Elevated mitochondrial DNA copy number and POL-γ expression but decreased expression of TFAM in murine intestine following therapeutic dose irradiation

Advances in Experimental Medicine and Biology

Volumn 701, Issue , 2011, Pages 201-206

  Zhang, Hengshan ^a   Maguire, David J ^b   Zhang, Mei ^c   Zhang, Lurong ^c   Okunieff, Paul ^c  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; DNA DIRECTED DNA POLYMERASE GAMMA; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; RNA 18S;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE LOSS; LOW ENERGY RADIATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIATION DOSE; REAL TIME POLYMERASE CHAIN REACTION; RNA GENE; SMALL INTESTINE MUCOSA; UPREGULATION;

EID: 84934435084     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-7756-4_27     Document Type: Conference Paper

References (9)

1. Purkayastha SJ, Milligan R, and Bernhard WA (2007) On the chemical yield of base lesions, strand breaks, and clustered damage generated in plasmid DNA by the direct effect of x rays. Radiat Res 168:357-366 (Pubitemid 351295139)
2. Yakes FM, and Van Houten B (1997)Mitochondrial DNAdamage ismore extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 94:514-519 (Pubitemid 27053665)
3. Iliakis G, Wang H, Perrault AR, et al. (2004) Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet Genome Res 104:14-20 (Pubitemid 38721048)
4. Larsen NB, Rasmussen M, and Rasmussen LJ (2005) Nuclear and mitochondrial DNA repair: Similar pathways? Mitochondrion 5:89-108 (Pubitemid 40485769)
5. Malakhova L, Bezlepkin VG, Antipova V, et al. (2005) The increase inmitochondrial DNAcopy number in the tissues of γ-irradiated mice. Cell Mol Biol Lett 10:721-732 (Pubitemid 43161696)
6. ZhangH,Maguire D, Swarts S, et al. (2009) Replication ofmurinemitochondrialDNAfollowing irradiation. Adv Exp Med Biol 645:43-48
7. Pfaffl MW (2001) A new mathematical model for relative quantification in real time RT-PCR. Nuc Acids Res 29:e45
8. Laemmli, UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
9. Denham JW, Hauer-Jensen M, Kron T, et al. (2000) Treatment-time- dependence models of early and delayed radiation injury in rat small intestine. Int J Radiat Biol Phys 48:871-887