 764-71.
    • (2001) Leukemia , vol.15 , pp. 764-771
    • Visani, G.1    Milligan, D.2    Leoni, F.3
  • 15
    • 0033846491 scopus 로고    scopus 로고
    • Combination regimen of cladribine (2-chlorodeoxyadenosine), cytarabine and G-CSF (CLAG) as induction therapy for patients with relapsed or refractory acute myeloid leukemia
    • Robak T, Wrzesien-Kus A, Lech-Maranda E, et al. Combination regimen of cladribine (2-chlorodeoxyadenosine), cytarabine and G-CSF (CLAG) as induction therapy for patients with relapsed or refractory acute myeloid leukemia. Leuk Lymphoma 2000; 39: 121-9.
    • (2000) Leuk Lymphoma , vol.39 , pp. 121-129
    • Robak, T.1    Wrzesien-Kus, A.2    Lech-Maranda, E.3
  • 16
    • 38049153331 scopus 로고    scopus 로고
    • Cladribine combined with high doses of arabinoside cytosine, mitoxantrone, and G-CSF (CLAG-M) is a highly effective salvage regimen in patients with refractory and relapsed acute myeloid leukemia of the poor risk: A final report of the Polish Adult Leukemia Group
    • Wierzbowska A, Robak T, Pluta A, et al. Cladribine combined with high doses of arabinoside cytosine, mitoxantrone, and G-CSF (CLAG-M) is a highly effective salvage regimen in patients with refractory and relapsed acute myeloid leukemia of the poor risk: A final report of the Polish Adult Leukemia Group. Eur J Haematol 2008; 80: 115-26.
    • (2008) Eur J Haematol , vol.80 , pp. 115-126
    • Wierzbowska, A.1    Robak, T.2    Pluta, A.3
  • 17
    • 0033964380 scopus 로고    scopus 로고
    • Results of treatment with hyper- CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia
    • Kantarjian HM, O'Brien S, Smith TL, et al. Results of treatment with hyper- CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. J Clin Oncol 2000; 18: 547-61.
    • (2000) J Clin Oncol , vol.18 , pp. 547-561
    • Kantarjian, H.M.1    O'Brien, S.2    Smith, T.L.3
  • 18
    • 0032812621 scopus 로고    scopus 로고
    • Hyper-CVAD program in Burkitt's-type adult acute lymphoblastic leukemia
    • Thomas DA, Cortes J, O'Brien S, et al. Hyper-CVAD program in Burkitt's-type adult acute lymphoblastic leukemia. J Clin Oncol 1999; 17: 2461-70.
    • (1999) J Clin Oncol , vol.17 , pp. 2461-2470
    • Thomas, D.A.1    Cortes, J.2    O'Brien, S.3
  • 19
    • 0019993892 scopus 로고
    • Metabolism and therapeutic efficacy of 9-beta-D-arabinofuranosyl- 2-fluoroadenine against murine leukemia P388
    • Avramis VI, Plunkett W. Metabolism and therapeutic efficacy of 9-beta-D-arabinofuranosyl- 2-fluoroadenine against murine leukemia P388. Cancer Res 1982; 42: 2587-91.
    • (1982) Cancer Res , vol.42 , pp. 2587-2591
    • Avramis, V.I.1    Plunkett, W.2
  • 20
    • 0020636463 scopus 로고
    • 2-Fluoro-ATP: A toxic metabolite of 9-beta-D-arabinosyl- 2-fluoroadenine
    • Avramis VI, Plunkett W. 2-Fluoro-ATP: A toxic metabolite of 9-beta-D-arabinosyl- 2-fluoroadenine. Biochem Biophys Res Commun 1983; 113: 35-43.
    • (1983) Biochem Biophys Res Commun , vol.113 , pp. 35-43
    • Avramis, V.I.1    Plunkett, W.2
  • 21
    • 0023261751 scopus 로고
    • Phosphorolytic cleavage of 2-fluoroadenine from 9-beta- D-arabinofuranosyl-2-fluoroadenine by Escherichia coli. A pathway for 2-fluoro- ATP production
    • Huang P, Plunkett W. Phosphorolytic cleavage of 2-fluoroadenine from 9-beta- D-arabinofuranosyl-2-fluoroadenine by Escherichia coli. A pathway for 2-fluoro- ATP production. Biochem Pharmacol 1987; 36: 2945-50.
