Integrated treatment of first episode psychosis with online training (e-learning): Study protocol for a randomised controlled trial

Trials

Volumn 15, Issue 1, 2014, Pages

  Barbeito, Sara ^a   Vega, Patricia ^a   de Azua, Sonia Ruiz ^a,b   Balanza Martinez, Vicent ^c,d   Colom, Francesc ^e   Lorente, Esther ^f   Luengo, Ana ^g   Cerrillo, Ester ^h,i   Crespo, José Manuel ^h,i   Pinto, Ana González ^a,b  

^a CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^f HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^g Inpatient Psychiatric Unit of the Clinical Hospital at Home of Valencia   (Spain)

^h BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

ⁱ HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BIOLOGICAL MARKER; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; NEUROLEPTIC AGENT;

ARTICLE; CLINICAL ASSESSMENT TOOL; CLINICAL EXAMINATION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DEMOGRAPHY; EDUCATION PROGRAM; EUROQOL QUESTIONNAIRE; FUNCTIONING ASSESSMENT SHORT TEST; GLOBAL ASSESSMENT OF FUNCTIONING SCALE; HAMILTON DEPRESSION RATING SCALE; HUMAN; LIEBOWITZ SOCIAL ANXIETY SCALE; MAJOR CLINICAL STUDY; MEDICAL INFORMATION SYSTEM; MOOD DISORDER; MORISKY GREEN ADHERENCE SCALE; ONLINE SYSTEM; PATIENT ASSESSMENT; POSITIVE AND NEGATIVE SYNDROME SCALE; PROTEIN BLOOD LEVEL; PSYCHIATRIST; PSYCHOEDUCATION; PSYCHOPHARMACOTHERAPY; PSYCHOSIS; PSYCHOTHERAPIST; PSYCHOTHERAPY; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCALE TO ASSESS UNAWARENESS OF MENTAL DISORDER; SINGLE BLIND PROCEDURE; SOCIAL ASPECT; SOCIAL INTERACTION; SPAIN; STATE TRAIT ANXIETY INVENTORY; STRAUSS AND CARPENTER PROGNOSTIC SCALE; TREATMENT OUTCOME; UNIVERSITY HOSPITAL; VIDEOCONFERENCING; WORLD HEALTH ORGANIZATION QUALITY OF LIFE INSTRUMENT WHOQOL BREF; AFFECT; BLOOD; CLINICAL PROTOCOL; CLINICAL TRIAL; EDUCATION; INTERNET; MEDICATION COMPLIANCE; METABOLISM; METHODOLOGY; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; PREDICTIVE VALUE; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; PSYCHOTIC DISORDERS; SOCIAL BEHAVIOR; STATISTICAL MODEL; TEACHING; TIME;

AFFECT; ANTIPSYCHOTIC AGENTS; BIOLOGICAL MARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CLINICAL PROTOCOLS; COMBINED MODALITY THERAPY; COMPUTER-ASSISTED INSTRUCTION; HUMANS; INTERNET; LINEAR MODELS; LOGISTIC MODELS; MEDICATION ADHERENCE; PREDICTIVE VALUE OF TESTS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTHERAPY; PSYCHOTIC DISORDERS; QUALITY OF LIFE; QUESTIONNAIRES; RESEARCH DESIGN; SINGLE-BLIND METHOD; SOCIAL BEHAVIOR; SPAIN; TIME FACTORS; TREATMENT OUTCOME;

EID: 84934289551     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/1745-6215-15-416     Document Type: Article

References (48)

