메뉴 건너뛰기




Volumn 1113, Issue , 2014, Pages 363-415

Sources of interindividual variability

Author keywords

Age; Disease; Gender; Interindividual variability; Pharmacogenetics; Pharmacogenomics; Pregnancy

Indexed keywords

ALCOHOL; AMITRIPTYLINE; CITALOPRAM; CLOPIDOGREL; CODEINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; FLUOROURACIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMIPRAMINE; ISONIAZID; MERCAPTOPURINE; METFORMIN; MORPHINE; NICOTINE; NORTRIPTYLINE; OMEPRAZOLE; OXYCODONE; PHENYTOIN; SUXAMETHONIUM; TACROLIMUS; THIOPURINE METHYLTRANSFERASE; TRIMIPRAMINE; VINCRISTINE; WARFARIN;

EID: 84934434958     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-758-7_17     Document Type: Article
Times cited : (36)

References (332)
  • 1
    • 36048939609 scopus 로고    scopus 로고
    • Mechanisms of cytochrome P450 substrate oxidation: MiniReview
    • Guengerich FP (2007) Mechanisms of cytochrome P450 substrate oxidation: MiniReview. J Biochem Mol Toxicol 21(4):163-168
    • (2007) J Biochem Mol Toxicol , vol.21 , Issue.4 , pp. 163-168
    • Guengerich, F.P.1
  • 2
    • 77955147593 scopus 로고    scopus 로고
    • Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver
    • doi:10. 1101/gr.103341.109
    • Yang X, Zhang B, Molony C et al (2010) Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res 20(8):1020-1036. doi:10. 1101/gr.103341.109
    • (2010) Genome Res , vol.20 , Issue.8 , pp. 1020-1036
    • Yang, X.1    Zhang, B.2    Molony, C.3
  • 3
    • 1542376174 scopus 로고    scopus 로고
    • Cytochrome P450 3A4 and Pglycoprotein expression in human small intestinal enterocytes and hepatocytes: A comparative analysis in paired tissue specimens
    • doi:10.1016/j.clpt.2003.10.008
    • von Richter O, Burk O, Fromm MF et al (2004) Cytochrome P450 3A4 and Pglycoprotein expression in human small intestinal enterocytes and hepatocytes: A comparative analysis in paired tissue specimens. Clin Pharmacol Ther 75(3):172-183. doi:10.1016/j.clpt.2003.10.008
    • (2004) Clin Pharmacol Ther , vol.75 , Issue.3 , pp. 172-183
    • Von Richter, O.1    Burk, O.2    Fromm, M.F.3
  • 4
    • 84863769832 scopus 로고    scopus 로고
    • Genetic polymorphisms affecting drug metabolism: Recent advances and clinical aspects
    • doi:10.1016/B978-0-12-398339-8.00004-5
    • Daly AK (2012) Genetic polymorphisms affecting drug metabolism: Recent advances and clinical aspects. Adv Pharmacol 63:137-167. doi:10.1016/B978-0-12- 398339-8.00004-5
    • (2012) Adv Pharmacol , vol.63 , pp. 137-167
    • Daly, A.K.1
  • 5
    • 84872899545 scopus 로고    scopus 로고
    • Pharmacogenomics of drugmetabolizing enzymes: A recent update on clinical implications and endogenous effects
    • doi:10. 1038/tpj.2012.45
    • Sim SC, Kacevska M, Ingelman-Sundberg M (2013) Pharmacogenomics of drugmetabolizing enzymes: A recent update on clinical implications and endogenous effects. Pharmacogenomics J 13(1):1-11. doi:10. 1038/tpj.2012.45
    • (2013) Pharmacogenomics J , vol.13 , Issue.1 , pp. 1-11
    • Sim, S.C.1    Kacevska, M.2    Ingelman-Sundberg, M.3
  • 6
    • 84875211310 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
    • doi:10.1016/j. pharmthera.2012.12.007
    • Zanger UM, Schwab M (2013) Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther 138(1):103-141. doi:10.1016/j. pharmthera.2012.12.007
    • (2013) Pharmacol Ther , vol.138 , Issue.1 , pp. 103-141
    • Zanger, U.M.1    Schwab, M.2
  • 7
    • 14544271524 scopus 로고    scopus 로고
    • Definition and clinical importance of haplotypes
    • doi:10.1146/annurev.med.56.082103.104540
    • Crawford DC, Nickerson DA (2005) Definition and clinical importance of haplotypes. Annu Rev Med 56:303-320. doi:10.1146/annurev.med.56.082103.104540
    • (2005) Annu Rev Med , vol.56 , pp. 303-320
    • Crawford, D.C.1    Nickerson, D.A.2
  • 8
    • 43049122356 scopus 로고    scopus 로고
    • From human genetics and genomics to pharmacogenetics and pharmacogenomics: Past lessons, future directions
    • doi:10.1080/03602530801952864
    • Nebert DW, Zhang G, Vesell ES (2008) From human genetics and genomics to pharmacogenetics and pharmacogenomics: Past lessons, future directions. Drug Metab Rev 40(2):187-224. doi:10.1080/03602530801952864
    • (2008) Drug Metab Rev , vol.40 , Issue.2 , pp. 187-224
    • Nebert, D.W.1    Zhang, G.2    Vesell, E.S.3
  • 9
    • 0025805934 scopus 로고
    • Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism
    • Gaedigk A, Blum M, Gaedigk R et al (1991) Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Hum Genet 48(5):943-950
    • (1991) Am J Hum Genet , vol.48 , Issue.5 , pp. 943-950
    • Gaedigk, A.1    Blum, M.2    Gaedigk, R.3
  • 10
    • 0037328994 scopus 로고    scopus 로고
    • Pharmacogenetics of the major polymorphic metabolizing enzymes
    • Daly AK (2003) Pharmacogenetics of the major polymorphic metabolizing enzymes. Fundam Clin Pharmacol 17(1):27-41
    • (2003) Fundam Clin Pharmacol , vol.17 , Issue.1 , pp. 27-41
    • Daly, A.K.1
  • 11
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • de Morais SM, Wilkinson GR, Blaisdell J et al (1994) The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem 269(22):15419-15422
    • (1994) J Biol Chem , vol.269 , Issue.22 , pp. 15419-15422
    • De Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 12
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmoller J, Bauer S et al (1997) Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences. Am J Hum Genet 60(2):284-295
    • (1997) Am J Hum Genet , vol.60 , Issue.2 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3
  • 13
    • 85011913445 scopus 로고    scopus 로고
    • Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift
    • Soyama A, Saito Y, Komamura K et al (2002) Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift. Drug Metab Pharmacokinet 17(4):374-377
    • (2002) Drug Metab Pharmacokinet , vol.17 , Issue.4 , pp. 374-377
    • Soyama, A.1    Saito, Y.2    Komamura, K.3
  • 14
    • 0028044085 scopus 로고
    • Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
    • De Morais SM,Wilkinson GR, Blaisdell J et al (1994) Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol 46(4):594-598
    • (1994) Mol Pharmacol , vol.46 , Issue.4 , pp. 594-598
    • De Morais, S.M.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 15
    • 15444340367 scopus 로고    scopus 로고
    • A new genetic defect in human CYP2C19: Mutation of the initiation codon is responsible for poor metabolism of Smephenytoin
    • Ferguson RJ, De Morais SM, Benhamou S et al (1998) A new genetic defect in human CYP2C19: Mutation of the initiation codon is responsible for poor metabolism of Smephenytoin. J Pharmacol Exp Ther 284(1):356-361
    • (1998) J Pharmacol Exp Ther , vol.284 , Issue.1 , pp. 356-361
    • Ferguson, R.J.1    De Morais, S.M.2    Benhamou, S.3
  • 16
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • doi:10.1038/86882
    • Kuehl P, Zhang J, Lin Y et al (2001) Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 27(4):383-391. doi:10.1038/86882
    • (2001) Nat Genet , vol.27 , Issue.4 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3
  • 17
    • 0036089341 scopus 로고    scopus 로고
    • Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism
    • Lin YS, Dowling AL, Quigley SD et al (2002) Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism. Mol Pharmacol 62(1):162-172
    • (2002) Mol Pharmacol , vol.62 , Issue.1 , pp. 162-172
    • Lin, Y.S.1    Dowling, A.L.2    Quigley, S.D.3
  • 18
    • 29144447089 scopus 로고    scopus 로고
    • Genetic signature consistent with selection against the CYP3A41B allele in non-African populations
    • Schirmer M, Toliat MR, Haberl M et al (2006) Genetic signature consistent with selection against the CYP3A41B allele in non-African populations. Pharmacogenet Genomics 16(1):59-71
    • (2006) Pharmacogenet Genomics , vol.16 , Issue.1 , pp. 59-71
    • Schirmer, M.1    Toliat, M.R.2    Haberl, M.3
  • 19
    • 84876078320 scopus 로고    scopus 로고
    • Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): Advances on polymorphisms, mechanisms, and clinical relevance
    • doi:10.3389/fgene.2013.00024
    • Zanger UM, Klein K (2013) Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): Advances on polymorphisms, mechanisms, and clinical relevance. Front Genet 4:24. doi:10.3389/fgene.2013.00024
    • (2013) Front Genet , vol.4 , pp. 24
    • Zanger, U.M.1    Klein, K.2
  • 20
    • 80455175971 scopus 로고    scopus 로고
    • Identification of novel CYP2D7-2D6 hybrids: Non-functional and functional variants
    • doi:10.3389/fphar.2010.00121
    • Gaedigk A, Jaime LK, Bertino JS Jr et al (2010) Identification of novel CYP2D7-2D6 hybrids: Non-functional and functional variants. Front Pharmacol 1:121. doi:10.3389/fphar.2010.00121
    • (2010) Front Pharmacol , vol.1 , pp. 121
    • Gaedigk, A.1    Jaime, L.K.2    Bertino Jr., J.S.3
  • 21
    • 24344500822 scopus 로고    scopus 로고
    • A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels
    • doi:10.1210/jc.2005-0307
    • Smit P, van Schaik RH, van der Werf M et al (2005) A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. J Clin Endocrinol Metab 90(9):5313-5316. doi:10.1210/jc.2005-0307
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.9 , pp. 5313-5316
    • Smit, P.1    Van Schaik, R.H.2    Van Der Werf, M.3
  • 22
    • 47549101437 scopus 로고    scopus 로고
    • Association of CYP3A71C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome
    • doi:10.1210/jc. 2008-0403
    • Goodarzi MO, Xu N, Azziz R (2008) Association of CYP3A71C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab 93(7):2909-2912. doi:10.1210/jc. 2008-0403
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.7 , pp. 2909-2912
    • Goodarzi, M.O.1    Xu, N.2    Azziz, R.3
  • 23
    • 84874025943 scopus 로고    scopus 로고
    • Nuclear receptors PXR and CAR: Implications for drug metabolism regulation, pharmacogenomics and beyond
    • doi:10.1517/17425255. 2013.754010
    • Chai X, Zeng S, Xie W (2013) Nuclear receptors PXR and CAR: Implications for drug metabolism regulation, pharmacogenomics and beyond. Expert Opin Drug Metab Toxicol 9(3):253-266. doi:10.1517/17425255. 2013.754010
    • (2013) Expert Opin Drug Metab Toxicol , vol.9 , Issue.3 , pp. 253-266
    • Chai, X.1    Zeng, S.2    Xie, W.3
  • 24
    • 67650841094 scopus 로고    scopus 로고
    • Sex differences in the expression of hepatic drug metabolizing enzymes
    • doi:10.1124/mol.109. 056705
    • Waxman DJ, Holloway MG (2009) Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol 76(2):215-228. doi:10.1124/mol.109. 056705
    • (2009) Mol Pharmacol , vol.76 , Issue.2 , pp. 215-228
    • Waxman, D.J.1    Holloway, M.G.2
  • 25
    • 0032929010 scopus 로고    scopus 로고
    • Genetic polymorphism in the 50-flanking region of human CYP1A2 gene: Effect on the CYP1A2 inducibility in humans
    • Nakajima M, Yokoi T, Mizutani M et al (1999) Genetic polymorphism in the 50-flanking region of human CYP1A2 gene: Effect on the CYP1A2 inducibility in humans. J Biochem 125(4):803-808
    • (1999) J Biochem , vol.125 , Issue.4 , pp. 803-808
    • Nakajima, M.1    Yokoi, T.2    Mizutani, M.3
  • 26
    • 0034790063 scopus 로고    scopus 로고
    • Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6
    • Zanger UM, Fischer J, Raimundo S et al (2001) Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6. Pharmacogenetics 11(7):573-585
    • (2001) Pharmacogenetics , vol.11 , Issue.7 , pp. 573-585
    • Zanger, U.M.1    Fischer, J.2    Raimundo, S.3
  • 27
    • 0032547341 scopus 로고    scopus 로고
    • Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    • Rebbeck TR, Jaffe JM, Walker AH et al (1998) Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J Natl Cancer Inst 90(16):1225-1229
    • (1998) J Natl Cancer Inst , vol.90 , Issue.16 , pp. 1225-1229
    • Rebbeck, T.R.1    Jaffe, J.M.2    Walker, A.H.3
  • 28
    • 0028867826 scopus 로고
    • The genetic basis of the reduced expression of bilirubin UDPglucuronosyltransferase 1 in Gilbert?s syndrome
    • doi:10.1056/NEJM199511023331802
    • Bosma PJ, Chowdhury JR, Bakker C et al (1995) The genetic basis of the reduced expression of bilirubin UDPglucuronosyltransferase 1 in Gilbert?s syndrome. N Engl J Med 333(18):1171-1175. doi:10.1056/NEJM199511023331802
    • (1995) N Engl J Med , vol.333 , Issue.18 , pp. 1171-1175
    • Bosma, P.J.1    Chowdhury, J.R.2    Bakker, C.3
  • 29
    • 0033841077 scopus 로고    scopus 로고
    • Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene
    • Raijmakers MT, Jansen PL, Steegers EA et al (2000) Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene. J Hepatol 33(3):348-351
    • (2000) J Hepatol , vol.33 , Issue.3 , pp. 348-351
    • Raijmakers, M.T.1    Jansen, P.L.2    Steegers, E.A.3
  • 30
    • 0032791711 scopus 로고    scopus 로고
    • Expression and inducibility of the human bilirubin UDPglucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: Evidence for both genetic and environmental influences
    • doi:10. 1002/hep.510300205
    • Ritter JK, Kessler FK, Thompson MT et al (1999) Expression and inducibility of the human bilirubin UDPglucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: Evidence for both genetic and environmental influences. Hepatology 30(2):476-484. doi:10. 1002/hep.510300205
    • (1999) Hepatology , vol.30 , Issue.2 , pp. 476-484
    • Ritter, J.K.1    Kessler, F.K.2    Thompson, M.T.3
  • 31
    • 17844410900 scopus 로고    scopus 로고
    • Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene
    • doi:10.1124/mol.104.007146
    • Lankisch TO, Vogel A, Eilermann S et al (2005) Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. Mol Pharmacol 67(5):1732-1739. doi:10.1124/mol.104.007146
    • (2005) Mol Pharmacol , vol.67 , Issue.5 , pp. 1732-1739
    • Lankisch, T.O.1    Vogel, A.2    Eilermann, S.3
  • 32
    • 0031949132 scopus 로고    scopus 로고
    • 10-Hydroxylation of nortriptyline in white persons with 0,1,2, 3, and 13 functional CYP2D6 genes
    • doi:10.1016/S0009-9236 (98 90040-6
    • Dalen P, Dahl ML, Bernal Ruiz ML et al (1998) 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharmacol Ther 63(4):444-452. doi:10.1016/S0009-9236 (98)90040-6
    • (1998) Clin Pharmacol Ther , vol.63 , Issue.4 , pp. 444-452
    • Dalen, P.1    Dahl, M.L.2    Bernal Ruiz, M.L.3
  • 33
    • 11144221180 scopus 로고    scopus 로고
    • Codeine intoxication associated with ultrarapid CYP2D6 metabolism
    • doi:10.1056/NEJMoa041888
    • Gasche Y, Daali Y, Fathi M et al (2004) Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med 351(27):2827-2831. doi:10.1056/NEJMoa041888
    • (2004) N Engl J Med , vol.351 , Issue.27 , pp. 2827-2831
    • Gasche, Y.1    Daali, Y.2    Fathi, M.3
  • 34
    • 73549100850 scopus 로고    scopus 로고
    • CYP2D7-2D6 hybrid tandems: Identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction
    • doi:10. 2217/pgs.09.133
    • Gaedigk A, Fuhr U, Johnson C et al (2010) CYP2D7-2D6 hybrid tandems: Identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction. Pharmacogenomics 11(1):43-53. doi:10. 2217/pgs.09.133
    • (2010) Pharmacogenomics , vol.11 , Issue.1 , pp. 43-53
    • Gaedigk, A.1    Fuhr, U.2    Johnson, C.3
  • 35
    • 0032751791 scopus 로고    scopus 로고
    • Detection of three genetic polymorphisms in the 50-flanking region and intron 1 of human CYP1A2 in the Japanese population
    • Chida M, Yokoi T, Fukui T et al (1999) Detection of three genetic polymorphisms in the 50-flanking region and intron 1 of human CYP1A2 in the Japanese population. Jpn J Cancer Res 90(9):899-902
    • (1999) Jpn J Cancer Res , vol.90 , Issue.9 , pp. 899-902
    • Chida, M.1    Yokoi, T.2    Fukui, T.3
  • 36
    • 0032908778 scopus 로고    scopus 로고
    • Functional significance of a C ! A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
    • Sachse C, Brockmoller J, Bauer S et al (1999) Functional significance of a C ! A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol 47(4):445-449
    • (1999) Br J Clin Pharmacol , vol.47 , Issue.4 , pp. 445-449
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3
  • 37
    • 0031737607 scopus 로고    scopus 로고
    • A genetic polymorphism in the regulatory sequences of human CYP2E1: Association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake
    • doi:10.1006/taap.1998. 8532
    • McCarver DG, Byun R, Hines RN et al (1998) A genetic polymorphism in the regulatory sequences of human CYP2E1: Association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake. Toxicol Appl Pharmacol 152(1):276-281. doi:10.1006/taap.1998. 8532
    • (1998) Toxicol Appl Pharmacol , vol.152 , Issue.1 , pp. 276-281
    • McCarver, D.G.1    Byun, R.2    Hines, R.N.3
  • 38
    • 23444432323 scopus 로고    scopus 로고
    • CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A71C allele
    • Sim SC, Edwards RJ, Boobis AR et al (2005) CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A71C allele. Pharmacogenet Genomics 15(9):625-631
    • (2005) Pharmacogenet Genomics , vol.15 , Issue.9 , pp. 625-631
    • Sim, S.C.1    Edwards, R.J.2    Boobis, A.R.3
  • 39
    • 30344457586 scopus 로고    scopus 로고
    • A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
    • doi:10.1016/j.clpt.2005. 10.002
    • Sim SC, Risinger C, Dahl ML et al (2006) A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin Pharmacol Ther 79(1):103-113. doi:10.1016/j.clpt.2005. 10.002
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.1 , pp. 103-113
    • Sim, S.C.1    Risinger, C.2    Dahl, M.L.3
  • 40
    • 77955061641 scopus 로고    scopus 로고
    • Pharmacogenetics and human genetic polymorphisms
