Identification of ideal peptides for heterovalent ligands

Methods in Molecular Biology

Volumn 1088, Issue , 2014, Pages 97-105

  Shrivastava, Ajay ^a   Von Wronski, Matthew ^a   Tweedle, Michael F ^a,b   Nunn, Adrian D ^a  

^a Bracco Research USA   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Cooperativity; Heterodimerization; Heterovalent ligands; Neutravidin cross competition; Peptide; Tetravalent; VEGFR 2

Indexed keywords

ANTIBODY; CYTOTOXIC AGENT; LIGAND; PEPTIDE; VASCULOTROPIN RECEPTOR 2;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIMERIZATION; DRUG DELIVERY SYSTEM; DRUG TARGETING; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SYNTHESIS;

AMINO ACID SEQUENCE; AVIDIN; BIOCHEMISTRY; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDES; SOLUTIONS; TRANSFECTION;

EID: 84934434327     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-673-3_7     Document Type: Article

References (9)

1. Ragupathi G, Gathuru J, Livingston P (2005) Antibody inducing polyvalent cancer vaccines. Cancer Treat Res 123:157-180
2. Dorsam RT, Gutkind JS (2007) G-proteincoupled receptors and cancer. Nat Rev 7:79-94
3. Reubi JC (2003) Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr Rev 24:389-427
4. Shrivastava A, von Wronski MA, Sato AK, Dransfi eld DT, Sexton D, Bogdan N et al (2005) A distinct strategy to generate highaffi nity peptide binders to receptor tyrosine kinases. Protein Eng Design Selection 18: 417-424
5. Mammen M, Choi SK, Whitesides GM (1998) Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors. Angew Chem Int Ed 37: 2754-2794
6. Bratthauer GL (1999) The avidin-biotin complex (ABC) method and other avidin-biotin binding methods. Methods Mol Biol 115:203-214
7. Pillai R, Marinelli ER, Swenson RE (2006) A fl exible method for preparation of peptide homo-and heterodimers functionalized with affi nity probes, chelating ligands, and latent conjugating groups. Biopolymers 84: 576-585
8. Hiller Y, Gershoni JM, Bayer EA, Wilcheck M (1987) Biotin binding to avidin. Oligosaccharide side not required for ligand association. Biochem J 248:167-171
9. Alon R, Bayer EA, Wilchek M (1990) Streptavidin contains an RYD sequence which mimics the RGD receptor domains of fi bronectin. Biochem Biophys Res Commun 170: 1236-1241