1. Dictionary of the Spanish Language. 22nd edition. Madrid: Real Academia Española; 2001.
2. Tournier M: First-episodes psychosis: clinical and epidemiological news. Encéphale 2013,39(Suppl 2):74-78.
3. Alvarez-Jimenez M, Gleeson JF, Henry LP, Harrigan SM, Harris MG, Amminger GP, Killackey E, Yung AR, Herrman H, Jackson HJ, McGorry PD: Prediction of a single psychotic episode: a 7.5-year, prospective study in first-episode psychosis. Schizophr Res 2011, 125:236-246. 10.1016/j.schres.2010.10.020.
4. Alvarez-Jimenez M, Priede A, Hetrick SE, Bendall S, Killackey E, Parker AG, McGorry PD, Gleeson JF: Risk factors for relapse following treatment for first episode psychosis: a systematic review and meta-analysis of longitudinal studies. Schizophr Res 2012, 139:116-128. 10.1016/j.schres.2012.05.007.
5. González-Pinto A, Aldama A, González C, Mosquera F, Arrasate M, Vieta E: Predictors of suicide in first-episode affective and nonaffective psychotic inpatients: five-year follow-up of patients from a catchment area in Vitoria, Spain. J Clin Psychiatry 2007, 68:242-247. 10.4088/JCP.v68n0209.
6. González-Pinto A, Vega P, Ibáñez B, Mosquera F, Barbeito S, Gutiérrez M, Ruiz de Azúa S, Ruiz I, Vieta E: Impact of cannabis and other drugs on age at onset of psychosis. J Clin Psychiatry 2008, 69:1210-1216. 10.4088/JCP.v69n0802.
7. Baeza I, Graell M, Moreno D, Castro-Fornieles J, Parellada M, González-Pinto A, Payá B, Soutullo C, de la Serna E, Arango C: Cannabis use in children and adolescents with first episode psychosis: influence on psychopathology and short-term outcome (CAFEPS study). Schizophr Res 2009, 113:129-137. 10.1016/j.schres.2009.04.005.
8. González-Pinto A, Alberich S, Barbeito S, Gutierrez M, Vega P, Ibáñez B, Haidar MK, Vieta E, Arango C: Cannabis and first-episode psychosis: different long-term outcomes depending on continued or discontinued use. Schizophr Bull 2011, 37:631-639. 10.1093/schbul/sbp126.
9. Colom C, Reinares M, Pacchiarotti I: Has number of previous episodes any effect on response to group psychoeducation in bipolar patients? A 5-year follow-up post hoc analysis. Acta Neuropsychiat 2010, 22:50-53. 10.1111/j.1601-5215.2010.00450.x.
10. González-Isasi A, Echeburúa E, Mosquera F, Ibáñez B, Aizpuru F, González-Pinto A: Long-term efficacy of psychological intervention program for patients with refractory bipolar disorder: a pilot study. Psychiatry Res 2010, 176:161-165. 10.1016/j.psychres.2008.06.047.
11. Wyatt RJ, Green MF, Tuma AH: Long-term morbidity associated with delayed treatment of first admission schizophrenic patients: a reanalysis of the Camarillo State Hospital data. Psychol Med 1997, 27:261-268. 10.1017/S0033291796004345.
12. Figuerido JL, Gutiérrez M, Mosquera F, Lalaguna B, González Pinto A: Involuntary hospitalization in the first psychotic episodes: associated factors. Actas Esp Psiquiatr 2000, 28:275-278.
13. Parellada M, Fraguas D, Bombín I, Otero S, Castro-Fornieles J, Baeza I, Gonzalez-Pinto A, Graell M, Soutullo C, Paya B, Arango C: Insight correlates in child- and adolescent-onset first episodes of psychosis: results from the CAFEPS study. Psychol Med 2009, 39:1433-1445. 10.1017/S0033291708004868.
14. Penn DL, Waldheter EJ, Perkins DO, Mueser KT, Lieberman JA: Psychosocial treatment for first-episode psychosis: a research update. Am J Psychiatry 2005, 162:2220-2232. 10.1176/appi.ajp.162.12.2220.
15. Lecardeur L: Cognitive behavior therapy after first-episodes psychosis. Encéphale 2013,39(Suppl 2):S115-S120.
16. Petersen L, Nordentoft M, Jeppesen P, Ohlenschaeger J, Thorup A, Christensen TØ, Krarup G, Dahlstrøm J, Haastrup B, Jørgensen P: Improving 1-year outcome in first-episode psychosis: OPUS trial. Br J Psychiatry 2005, 48:s98-s103.
17. Petersen L, Jeppesen P, Thorup A, Abel MB, Øhlenschlaeger J, Christensen TØ, Krarup G, Jørgensen P, Nordentoft M: A randomised multicentre trial of integrated versus standard treatment for patients with a first episode of psychotic illness. BMJ 2005, 331:602. 10.1136/bmj.38565.415000.E01.