    • doi:10.1042/BJ20100522
    • Daly AK (2010) Pharmacogenetics and human genetic polymorphisms. Biochem J 429(3):435-449. doi:10.1042/BJ20100522
    • (2010) Biochem J , vol.429 , Issue.3 , pp. 435-449
    • Daly, A.K.1
  • 41
    • 27544486754 scopus 로고    scopus 로고
    • Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles
    • doi:10.1016/j.bbrc. 2005.09.020
    • Rodriguez-Antona C, Sayi JG, Gustafsson LL et al (2005) Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles. Biochem Biophys Res Commun 338(1):299-305. doi:10.1016/j.bbrc. 2005.09.020
    • (2005) Biochem Biophys Res Commun , vol.338 , Issue.1 , pp. 299-305
    • Rodriguez-Antona, C.1    Sayi, J.G.2    Gustafsson, L.L.3
  • 42
    • 0347359079 scopus 로고    scopus 로고
    • Increased transcriptional activity of the CYP3A41B promoter variant
    • doi:10. 1002/em.10199
    • Amirimani B, Ning B, Deitz AC et al (2003) Increased transcriptional activity of the CYP3A41B promoter variant. Environ Mol Mutagen 42(4):299-305. doi:10. 1002/em.10199
    • (2003) Environ Mol Mutagen , vol.42 , Issue.4 , pp. 299-305
    • Amirimani, B.1    Ning, B.2    Deitz, A.C.3
  • 43
    • 0036219998 scopus 로고    scopus 로고
    • Common allelic variants of cytochrome P4503A4 and their prevalence in different populations
    • Lamba JK, Lin YS, Thummel K et al (2002) Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics 12(2):121-132
    • (2002) Pharmacogenetics , vol.12 , Issue.2 , pp. 121-132
    • Lamba, J.K.1    Lin, Y.S.2    Thummel, K.3
  • 44
    • 0345643389 scopus 로고    scopus 로고
    • Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 50-upstream regulatory region
    • doi:10.1006/bbrc.1999. 0752
    • Westlind A, Lofberg L, Tindberg N et al (1999) Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 50-upstream regulatory region. Biochem Biophys Res Commun 259(1):201-205. doi:10.1006/bbrc.1999. 0752
    • (1999) Biochem Biophys Res Commun , vol.259 , Issue.1 , pp. 201-205
    • Westlind, A.1    Lofberg, L.2    Tindberg, N.3
  • 45
    • 0032693405 scopus 로고    scopus 로고
    • Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: Mechanism for TPMT protein deficiency inherited by TPMT2, TPMT3A, TPMT3B or TPMT3C
    • Tai HL, Fessing MY, Bonten EJ et al (1999) Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: Mechanism for TPMT protein deficiency inherited by TPMT2, TPMT3A, TPMT3B or TPMT3C. Pharmacogenetics 9(5):641-650
    • (1999) Pharmacogenetics , vol.9 , Issue.5 , pp. 641-650
    • Tai, H.L.1    Fessing, M.Y.2    Bonten, E.J.3
  • 46
    • 0029736709 scopus 로고    scopus 로고
    • Genetic polymorphism of thiopurine Smethyltransferase: Clinical importance and molecular mechanisms
    • Krynetski EY, Tai HL, Yates CR et al (1996) Genetic polymorphism of thiopurine Smethyltransferase: Clinical importance and molecular mechanisms. Pharmacogenetics 6(4):279-290
    • (1996) Pharmacogenetics , vol.6 , Issue.4 , pp. 279-290
    • Krynetski, E.Y.1    Tai, H.L.2    Yates, C.R.3
  • 47
    • 0027965620 scopus 로고
    • Genetic analysis of the Chinese cytochrome P4502D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
    • Johansson I, Oscarson M, Yue QY et al (1994) Genetic analysis of the Chinese cytochrome P4502D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol 46(3):452-459
    • (1994) Mol Pharmacol , vol.46 , Issue.3 , pp. 452-459
    • Johansson, I.1    Oscarson, M.2    Yue, Q.Y.3
  • 48
    • 40949103607 scopus 로고    scopus 로고
    • Pharmacogenetics of the constitutive androstane receptor
    • doi:10.2217/14622416.9.1.71
    • Lamba JK (2008) Pharmacogenetics of the constitutive androstane receptor. Pharmacogenomics 9(1):71-83. doi:10.2217/14622416.9.1.71
    • (2008) Pharmacogenomics , vol.9 , Issue.1 , pp. 71-83
    • Lamba, J.K.1
  • 49
    • 20644435582 scopus 로고    scopus 로고
    • Polymorphisms of human nuclear receptors that control expression of drug-metabolizing enzymes
    • Okey AB, Boutros PC, Harper PA (2005) Polymorphisms of human nuclear receptors that control expression of drug-metabolizing enzymes. Pharmacogenet Genomics 15(6):371-379
    • (2005) Pharmacogenet Genomics , vol.15 , Issue.6 , pp. 371-379
    • Okey, A.B.1    Boutros, P.C.2    Harper, P.A.3
  • 50
    • 61549104490 scopus 로고    scopus 로고
    • PXR: A xenobiotic receptor of diverse function implicated in pharmacogenetics
    • doi:10.2217/14622416.9.11.1695
    • Zhang B, Xie W, Krasowski MD (2008) PXR: A xenobiotic receptor of diverse function implicated in pharmacogenetics. Pharmacogenomics 9(11):1695-1709. doi:10.2217/14622416.9.11.1695
    • (2008) Pharmacogenomics , vol.9 , Issue.11 , pp. 1695-1709
    • Zhang, B.1    Xie, W.2    Krasowski, M.D.3
  • 51
    • 79955579254 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    • doi:10. 1371/journal.pgen.1002033
    • Cornelis MC, Monda KL, Yu K et al (2011) Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet 7(4):e1002033. doi:10. 1371/journal.pgen. 1002033
    • (2011) PLoS Genet , vol.7 , Issue.4
    • Cornelis, M.C.1    Monda, K.L.2    Yu, K.3
  • 52
    • 84865334258 scopus 로고    scopus 로고
    • Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption
    • doi:10. 3945/ajcn.112.038794
    • Josse AR, Da Costa LA, Campos H et al (2012) Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption. Am J Clin Nutr 96(3):665-671. doi:10. 3945/ajcn.112.038794
    • (2012) Am J Clin Nutr , vol.96 , Issue.3 , pp. 665-671
    • Josse, A.R.1    Da Costa, L.A.2    Campos, H.3
  • 53
    • 23144450525 scopus 로고    scopus 로고
    • Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population
    • Ikeda S, Kurose K, Ozawa S et al (2003) Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population. Drug Metab Pharmacokinet 18(6):413-418
    • (2003) Drug Metab Pharmacokinet , vol.18 , Issue.6 , pp. 413-418
    • Ikeda, S.1    Kurose, K.2    Ozawa, S.3
  • 54
    • 26244454187 scopus 로고    scopus 로고
    • Functional analysis of four naturally occurring variants of human constitutive androstane receptor
    • doi:10.1016/j.ymgme. 2005.05.011
    • Ikeda S, Kurose K, Jinno Het al (2005) Functional analysis of four naturally occurring variants of human constitutive androstane receptor. Mol Genet Metab 86(1-2):314-319. doi:10.1016/j.ymgme. 2005.05.011
    • (2005) Mol Genet Metab , vol.86 , Issue.1-2 , pp. 314-319
    • Ikeda, S.1    Kurose, K.2    Jinno, H.3
  • 55
    • 0038128342 scopus 로고    scopus 로고
    • Constitutive androstane receptor and pregnane X receptor gene expression in human liver: Interindividual variability and correlation with CYP2B6 mRNA levels
    • Chang TK, Bandiera SM, Chen J (2003) Constitutive androstane receptor and pregnane X receptor gene expression in human liver: Interindividual variability and correlation with CYP2B6 mRNA levels. Drug Metabol Dispos 31(1):7-10
    • (2003) Drug Metabol Dispos , vol.31 , Issue.1 , pp. 7-10
    • Chang, T.K.1    Bandiera, S.M.2    Chen, J.3
  • 56
    • 10744221053 scopus 로고    scopus 로고
    • Hepatic CYP2B6 expression: Gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression
    • doi:10.1124/jpet.103. 054866
    • Lamba V, Lamba J, Yasuda K et al (2003) Hepatic CYP2B6 expression: Gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther 307(3):906-922. doi:10.1124/jpet.103. 054866
    • (2003) J Pharmacol Exp Ther , vol.307 , Issue.3 , pp. 906-922
    • Lamba, V.1    Lamba, J.2    Yasuda, K.3
  • 57
    • 80051685348 scopus 로고    scopus 로고
    • Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens
    • doi:10.1093/jac/dkr272
    • Wyen C, Hendra H, Siccardi M et al (2011) Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens. J Antimicrob Chemother 66(9):2092-2098. doi:10.1093/jac/dkr272
    • (2011) J Antimicrob Chemother , vol.66 , Issue.9 , pp. 2092-2098
    • Wyen, C.1    Hendra, H.2    Siccardi, M.3
  • 58
    • 23144435169 scopus 로고    scopus 로고
    • Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics
    • Lamba J, Lamba V, Schuetz E (2005) Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics. Curr Drug Metab 6(4):369-383
    • (2005) Curr Drug Metab , vol.6 , Issue.4 , pp. 369-383
    • Lamba, J.1    Lamba, V.2    Schuetz, E.3
  • 59
    • 10744221611 scopus 로고    scopus 로고
    • Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver
    • doi:10.1124/mol.65.3.496
    • Jinno H, Tanaka-Kagawa T, Hanioka N et al (2004) Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver. Mol Pharmacol 65(3):496-502. doi:10.1124/mol.65.3.496
    • (2004) Mol Pharmacol , vol.65 , Issue.3 , pp. 496-502
    • Jinno, H.1    Tanaka-Kagawa, T.2    Hanioka, N.3
  • 60
    • 27544477927 scopus 로고    scopus 로고
    • Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3)
    • doi:10.1124/mol.105. 013417
    • Auerbach SS, Stoner MA, Su S et al (2005) Retinoid X receptor-alpha- dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). Mol Pharmacol 68(5):1239-1253. doi:10.1124/mol.105. 013417
    • (2005) Mol Pharmacol , vol.68 , Issue.5 , pp. 1239-1253
    • Auerbach, S.S.1    Stoner, M.A.2    Su, S.3
  • 61
    • 79953107915 scopus 로고    scopus 로고
    • Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor
    • doi:10.1093/toxsci/kfq394
    • DeKeyser JG, Laurenzana EM, Peterson EC et al (2011) Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor. Toxicol Sci 120(2):381-391. doi:10.1093/toxsci/kfq394
    • (2011) Toxicol Sci , vol.120 , Issue.2 , pp. 381-391
    • Dekeyser, J.G.1    Laurenzana, E.M.2    Peterson, E.C.3
  • 62
    • 78650210692 scopus 로고    scopus 로고
    • Nuclear receptor-mediated induction of CYP450 by antiretrovirals: Functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans
    • doi:10.1097/QAI. 0b013e3181f52f0c
    • Svard J, Spiers JP, Mulcahy F et al (2010) Nuclear receptor-mediated induction of CYP450 by antiretrovirals: Functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans. J Acquir Immune Defic Syndr 55(5):536-549. doi:10.1097/QAI. 0b013e3181f52f0c
    • (2010) J Acquir Immune Defic Syndr , vol.55 , Issue.5 , pp. 536-549
    • Svard, J.1    Spiers, J.P.2    Mulcahy, F.3
  • 63
    • 78650737749 scopus 로고    scopus 로고
    • Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin
    • doi:10.1124/dmd.110. 035246
    • Chung JY, Cho JY, Lim HS et al (2011) Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin. Drug Metabol Dispos 39(1):92-97. doi:10.1124/dmd.110. 035246
    • (2011) Drug Metabol Dispos , vol.39 , Issue.1 , pp. 92-97
    • Chung, J.Y.1    Cho, J.Y.2    Lim, H.S.3
  • 64
    • 53349160769 scopus 로고    scopus 로고
    • Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C ! T) with reduced concentrations of unboosted atazanavir
    • doi:10.1086/592304
    • Siccardi M, D?Avolio A, Baietto L et al (2008) Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C ! T) with reduced concentrations of unboosted atazanavir. Clin Infect Dis 47(9):1222-1225. doi:10.1086/592304
    • (2008) Clin Infect Dis , vol.47 , Issue.9 , pp. 1222-1225
    • Siccardi, M.1    Davolio, A.2    Baietto, L.3
  • 65
    • 0346251165 scopus 로고    scopus 로고
    • Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter
    • doi:10.1007/s10038-003-0076-5
    • Uno Y, Sakamoto Y, Yoshida K et al (2003) Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter. J Hum Genet 48(11):594-597. doi:10.1007/s10038-003-0076-5
    • (2003) J Hum Genet , vol.48 , Issue.11 , pp. 594-597
    • Uno, Y.1    Sakamoto, Y.2    Yoshida, K.3
  • 66
    • 66649086262 scopus 로고    scopus 로고
    • The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation
    • doi:10.1124/dmd.108. 025213
    • Lin YS, Yasuda K, Assem M et al (2009) The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. Drug Metabol Dispos 37(6):1295-1304. doi:10.1124/dmd.108. 025213
    • (2009) Drug Metabol Dispos , vol.37 , Issue.6 , pp. 1295-1304
    • Lin, Y.S.1    Yasuda, K.2    Assem, M.3
  • 67
    • 0034921210 scopus 로고    scopus 로고
    • Identification and functional characterization of a new CYP2C9 variant (CYP2C95) expressed among African Americans
    • Dickmann LJ, Rettie AE, Kneller MB et al (2001) Identification and functional characterization of a new CYP2C9 variant (CYP2C95) expressed among African Americans. Mol Pharmacol 60(2):382-387
    • (2001) Mol Pharmacol , vol.60 , Issue.2 , pp. 382-387
    • Dickmann, L.J.1    Rettie, A.E.2    Kneller, M.B.3
  • 68
    • 0028275147 scopus 로고
    • Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase
    • Farres J, Wang X, Takahashi K et al (1994) Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem 269(19):13854-13860
    • (1994) J Biol Chem , vol.269 , Issue.19 , pp. 13854-13860
    • Farres, J.1    Wang, X.2    Takahashi, K.3
  • 69
    • 0034617452 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; In vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse
    • Kitagawa K, Kawamoto T, Kunugita N et al (2000) Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett 476(3):306-311
    • (2000) FEBS Lett , vol.476 , Issue.3 , pp. 306-311
    • Kitagawa, K.1    Kawamoto, T.2    Kunugita, N.3
  • 70
    • 0032844187 scopus 로고    scopus 로고
    • Olanzapine. Pharmacokinetic and pharmacodynamic profile
    • Callaghan JT, Bergstrom RF, Ptak LR et al (1999) Olanzapine. Pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet 37(3):177-193
    • (1999) Clin Pharmacokinet , vol.37 , Issue.3 , pp. 177-193
    • Callaghan, J.T.1    Bergstrom, R.F.2    Ptak, L.R.3
  • 71
    • 0031030609 scopus 로고    scopus 로고
    • Disposition and biotransformation of the antipsychotic agent olanzapine in humans
    • Kassahun K, Mattiuz E, Nyhart E Jr et al (1997) Disposition and biotransformation of the antipsychotic agent olanzapine in humans. Drug Metabol Dispos 25(1):81-93
    • (1997) Drug Metabol Dispos , vol.25 , Issue.1 , pp. 81-93
    • Kassahun, K.1    Mattiuz, E.2    Nyhart Jr., E.3
  • 72
    • 84864138748 scopus 로고    scopus 로고
    • UGT1A43 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems
    • doi:10.1038/clpt.2012.46
    • Haslemo T, Loryan I, Ueda N et al (2012) UGT1A43 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems. Clin Pharmacol Ther 92(2):221-227. doi:10.1038/clpt. 2012.46
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.2 , pp. 221-227
    • Haslemo, T.1    Loryan, I.2    Ueda, N.3
  • 73
    • 33646183072 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites
    • doi:10. 1016/j.clpt.2006.01.009
    • Lalovic B, Kharasch E, Hoffer C et al (2006) Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites. Clin Pharmacol Ther 79(5):461-479. doi:10. 1016/j.clpt.2006.01.009
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.5 , pp. 461-479
    • Lalovic, B.1    Kharasch, E.2    Hoffer, C.3
  • 74
    • 77952808783 scopus 로고    scopus 로고
    • The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone
    • doi:10.1111/j.1476-5381.2010.00673.x
    • Samer CF, Daali Y, Wagner M et al (2010) The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone. Br J Pharmacol 160(4):907-918. doi:10.1111/j.1476-5381.2010.00673.x
    • (2010) Br J Pharmacol , vol.160 , Issue.4 , pp. 907-918
    • Samer, C.F.1    Daali, Y.2    Wagner, M.3
  • 75
    • 84857761731 scopus 로고    scopus 로고
    • Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: Implications in the clinical trials for novel drug development
    • Kurose K, Sugiyama E, Saito Y (2012) Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: Implications in the clinical trials for novel drug development. Drug Metab Pharmacokinet 27(1):9-54
    • (2012) Drug Metab Pharmacokinet , vol.27 , Issue.1 , pp. 9-54
    • Kurose, K.1    Sugiyama, E.2    Saito, Y.3
  • 76
    • 84857273073 scopus 로고    scopus 로고
    • Cytochrome P450 variations in different ethnic populations
    • doi:10.1517/17425255. 2012.657626
    • McGraw J, Waller D (2012) Cytochrome P450 variations in different ethnic populations. Expert Opin Drug Metab Toxicol 8(3):371-382. doi:10.1517/17425255. 2012.657626
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , Issue.3 , pp. 371-382
    • McGraw, J.1    Waller, D.2
  • 77
    • 6344285930 scopus 로고    scopus 로고
    • Genetic variation in eleven phase i drug metabolism genes in an ethnically diverse population
    • doi:10.1517/14622416.5.7. 895
    • Solus JF, Arietta BJ, Harris JR et al (2004) Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics 5(7):895-931. doi:10.1517/14622416.5.7. 895
    • (2004) Pharmacogenomics , vol.5 , Issue.7 , pp. 895-931
    • Solus, J.F.1    Arietta, B.J.2    Harris, J.R.3
  • 78
    • 54949144309 scopus 로고    scopus 로고
    • Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
    • doi:10.1007/s00216-008-2291-6
    • Zanger UM, Turpeinen M, Klein K et al (2008) Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Anal Bioanal Chem 392(6):1093-1108. doi:10.1007/s00216-008- 2291-6
    • (2008) Anal Bioanal Chem , vol.392 , Issue.6 , pp. 1093-1108
    • Zanger, U.M.1    Turpeinen, M.2    Klein, K.3
  • 79
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV (1999) Pharmacogenomics: Translating functional genomics into rational therapeutics. Science 286(5439):487-491
    • (1999) Science , vol.286 , Issue.5439 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 80
    • 2642570170 scopus 로고    scopus 로고
    • Moving towards individualized medicine with pharmacogenomics
    • doi:10.1038/nature02626
    • Evans WE, Relling MV (2004) Moving towards individualized medicine with pharmacogenomics. Nature 429(6990):464-468. doi:10.1038/nature02626
    • (2004) Nature , vol.429 , Issue.6990 , pp. 464-468
    • Evans, W.E.1    Relling, M.V.2
  • 81
    • 0022397321 scopus 로고