    • (1987) Biochem Pharmacol , vol.36 , pp. 2945-2950
    • Huang, P.1    Plunkett, W.2
  • 22
    • 0036892524 scopus 로고    scopus 로고
    • Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: A Southwest Oncology Group study
    • Anderson JE, Kopecky KJ, Willman CL, et al. Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: A Southwest Oncology Group study. Blood 2002; 100: 3869-76.
    • (2002) Blood , vol.100 , pp. 3869-3876
    • Anderson, J.E.1    Kopecky, K.J.2    Willman, C.L.3
  • 23
    • 0035469856 scopus 로고    scopus 로고
    • Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: The results of the United Kingdom Medical Research Council AML11 trial
    • Goldstone AH, Burnett AK, Wheatley K, et al. Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: The results of the United Kingdom Medical Research Council AML11 trial. Blood 2001; 98: 1302-11.
    • (2001) Blood , vol.98 , pp. 1302-1311
    • Goldstone, A.H.1    Burnett, A.K.2    Wheatley, K.3
  • 24
    • 0037445122 scopus 로고    scopus 로고
    • Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers
    • Kantarjian HM, Gandhi V, Kozuch P, et al. Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. J Clin Oncol 2003; 21: 1167-73.
    • (2003) J Clin Oncol , vol.21 , pp. 1167-1173
    • Kantarjian, H.M.1    Gandhi, V.2    Kozuch, P.3
  • 25
    • 9144222570 scopus 로고    scopus 로고
    • Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia
    • Jeha S, Gandhi V, Chan KW, et al. Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia. Blood 2004; 103: 784-9.
    • (2004) Blood , vol.103 , pp. 784-789
    • Jeha, S.1    Gandhi, V.2    Chan, K.W.3
  • 26
    • 77952491723 scopus 로고    scopus 로고
    • European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy
    • Burnett AK, Russell NH, Kell J, et al. European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy. J Clin Oncol 2010; 28: 2389-95.
    • (2010) J Clin Oncol , vol.28 , pp. 2389-2395
    • Burnett, A.K.1    Russell, N.H.2    Kell, J.3
  • 27
    • 78349295261 scopus 로고    scopus 로고
    • Southwest Oncology Group Study S0530: A phase 2 trial of clofarabine and cytarabine for relapsed or refractory acute lymphocytic leukaemia
    • Advani AS, Gundacker HM, Sala-Torra O, et al. Southwest Oncology Group Study S0530: A phase 2 trial of clofarabine and cytarabine for relapsed or refractory acute lymphocytic leukaemia. Br J Haematol 2010; 151: 430-4.
    • (2010) Br J Haematol , vol.151 , pp. 430-434
    • Advani, A.S.1    Gundacker, H.M.2    Sala-Torra, O.3
  • 28
    • 84864050584 scopus 로고    scopus 로고
    • Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the CLASSIC I Trial
    • Faderl S, Wetzler M, Rizzieri D, et al. Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the CLASSIC I Trial. J Clin Oncol 2012; 30: 2492-9.
    • (2012) J Clin Oncol , vol.30 , pp. 2492-2499
    • Faderl, S.1    Wetzler, M.2    Rizzieri, D.3
  • 29
    • 84869192249 scopus 로고    scopus 로고
    • Cytarabine and clofarabine after high-dose cytarabine in relapsed or refractory AML patients
    • Scappini B, Gianfaldoni G, Caracciolo F, et al. Cytarabine and clofarabine after high-dose cytarabine in relapsed or refractory AML patients. Am J Hematol 2012; 87: 1047-51.
    • (2012) Am J Hematol , vol.87 , pp. 1047-1051
    • Scappini, B.1    Gianfaldoni, G.2    Caracciolo, F.3
  • 30
    • 70349904430 scopus 로고    scopus 로고
    • Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia
    • Locatelli F, Testi AM, Bernardo ME, et al. Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia. Br J Haematol 2009; 147: 371-8.
    • (2009) Br J Haematol , vol.147 , pp. 371-378
    • Locatelli, F.1    Testi, A.M.2    Bernardo, M.E.3
  • 31
    • 82955207681 scopus 로고    scopus 로고
    • Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
    • Hijiya N, Thomson B, Isakoff MS, et al. Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. Blood 2011; 118: 6043-9.
    • (2011) Blood , vol.118 , pp. 6043-6349
    • Hijiya, N.1    Thomson, B.2    Isakoff, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.