    • Polymorphic metabolism of metoprolol: Clinical studies
    • Silas JH, McGourty JC, Lennard MS et al (1985) Polymorphic metabolism of metoprolol: Clinical studies. Eur J Clin Pharmacol 28(Suppl):85-88
    • (1985) Eur J Clin Pharmacol , vol.28 , Issue.SUPPL. , pp. 85-88
    • Silas, J.H.1    McGourty, J.C.2    Lennard, M.S.3
  • 83
    • 0031668683 scopus 로고    scopus 로고
    • Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes
    • doi:10.1016/S0009-9236(98)90069-8
    • Yue QY, Zhong ZH, Tybring G et al (1998) Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes. Clin Pharmacol Ther 64(4):384-390. doi:10.1016/S0009-9236(98) 90069-8
    • (1998) Clin Pharmacol Ther , vol.64 , Issue.4 , pp. 384-390
    • Yue, Q.Y.1    Zh, Z.2    Tybring, G.3
  • 84
    • 33645113878 scopus 로고    scopus 로고
    • The relevance of CYP2D6 genetic polymorphism on chronic metoprolol therapy in cardiovascular patients
    • doi:10. 1111/j.1365-2710.2006.00699.x
    • Ismail R, Teh LK (2006) The relevance of CYP2D6 genetic polymorphism on chronic metoprolol therapy in cardiovascular patients. J Clin Pharm Ther 31(1):99-109. doi:10. 1111/j.1365-2710.2006.00699.x
    • (2006) J Clin Pharm Ther , vol.31 , Issue.1 , pp. 99-109
    • Ismail, R.1    Teh, L.K.2
  • 85
    • 0013499111 scopus 로고    scopus 로고
    • Disposition and metabolic fate of atomoxetine hydrochloride: The role of CYP2D6 in human disposition and metabolism
    • Sauer JM, Ponsler GD, Mattiuz EL et al (2003) Disposition and metabolic fate of atomoxetine hydrochloride: The role of CYP2D6 in human disposition and metabolism. Drug Metabol Dispos 31(1):98-107
    • (2003) Drug Metabol Dispos , vol.31 , Issue.1 , pp. 98-107
    • Sauer, J.M.1    Ponsler, G.D.2    Mattiuz, E.L.3
  • 86
    • 84876665512 scopus 로고    scopus 로고
    • Clinical pharmacogenetics implementation consortium guideline for cyp2d6 and cyp2c19 genotypes and dosing of tricyclic antidepressants
    • doi:10.1038/clpt.2013.2
    • Hicks JK, Swen JJ, Thorn CF et al (2013) Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants. Clin Pharmacol Ther 93:402-408. doi:10.1038/clpt.2013.2
    • (2013) Clin Pharmacol Ther , vol.93 , pp. 402-408
    • Hicks, J.K.1    Swen, J.J.2    Thorn, C.F.3
  • 87
    • 70349386728 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part II
    • doi:10.2165/11318070-000000000-00000
    • Zhou SF (2009) Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part II. Clin Pharmacokinet 48(12):761-804. doi:10.2165/11318070- 000000000-00000
    • (2009) Clin Pharmacokinet , vol.48 , Issue.12 , pp. 761-804
    • Zhou, S.F.1
  • 88
    • 0036929584 scopus 로고    scopus 로고
    • Safety profile of atomoxetine in the treatment of children and adolescents with ADHD
    • Wernicke JF, Kratochvil CJ (2002) Safety profile of atomoxetine in the treatment of children and adolescents with ADHD. J Clin Psychiatry 63(Suppl 12):50-55
    • (2002) J Clin Psychiatry , vol.63 , Issue.SUPPL. 12 , pp. 50-55
    • Wernicke, J.F.1    Kratochvil, C.J.2
  • 89
    • 84855968708 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype
    • doi:10.1038/clpt.2011.287
    • Crews KR, Gaedigk A, Dunnenberger HM et al (2012) Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clin Pharmacol Ther 91(2):321-326. doi:10.1038/clpt.2011.287
    • (2012) Clin Pharmacol Ther , vol.91 , Issue.2 , pp. 321-326
    • Crews, K.R.1    Gaedigk, A.2    Dunnenberger, H.M.3
  • 90
    • 34547644659 scopus 로고    scopus 로고
    • Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
    • doi:10.1038/sj. tpj.6500406
    • Kirchheiner J, Schmidt H, Tzvetkov M et al (2007) Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J 7(4):257-265. doi:10.1038/sj. tpj.6500406
    • (2007) Pharmacogenomics J , vol.7 , Issue.4 , pp. 257-265
    • Kirchheiner, J.1    Schmidt, H.2    Tzvetkov, M.3
  • 91
    • 0031836669 scopus 로고    scopus 로고
    • Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine
    • doi:10.1016/S0009-9236(98)90104-7
    • Brynne N, Dalen P, Alvan G et al (1998) Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine. Clin Pharmacol Ther 63(5):529-539. doi:10.1016/S0009-9236(98)90104-7
    • (1998) Clin Pharmacol Ther , vol.63 , Issue.5 , pp. 529-539
    • Brynne, N.1    Dalen, P.2    Alvan, G.3
  • 92
    • 0035018421 scopus 로고    scopus 로고
    • Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers
    • Eap CB, Bondolfi G, Zullino D et al (2001) Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers. J Clin Psychopharmacol 21(3):330-334
    • (2001) J Clin Psychopharmacol , vol.21 , Issue.3 , pp. 330-334
    • Eap, C.B.1    Bondolfi, G.2    Zullino, D.3
  • 93
    • 0034901683 scopus 로고    scopus 로고
    • Influence of CYP2D6 genotype and medication on the sparteine metabolic ratio of psychiatric patients
    • Lohmann PL, Rao ML, Ludwig M et al (2001) Influence of CYP2D6 genotype and medication on the sparteine metabolic ratio of psychiatric patients. Eur J Clin Pharmacol 57(4):289-295
    • (2001) Eur J Clin Pharmacol , vol.57 , Issue.4 , pp. 289-295
    • Lohmann, P.L.1    Rao, M.L.2    Ludwig, M.3
  • 94
    • 0026606822 scopus 로고
    • The relationship between paroxetine and the sparteine oxidation polymorphism
    • Sindrup SH, Brosen K, Gram LF et al (1992) The relationship between paroxetine and the sparteine oxidation polymorphism. Clin Pharmacol Ther 51(3):278-287
    • (1992) Clin Pharmacol Ther , vol.51 , Issue.3 , pp. 278-287
    • Sindrup, S.H.1    Brosen, K.2    Gram, L.F.3
  • 95
    • 0034792584 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
    • Goldstein JA (2001) Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol 52(4):349-355
    • (2001) Br J Clin Pharmacol , vol.52 , Issue.4 , pp. 349-355
    • Goldstein, J.A.1
  • 96
    • 25644459349 scopus 로고    scopus 로고
    • Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitorbased therapies
    • Furuta T, Shirai N, Sugimoto M et al (2005) Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitorbased therapies. Drug Metab Pharmacokinet 20(3):153-167
    • (2005) Drug Metab Pharmacokinet , vol.20 , Issue.3 , pp. 153-167
    • Furuta, T.1    Shirai, N.2    Sugimoto, M.3
  • 97
    • 0000140377 scopus 로고    scopus 로고
    • Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer
    • Furuta T, Ohashi K, Kamata T et al (1998) Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med 129(12):1027-1030
    • (1998) Ann Intern Med , vol.129 , Issue.12 , pp. 1027-1030
    • Furuta, T.1    Ohashi, K.2    Kamata, T.3
  • 98
    • 0029842851 scopus 로고    scopus 로고
    • The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype
    • Wan J, Xia H, He N et al (1996) The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype. Br J Clin Pharmacol 42(4):471-474
    • (1996) Br J Clin Pharmacol , vol.42 , Issue.4 , pp. 471-474
    • Wan, J.1    Xia, H.2    He, N.3
  • 99
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • doi:10.1038/sj.mp.4001494
    • Kirchheiner J, Nickchen K, Bauer M et al (2004) Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response. Mol Psychiatry 9(5):442-473. doi:10.1038/sj.mp.4001494
    • (2004) Mol Psychiatry , vol.9 , Issue.5 , pp. 442-473
    • Kirchheiner, J.1    Nickchen, K.2    Bauer, M.3
  • 100
    • 71849088050 scopus 로고    scopus 로고
    • Pharmacogenetics of antimalarial drugs: Effect on metabolism and transport
    • doi:10.1016/S1473-3099 (09 70320-2
    • Kerb R, Fux R, Morike K et al (2009) Pharmacogenetics of antimalarial drugs: Effect on metabolism and transport. Lancet Infect Dis 9(12):760-774. doi:10.1016/S1473-3099 (09)70320-2
    • (2009) Lancet Infect Dis , vol.9 , Issue.12 , pp. 760-774
    • Kerb, R.1    Fux, R.2    Morike, K.3
  • 101
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • doi:10.1056/NEJMoa0809171
    • Mega JL, Close SL, Wiviott SD et al (2009) Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med 360(4):354-362. doi:10.1056/ NEJMoa0809171
    • (2009) N Engl J Med , vol.360 , Issue.4 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 102
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • doi:10.1001/jama. 2009.1232
    • Shuldiner AR, O?Connell JR, Bliden KP et al (2009) Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 302(8):849-857. doi:10.1001/jama. 2009.1232
    • (2009) JAMA , vol.302 , Issue.8 , pp. 849-857
    • Shuldiner, A.R.1    Oconnell, J.R.2    Bliden, K.P.3
  • 103
    • 84877992788 scopus 로고    scopus 로고
    • Regulatory polymorphisms in CYP2C19 affecting hepatic expression
    • doi:10.1515/dmdi-2012-0038
    • Sanford JC, Guo Y, Sadee W et al (2013) Regulatory polymorphisms in CYP2C19 affecting hepatic expression. Drug Metabol Drug Interact 28(1):23-30. doi:10.1515/dmdi-2012-0038
    • (2013) Drug Metabol Drug Interact , vol.28 , Issue.1 , pp. 23-30
    • Sanford, J.C.1    Guo, Y.2    Sadee, W.3
  • 104
    • 84863082704 scopus 로고    scopus 로고
    • The gainof-function variant allele CYP2C1917: A double-edged sword between thrombosis and bleeding in clopidogrel-treated patients
    • doi:10.1111/j.1538-7836.2011.04570.x
    • Li Y, Tang HL, Hu YF et al (2012) The gainof-function variant allele CYP2C1917: A double-edged sword between thrombosis and bleeding in clopidogrel-treated patients. JTH 10(2):199-206. doi:10.1111/j.1538-7836.2011. 04570.x
    • (2012) JTH , vol.10 , Issue.2 , pp. 199-206
    • Li, Y.1    Tang, H.L.2    Hu, Y.F.3
  • 105
    • 84883170442 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy: 2013 update
    • doi:10.1038/clpt.2013.105
    • Scott SA, Sangkuhl K, Stein CM et al (2013) Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy: 2013 update. Clin Pharmacol Ther 94:317-323. doi:10.1038/clpt.2013.105
    • (2013) Clin Pharmacol Ther , vol.94 , pp. 317-323
    • Scott, S.A.1    Sangkuhl, K.2    Stein, C.M.3
  • 106
    • 0036914221 scopus 로고    scopus 로고
    • Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance
    • doi:10.1067/mcp. 2002.129321
    • Scordo MG, Pengo V, Spina E et al (2002) Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther 72(6):702-710. doi:10.1067/mcp. 2002.129321
    • (2002) Clin Pharmacol Ther , vol.72 , Issue.6 , pp. 702-710
    • Scordo, M.G.1    Pengo, V.2    Spina, E.3
  • 107
    • 60849097257 scopus 로고    scopus 로고
    • Estimation of the warfarin dose with clinical and pharmacogenetic data
    • doi:10.1056/NEJMoa0809329
    • Klein TE, Altman RB, Eriksson N et al (2009) Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med 360(8):753-764. doi:10.1056/NEJMoa0809329
    • (2009) N Engl J Med , vol.360 , Issue.8 , pp. 753-764
    • Klein, T.E.1    Altman, R.B.2    Eriksson, N.3
  • 108
    • 19144373497 scopus 로고    scopus 로고
    • CYP2C9 haplotype structure in European American warfarin patients and association with clinical outcomes
    • doi:10.1016/j.clpt. 2005.01.019
    • Veenstra DL, Blough DK, Higashi MK et al (2005) CYP2C9 haplotype structure in European American warfarin patients and association with clinical outcomes. Clin Pharmacol Ther 77(5):353-364. doi:10.1016/j.clpt. 2005.01.019
    • (2005) Clin Pharmacol Ther , vol.77 , Issue.5 , pp. 353-364
    • Veenstra, D.L.1    Blough, D.K.2    Higashi, M.K.3
  • 109
    • 0037012465 scopus 로고    scopus 로고
    • Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy
    • Higashi MK, Veenstra DL, Kondo LM et al (2002) Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA 287(13):1690-1698
    • (2002) JAMA , vol.287 , Issue.13 , pp. 1690-1698
    • Higashi, M.K.1    Veenstra, D.L.2    Kondo, L.M.3
  • 110
    • 0032819729 scopus 로고    scopus 로고
    • Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin
    • Aynacioglu AS, Brockmoller J, Bauer S et al (1999) Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin. Br J Clin Pharmacol 48(3):409-415
    • (1999) Br J Clin Pharmacol , vol.48 , Issue.3 , pp. 409-415
    • Aynacioglu, A.S.1    Brockmoller, J.2    Bauer, S.3
  • 111
    • 0030858160 scopus 로고    scopus 로고
    • Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy
    • doi:10.1016/S0009-9236(97)90031-X
    • Odani A, Hashimoto Y, Otsuki Y et al (1997) Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy. Clin Pharmacol Ther 62(3):287-292. doi:10.1016/S0009- 9236(97)90031-X
    • (1997) Clin Pharmacol Ther , vol.62 , Issue.3 , pp. 287-292
    • Odani, A.1    Hashimoto, Y.2    Otsuki, Y.3
  • 112
    • 0036217595 scopus 로고    scopus 로고
    • Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans
    • Shon JH, Yoon YR, Kim KA et al (2002) Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans. Pharmacogenetics 12(2):111-119
    • (2002) Pharmacogenetics , vol.12 , Issue.2 , pp. 111-119
    • Shon, J.H.1    Yoon, Y.R.2    Kim, K.A.3
  • 113
    • 0029658591 scopus 로고    scopus 로고
    • The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism
    • Sullivan-Klose TH, Ghanayem BI, Bell DA et al (1996) The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics 6(4):341-349
    • (1996) Pharmacogenetics , vol.6 , Issue.4 , pp. 341-349
    • Sullivan-Klose, T.H.1    Ghanayem, B.I.2    Bell, D.A.3
  • 114
    • 0032891790 scopus 로고    scopus 로고
    • Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C93 allele
    • Kidd RS, Straughn AB, Meyer MC et al (1999) Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C93 allele. Pharmacogenetics 9(1):71-80
    • (1999) Pharmacogenetics , vol.9 , Issue.1 , pp. 71-80
    • Kidd, R.S.1    Straughn, A.B.2    Meyer, M.C.3
  • 115
    • 29244482237 scopus 로고    scopus 로고
    • Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: Clinical relevance
    • Kirchheiner J, Roots I, Goldammer M et al (2005) Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: Clinical relevance. Clin Pharmacokinet 44(12):1209-1225
    • (2005) Clin Pharmacokinet , vol.44 , Issue.12 , pp. 1209-1225
    • Kirchheiner, J.1    Roots, I.2    Goldammer, M.3
  • 116
    • 0033040522 scopus 로고    scopus 로고
    • Phenotypic and genotypic investigations of a healthy volunteer deficient in the conversion of losartan to its active metabolite E-3174
    • doi:10.1016/S0009-9236( 99)70114-1
    • McCrea JB, Cribb A, Rushmore T et al (1999) Phenotypic and genotypic investigations of a healthy volunteer deficient in the conversion of losartan to its active metabolite E-3174. Clin Pharmacol Ther 65(3):348-352. doi:10.1016/S0009-9236( 99)70114-1
    • (1999) Clin Pharmacol Ther , vol.65 , Issue.3 , pp. 348-352
    • McCrea, J.B.1    Cribb, A.2    Rushmore, T.3
  • 117
    • 0344303632 scopus 로고    scopus 로고
    • Effect of the single CYP2C93 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects
    • doi:10.1007/s00228-003-0664-5
    • Sekino K, Kubota T, Okada Y et al (2003) Effect of the single CYP2C93 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects. Eur J Clin Pharmacol 59(8-9):589-592. doi:10.1007/s00228-003-0664-5
    • (2003) Eur J Clin Pharmacol , vol.59 , Issue.8-9 , pp. 589-592
    • Sekino, K.1    Kubota, T.2    Okada, Y.3
  • 118
    • 77949756362 scopus 로고    scopus 로고
    • Genome-wide association studies in pharmacogenomics
    • doi:10.1038/nrg2751
    • Daly AK (2010) Genome-wide association studies in pharmacogenomics. Nat Rev Genet 11(4):241-246. doi:10.1038/nrg2751
    • (2010) Nat Rev Genet , vol.11 , Issue.4 , pp. 241-246
    • Daly, A.K.1
  • 119
    • 12144286933 scopus 로고    scopus 로고
    • The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients
    • Haufroid V, Mourad M, Van Kerckhove V et al (2004) The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenetics 14(3):147-154
    • (2004) Pharmacogenetics , vol.14 , Issue.3 , pp. 147-154
    • Haufroid, V.1    Mourad, M.2    Van Kerckhove, V.3
  • 120
    • 0041831261 scopus 로고    scopus 로고
    • Genetic polymorphisms of the CYP3A4 CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus
    • doi:10. 1016/S0009-9236(03 00168-1
    • Hesselink DA, van Schaik RH, van der Heiden IP et al (2003) Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. Clin Pharmacol Ther 74(3):245-254. doi:10. 1016/S0009-9236(03)00168-1
    • (2003) Clin Pharmacol Ther , vol.74 , Issue.3 , pp. 245-254
    • Hesselink, D.A.1    Van Schaik, R.H.2    Van Der Heiden, I.P.3
  • 121
    • 2942588886 scopus 로고    scopus 로고
    • The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation
    • doi:10.1111/j. 1600-6143.2004.00435.x
    • MacPhee IA, Fredericks S, Tai T et al (2004) The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation. Am J Transplant 4(6):914-919. doi:10.1111/j. 1600-6143.2004.00435.x
    • (2004) Am J Transplant , vol.4 , Issue.6 , pp. 914-919
    • Macphee, I.A.1    Fredericks, S.2    Tai, T.3
  • 122
    • 0242332169 scopus 로고    scopus 로고
    • Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients
    • doi:10.1097/01.TP. 0000090753.99170.89
    • Thervet E, Anglicheau D, King B et al (2003) Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients. Transplantation 76(8):1233-1235. doi:10.1097/01.TP. 0000090753.99170.89
    • (2003) Transplantation , vol.76 , Issue.8 , pp. 1233-1235
    • Thervet, E.1    Anglicheau, D.2    King, B.3
  • 123
    • 77952954641 scopus 로고    scopus 로고
    • Use of pharmacogenetics to optimize immunosuppressive therapy
    • doi:10.1097/FTD.0b013e3181dca995
    • Macphee IA (2010) Use of pharmacogenetics to optimize immunosuppressive therapy. Ther Drug Monit 32(3):261-264. doi:10.1097/FTD.0b013e3181dca995
    • (2010) Ther Drug Monit , vol.32 , Issue.3 , pp. 261-264
    • Macphee, I.A.1
  • 124
    • 84869501187 scopus 로고    scopus 로고
    • Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition
    • doi:10.1038/clpt.2012.175
    • Zheng S, Tasnif Y, Hebert MF et al (2012) Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition. Clin Pharmacol Ther 92(6):737-745. doi:10.1038/clpt. 2012.175
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.6 , pp. 737-745
    • Zheng, S.1    Tasnif, Y.2    Hebert, M.F.3
  • 125
    • 34247371529 scopus 로고    scopus 로고
    • Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes
    • doi:10.1124/jpet.106. 118471
    • Dennison JB, Jones DR, Renbarger JL et al (2007) Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes. J Pharmacol Exp Ther 321(2):553-563. doi:10.1124/jpet.106. 118471
    • (2007) J Pharmacol Exp Ther , vol.321 , Issue.2 , pp. 553-563
    • Dennison, J.B.1    Jones, D.R.2    Renbarger, J.L.3
  • 126
    • 52649141149 scopus 로고    scopus 로고
    • Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes
    • doi:10.1124/jpet.108.139998
    • Dennison JB, Mohutsky MA, Barbuch RJ et al (2008) Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes. J Pharmacol Exp Ther 327(1):248-257. doi:10.1124/jpet.108.139998
    • (2008) J Pharmacol Exp Ther , vol.327 , Issue.1 , pp. 248-257
    • Dennison, J.B.1    Mohutsky, M.A.2    Barbuch, R.J.3
  • 127
    • 78651110078 scopus 로고    scopus 로고
    • Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia
    • doi:10.1002/pbc.22845
    • Egbelakin A, Ferguson MJ, MacGill EA et al (2011) Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 56(3):361-367. doi:10.1002/pbc.22845
    • (2011) Pediatr Blood Cancer , vol.56 , Issue.3 , pp. 361-367
    • Egbelakin, A.1    Ferguson, M.J.2    Macgill, E.A.3
  • 128
    • 0142250945 scopus 로고    scopus 로고
    • Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European-and African-American men and women
    • doi:10.1097/01.fpc. 0000054118.14659.48
    • Floyd MD, Gervasini G, Masica AL et al (2003) Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European-and African-American men and women. Pharmacogenetics 13(10):595-606. doi:10.1097/01.fpc. 0000054118.14659.48
    • (2003) Pharmacogenetics , vol.13 , Issue.10 , pp. 595-606
    • Floyd, M.D.1    Gervasini, G.2    Masica, A.L.3
  • 129
    • 0036731724 scopus 로고    scopus 로고
    • Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies
    • Goh BC, Lee SC, Wang LZ et al (2002) Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies. J Clin Oncol 20(17):3683-3690
    • (2002) J Clin Oncol , vol.20 , Issue.17 , pp. 3683-3690
    • Goh, B.C.1    Lee, S.C.2    Wang, L.Z.3
  • 130
    • 0036892578 scopus 로고    scopus 로고
    • Pharmacokinetics of midazolam and 10-hydroxymidazolam in Chinese with different CYP3A5 genotypes
    • Shih PS, Huang JD (2002) Pharmacokinetics of midazolam and 10-hydroxymidazolam in Chinese with different CYP3A5 genotypes. Drug Metabol Dispos 30(12):1491-1496
    • (2002) Drug Metabol Dispos , vol.30 , Issue.12 , pp. 1491-1496
    • Shih, P.S.1    Huang, J.D.2
  • 131
    • 2942560581 scopus 로고    scopus 로고
    • Cyp3a5 genotype and midazolam clearance in australian patients receiving chemotherapy
    • doi:10. 1016/j.clpt.2004.02.005
    • Wong M, Balleine RL, Collins M et al (2004) CYP3A5 genotype and midazolam clearance in Australian patients receiving chemotherapy. Clin Pharmacol Ther 75(6):529-538. doi:10. 1016/j.clpt.2004.02.005
    • (2004) Clin Pharmacol Ther , vol.75 , Issue.6 , pp. 529-538
    • Wong, M.1    Balleine, R.L.2    Collins, M.3
  • 132
    • 3542998143 scopus 로고    scopus 로고
    • Effect of the CYP3A5 genotype on the pharmacokinetics of intravenous midazolam during inhibited and induced metabolic states
    • doi:10.1016/j.clpt. 2004.03.009
    • Yu KS, Cho JY, Jang IJ et al (2004) Effect of the CYP3A5 genotype on the pharmacokinetics of intravenous midazolam during inhibited and induced metabolic states. Clin Pharmacol Ther 76(2):104-112. doi:10.1016/j.clpt. 2004.03.009
    • (2004) Clin Pharmacol Ther , vol.76 , Issue.2 , pp. 104-112
    • Yu, K.S.1    Cho, J.Y.2    Jang, I.J.3
  • 133
    • 76949108596 scopus 로고    scopus 로고
    • CYP3A41G genetic polymorphism influences CYP3A activity and response to fentanyl in Chinese gynecologic patients
    • doi:10.1007/s00228-009-0726-4
    • Zhang W, Chang YZ, Kan QC et al (2010) CYP3A41G genetic polymorphism influences CYP3A activity and response to fentanyl in Chinese gynecologic patients. Eur J Clin Pharmacol 66(1):61-66. doi:10.1007/s00228-009-0726-4
    • (2010) Eur J Clin Pharmacol , vol.66 , Issue.1 , pp. 61-66
    • Zhang, W.1    Chang, Y.Z.2    Kan, Q.C.3
  • 134
    • 79960810087 scopus 로고    scopus 로고
    • Impact of the CYP3A41G polymorphism and its combination with CYP3A5 genotypes on tacrolimus pharmacokinetics in renal transplant patients
    • doi:10.2217/pgs.11.33
    • Miura M, Satoh S, Kagaya H et al (2011) Impact of the CYP3A41G polymorphism and its combination with CYP3A5 genotypes on tacrolimus pharmacokinetics in renal transplant patients. Pharmacogenomics 12(7):977-984. doi:10.2217/pgs.11.33
    • (2011) Pharmacogenomics , vol.12 , Issue.7 , pp. 977-984
    • Miura, M.1    Satoh, S.2    Kagaya, H.3
  • 135
    • 79960633918 scopus 로고    scopus 로고
    • Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs
    • doi:10.1038/tpj.2010.28
    • Wang D, Guo Y, Wrighton SA et al (2011) Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs. Pharmacogenomics J 11(4):274-286. doi:10.1038/tpj.2010.28
    • (2011) Pharmacogenomics J , vol.11 , Issue.4 , pp. 274-286
    • Wang, D.1    Guo, Y.2    Wrighton, S.A.3
  • 136
    • 80054924410 scopus 로고    scopus 로고
    • A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients
    • doi:10. 1373/clinchem.2011.165613
    • Elens L, Bouamar R, Hesselink DA et al (2011) A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients. Clin Chem 57(11):1574-1583. doi:10. 1373/clinchem.2011.165613
    • (2011) Clin Chem , vol.57 , Issue.11 , pp. 1574-1583
    • Elens, L.1    Bouamar, R.2    Hesselink, D.A.3
  • 137
    • 84872523142 scopus 로고    scopus 로고
    • CYP3A4 intron 6 C > T SNP (CYP3A422) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin
    • doi:10.2217/pgs.12.202
    • Elens L, Nieuweboer A, Clarke SJ et al (2013) CYP3A4 intron 6 C T SNP (CYP3A422) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin. Pharmacogenomics 14(2):137-149. doi:10.2217/pgs.12.202
    • (2013) Pharmacogenomics , vol.14 , Issue.2 , pp. 137-149
    • Elens, L.1    Nieuweboer, A.2    Clarke, S.J.3
  • 138
    • 0033020642 scopus 로고    scopus 로고
    • Glucuronidation in humans. Pharmacogenetic and developmental aspects
    • de Wildt SN, Kearns GL, Leeder JS et al (1999) Glucuronidation in humans. Pharmacogenetic and developmental aspects. Clin Pharmacokinet 36(6):439-452
    • (1999) Clin Pharmacokinet , vol.36 , Issue.6 , pp. 439-452
    • De Wildt, S.N.1    Kearns, G.L.2    Leeder, J.S.3
  • 139
    • 3242769758 scopus 로고    scopus 로고
    • Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38
    • doi:10.1177/0091270004267159
    • Paoluzzi L, Singh AS, Price DK et al (2004) Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38. J Clin Pharmacol 44(8):854-860. doi:10.1177/0091270004267159
    • (2004) J Clin Pharmacol , vol.44 , Issue.8 , pp. 854-860
    • Paoluzzi, L.1    Singh, A.S.2    Price, D.K.3
  • 140
    • 2342459714 scopus 로고    scopus 로고
    • Genetic variants in the UDPglucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
    • doi:10.1200/JCO.2004.07.173
    • Innocenti F, Undevia SD, Iyer L et al (2004) Genetic variants in the UDPglucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 22(8):1382-1388. doi:10.1200/JCO.2004.07.173
    • (2004) J Clin Oncol , vol.22 , Issue.8 , pp. 1382-1388
    • Innocenti, F.1    Undevia, S.D.2    Iyer, L.3
  • 141
    • 0034671387 scopus 로고    scopus 로고
    • Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: A pharmacogenetic analysis
    • Ando Y, Saka H, Ando M et al (2000) Polymorphisms of UDP- glucuronosyltransferase gene and irinotecan toxicity: A pharmacogenetic analysis. Cancer Res 60(24):6921-6926
    • (2000) Cancer Res , vol.60 , Issue.24 , pp. 6921-6926
    • Ando, Y.1    Saka, H.2    Ando, M.3
  • 142
    • 0036025450 scopus 로고    scopus 로고
    • UGT1A128 polymorphism as a determinant of irinotecan disposition and toxicity
    • Iyer L, Das S, Janisch L et al (2002) UGT1A128 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J 2(1):43-47
    • (2002) Pharmacogenomics J , vol.2 , Issue.1 , pp. 43-47
    • Iyer, L.1    Das, S.2    Janisch, L.3
  • 143
    • 4344632633 scopus 로고    scopus 로고
    • Ugt1a1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer
    • doi:10.1038/sj.bjc.6602042
    • Marcuello E, Altes A, Menoyo A et al (2004) UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer. Br J Cancer 91(4):678-682. doi:10.1038/sj.bjc.6602042
    • (2004) Br J Cancer , vol.91 , Issue.4 , pp. 678-682
    • Marcuello, E.1    Altes, A.2    Menoyo, A.3
  • 144
    • 66849111193 scopus 로고    scopus 로고
    • Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    • doi:10.1200/JCO. 2008.20.6300
    • Innocenti F, Kroetz DL, Schuetz E et al (2009) Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. J Clin Oncol 27(16):2604-2614. doi:10.1200/JCO. 2008.20.6300
    • (2009) J Clin Oncol , vol.27 , Issue.16 , pp. 2604-2614
    • Innocenti, F.1    Kroetz, D.L.2    Schuetz, E.3
  • 145
    • 12944329893 scopus 로고    scopus 로고
    • UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan
    • Carlini LE, Meropol NJ, Bever J et al (2005) UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res 11(3):1226-1236
    • (2005) Clin Cancer Res , vol.11 , Issue.3 , pp. 1226-1236
    • Carlini, L.E.1    Meropol, N.J.2    Bever, J.3
  • 146
    • 1842532189 scopus 로고    scopus 로고
    • Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDPglucuronosyltransferase UGT1A4
    • doi:10.1002/hep.20131
    • Ehmer U, Vogel A, Schutte JK et al (2004) Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDPglucuronosyltransferase UGT1A4. Hepatology 39(4):970-977. doi:10.1002/hep.20131
    • (2004) Hepatology , vol.39 , Issue.4 , pp. 970-977
    • Ehmer, U.1    Vogel, A.2    Schutte, J.K.3
  • 147
    • 82255193120 scopus 로고    scopus 로고
    • Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes
    • doi:10. 2217/pgs.11.105
    • Zhou J, Argikar UA, Remmel RP (2011) Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes. Pharmacogenomics 12(12):1671-1679. doi:10. 2217/pgs.11.105
    • (2011) Pharmacogenomics , vol.12 , Issue.12 , pp. 1671-1679
    • Zhou, J.1    Argikar, U.A.2    Remmel, R.P.3
  • 148
    • 80051792894 scopus 로고    scopus 로고
    • Olanzapine metabolism and the significance of UGT1A448Vand UGT2B1067Y variants
    • doi:10.1097/FPC. 0b013e328348c76b
    • Erickson-Ridout KK, Zhu J, Lazarus P (2011) Olanzapine metabolism and the significance of UGT1A448Vand UGT2B1067Y variants. Pharmacogenet Genomics 21(9):539-551. doi:10.1097/FPC. 0b013e328348c76b
    • (2011) Pharmacogenet Genomics , vol.21 , Issue.9 , pp. 539-551
    • Erickson-Ridout, K.K.1    Zhu, J.2    Lazarus, P.3
  • 149
    • 79957956347 scopus 로고    scopus 로고
    • The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy
    • doi:10.1016/j.eplepsyres. 2011.01.016
    • Gulcebi MI, Ozkaynakci A, Goren MZ et al (2011) The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy. Epilepsy Res 95(1-2):1-8. doi:10.1016/j.eplepsyres. 2011.01.016
    • (2011) Epilepsy Res , vol.95 , Issue.1-2 , pp. 1-8
    • Gulcebi, M.I.1    Ozkaynakci, A.2    Goren, M.Z.3
  • 150
    • 4344579337 scopus 로고    scopus 로고
    • Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy
    • Evans WE (2004) Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy. Ther Drug Monit 26(2):186-191
    • (2004) Ther Drug Monit , vol.26 , Issue.2 , pp. 186-191
    • Evans, W.E.1
  • 151
    • 0024575209 scopus 로고
    • Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant
    • doi:10.1172/JCI113875
    • Crabb DW, Edenberg HJ, Bosron WF et al (1989) Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest 83(1):314-316. doi:10.1172/JCI113875
    • (1989) J Clin Invest , vol.83 , Issue.1 , pp. 314-316
    • Crabb, D.W.1    Edenberg, H.J.2    Bosron, W.F.3
  • 152
    • 0028840209 scopus 로고
    • The aldehyde dehydrogenase ALDH22 allele exhibits dominance over ALDH21 in transduced HeLa cells
    • doi:10.1172/JCI118272
    • Xiao Q, Weiner H, Johnston T et al (1995) The aldehyde dehydrogenase ALDH22 allele exhibits dominance over ALDH21 in transduced HeLa cells. J Clin Invest 96(5):2180-2186. doi:10.1172/JCI118272
    • (1995) J Clin Invest , vol.96 , Issue.5 , pp. 2180-2186
    • Xiao, Q.1    Weiner, H.2    Johnston, T.3
  • 153
    • 0028557504 scopus 로고
    • Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism
    • Mizoi Y, Yamamoto K, Ueno Y et al (1994) Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol 29(6):707-710
    • (1994) Alcohol Alcohol , vol.29 , Issue.6 , pp. 707-710
    • Mizoi, Y.1    Yamamoto, K.2    Ueno, Y.3
  • 154
    • 33646840890 scopus 로고    scopus 로고
    • Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action
    • Wall TL (2005) Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. Ther Drug Monit 27(6):700-703
    • (2005) Ther Drug Monit , vol.27 , Issue.6 , pp. 700-703
    • Wall, T.L.1
  • 155
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil
    • doi:10.1016/j.ejca.2003. 12.004
    • van Kuilenburg AB (2004) Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur J Cancer 40(7):939-950. doi:10.1016/j.ejca.2003. 12.004
    • (2004) Eur J Cancer , vol.40 , Issue.7 , pp. 939-950
    • Van Kuilenburg, A.B.1
  • 156
    • 25144516296 scopus 로고    scopus 로고
    • Pregnancy-induced changes in pharmacokinetics: A mechanisticbased approach
    • Anderson GD (2005) Pregnancy-induced changes in pharmacokinetics: A mechanisticbased approach. Clin Pharmacokinet 44(10):989-1008
    • (2005) Clin Pharmacokinet , vol.44 , Issue.10 , pp. 989-1008
    • Anderson, G.D.1
  • 157
    • 43049154812 scopus 로고    scopus 로고
    • The ontogeny of drug metabolism enzymes and implications for adverse drug events
    • doi:10.1016/j. pharmthera.2008 02.005
    • Hines RN (2008) The ontogeny of drug metabolism enzymes and implications for adverse drug events. Pharmacol Ther 118(2):250-267. doi:10.1016/j. pharmthera.2008.02.005
    • (2008) Pharmacol Ther , vol.118 , Issue.2 , pp. 250-267
    • Hines, R.N.1
  • 158
    • 70349603042 scopus 로고    scopus 로고
    • Pharmacokinetics and dosage adjustment in patients with renal dysfunction
    • doi:10.1007/s00228-009-0678-8
    • Verbeeck RK, Musuamba FT (2009) Pharmacokinetics and dosage adjustment in patients with renal dysfunction. Eur J Clin Pharmacol 65(8):757-773. doi:10.1007/s00228-009-0678-8
    • (2009) Eur J Clin Pharmacol , vol.65 , Issue.8 , pp. 757-773
    • Verbeeck, R.K.1    Musuamba, F.T.2
  • 159
    • 2942566177 scopus 로고    scopus 로고
    • Cytochrome P450 and liver diseases
    • Villeneuve JP, Pichette V (2004) Cytochrome P450 and liver diseases. Curr Drug Metab 5(3):273-282
    • (2004) Curr Drug Metab , vol.5 , Issue.3 , pp. 273-282
    • Villeneuve, J.P.1    Pichette, V.2
  • 160
    • 20444458809 scopus 로고    scopus 로고
    • Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (Child-Pugh classes A, B, and C): Characterization by dynamic liver function tests
    • doi:10. 1016/j.clpt.2005.02.003
    • Brockmoller J, Thomsen T, Wittstock M et al (2005) Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (Child-Pugh classes A, B, and C): Characterization by dynamic liver function tests. Clin Pharmacol Ther 77(6):529-541. doi:10. 1016/j.clpt.2005.02.003
    • (2005) Clin Pharmacol Ther , vol.77 , Issue.6 , pp. 529-541
    • Brockmoller, J.1    Thomsen, T.2    Wittstock, M.3
  • 161
    • 60349107936 scopus 로고    scopus 로고
    • Assessment of the impact of renal impairment on systemic exposure of new molecular entities: Evaluation of recent new drug applications
    • doi:10.1038/clpt.2008.208
    • Zhang Y, Zhang L, Abraham S et al (2009) Assessment of the impact of renal impairment on systemic exposure of new molecular entities: Evaluation of recent new drug applications. Clin Pharmacol Ther 85(3):305-311. doi:10.1038/clpt.2008.208
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.3 , pp. 305-311
    • Zhang, Y.1    Zhang, L.2    Abraham, S.3
  • 162
    • 0027444634 scopus 로고
    • Measuring lidocaine metabolite-monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis
    • Huang YS, Lee SD, Deng JF et al (1993) Measuring lidocaine metabolite-monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis. J Hepatol 19(1):140-147
    • (1993) J Hepatol , vol.19 , Issue.1 , pp. 140-147
    • Huang, Y.S.1    Lee, S.D.2    Deng, J.F.3
  • 163
    • 0028348482 scopus 로고
    • Hepatic lidocaine metabolism and liver histology in patients with chronic hepatitis and cirrhosis
    • Shiffman ML, Luketic VA, Sanyal AJ et al (1994) Hepatic lidocaine metabolism and liver histology in patients with chronic hepatitis and cirrhosis. Hepatology 19(4):933-940
    • (1994) Hepatology , vol.19 , Issue.4 , pp. 933-940
    • Shiffman, M.L.1    Luketic, V.A.2    Sanyal, A.J.3
  • 164
    • 0023244021 scopus 로고
    • Hepatic clearance of D-sorbitol. Noninvasive test for evaluating functional liver plasma flow
    • Molino G, Cavanna A, Avagnina P et al (1987) Hepatic clearance of D-sorbitol. Noninvasive test for evaluating functional liver plasma flow. Dig Dis Sci 32(7):753-758
    • (1987) Dig Dis Sci , vol.32 , Issue.7 , pp. 753-758
    • Molino, G.1    Cavanna, A.2    Avagnina, P.3
  • 165
    • 0023730792 scopus 로고
    • Steadystate extrarenal sorbitol clearance as a measure of hepatic plasma flow
    • Zeeh J, Lange H, Bosch J et al (1988) Steadystate extrarenal sorbitol clearance as a measure of hepatic plasma flow. Gastroenterology 95(3):749-759
    • (1988) Gastroenterology , vol.95 , Issue.3 , pp. 749-759
    • Zeeh, J.1    Lange, H.2    Bosch, J.3
  • 166
    • 33646076957 scopus 로고    scopus 로고
    • Evaluation of liver function for hepatic resection
    • doi:10. 1016/j.transproceed.2006.01.048
    • Fazakas J, Mandli T, Ther G et al (2006) Evaluation of liver function for hepatic resection. Transplant Proc 38(3):798-800. doi:10. 1016/j.transproceed. 2006.01.048
    • (2006) Transplant Proc , vol.38 , Issue.3 , pp. 798-800
    • Fazakas, J.1    Mandli, T.2    Ther, G.3
  • 167
    • 44349162285 scopus 로고    scopus 로고
    • Prognostic value of the monoethylglycinexylidide (MEGX)-test prior to liver resection
    • Lorf T, Schnitzbauer AA, Schaefers SK et al (2008) Prognostic value of the monoethylglycinexylidide (MEGX)-test prior to liver resection. Hepatogastroenterology 55(82-83):539-543
    • (2008) Hepatogastroenterology , vol.55 , Issue.82-83 , pp. 539-543
    • Lorf, T.1    Schnitzbauer, A.A.2    Schaefers, S.K.3
  • 168
    • 0028928044 scopus 로고
    • Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis
    • George J, Liddle C, Murray M et al (1995) Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis. Biochem Pharmacol 49(7):873-881
    • (1995) Biochem Pharmacol , vol.49 , Issue.7 , pp. 873-881
    • George, J.1    Liddle, C.2    Murray, M.3
  • 169
    • 0028801475 scopus 로고
    • Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease
    • George J, Murray M, Byth K et al (1995) Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease. Hepatology 21(1):120-128
    • (1995) Hepatology , vol.21 , Issue.1 , pp. 120-128
    • George, J.1    Murray, M.2    Byth, K.3
  • 170
    • 33748170694 scopus 로고    scopus 로고
    • Liver disease selectively modulates cytochrome P450-mediated metabolism
    • doi:10. 1016/j.clpt.2006.05.006
    • Frye RF, Zgheib NK, Matzke GR et al (2006) Liver disease selectively modulates cytochrome P450-mediated metabolism. Clin Pharmacol Ther 80(3):235-245. doi:10. 1016/j.clpt.2006.05.006
    • (2006) Clin Pharmacol Ther , vol.80 , Issue.3 , pp. 235-245
    • Frye, R.F.1    Zgheib, N.K.2    Matzke, G.R.3
  • 171
    • 0033665249 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics of repaglinide in subjects with chronic liver disease
    • Hatorp V, Walther KH, Christensen MS et al (2000) Single-dose pharmacokinetics of repaglinide in subjects with chronic liver disease. J Clin Pharmacol 40(2):142-152
    • (2000) J Clin Pharmacol , vol.40 , Issue.2 , pp. 142-152
    • Hatorp, V.1    Walther, K.H.2    Christensen, M.S.3
  • 172
    • 0031847721 scopus 로고    scopus 로고
    • Selective effect of liver disease on the activities of specific metabolizing enzymes: Investigation of cytochromes P450 2C19 and 2D6
    • doi:10.1016/S0009-9236(98)90017-0
    • Adedoyin A, Arns PA, Richards WO et al (1998) Selective effect of liver disease on the activities of specific metabolizing enzymes: Investigation of cytochromes P450 2C19 and 2D6. Clin Pharmacol Ther 64(1):8-17. doi:10.1016/S0009-9236(98)90017-0
    • (1998) Clin Pharmacol Ther , vol.64 , Issue.1 , pp. 8-17
    • Adedoyin, A.1    Arns, P.A.2    Richards, W.O.3
  • 173
    • 0036394803 scopus 로고    scopus 로고
    • Pharmacokinetics of omeprazole given by continuous intravenous infusion to patients with varying degrees of hepatic dysfunction
    • Pique JM, Feu F, de Prada G et al (2002) Pharmacokinetics of omeprazole given by continuous intravenous infusion to patients with varying degrees of hepatic dysfunction. Clin Pharmacokinet 41(12):999-1004
    • (2002) Clin Pharmacokinet , vol.41 , Issue.12 , pp. 999-1004
    • Pique, J.M.1    Feu, F.2    De Prada, G.3
  • 174
    • 0036094692 scopus 로고    scopus 로고
    • Pharmacokinetic study of esomeprazole in patients with hepatic impairment
    • Sjovall H, Bjornsson E, Holmberg J et al (2002) Pharmacokinetic study of esomeprazole in patients with hepatic impairment. Eur J Gastroenterol Hepatol 14(5):491-496
    • (2002) Eur J Gastroenterol Hepatol , vol.14 , Issue.5 , pp. 491-496
    • Sjovall, H.1    Bjornsson, E.2    Holmberg, J.3
  • 175
    • 21044458297 scopus 로고    scopus 로고
    • Effect of hepatic impairment on the multiple-dose pharmacokinetics of ranolazine sustainedrelease tablets
    • doi:10.1177/0091270005276739
    • Abdallah H, Jerling M (2005) Effect of hepatic impairment on the multiple-dose pharmacokinetics of ranolazine sustainedrelease tablets. J Clin Pharmacol 45(7):802-809. doi:10.1177/0091270005276739
    • (2005) J Clin Pharmacol , vol.45 , Issue.7 , pp. 802-809
    • Abdallah, H.1    Jerling, M.2
  • 176
    • 0035192078 scopus 로고    scopus 로고
    • Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: Effects of transjugular intrahepatic portosystemic shunts
    • doi:10. 1053/jhep.2001.29306
    • Chalasani N, Gorski JC, Patel NH et al (2001) Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: Effects of transjugular intrahepatic portosystemic shunts. Hepatology 34(6):1103-1108. doi:10. 1053/jhep.2001.29306
    • (2001) Hepatology , vol.34 , Issue.6 , pp. 1103-1108
    • Chalasani, N.1    Gorski, J.C.2    Patel, N.H.3
  • 177
    • 0022494957 scopus 로고
    • Nifedipine: Kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration
    • Kleinbloesem CH, van Harten J, Wilson JP et al (1986) Nifedipine: Kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration. Clin Pharmacol Ther 40(1):21-28
    • (1986) Clin Pharmacol Ther , vol.40 , Issue.1 , pp. 21-28
    • Kleinbloesem, C.H.1    Van Harten, J.2    Wilson, J.P.3
  • 178
    • 0344936450 scopus 로고
    • Rate of metabolism of tolbutamide in test subjects with liver disease or with impaired renal function
    • Nelson E (1964) Rate of metabolism of tolbutamide in test subjects with liver disease or with impaired renal function. Am J Med Sci 248:657-659
    • (1964) Am J Med Sci , vol.248 , pp. 657-659
    • Nelson, E.1
  • 179
    • 0037374404 scopus 로고    scopus 로고
    • Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites
    • doi:10.1067/mcp.2003.25
    • Chalon SA, Desager JP, Desante KA et al (2003) Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites. Clin Pharmacol Ther 73(3):178-191. doi:10.1067/mcp.2003.25
    • (2003) Clin Pharmacol Ther , vol.73 , Issue.3 , pp. 178-191
    • Chalon, S.A.1    Desager, J.P.2    Desante, K.A.3
  • 180
    • 0025756474 scopus 로고
    • Is glucuronidation truly preserved in patients with liver disease
    • Hoyumpa AM, Schenker S (1991) Is glucuronidation truly preserved in patients with liver disease Hepatology 13(4):786-795
    • (1991) Hepatology , vol.13 , Issue.4 , pp. 786-795
    • Hoyumpa, A.M.1    Schenker, S.2
  • 181
    • 0343384277 scopus 로고    scopus 로고
    • Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases
    • Elekima OT, Mills CO, Ahmad A et al (2000) Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases. Liver 20(1):45-50
    • (2000) Liver , vol.20 , Issue.1 , pp. 45-50
    • Elekima, O.T.1    Mills, C.O.2    Ahmad, A.3
  • 182
    • 84874094715 scopus 로고    scopus 로고
    • Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease
    • doi:10.1124/dmd.112. 048439
    • Hardwick RN, Ferreira DW, More VR et al (2013) Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease. Drug Metabol Dispos 41(3):554-561. doi:10.1124/dmd.112. 048439
    • (2013) Drug Metabol Dispos , vol.41 , Issue.3 , pp. 554-561
    • Hardwick, R.N.1    Ferreira, D.W.2    More, V.R.3
  • 183
    • 0028857915 scopus 로고
    • Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease. An update
    • Morgan DJ, McLean AJ (1995) Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease. An update. Clin Pharmacokinet 29(5):370-391
    • (1995) Clin Pharmacokinet , vol.29 , Issue.5 , pp. 370-391
    • Morgan, D.J.1    McLean, A.J.2
  • 184
    • 38949102772 scopus 로고    scopus 로고
    • Enzyme inhibition and induction in liver disease
    • Palatini P, De Martin S, Pegoraro P et al (2008) Enzyme inhibition and induction in liver disease. Curr Clin Pharmacol 3(1):56-69
    • (2008) Curr Clin Pharmacol , vol.3 , Issue.1 , pp. 56-69
    • Palatini, P.1    De Martin, S.2    Pegoraro, P.3
  • 186
    • 0033844080 scopus 로고    scopus 로고
    • Immunoquantitation of FMO1 in human liver, kidney, and intestine
    • Yeung CK, Lang DH, Thummel KE et al (2000) Immunoquantitation of FMO1 in human liver, kidney, and intestine. Drug Metabol Dispos 28(9):1107-1111
    • (2000) Drug Metabol Dispos , vol.28 , Issue.9 , pp. 1107-1111
    • Yeung, C.K.1    Lang, D.H.2    Thummel, K.E.3
  • 187
    • 84877620041 scopus 로고    scopus 로고
    • CYP3A5 gene variation influences cyclosporine a metabolite formation and renal cyclosporine disposition
    • doi:10.1097/TP. 0b013e31827e6ad9
    • Zheng S, Tasnif Y, Hebert MF et al (2013) CYP3A5 gene variation influences cyclosporine a metabolite formation and renal cyclosporine disposition. Transplantation 95(6):821-827. doi:10.1097/TP. 0b013e31827e6ad9
    • (2013) Transplantation , vol.95 , Issue.6 , pp. 821-827
    • Zheng, S.1    Tasnif, Y.2    Hebert, M.F.3
  • 188
    • 4644280019 scopus 로고    scopus 로고
    • In vitro metabolism of cyclosporine A by human kidney CYP3A5
    • doi:10.1016/j.bcp.2004. 07.012
    • Dai Y, Iwanaga K, Lin YS et al (2004) In vitro metabolism of cyclosporine A by human kidney CYP3A5. Biochem Pharmacol 68(9):1889-1902. doi:10.1016/j.bcp.2004. 07.012
    • (2004) Biochem Pharmacol , vol.68 , Issue.9 , pp. 1889-1902
    • Dai, Y.1    Iwanaga, K.2    Lin, Y.S.3
  • 189
    • 0442313592 scopus 로고    scopus 로고
    • Effects of renal diseases on the regulation and expression of renal and hepatic drugmetabolizing enzymes: A review
    • doi:10.1080/00498250310001638460
    • Korashy HM, Elbekai RH, El-Kadi AO (2004) Effects of renal diseases on the regulation and expression of renal and hepatic drugmetabolizing enzymes: A review. Xenobiotica 34(1):1-29. doi:10.1080/00498250310001638460
    • (2004) Xenobiotica , vol.34 , Issue.1 , pp. 1-29
    • Korashy, H.M.1    Elbekai, R.H.2    El-Kadi, A.O.3
  • 190
    • 0037539996 scopus 로고    scopus 로고
    • Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease
    • Dowling TC, Briglia AE, Fink JC et al (2003) Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease. Clin Pharmacol Ther 73(5):427-434
    • (2003) Clin Pharmacol Ther , vol.73 , Issue.5 , pp. 427-434
    • Dowling, T.C.1    Briglia, A.E.2    Fink, J.C.3
  • 191
    • 70349902844 scopus 로고    scopus 로고
    • ESRD impairs nonrenal clearance of fexofenadine but not midazolam
    • doi:10.1681/ASN. 2009010082
    • Nolin TD, Frye RF, Le P et al (2009) ESRD impairs nonrenal clearance of fexofenadine but not midazolam. JASN 20(10):2269-2276. doi:10.1681/ASN. 2009010082
    • (2009) JASN , vol.20 , Issue.10 , pp. 2269-2276
    • Nolin, T.D.1    Frye Le, R.F.P.2
  • 192
    • 0027290584 scopus 로고
    • Effect of renal failure on drug metabolism by the liver
    • Elston AC, Bayliss MK, Park GR (1993) Effect of renal failure on drug metabolism by the liver. Br J Anaesth 71(2):282-290
    • (1993) Br J Anaesth , vol.71 , Issue.2 , pp. 282-290
    • Elston, A.C.1    Bayliss, M.K.2    Park, G.R.3
  • 193
    • 0019291189 scopus 로고
    • Influence of renal failure on the hepatic clearance of bufuralol in man
    • Balant L, Francis RJ, Tozer TN et al (1980) Influence of renal failure on the hepatic clearance of bufuralol in man. J Pharmacokinet Biopharm 8(5):421-438
    • (1980) J Pharmacokinet Biopharm , vol.8 , Issue.5 , pp. 421-438
    • Balant, L.1    Francis, R.J.2    Tozer, T.N.3
  • 194
    • 0022885624 scopus 로고
    • Renal disease and drug metabolism: An overview
    • Gibson TP (1986) Renal disease and drug metabolism: An overview. Am J Kidney Dis 8(1):7-17
    • (1986) Am J Kidney Dis , vol.8 , Issue.1 , pp. 7-17
    • Gibson, T.P.1
  • 195
    • 0025757336 scopus 로고
    • The effect of renal failure on hepatic drug clearance
    • Touchette MA, Slaughter RL (1991) The effect of renal failure on hepatic drug clearance. Ann Pharmacother 25(11):1214-1224
    • (1991) Ann Pharmacother , vol.25 , Issue.11 , pp. 1214-1224
    • Touchette, M.A.1    Slaughter, R.L.2
  • 196
    • 55549146147 scopus 로고    scopus 로고
    • Effect of hemodialysis on hepatic cytochrome P450 functional expression
    • Michaud J, Nolin TD, Naud J et al (2008) Effect of hemodialysis on hepatic cytochrome P450 functional expression. J Pharmacol Sci 108(2):157-163
    • (2008) J Pharmacol Sci , vol.108 , Issue.2 , pp. 157-163
    • Michaud, J.1    Nolin, T.D.2    Naud, J.3
  • 197
    • 33749592177 scopus 로고    scopus 로고
    • Relation between number of prescribed medication and outcome in peritoneal dialysis patients
    • Szeto CC, Chow KM, Kwan BC et al (2006) Relation between number of prescribed medication and outcome in peritoneal dialysis patients. Clin Nephrol 66(4):256-262
    • (2006) Clin Nephrol , vol.66 , Issue.4 , pp. 256-262
    • Szeto, C.C.1    Chow, K.M.2    Kwan, B.C.3
  • 198
    • 0028596404 scopus 로고
    • Gender differences in human pharmacokinetics and pharmacodynamics
    • Fletcher CV, Acosta EP, Strykowski JM (1994) Gender differences in human pharmacokinetics and pharmacodynamics. J Adolesc Health 15(8):619-629
    • (1994) J Adolesc Health , vol.15 , Issue.8 , pp. 619-629
    • Fletcher, C.V.1    Acosta, E.P.2    Strykowski, J.M.3
  • 199
    • 0029128720 scopus 로고
    • Gender effects in pharmacokinetics and pharmacodynamics
    • Harris RZ, Benet LZ, Schwartz JB (1995) Gender effects in pharmacokinetics and pharmacodynamics. Drugs 50(2):222-239
    • (1995) Drugs , vol.50 , Issue.2 , pp. 222-239
    • Harris, R.Z.1    Benet, L.Z.2    Schwartz, J.B.3
  • 200
    • 4444278991 scopus 로고    scopus 로고
    • The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes
    • doi:10.1016/j.taap.2004. 01.010
    • Parkinson A, Mudra DR, Johnson C et al (2004) The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicol Appl Pharmacol 199(3):193-209. doi:10.1016/j.taap.2004. 01.010
    • (2004) Toxicol Appl Pharmacol , vol.199 , Issue.3 , pp. 193-209
    • Parkinson, A.1    Mudra, D.R.2    Johnson, C.3
  • 201
    • 0026708362 scopus 로고
    • Effect of age and gender on the activity of human hepatic CYP3A
    • Hunt CM, Westerkam WR, Stave GM (1992) Effect of age and gender on the activity of human hepatic CYP3A. Biochem Pharmacol 44(2):275-283
    • (1992) Biochem Pharmacol , vol.44 , Issue.2 , pp. 275-283
    • Hunt, C.M.1    Westerkam, W.R.2    Stave, G.M.3
  • 202
    • 0030872675 scopus 로고    scopus 로고
    • Gender differences in psychotropic drug metabolism
    • Pollock BG (1997) Gender differences in psychotropic drug metabolism. Psychopharmacol Bull 33(2):235-241
    • (1997) Psychopharmacol Bull , vol.33 , Issue.2 , pp. 235-241
    • Pollock, B.G.1
  • 203
    • 40049103597 scopus 로고    scopus 로고
    • 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: Relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians
    • doi:10.1097/FPC.0b013e3282f50ee9
    • Diczfalusy U, Miura J, Roh HK et al (2008) 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: Relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians. Pharmacogenet Genomics 18(3):201-208. doi:10.1097/FPC.0b013e3282f50ee9
    • (2008) Pharmacogenet Genomics , vol.18 , Issue.3 , pp. 201-208
    • Diczfalusy, U.1    Miura, J.2    Roh, H.K.3
  • 204
    • 0141532282 scopus 로고    scopus 로고
    • Sex is a major determinant of CYP3A4 expression in human liver
    • doi:10.1053/jhep.2003.50393
    • Wolbold R, Klein K, Burk O et al (2003) Sex is a major determinant of CYP3A4 expression in human liver. Hepatology 38(4):978-988. doi:10.1053/jhep. 2003.50393
    • (2003) Hepatology , vol.38 , Issue.4 , pp. 978-988
    • Wolbold, R.1    Klein, K.2    Burk, O.3
  • 205
    • 77950953973 scopus 로고    scopus 로고
    • Sex-dependent differences in cytochrome P450 3A activity as assessed by midazolam disposition in humans: A meta-analysis
    • doi:10.1124/dmd.109. 031328
    • Hu ZY, Zhao YS (2010) Sex-dependent differences in cytochrome P450 3A activity as assessed by midazolam disposition in humans: A meta-analysis. Drug Metabol Dispos 38(5):817-823. doi:10.1124/dmd.109. 031328
    • (2010) Drug Metabol Dispos , vol.38 , Issue.5 , pp. 817-823
    • Hu, Z.Y.1    Zhao, Y.S.2
  • 206
    • 84862590014 scopus 로고    scopus 로고
    • Sex differences in the clearance of CYP3A4 substrates: Exploring possible reasons for the substrate dependency and lack of consensus
    • Chetty M, Mattison D, Rostami-Hodjegan A (2012) Sex differences in the clearance of CYP3A4 substrates: Exploring possible reasons for the substrate dependency and lack of consensus. Curr Drug Metab 13(6):778-786
    • (2012) Curr Drug Metab , vol.13 , Issue.6 , pp. 778-786
    • Chetty, M.1    Mattison, D.2    Rostami-Hodjegan, A.3
  • 207
    • 0029616617 scopus 로고
    • Interindividual variation in expression of Pglycoprotein in normal human liver and secondary hepatic neoplasms
    • Schuetz EG, Furuya KN, Schuetz JD (1995) Interindividual variation in expression of Pglycoprotein in normal human liver and secondary hepatic neoplasms. J Pharmacol Exp Ther 275(2):1011-1018
    • (1995) J Pharmacol Exp Ther , vol.275 , Issue.2 , pp. 1011-1018
    • Schuetz, E.G.1    Furuya, K.N.2    Schuetz, J.D.3
  • 208
    • 14044276929 scopus 로고    scopus 로고
    • Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression
    • doi:10.1124/dmd.104. 002469
    • Paine MF, Ludington SS, Chen ML et al (2005) Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression Drug Metabol Dispos 33(3):426-433. doi:10.1124/dmd.104. 002469
    • (2005) Drug Metabol Dispos , vol.33 , Issue.3 , pp. 426-433
    • Paine, M.F.1    Ludington, S.S.2    Chen, M.L.3
  • 209
    • 0026621673 scopus 로고
    • Racial and gender differences in Nacetyltransferase, xanthine oxidase, and CYP1A2 activities
    • Relling MV, Lin JS, Ayers GD et al (1992) Racial and gender differences in Nacetyltransferase, xanthine oxidase, and CYP1A2 activities. Clin Pharmacol Ther 52(6):643-658
    • (1992) Clin Pharmacol Ther , vol.52 , Issue.6 , pp. 643-658
    • Relling, M.V.1    Lin, J.S.2    Ayers, G.D.3
  • 210
    • 0029035739 scopus 로고
    • Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms
    • doi:10.1016/0009-9236(95)90227-9
    • Kim RB, O?Shea D (1995) Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms. Clin Pharmacol Ther 57(6):645-655. doi:10.1016/0009-9236(95) 90227-9
    • (1995) Clin Pharmacol Ther , vol.57 , Issue.6 , pp. 645-655
    • Kim, R.B.1    Oshea, D.2
  • 211
    • 10044230234 scopus 로고    scopus 로고
    • Bioequivalence revisited: Influence of age and sex on CYP enzymes
    • doi:10.1016/j.clpt.2004. 08.021
    • Bebia Z, Buch SC, Wilson JW et al (2004) Bioequivalence revisited: Influence of age and sex on CYP enzymes. Clin Pharmacol Ther 76(6):618-627. doi:10.1016/j.clpt.2004. 08.021
    • (2004) Clin Pharmacol Ther , vol.76 , Issue.6 , pp. 618-627
    • Bebia, Z.1    Buch, S.C.2    Wilson, J.W.3
  • 212
    • 0027433251 scopus 로고
    • Human liver dehydroepiandrosterone sulfotransferase: Nature and extent of individual variation
    • Aksoy IA, Sochorova V, Weinshilboum RM (1993) Human liver dehydroepiandrosterone sulfotransferase: Nature and extent of individual variation. Clin Pharmacol Ther 54(5):498-506
    • (1993) Clin Pharmacol Ther , vol.54 , Issue.5 , pp. 498-506
    • Aksoy, I.A.1    Sochorova, V.2    Weinshilboum, R.M.3
  • 213
    • 0032712466 scopus 로고    scopus 로고
    • Interethnic and interindividual variabilities of platelet sulfotransferases activity in Italians and Finns
    • Brittelli A, De Santi C, Raunio H et al (1999) Interethnic and interindividual variabilities of platelet sulfotransferases activity in Italians and Finns. Eur J Clin Pharmacol 55(9):691-695
    • (1999) Eur J Clin Pharmacol , vol.55 , Issue.9 , pp. 691-695
    • Brittelli, A.1    De Santi, C.2    Raunio, H.3
  • 214
    • 0031853575 scopus 로고    scopus 로고
    • Gender-related seasonality of human platelet phenolsulfotransferase activity
    • Marazziti D, Palego L, Rossi A et al (1998) Gender-related seasonality of human platelet phenolsulfotransferase activity. Neuropsychobiology 38(1):1-5
    • (1998) Neuropsychobiology , vol.38 , Issue.1 , pp. 1-5
    • Marazziti, D.1    Palego, L.2    Rossi, A.3
  • 215
    • 0025119634 scopus 로고
    • Human liver catechol-O-methyltransferase pharmacogenetics
    • Boudikova B, Szumlanski C, Maidak B et al (1990) Human liver catechol-O-methyltransferase pharmacogenetics. Clin Pharmacol Ther 48(4):381-389
    • (1990) Clin Pharmacol Ther , vol.48 , Issue.4 , pp. 381-389
    • Boudikova, B.1    Szumlanski, C.2    Maidak, B.3
  • 216
    • 0028264457 scopus 로고
    • Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans
    • McLeod HL, Fang L, Luo X et al (1994) Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans. J Pharmacol Exp Ther 270(1):26-29
    • (1994) J Pharmacol Exp Ther , vol.270 , Issue.1 , pp. 26-29
    • McLeod, H.L.1    Fang, L.2    Luo, X.3
  • 217
    • 0028044714 scopus 로고
    • Thiopurine methyltransferase activity in American white subjects and black subjects
    • McLeod HL, Lin JS, Scott EP et al (1994) Thiopurine methyltransferase activity in American white subjects and black subjects. Clin Pharmacol Ther 55(1):15-20
    • (1994) Clin Pharmacol Ther , vol.55 , Issue.1 , pp. 15-20
    • McLeod, H.L.1    Lin, J.S.2    Scott, E.P.3
  • 218
    • 0035197725 scopus 로고    scopus 로고
    • Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP- glucuronosyltransferase isoforms
    • Court MH, Duan SX, von Moltke LL et al (2001) Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 299(3):998-1006
    • (2001) J Pharmacol Exp Ther , vol.299 , Issue.3 , pp. 998-1006
    • Court, M.H.1    Duan, S.X.2    Von Moltke, L.L.3
  • 219
    • 0028018821 scopus 로고
    • The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes
    • Bock KW, Schrenk D, Forster A et al (1994) The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes. Pharmacogenetics 4(4):209-218
    • (1994) Pharmacogenetics , vol.4 , Issue.4 , pp. 209-218
    • Bock, K.W.1    Schrenk, D.2    Forster, A.3
  • 220
    • 0021032120 scopus 로고
    • Influence of sex and oral contraceptive steroids on paracetamol metabolism
    • Miners JO, Attwood J, Birkett DJ (1983) Influence of sex and oral contraceptive steroids on paracetamol metabolism. Br J Clin Pharmacol 16(5):503-509
    • (1983) Br J Clin Pharmacol , vol.16 , Issue.5 , pp. 503-509
    • Miners, J.O.1    Attwood, J.2    Birkett, D.J.3
  • 221
    • 0025569391 scopus 로고
    • Sex differences in the subunits of glutathione-S-transferase isoenzyme from rat and human kidney
    • Butera L, Feinfeld DA, Bhargava M (1990) Sex differences in the subunits of glutathione-S-transferase isoenzyme from rat and human kidney. Enzyme 43(4):175-182
    • (1990) Enzyme , vol.43 , Issue.4 , pp. 175-182
    • Butera, L.1    Feinfeld, D.A.2    Bhargava, M.3
  • 222
    • 84859527366 scopus 로고    scopus 로고
    • Effect of the ethinylestradiol/levonorgestrel combined oral contraceptive on the activity of cytochrome P4503A in obese women
    • doi:10.1111/j.1365-2125.2012.04209.x
    • Edelman A, Munar M, Elman MR et al (2012) Effect of the ethinylestradiol/levonorgestrel combined oral contraceptive on the activity of cytochrome P4503A in obese women. Br J Clin Pharmacol 74(3):510-514. doi:10.1111/j.1365-2125.2012.04209.x
    • (2012) Br J Clin Pharmacol , vol.74 , Issue.3 , pp. 510-514
    • Edelman, A.1    Munar, M.2    Elman, M.R.3
  • 223
    • 0033770918 scopus 로고    scopus 로고
    • Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 10-hydroxylation
    • Palovaara S, Kivisto KT, Tapanainen P et al (2000) Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 10-hydroxylation. Br J Clin Pharmacol 50(4):333-337
    • (2000) Br J Clin Pharmacol , vol.50 , Issue.4 , pp. 333-337
    • Palovaara, S.1    Kivisto, K.T.2    Tapanainen, P.3
  • 224
    • 0036164019 scopus 로고    scopus 로고
    • The effects of an oral contraceptive containing ethinyloestradiol and norgestrel on CYP3A activity
    • Belle DJ, Callaghan JT, Gorski JC et al (2002) The effects of an oral contraceptive containing ethinyloestradiol and norgestrel on CYP3A activity. Br J Clin Pharmacol 53(1):67-74
    • (2002) Br J Clin Pharmacol , vol.53 , Issue.1 , pp. 67-74
    • Belle, D.J.1    Callaghan, J.T.2    Gorski, J.C.3
  • 225
    • 0037275143 scopus 로고    scopus 로고
    • The influence of sex on pharmacokinetics
    • Schwartz JB (2003) The influence of sex on pharmacokinetics. Clin Pharmacokinet 42(2):107-121
    • (2003) Clin Pharmacokinet , vol.42 , Issue.2 , pp. 107-121
    • Schwartz, J.B.1
  • 226
    • 0027304072 scopus 로고
    • Gender differences in hepatic induction and inhibition of theophylline pharmacokinetics and metabolism
    • Jennings TS, Nafziger AN, Davidson L et al (1993) Gender differences in hepatic induction and inhibition of theophylline pharmacokinetics and metabolism. J Lab Clin Med 122(2):208-216
    • (1993) J Lab Clin Med , vol.122 , Issue.2 , pp. 208-216
    • Jennings, T.S.1    Nafziger, A.N.2    Davidson, L.3
  • 227
    • 0042833213 scopus 로고    scopus 로고
    • The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity
    • doi:10.1016/S0009-9236(03)00187-5
    • Gorski JC, Vannaprasaht S, Hamman MA et al (2003) The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity. Clin Pharmacol Ther 74(3):275-287. doi:10.1016/S0009-9236(03)00187-5
    • (2003) Clin Pharmacol Ther , vol.74 , Issue.3 , pp. 275-287
    • Gorski, J.C.1    Vannaprasaht, S.2    Hamman, M.A.3
  • 228
    • 0035103616 scopus 로고    scopus 로고
    • Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers
    • Hagg S, Spigset O, Dahlqvist R (2001) Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers. Br J Clin Pharmacol 51(2):169-173
    • (2001) Br J Clin Pharmacol , vol.51 , Issue.2 , pp. 169-173
    • Hagg, S.1    Spigset, O.2    Dahlqvist, R.3
  • 229
    • 0033933541 scopus 로고    scopus 로고
    • Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates
    • Labbe L, Sirois C, Pilote S et al (2000) Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates. Pharmacogenetics 10(5):425-438
    • (2000) Pharmacogenetics , vol.10 , Issue.5 , pp. 425-438
    • Labbe, L.1    Sirois, C.2    Pilote, S.3
  • 230
    • 0032983850 scopus 로고    scopus 로고
    • CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: Indications for oral contraceptive-related gender differences
    • Tamminga WJ, Wemer J, Oosterhuis B et al (1999) CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: Indications for oral contraceptive-related gender differences. Eur J Clin Pharmacol 55(3):177-184
    • (1999) Eur J Clin Pharmacol , vol.55 , Issue.3 , pp. 177-184
    • Tamminga, W.J.1    Wemer, J.2    Oosterhuis, B.3
  • 231
    • 80052680628 scopus 로고    scopus 로고
    • Clinical therapeutics in pregnancy
    • doi:10.1155/2011/783528
    • Feghali MN, Mattison DR (2011) Clinical therapeutics in pregnancy. J Biomed Biotechnol 2011:783528. doi:10.1155/2011/783528
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 783528
    • Feghali, M.N.1    Mattison, D.R.2
  • 232
    • 13444269471 scopus 로고    scopus 로고
    • Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy
    • doi:10.1016/j.ajog.2004. 08.030
    • Tracy TS, Venkataramanan R, GloverDD et al (2005) Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy. Am J Obstet Gynecol 192(2):633-639. doi:10.1016/j.ajog.2004. 08.030
    • (2005) Am J Obstet Gynecol , vol.192 , Issue.2 , pp. 633-639
    • Tracy, T.S.1    Venkataramanan, R.2    Glover, D.D.3
  • 233
    • 49149083537 scopus 로고    scopus 로고
    • Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: A University of Washington specialized center of research study
    • doi:10.1038/clpt.2008.1
    • Hebert MF, Easterling TR, Kirby B et al (2008) Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: A University of Washington specialized center of research study. Clin Pharmacol Ther 84(2):248-253. doi:10.1038/clpt.2008.1
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.2 , pp. 248-253
    • Hebert, M.F.1    Easterling, T.R.2    Kirby, B.3
  • 234
    • 0021844122 scopus 로고
    • Pregnancy-induced increase in metoprolol metabolism
    • Hogstedt S, Lindberg B, Peng DR et al (1985) Pregnancy-induced increase in metoprolol metabolism. Clin Pharmacol Ther 37(6):688-692
    • (1985) Clin Pharmacol Ther , vol.37 , Issue.6 , pp. 688-692
    • Hogstedt, S.1    Lindberg, B.2    Peng, D.R.3
  • 235
    • 63849125212 scopus 로고    scopus 로고
    • Clonidine pharmacokinetics in pregnancy
    • doi:10.1124/dmd.108.024984
    • Buchanan ML, Easterling TR, Carr DB et al (2009) Clonidine pharmacokinetics in pregnancy. Drug Metabol Dispos 37(4):702-705. doi:10.1124/dmd.108.024984
    • (2009) Drug Metabol Dispos , vol.37 , Issue.4 , pp. 702-705
    • Buchanan, M.L.1    Easterling, T.R.2    Carr, D.B.3
  • 236
    • 70349094422 scopus 로고    scopus 로고
    • Effect of cytochrome P450 2D6 genotype on maternal paroxetine plasma concentrations during pregnancy
    • doi:10.2165/11318050-000000000-00000
    • Ververs FF, Voorbij HA, Zwarts P et al (2009) Effect of cytochrome P450 2D6 genotype on maternal paroxetine plasma concentrations during pregnancy. Clin Pharmacokinet 48(10):677-683. doi:10.2165/11318050-000000000-00000
    • (2009) Clin Pharmacokinet , vol.48 , Issue.10 , pp. 677-683
    • Ververs, F.F.1    Voorbij, H.A.2    Zwarts, P.3
  • 237
    • 67349105306 scopus 로고    scopus 로고
    • Are we optimizing gestational diabetes treatment with glyburide the pharmacologic basis for better clinical practice
    • doi:10. 1038/clpt.2009.5
    • Hebert MF, Ma X, Naraharisetti SB et al (2009) Are we optimizing gestational diabetes treatment with glyburide The pharmacologic basis for better clinical practice. Clin Pharmacol Ther 85(6):607-614. doi:10. 1038/clpt.2009.5
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.6 , pp. 607-614
    • Hebert, M.F.1    Ma, X.2    Naraharisetti, S.B.3
  • 238
    • 38949136345 scopus 로고    scopus 로고
    • Effects of pregnancy and contraception on lamotrigine disposition: New insights through analysis of lamotrigine metabolites
    • doi:10.1016/j.seizure. 2007.11.017
    • Ohman I, Luef G, Tomson T (2008) Effects of pregnancy and contraception on lamotrigine disposition: New insights through analysis of lamotrigine metabolites. Seizure 17(2):199-202. doi:10.1016/j.seizure. 2007.11.017
    • (2008) Seizure , vol.17 , Issue.2 , pp. 199-202
    • Ohman, I.1    Luef, G.2    Tomson, T.3
  • 239
    • 77950950434 scopus 로고    scopus 로고
    • Pharmacokinetics of metformin during pregnancy
    • doi:10.1124/dmd.109.031245
    • Eyal S, Easterling TR, Carr D et al (2010) Pharmacokinetics of metformin during pregnancy. Drug Metabol Dispos 38(5):833-840. doi:10.1124/dmd.109.031245
    • (2010) Drug Metabol Dispos , vol.38 , Issue.5 , pp. 833-840
    • Eyal, S.1    Easterling, T.R.2    Carr, D.3
  • 240
    • 0027963634 scopus 로고
    • The expression and environmental regulation of P450 enzymes in human placenta
    • doi:10.3109/10408449409021606
    • Pasanen M, Pelkonen O (1994) The expression and environmental regulation of P450 enzymes in human placenta. Crit Rev Toxicol 24(3):211-229. doi:10.3109/10408449409021606
    • (1994) Crit Rev Toxicol , vol.24 , Issue.3 , pp. 211-229
    • Pasanen, M.1    Pelkonen, O.2
  • 241
    • 84866163353 scopus 로고    scopus 로고
    • Drug interactions at the human placenta: What is the evidence
    • doi:10.3389/fphar.2012.00126
    • Rubinchik-Stern M, Eyal S (2012) Drug interactions at the human placenta: What is the evidence Front Pharmacol 3:126. doi:10.3389/fphar.2012.00126
    • (2012) Front Pharmacol , vol.3 , pp. 126
    • Rubinchik-Stern, M.1    Eyal, S.2
  • 242
    • 84874709659 scopus 로고    scopus 로고
    • Antiepileptic drug treatment in pregnancy: Changes in drug disposition and their clinical implications
    • doi:10.1111/epi.12109
    • Tomson T, Landmark CJ, Battino D (2013) Antiepileptic drug treatment in pregnancy: Changes in drug disposition and their clinical implications. Epilepsia 54(3):405-414. doi:10.1111/epi.12109
    • (2013) Epilepsia , vol.54 , Issue.3 , pp. 405-414
    • Tomson, T.1    Landmark, C.J.2    Battino, D.3
  • 243
    • 27944474395 scopus 로고    scopus 로고
    • Changes to methadone clearance during pregnancy
    • doi:10.1007/s00228-005-0035-5
    • Wolff K, Boys A, Rostami-Hodjegan A et al (2005) Changes to methadone clearance during pregnancy. Eur J Clin Pharmacol 61(10):763-768. doi:10.1007/s00228-005-0035-5
    • (2005) Eur J Clin Pharmacol , vol.61 , Issue.10 , pp. 763-768
    • Wolff, K.1    Boys, A.2    Rostami-Hodjegan, A.3
  • 244
    • 10044296972 scopus 로고    scopus 로고
    • The pharmacokinetics of nelfinavir and M8 during pregnancy and post partum
    • doi:10. 1016/j.clpt.2004.08.011
    • van Heeswijk RP, Khaliq Y, Gallicano KD et al (2004) The pharmacokinetics of nelfinavir and M8 during pregnancy and post partum. Clin Pharmacol Ther 76(6):588-597. doi:10. 1016/j.clpt.2004.08.011
    • (2004) Clin Pharmacol Ther , vol.76 , Issue.6 , pp. 588-597
    • Van Heeswijk, R.P.1    Khaliq, Y.2    Gallicano, K.D.3
  • 245
    • 77952572759 scopus 로고    scopus 로고
    • Altered drug metabolism during pregnancy: Hormonal regulation of drug-metabolizing enzymes
    • doi:10. 1517/17425251003677755
    • Jeong H (2010) Altered drug metabolism during pregnancy: Hormonal regulation of drug-metabolizing enzymes. Expert Opin Drug Metab Toxicol 6(6):689-699. doi:10. 1517/17425251003677755
    • (2010) Expert Opin Drug Metab Toxicol , vol.6 , Issue.6 , pp. 689-699
    • Jeong, H.1
  • 246
    • 36048959792 scopus 로고    scopus 로고
    • Ontogeny of human hepatic cytochromes P450
    • Hines RN (2007) Ontogeny of human hepatic cytochromes P450. J Biochem Mol Toxicol 21(4):169-175
    • (2007) J Biochem Mol Toxicol , vol.21 , Issue.4 , pp. 169-175
    • Hines, R.N.1
  • 247
    • 0142210233 scopus 로고    scopus 로고
    • Developmental expression of the major human hepatic CYP3A enzymes
    • doi:10.1124/jpet.103.054841
    • Stevens JC, Hines RN, Gu C et al (2003) Developmental expression of the major human hepatic CYP3A enzymes. J Pharmacol Exp Ther 307(2):573-582. doi:10.1124/jpet.103.054841
    • (2003) J Pharmacol Exp Ther , vol.307 , Issue.2 , pp. 573-582
    • Stevens, J.C.1    Hines, R.N.2    Gu, C.3
  • 248
    • 0141519338 scopus 로고    scopus 로고
    • Human hepatic cyp2e1 expression during development
    • doi:10.1124/jpet. 102.053124
    • Johnsrud EK, Koukouritaki SB, Divakaran K et al (2003) Human hepatic CYP2E1 expression during development. J Pharmacol Exp Ther 307(1):402-407. doi:10.1124/jpet. 102.053124
    • (2003) J Pharmacol Exp Ther , vol.307 , Issue.1 , pp. 402-407
    • Johnsrud, E.K.1    Koukouritaki, S.B.2    Divakaran, K.3
  • 249
    • 0026042787 scopus 로고
    • Expression of CYP2D6 in developing human liver
    • Treluyer JM, Jacqz-Aigrain E, Alvarez F et al (1991) Expression of CYP2D6 in developing human liver. Eur J Biochem 202(2):583-588
    • (1991) Eur J Biochem , vol.202 , Issue.2 , pp. 583-588
    • Treluyer, J.M.1    Jacqz-Aigrain, E.2    Alvarez, F.3
  • 250
    • 33947355059 scopus 로고    scopus 로고
    • Ontogeny of dextromethorphan O-and Ndemethylation in the first year of life
    • doi:10. 1038/sj.clpt.6100101
    • Blake MJ, Gaedigk A, Pearce RE et al (2007) Ontogeny of dextromethorphan O-and Ndemethylation in the first year of life. Clin Pharmacol Ther 81(4):510-516. doi:10. 1038/sj.clpt.6100101
    • (2007) Clin Pharmacol Ther , vol.81 , Issue.4 , pp. 510-516
    • Blake, M.J.1    Gaedigk, A.2    Pearce, R.E.3
  • 251
    • 1342344547 scopus 로고    scopus 로고
    • Developmental expression of human hepatic CYP2C9 and CYP2C19
    • doi:10.1124/jpet.103.060137
    • Koukouritaki SB, Manro JR, Marsh SA et al (2004) Developmental expression of human hepatic CYP2C9 and CYP2C19. J Pharmacol Exp Ther 308(3):965-974. doi:10.1124/jpet.103.060137
    • (2004) J Pharmacol Exp Ther , vol.308 , Issue.3 , pp. 965-974
    • Koukouritaki, S.B.1    Manro, J.R.2    Marsh, S.A.3
  • 252
    • 0032005988 scopus 로고    scopus 로고
    • Delayed ontogenesis of CYP1A2 in the human liver
    • Sonnier M, Cresteil T (1998) Delayed ontogenesis of CYP1A2 in the human liver. Eur J Biochem 251(3):893-898
    • (1998) Eur J Biochem , vol.251 , Issue.3 , pp. 893-898
    • Sonnier, M.1    Cresteil, T.2
  • 253
    • 0031452340 scopus 로고    scopus 로고
    • A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy
    • Tateishi T, Nakura H, Asoh M et al (1997) A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy. Life Sci 61(26):2567-2574
    • (1997) Life Sci , vol.61 , Issue.26 , pp. 2567-2574
    • Tateishi, T.1    Nakura, H.2    Asoh, M.3
  • 254
    • 0036157094 scopus 로고    scopus 로고
    • Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression
    • doi:10.1203/00006450-200202000-00018
    • Koukouritaki SB, Simpson P, Yeung CK et al (2002) Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression. Pediatr Res 51(2):236-243. doi:10.1203/00006450-200202000-00018
    • (2002) Pediatr Res , vol.51 , Issue.2 , pp. 236-243
    • Koukouritaki, S.B.1    Simpson, P.2    Yeung, C.K.3
  • 255
    • 0015009635 scopus 로고
    • Developmental changes and polymorphism in human alcohol dehydrogenase
    • Smith M, Hopkinson DA, Harris H (1971) Developmental changes and polymorphism in human alcohol dehydrogenase. Ann Hum Genet 34(3):251-271
    • (1971) Ann Hum Genet , vol.34 , Issue.3 , pp. 251-271
    • Smith, M.1    Hopkinson, D.A.2    Harris, H.3
  • 256
    • 84863664786 scopus 로고    scopus 로고
    • Ontogeny of hepatic glucuronidation; Methods and results
    • Krekels EH, Danhof M, Tibboel D et al (2012) Ontogeny of hepatic glucuronidation; methods and results. Curr Drug Metab 13(6):728-743
    • (2012) Curr Drug Metab , vol.13 , Issue.6 , pp. 728-743
    • Krekels, E.H.1    Danhof, M.2    Tibboel, D.3
  • 257
    • 33751216754 scopus 로고    scopus 로고
    • Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants
    • doi:10.1203/01.pdr. 0000245909.74166.00
    • Blake MJ, Abdel-Rahman SM, Pearce RE et al (2006) Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants. Pediatr Res 60(6):717-723. doi:10.1203/01.pdr. 0000245909.74166.00
    • (2006) Pediatr Res , vol.60 , Issue.6 , pp. 717-723
    • Blake, M.J.1    Abdel-Rahman, S.M.2    Pearce, R.E.3
  • 258
    • 0028786903 scopus 로고
    • Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part II. Phenytoin, carbamazepine, sulthiame, lamotrigine, vigabatrin, oxcarbazepine and felbamate
    • Battino D, Estienne M, Avanzini G (1995) Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part II. Phenytoin, carbamazepine, sulthiame, lamotrigine, vigabatrin, oxcarbazepine and felbamate. Clin Pharmacokinet 29(5):341-369
    • (1995) Clin Pharmacokinet , vol.29 , Issue.5 , pp. 341-369
    • Battino, D.1    Estienne, M.2    Avanzini, G.3
  • 259
    • 0038556715 scopus 로고    scopus 로고
    • Atomoxetine pharmacokinetics in children and adolescents with attention deficit hyperactivity disorder
    • doi:10.1089/104454603321666199
    • Witcher JW, Long A, Smith B et al (2003) Atomoxetine pharmacokinetics in children and adolescents with attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 13(1):53-63. doi:10.1089/104454603321666199
    • (2003) J Child Adolesc Psychopharmacol , vol.13 , Issue.1 , pp. 53-63
    • Witcher, J.W.1    Long, A.2    Smith, B.3
  • 260
    • 0024565751 scopus 로고
    • The effect of age upon liver volume and apparent liver blood flow in healthy man
    • Wynne HA, Cope LH, Mutch E et al (1989) The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology 9(2):297-301
    • (1989) Hepatology , vol.9 , Issue.2 , pp. 297-301
    • Wynne, H.A.1    Cope, L.H.2    Mutch, E.3
  • 261
    • 0037261396 scopus 로고    scopus 로고
    • Effects of age and sex on the disposition of retigabine
    • doi:10.1067/mcp.2003.12
    • Hermann R, Ferron GM, Erb K et al (2003) Effects of age and sex on the disposition of retigabine. Clin Pharmacol Ther 73(1):61-70. doi:10.1067/mcp. 2003.12
    • (2003) Clin Pharmacol Ther , vol.73 , Issue.1 , pp. 61-70
    • Hermann, R.1    Ferron, G.M.2    Erb, K.3
  • 262
    • 0025797319 scopus 로고
    • Single dose pharmacokinetics and pharmacodynamics of oral oxazepam in very elderly institutionalised subjects
    • Sonne J, Loft S, Dossing M et al (1991) Single dose pharmacokinetics and pharmacodynamics of oral oxazepam in very elderly institutionalised subjects. Br J Clin Pharmacol 31(6):719-722
    • (1991) Br J Clin Pharmacol , vol.31 , Issue.6 , pp. 719-722
    • Sonne, J.1    Loft, S.2    Dossing, M.3
  • 263
    • 0023792660 scopus 로고
    • Comparison of paracetamol metabolism in young adult and elderly males
    • Miners JO, Penhall R, Robson RA et al (1988) Comparison of paracetamol metabolism in young adult and elderly males. Eur J Clin Pharmacol 35(2):157-160
    • (1988) Eur J Clin Pharmacol , vol.35 , Issue.2 , pp. 157-160
    • Miners, J.O.1    Penhall, R.2    Robson, R.A.3
  • 264
    • 58149269468 scopus 로고    scopus 로고
    • Use of prescription and over-thecounter medications and dietary supplements among older adults in the United States
    • doi:10.1001/jama.2008.892
    • Qato DM, Alexander GC, Conti RM et al (2008) Use of prescription and over-thecounter medications and dietary supplements among older adults in the United States. JAMA 300(24):2867-2878. doi:10.1001/jama.2008.892
    • (2008) JAMA , vol.300 , Issue.24 , pp. 2867-2878
    • Qato, D.M.1    Alexander, G.C.2    Conti, R.M.3
  • 265
    • 0025883637 scopus 로고
    • Diet and cimetidine induce comparable changes in theophylline metabolism in normal subjects
    • Anderson KE, McCleery RB, Vesell ES et al (1991) Diet and cimetidine induce comparable changes in theophylline metabolism in normal subjects. Hepatology 13(5):941-946
    • (1991) Hepatology , vol.13 , Issue.5 , pp. 941-946
    • Anderson, K.E.1    McCleery, R.B.2    Vesell, E.S.3
  • 266
    • 0021956568 scopus 로고
    • The effect of diet on the metabolism of long acting theophylline
    • Tinkelman DG, Edelman L, Decouto J et al (1985) The effect of diet on the metabolism of long acting theophylline. Ann Allergy 54(4):280-283
    • (1985) Ann Allergy , vol.54 , Issue.4 , pp. 280-283
    • Tinkelman, D.G.1    Edelman, L.2    Decouto, J.3
  • 267
    • 0034051263 scopus 로고    scopus 로고
    • Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: Changes in caffeine metabolite ratios in response to controlled vegetable diets
    • Lampe JW, King IB, Li S et al (2000) Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: Changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis 21(6):1157-1162
    • (2000) Carcinogenesis , vol.21 , Issue.6 , pp. 1157-1162
    • Lampe, J.W.1    King, I.B.2    Li, S.3
  • 268
    • 0027960793 scopus 로고
    • Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans
    • Sinha R, Rothman N, Brown ED et al (1994) Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans. Cancer Res 54(23):6154-6159
    • (1994) Cancer Res , vol.54 , Issue.23 , pp. 6154-6159
    • Sinha, R.1    Rothman, N.2    Brown, E.D.3
  • 269
    • 0018375191 scopus 로고
    • Drug metabolism in malnourished children: A study with antipyrine
    • Homeida M, Karrar ZA, Roberts CJ (1979) Drug metabolism in malnourished children: A study with antipyrine. Arch Dis Child 54(4):299-302
    • (1979) Arch Dis Child , vol.54 , Issue.4 , pp. 299-302
    • Homeida, M.1    Karrar, Z.A.2    Roberts, C.J.3
  • 270
    • 0027537097 scopus 로고
    • On the intraindividual variability and chronobiology of cyclosporine pharmacokinetics in renal transplantation
    • Ohlman S, Lindholm A, Hagglund H et al (1993) On the intraindividual variability and chronobiology of cyclosporine pharmacokinetics in renal transplantation. Eur J Clin Pharmacol 44(3):265-269
    • (1993) Eur J Clin Pharmacol , vol.44 , Issue.3 , pp. 265-269
    • Ohlman, S.1    Lindholm, A.2    Hagglund, H.3
  • 271
    • 0020261684 scopus 로고
    • Physiologic and temporal variation in hepatic elimination of midazolam
    • Klotz U, Ziegler G (1982) Physiologic and temporal variation in hepatic elimination of midazolam. Clin Pharmacol Ther 32(1):107-112
    • (1982) Clin Pharmacol Ther , vol.32 , Issue.1 , pp. 107-112
    • Klotz, U.1    Ziegler, G.2
  • 272
    • 0034074665 scopus 로고    scopus 로고
    • Circadian variation of the urinary 6betahydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity
    • Ohno M, Yamaguchi I, Ito T et al (2000) Circadian variation of the urinary 6betahydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity. Eur J Clin Pharmacol 55(11-12):861-865
    • (2000) Eur J Clin Pharmacol , vol.55 , Issue.11-12 , pp. 861-865
    • Ohno, M.1    Yamaguchi, I.2    Ito, T.3
  • 273
    • 79955043225 scopus 로고    scopus 로고
    • Seasonal variation in blood drug concentrations and a potential relationship to vitamin D
    • doi:10.1124/dmd.111. 038125
    • Lindh JD, Andersson ML, Eliasson E et al (2011) Seasonal variation in blood drug concentrations and a potential relationship to vitamin D. Drug Metabol Dispos 39(5):933-937. doi:10.1124/dmd.111. 038125
    • (2011) Drug Metabol Dispos , vol.39 , Issue.5 , pp. 933-937
    • Lindh, J.D.1    Andersson, M.L.2    Eliasson, E.3
  • 274
    • 84860685116 scopus 로고    scopus 로고
    • Intestinal cyp3a4 and midazolam disposition in vivo associate with vdr polymorphisms and show seasonal variation
    • doi:10. 1016/j.bcp.2012.03.017
    • Thirumaran RK, Lamba JK, Kim RB et al (2012) Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation. Biochem Pharmacol 84(1):104-112. doi:10. 1016/j.bcp.2012.03.017
    • (2012) Biochem Pharmacol , vol.84 , Issue.1 , pp. 104-112
    • Thirumaran, R.K.1    Lamba, J.K.2    Kim, R.B.3
  • 275
    • 33144485957 scopus 로고    scopus 로고
    • Regulation of drug-metabolizing enzymes and transporters in inflammation
    • doi:10.1146/annurev.pharmtox.46.120604. 141059
    • Aitken AE, Richardson TA, Morgan ET (2006) Regulation of drug-metabolizing enzymes and transporters in inflammation. Annu Rev Pharmacol Toxicol 46:123-149. doi:10.1146/annurev.pharmtox.46.120604. 141059
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 123-149
    • Aitken, A.E.1    Richardson, T.A.2    Morgan, E.T.3
  • 276
    • 62649091120 scopus 로고    scopus 로고
    • Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics
    • doi:10.1038/clpt.2008.302
    • Morgan ET (2009) Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics. Clin Pharmacol Ther 85(4):434-438. doi:10.1038/clpt.2008.302
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.4 , pp. 434-438
    • Morgan, E.T.1
  • 277
    • 38749091688 scopus 로고    scopus 로고
    • Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer
    • doi:10.1124/dmd.107. 018747
    • Morgan ET, Goralski KB, Piquette-Miller M et al (2008) Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metabol Dispos 36(2):205-216. doi:10.1124/dmd.107. 018747
    • (2008) Drug Metabol Dispos , vol.36 , Issue.2 , pp. 205-216
    • Morgan, E.T.1    Goralski, K.B.2    Piquette-Miller, M.3
  • 278
    • 0029858786 scopus 로고    scopus 로고
    • Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini
    • Satarug S, Lang MA, Yongvanit P et al (1996) Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini. Cancer Epidemiol Biomark Pre 5(10):795-800
    • (1996) Cancer Epidemiol Biomark Pre , vol.5 , Issue.10 , pp. 795-800
    • Satarug, S.1    Lang, M.A.2    Yongvanit, P.3
  • 279
    • 0343294009 scopus 로고    scopus 로고
    • Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: Relationship with sudden infant death syndrome
    • Treluyer JM, Benech H, Colin I et al (2000) Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: Relationship with sudden infant death syndrome. Pediatr Res 47(5):677-683
    • (2000) Pediatr Res , vol.47 , Issue.5 , pp. 677-683
    • Treluyer, J.M.1    Benech, H.2    Colin, I.3
  • 280
    • 0004283269 scopus 로고    scopus 로고
    • Cytochrome P-450 expression in sudden infant death syndrome
    • Treluyer JM, Cheron G, Sonnier M et al (1996) Cytochrome P-450 expression in sudden infant death syndrome. Biochem Pharmacol 52(3):497-504
    • (1996) Biochem Pharmacol , vol.52 , Issue.3 , pp. 497-504
    • Treluyer, J.M.1    Cheron, G.2    Sonnier, M.3
  • 281
    • 77954461644 scopus 로고    scopus 로고
    • Variability in drug metabolizing enzyme activity in HIV-infected patients
    • doi:10.1007/s00228-009-0777-6
    • Jones AE, Brown KC,Werner RE et al (2010) Variability in drug metabolizing enzyme activity in HIV-infected patients. Eur J Clin Pharmacol 66(5):475-485. doi:10.1007/s00228-009-0777-6
    • (2010) Eur J Clin Pharmacol , vol.66 , Issue.5 , pp. 475-485
    • Jones, A.E.1    Brown, K.C.2    Werner, R.E.3
  • 282
    • 78651069086 scopus 로고    scopus 로고
    • Do activities of cytochrome P450 (CYP)3A CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients
    • doi:10.3851/IMP1648
    • Jetter A, Fatkenheuer G, Frank D et al (2010) Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients Antivir Ther 15(7):975-983. doi:10.3851/IMP1648
    • (2010) Antivir Ther , vol.15 , Issue.7 , pp. 975-983
    • Jetter, A.1    Fatkenheuer, G.2    Frank, D.3
  • 283
    • 0018190964 scopus 로고
    • Altered theophylline pharmacokinetics during acute respiratory viral illness
    • Chang KC, Bell TD, Lauer BA et al (1978) Altered theophylline pharmacokinetics during acute respiratory viral illness. Lancet 1(8074):1132-1133
    • (1978) Lancet , vol.1 , Issue.8074 , pp. 1132-1133
    • Chang, K.C.1    Bell, T.D.2    Lauer, B.A.3
  • 284
    • 0020056612 scopus 로고
    • Altered theophylline clearance during an influenza B outbreak
    • Kraemer MJ, Furukawa CT, Koup JR et al (1982) Altered theophylline clearance during an influenza B outbreak. Pediatrics 69(4):476-480
    • (1982) Pediatrics , vol.69 , Issue.4 , pp. 476-480
    • Kraemer, M.J.1    Furukawa, C.T.2    Koup, J.R.3
  • 285
    • 19444385310 scopus 로고    scopus 로고
    • Reducing the global burden of sepsis in infants and children: A clinical practice research agenda
    • doi:10. 1097/01.PCC.0000161574.36857.CA
    • Carcillo JA (2005) Reducing the global burden of sepsis in infants and children: A clinical practice research agenda. Pediatr Crit Care Med 6(3 Suppl):S157-S164. doi:10. 1097/01.PCC.0000161574.36857.CA
    • (2005) Pediatr Crit Care Med , vol.6 , Issue.3 SUPPL. , pp. 157-164
    • Carcillo, J.A.1
  • 286
    • 0038243605 scopus 로고    scopus 로고
    • Cytochrome P450 3A4 activity after surgical stress
    • doi:10.1097/01.CCM. 0000063040.24541.49
    • Haas CE, Kaufman DC, Jones CE et al (2003) Cytochrome P450 3A4 activity after surgical stress. Crit Care Med 31(5):1338-1346. doi:10.1097/01.CCM. 0000063040.24541.49
    • (2003) Crit Care Med , vol.31 , Issue.5 , pp. 1338-1346
    • Haas, C.E.1    Kaufman, D.C.2    Jones, C.E.3
  • 287
    • 63849225881 scopus 로고    scopus 로고
    • Dual mechanisms of CYP3A protein regulation by proinflammatory cytokine stimulation in primary hepatocyte cultures
    • doi:10.1124/dmd.108. 026187
    • Lee CM, Pohl J, Morgan ET (2009) Dual mechanisms of CYP3A protein regulation by proinflammatory cytokine stimulation in primary hepatocyte cultures. Drug Metabol Dispos 37(4):865-872. doi:10.1124/dmd.108. 026187
    • (2009) Drug Metabol Dispos , vol.37 , Issue.4 , pp. 865-872
    • Lee, C.M.1    Pohl, J.2    Morgan, E.T.3
  • 288
    • 0028332406 scopus 로고
    • Acute-phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics
    • Chen YL, Le Vraux V, Leneveu A et al (1994) Acute-phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics. Clin Pharmacol Ther 55(6):649-660
    • (1994) Clin Pharmacol Ther , vol.55 , Issue.6 , pp. 649-660
    • Chen, Y.L.1    Le Vraux, V.2    Leneveu, A.3
  • 289
    • 79955465387 scopus 로고    scopus 로고
    • Disease-drug-drug interaction involving tocilizumab and simvastatin in patients with rheumatoid arthritis
    • doi:10.1038/clpt.2011.35
    • Schmitt C, Kuhn B, Zhang X et al (2011) Disease-drug-drug interaction involving tocilizumab and simvastatin in patients with rheumatoid arthritis. Clin Pharmacol Ther 89(5):735-740. doi:10.1038/clpt.2011.35
    • (2011) Clin Pharmacol Ther , vol.89 , Issue.5 , pp. 735-740
    • Schmitt, C.1    Kuhn, B.2    Zhang, X.3
  • 290
    • 79960606980 scopus 로고    scopus 로고
    • Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drugmetabolizing enzymes in human hepatocyte culture
    • doi:10.1124/dmd.111. 038679
    • Dickmann LJ, Patel SK, Rock DA et al (2011) Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drugmetabolizing enzymes in human hepatocyte culture. Drug Metabol Dispos 39(8):1415-1422. doi:10.1124/dmd.111. 038679
    • (2011) Drug Metabol Dispos , vol.39 , Issue.8 , pp. 1415-1422
    • Dickmann, L.J.1    Patel, S.K.2    Rock, D.A.3
  • 291
    • 84872223878 scopus 로고    scopus 로고
    • Effect of peginterferon alfa-2a (40KD) on cytochrome P450 isoenzyme activity
    • doi:10.1111/j. 1365-2125.2012.04373.x
    • Brennan BJ, Xu ZX, Grippo JF (2013) Effect of peginterferon alfa-2a (40KD) on cytochrome P450 isoenzyme activity. Br J Clin Pharmacol 75(2):497-506. doi:10.1111/j. 1365-2125.2012.04373.x
    • (2013) Br J Clin Pharmacol , vol.75 , Issue.2 , pp. 497-506
    • Brennan, B.J.1    Xu, Z.X.2    Grippo, J.F.3
  • 292
    • 49949087028 scopus 로고    scopus 로고
    • Is this the drug or dose for you Impact and consideration of ethnic factors in global drug development, regulatory review, and clinical practice
    • doi:10. 1038/clpt.2008.144
    • Huang SM, Temple R (2008) Is this the drug or dose for you Impact and consideration of ethnic factors in global drug development, regulatory review, and clinical practice. Clin Pharmacol Ther 84(3):287-294. doi:10. 1038/clpt.2008.144
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.3 , pp. 287-294
    • Huang, S.M.1    Temple, R.2
  • 293
    • 0025757011 scopus 로고
    • Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples
    • Guengerich FP, Turvy CG (1991) Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples. J Pharmacol Exp Ther 256(3):1189-1194
    • (1991) J Pharmacol Exp Ther , vol.256 , Issue.3 , pp. 1189-1194
    • Guengerich, F.P.1    Turvy, C.G.2
  • 294
    • 0028900559 scopus 로고
    • Cyp3a4 and cyp2a6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients
    • Sotaniemi EA, Rautio A, Backstrom M et al (1995) CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients. Br J Clin Pharmacol 39(1):71-76
    • (1995) Br J Clin Pharmacol , vol.39 , Issue.1 , pp. 71-76
    • Sotaniemi, E.A.1    Rautio, A.2    Backstrom, M.3
  • 295
    • 0032937925 scopus 로고    scopus 로고
    • Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers
    • Furlan V, Demirdjian S, Bourdon O et al (1999) Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers. J Pharmacol Exp Ther 289(2):1169-1175
    • (1999) J Pharmacol Exp Ther , vol.289 , Issue.2 , pp. 1169-1175
    • Furlan, V.1    Demirdjian, S.2    Bourdon, O.3
  • 296
    • 0034856932 scopus 로고    scopus 로고
    • Influence of cirrhosis on lamotrigine pharmacokinetics
    • Marcellin P, de Bony F, Garret C et al (2001) Influence of cirrhosis on lamotrigine pharmacokinetics. Br J Clin Pharmacol 51(5):410-414
    • (2001) Br J Clin Pharmacol , vol.51 , Issue.5 , pp. 410-414
    • Marcellin, P.1    De Bony, F.2    Garret, C.3
  • 297
    • 0033950125 scopus 로고    scopus 로고
    • Pharmacokinetics of repaglinide in subjects with renal impairment
    • doi:10.1067/mcp. 2000.103973
    • Marbury TC, Ruckle JL, Hatorp V et al (2000) Pharmacokinetics of repaglinide in subjects with renal impairment. Clin Pharmacol Ther 67(1):7-15. doi:10.1067/mcp. 2000.103973
    • (2000) Clin Pharmacol Ther , vol.67 , Issue.1 , pp. 7-15
    • Marbury, T.C.1    Ruckle, J.L.2    Hatorp, V.3
  • 298
    • 0344453817 scopus 로고    scopus 로고
    • Pharmacokinetics of rosiglitazone in patients with varying degrees of renal insufficiency
    • Chapelsky MC, Thompson-Culkin K, Miller AK et al (2003) Pharmacokinetics of rosiglitazone in patients with varying degrees of renal insufficiency. J Clin Pharmacol 43(3):252-259
    • (2003) J Clin Pharmacol , vol.43 , Issue.3 , pp. 252-259
    • Chapelsky, M.C.1    Thompson-Culkin, K.2    Miller, A.K.3
  • 299
    • 0036630554 scopus 로고    scopus 로고
    • Pharmacokinetics of rosiglitazone in patients with end-stage renal disease
    • Thompson-Culkin K, Zussman B, Miller AK et al (2002) Pharmacokinetics of rosiglitazone in patients with end-stage renal disease. J Int Med Res 30(4):391-399
    • (2002) J Int Med Res , vol.30 , Issue.4 , pp. 391-399
    • Thompson-Culkin, K.1    Zussman, B.2    Miller, A.K.3
  • 300
    • 55949110268 scopus 로고    scopus 로고
    • Pharmacokinetics of single-dose rosiglitazone in chronic ambulatory peritoneal dialysis patients
    • doi:10.1111/j.1365-2710. 2008.00967.x
    • Aramwit P, Supasyndh O, Sriboonruang T (2008) Pharmacokinetics of single-dose rosiglitazone in chronic ambulatory peritoneal dialysis patients. J Clin Pharm Ther 33(6):685-690. doi:10.1111/j.1365-2710. 2008.00967.x
    • (2008) J Clin Pharm Ther , vol.33 , Issue.6 , pp. 685-690
    • Aramwit, P.1    Supasyndh, O.2    Sriboonruang, T.3
  • 301
    • 0038031678 scopus 로고    scopus 로고
    • Cytochrome P4502C9 activity in end-stage renal disease
    • Dreisbach AW, Japa S, Gebrekal AB et al (2003) Cytochrome P4502C9 activity in end-stage renal disease. Clin Pharmacol Ther 73(5):475-477
    • (2003) Clin Pharmacol Ther , vol.73 , Issue.5 , pp. 475-477
    • Dreisbach, A.W.1    Japa, S.2    Gebrekal, A.B.3
  • 302
    • 0021024036 scopus 로고
    • The pharmacokinetics of midazolam in chronic renal failure patients
    • Vinik HR, Reves JG, Greenblatt DJ et al (1983) The pharmacokinetics of midazolam in chronic renal failure patients. Anesthesiology 59(5):390-394
    • (1983) Anesthesiology , vol.59 , Issue.5 , pp. 390-394
    • Vinik, H.R.1    Reves, J.G.2    Greenblatt, D.J.3
  • 303
    • 0036118848 scopus 로고    scopus 로고
    • Comparative human pharmacokinetics and metabolism of single-dose oral and intravenous sildenafil
    • Muirhead GJ, Rance DJ, Walker DK et al (2002) Comparative human pharmacokinetics and metabolism of single-dose oral and intravenous sildenafil. Br J Clin Pharmacol 53(Suppl 1):13S-20S
    • (2002) Br J Clin Pharmacol , vol.53 , Issue.SUPPL. 1 , pp. 13-20
    • Muirhead, G.J.1    Rance, D.J.2    Walker, D.K.3
  • 304
    • 0024416484 scopus 로고
    • Zidovudine disposition in patients with severe renal impairment: Influence of hemodialysis
    • Singlas E, Pioger JC, Taburet AM et al (1989) Zidovudine disposition in patients with severe renal impairment: Influence of hemodialysis. Clin Pharmacol Ther 46(2):190-197
    • (1989) Clin Pharmacol Ther , vol.46 , Issue.2 , pp. 190-197
    • Singlas, E.1    Pioger, J.C.2    Taburet, A.M.3
  • 305
    • 0027732732 scopus 로고
    • Decreased acetylation of isoniazid in chronic renal failure
    • Kim YG, Shin JG, Shin SG et al (1993) Decreased acetylation of isoniazid in chronic renal failure. Clin Pharmacol Ther 54(6):612-620
    • (1993) Clin Pharmacol Ther , vol.54 , Issue.6 , pp. 612-620
    • Kim, Y.G.1    Shin, J.G.2    Shin, S.G.3
  • 306
    • 0020517769 scopus 로고
    • Pharmacokinetics of caffeine during and after pregnancy
    • Brazier JL, Ritter J, Berland M et al (1983) Pharmacokinetics of caffeine during and after pregnancy. Dev Pharmacol Ther 6(5):315-322
    • (1983) Dev Pharmacol Ther , vol.6 , Issue.5 , pp. 315-322
    • Brazier, J.L.1    Ritter, J.2    Berland, M.3
  • 307
    • 0019972360 scopus 로고
    • Delayed elimination of caffeine by women in the last 2 weeks of pregnancy
    • Parsons WD, Pelletier JG (1982) Delayed elimination of caffeine by women in the last 2 weeks of pregnancy. Can Med Assoc J 127(5):377-380
    • (1982) Can Med Assoc J , vol.127 , Issue.5 , pp. 377-380
    • Parsons, W.D.1    Pelletier, J.G.2
  • 309
    • 0023241383 scopus 로고
    • Longitudinal effects of pregnancy on the pharmacokinetics of theophylline
    • Gardner MJ, Schatz M, Cousins L et al (1987) Longitudinal effects of pregnancy on the pharmacokinetics of theophylline. Eur J Clin Pharmacol 32(3):289-295
    • (1987) Eur J Clin Pharmacol , vol.32 , Issue.3 , pp. 289-295
    • Gardner, M.J.1    Schatz, M.2    Cousins, L.3
  • 310
    • 0030978347 scopus 로고    scopus 로고
    • Transdermal nicotine replacement in pregnancy: Maternal pharmacokinetics and fetal effects
    • Wright LN, Thorp JM Jr, Kuller JA et al (1997) Transdermal nicotine replacement in pregnancy: Maternal pharmacokinetics and fetal effects. Am J Obstet Gynecol 176(5):1090-1094
    • (1997) Am J Obstet Gynecol , vol.176 , Issue.5 , pp. 1090-1094
    • Wright, L.N.1    Thorp Jr., J.M.2    Kuller, J.A.3
  • 311
    • 84859758788 scopus 로고    scopus 로고
    • Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum
    • doi:10.1097/QAI. 0b013e31823ff052
    • Cressey TR, Stek A, Capparelli E et al (2012) Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum. J Acquir Immune Defic Syndr 59(3):245-252. doi:10.1097/QAI. 0b013e31823ff052
    • (2012) J Acquir Immune Defic Syndr , vol.59 , Issue.3 , pp. 245-252
    • Cressey, T.R.1    Stek, A.2    Capparelli, E.3
  • 312
    • 0024410655 scopus 로고
    • The effect of pregnancy in humans on the pharmacokinetics of stable isotope labelled phenytoin
    • Dickinson RG, Hooper WD, Wood B et al (1989) The effect of pregnancy in humans on the pharmacokinetics of stable isotope labelled phenytoin. Br J Clin Pharmacol 28(1):17-27
    • (1989) Br J Clin Pharmacol , vol.28 , Issue.1 , pp. 17-27
    • Dickinson, R.G.1    Hooper, W.D.2    Wood, B.3
  • 313
    • 0028295778 scopus 로고
    • Disposition of carbamazepine and phenytoin in pregnancy
    • Tomson T, Lindbom U, Ekqvist B et al (1994) Disposition of carbamazepine and phenytoin in pregnancy. Epilepsia 35(1):131-135
    • (1994) Epilepsia , vol.35 , Issue.1 , pp. 131-135
    • Tomson, T.1    Lindbom, U.2    Ekqvist, B.3
  • 314
    • 0242320357 scopus 로고    scopus 로고
    • The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria
    • doi:10.1007/s00228-003-0652-9
    • McGready R, Stepniewska K, Edstein MD et al (2003) The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria. Eur J Clin Pharmacol 59(7):545-552. doi:10.1007/s00228-003-0652-9
    • (2003) Eur J Clin Pharmacol , vol.59 , Issue.7 , pp. 545-552
    • McGready, R.1    Stepniewska, K.2    Edstein, M.D.3
  • 315
    • 10744230915 scopus 로고    scopus 로고
    • Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil
    • doi:10.1007/s00228-003-0651-x
    • McGready R, Stepniewska K, Seaton E et al (2003) Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil. Eur J Clin Pharmacol 59(7):553-557. doi:10.1007/s00228-003-0651-x
    • (2003) Eur J Clin Pharmacol , vol.59 , Issue.7 , pp. 553-557
    • McGready, R.1    Stepniewska, K.2    Seaton, E.3
  • 316
    • 0030699314 scopus 로고    scopus 로고
    • Induction of CYP2D6 in pregnancy
    • doi:10. 1016/S0009-9236(97 90118-1
    • Wadelius M, Darj E, Frenne G et al (1997) Induction of CYP2D6 in pregnancy. Clin Pharmacol Ther 62(4):400-407. doi:10. 1016/S0009-9236(97)90118-1
    • (1997) Clin Pharmacol Ther , vol.62 , Issue.4 , pp. 400-407
    • Wadelius, M.1    Darj, E.2    Frenne, G.3
  • 317
    • 0026031856 scopus 로고
    • Pharmacokinetic disposition of zidovudine during pregnancy
    • Watts DH, Brown ZA, Tartaglione T et al (1991) Pharmacokinetic disposition of zidovudine during pregnancy. J Infect Dis 163(2):226-232
    • (1991) J Infect Dis , vol.163 , Issue.2 , pp. 226-232
    • Watts, D.H.1    Brown, Z.A.2    Tartaglione, T.3
  • 318
    • 0027243089 scopus 로고
    • The pharmacokinetics and safety of zidovudine in the third trimester of pregnancy for women infected with human immunodeficiency virus and their infants: Phase i acquired immunodeficiency syndrome clinical trials group study (protocol 082)
    • Zidovudine Collaborative Working Group
    • O?Sullivan MJ, Boyer PJ, Scott GB et al (1993) The pharmacokinetics and safety of zidovudine in the third trimester of pregnancy for women infected with human immunodeficiency virus and their infants: Phase I acquired immunodeficiency syndrome clinical trials group study (protocol 082). Zidovudine Collaborative Working Group. Am J Obstet Gynecol 168(5):1510-1516
    • (1993) Am J Obstet Gynecol , vol.168 , Issue.5 , pp. 1510-1516
    • Osullivan, M.J.1    Boyer, P.J.2    Scott, G.B.3
  • 319
    • 0034889440 scopus 로고    scopus 로고
    • The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and Nacetyltransferase activities in humans
    • doi:10. 1067/mcp.2001.116495
    • Tsutsumi K, Kotegawa T, Matsuki S et al (2001) The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and Nacetyltransferase activities in humans. Clin Pharmacol Ther 70(2):121-125. doi:10. 1067/mcp.2001.116495
    • (2001) Clin Pharmacol Ther , vol.70 , Issue.2 , pp. 121-125
    • Tsutsumi, K.1    Kotegawa, T.2    Matsuki, S.3
  • 320
    • 0028278064 scopus 로고
    • Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults
    • Cazeneuve C, Pons G, Rey E et al (1994) Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults. Br J Clin Pharmacol 37(5):405-412
    • (1994) Br J Clin Pharmacol , vol.37 , Issue.5 , pp. 405-412
    • Cazeneuve, C.1    Pons, G.2    Rey, E.3
  • 321
    • 33747835599 scopus 로고    scopus 로고
    • Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations
    • doi:10.1517/17425255.1.3. 447
    • Strolin Benedetti M, Whomsley R, Baltes EL (2005) Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations. Expert Opin Drug Metab Toxicol 1(3):447-471. doi:10.1517/17425255.1.3. 447
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , Issue.3 , pp. 447-471
    • Strolin Benedetti, M.1    Whomsley, R.2    Baltes, E.L.3
  • 322
    • 0034212519 scopus 로고    scopus 로고
    • Expression of biotransformation enzymes in human fetal olfactory mucosa: Potential roles in developmental toxicity
    • doi:10.1006/taap.2000. 8923
    • Gu J, Su T, Chen Y et al (2000) Expression of biotransformation enzymes in human fetal olfactory mucosa: Potential roles in developmental toxicity. Toxicol Appl Pharmacol 165(2):158-162. doi:10.1006/taap.2000. 8923
    • (2000) Toxicol Appl Pharmacol , vol.165 , Issue.2 , pp. 158-162
    • Gu, J.1    Su, T.2    Chen, Y.3
  • 323
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M et al (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270(1):414-423
    • (1994) J Pharmacol Exp Ther , vol.270 , Issue.1 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3
  • 324
    • 0029128788 scopus 로고
    • Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
    • George J, Byth K, Farrell GC (1995) Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver. Biochem Pharmacol 50(5):727-730
    • (1995) Biochem Pharmacol , vol.50 , Issue.5 , pp. 727-730
    • George, J.1    Byth, K.2    Farrell, G.C.3
  • 325
    • 0029938610 scopus 로고    scopus 로고
    • Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period
    • Vieira I, Sonnier M, Cresteil T (1996) Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period. Eur J Biochem 238(2):476-483
    • (1996) Eur J Biochem , vol.238 , Issue.2 , pp. 476-483
    • Vieira, I.1    Sonnier, M.2    Cresteil, T.3
  • 326
    • 2342460306 scopus 로고    scopus 로고
    • Drug metabolism and ageing
    • doi:10.1111/j.1365-2125. 2004.02096.x
    • Kinirons MT, O?Mahony MS (2004) Drug metabolism and ageing. Br J Clin Pharmacol 57(5):540-544. doi:10.1111/j.1365-2125. 2004.02096.x
    • (2004) Br J Clin Pharmacol , vol.57 , Issue.5 , pp. 540-544
    • Kinirons, M.T.1    Omahony, M.S.2
  • 327
    • 0030750270 scopus 로고    scopus 로고
    • Expression of cyp3a in the human liver-evidence that the shift between cyp3a7 and cyp3a4 occurs immediately after birth
    • Lacroix D, Sonnier M, Moncion A et al (1997) Expression of CYP3A in the human liver-evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth. Eur J Biochem 247(2):625-634
    • (1997) Eur J Biochem , vol.247 , Issue.2 , pp. 625-634
    • Lacroix, D.1    Sonnier, M.2    Moncion, A.3
  • 328
    • 0018574014 scopus 로고
    • Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver
    • Onishi S, Kawade N, Itoh S et al (1979) Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver. Biochem J 184(3):705-707
    • (1979) Biochem J , vol.184 , Issue.3 , pp. 705-707
    • Onishi, S.1    Kawade, N.2    Itoh, S.3
  • 329
    • 0036150897 scopus 로고    scopus 로고
    • Developmental aspects of human hepatic drug glucuronidation in young children and adults
    • Strassburg CP, Strassburg A, Kneip S et al (2002) Developmental aspects of human hepatic drug glucuronidation in young children and adults. Gut 50(2):259-265
    • (2002) Gut , vol.50 , Issue.2 , pp. 259-265
    • Strassburg, C.P.1    Strassburg, A.2    Kneip, S.3
  • 330
    • 33644754574 scopus 로고    scopus 로고
    • Developmental expression of aryl, estrogen, and hydroxysteroid sulfotransferases in pre-and postnatal human liver
    • doi:10.1124/jpet.105.093633
    • Duanmu Z, Weckle A, Koukouritaki SB et al (2006) Developmental expression of aryl, estrogen, and hydroxysteroid sulfotransferases in pre-and postnatal human liver. J Pharmacol Exp Ther 316(3):1310-1317. doi:10.1124/jpet.105.093633
    • (2006) J Pharmacol Exp Ther , vol.316 , Issue.3 , pp. 1310-1317
    • Duanmu, Z.1    Weckle, A.2    Koukouritaki, S.B.3
  • 331
    • 0025831505 scopus 로고
    • Interindividual variability in the glucuronidation and sulphation of ethinyloestradiol in human liver
    • Temellini A, Giuliani L, Pacifici GM (1991) Interindividual variability in the glucuronidation and sulphation of ethinyloestradiol in human liver. Br J Clin Pharmacol 31(6):661-664
    • (1991) Br J Clin Pharmacol , vol.31 , Issue.6 , pp. 661-664
    • Temellini, A.1    Giuliani, L.2    Pacifici, G.M.3
  • 332
    • 0024965225 scopus 로고
    • The development expression of alpha-, muand pi-class glutathione S-transferases in human liver
    • Strange RC, Howie AF, Hume R et al (1989) The development expression of alpha-, muand pi-class glutathione S-transferases in human liver. Biochim Biophys Acta 993(2-3):186-190
    • (1989) Biochim Biophys Acta , vol.993 , Issue.2-3 , pp. 186-190
    • Strange, R.C.1    Howie, A.F.2    Hume, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.