18. Thorup AP, Petersen L, Jeppesen P, Ohlenschlaeger J, Christensen T, Krarup G, Jørgensen P, Nordentoft M: Integrated treatment ameliorates negative symptoms in first episode psychosis-results from the Danish OPUS trial. Schizophr Res 2005, 79:95-105. 10.1016/j.schres.2004.12.020.
19. Bertelsen M, Jeppesen P, Petersen L, Thorup A, Øhlenschlaeger J, le Quach P, Christensen TØ, Krarup G, Jørgensen P, Nordentoft M: Five-year follow-up of a randomized multicenter trial of intensive early intervention vs standard treatment for patients with a first episode of psychotic illness: the OPUS trial. Arch Gen Psychiatry 2008, 65:762-771. 10.1001/archpsyc.65.7.762.
20. Nordentoft M, Jeppesen P, Abel M, Kassow P, Petersen L, Thorup A, Krarup G, Hemmingsen R, Jørgensen P: OPUS study: suicidal behaviour, suicidal ideation and hopelessness among patients with first-episode psychosis. One-year follow-up of a randomised controlled trial. Br J Psychiatry Supplement 2002, 43:98-106.
21. Kobak KA, Craske MG, Rose RD, Wolitsky-Taylor K: Web-based therapist training on cognitive behavior therapy for anxiety disorders: a pilot study. Psychotherapy (Chic) 2013,50(2):235-247.
22. Kulier R, Coppus SF, Zamora J, Hadley J, Malick S, Das K, Weinbrenner S, Meyerrose B, Decsi T, Horvath AR, Nagy E, Emparanza JI, Arvanitis TN, Burls A, Cabello JB, Kaczor M, Zanrei G, Pierer K, Stawiarz K, Kunz R, Mol BW, Khan KS: The effectiveness of a clinically integrated e-learning course in evidence-based medicine: a cluster randomised controlled trial. BMC Med Educ 2009, 12:9-21.
23. Kay SR, Fiszbein A, Opler LA: The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987, 13:261-276. 10.1093/schbul/13.2.261.
24. Peralta V, Cuesta M: Validación de la escala de los síndromes positivo y negativo (PANNS) en una muestra de esquizofrénicos españoles. Actas Luso Esp Neurol Psiquiatr 1994, 22:171-177.
25. Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA: Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press; 1983.
26. Bermúdez J: Anxiety and performance. Rev Psicol Gen Apl 1978, 151:183-207.
27. Guillén-Riquelme A, Buela-Casal G: Actualización psicométrica y funcionamiento diferencial de los ítems en el State Trait Anxiety Inventory (STAI). Psicothema 2011, 23:510-515.
28. Liebowitz MR: Social Phobia. Mod Probl Pharmacopsychiatry 1987, 22:141-173.
29. Bobes J, Badía X, Luque A, García M, González MP, Dal-Ré R: Validation of the Spanish version of the Liebowitz social anxiety scale, social anxiety and distress scale and Sheehan disability inventory for the evaluation of social phobia. Med Clin (Barc) 1999, 112:530-538.
30. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960, 23:56-62. 10.1136/jnnp.23.1.56.
31. Ramos-Brieva JA, Cordero A: Validación de la versión castellana de la escala Hamilton para la depresión. Actas Luso Esp Neurol Psiquiatr 1986, 14:335-338.
32. Amador XF, Strauss DH, Yale SA, Flaum MM, Endicott J, Gorman JM: Assessment of insight in psychosis. Am J Psychiatry 1993, 150:873-879.
33. Ruiz A, Pousa E, Duñó R, Crosas J, Cuppa S, García C: Spanish adaptation of the Scale to Assess Unawareness of Mental Disorder (SUMD). Actas Esp Psiquiatr 2008, 36:111-1198.
34. Strauss SJ, Carpenter WTJ: The prediction of outcome in schizophrenia: part I. Characteristics of outcome. Arch Gen Psychiatry 1972, 27:739-746. 10.1001/archpsyc.1972.01750300011002.
35. Strauss SJ, Carpenter WTJ: The prediction of outcome in schizophrenia. II. Relationships between predictor and outcome variables: a report from the WHO pilot international pilot study of schizophrenia. Arch Gen Psychiatry 1974, 31:37-42. 10.1001/archpsyc.1974.01760130021003.
36. Strauss SJ, Carpenter WTJ: Characteristic symptoms and outcome is schizophrenia. Arch Gen Psychiatry 1974, 30:37-42. 10.1001/archpsyc.1974.01760070023004.
37. Ahuir M, Bernardo M, de la Serna E, Ochoa S, Carlson J, Escartín G, Gutiérrez-Zotes A, Valero J, Salamero M, Cañizares S, Fernández-Egea E, Cañete J, Gallo P: Adaptation and validation of the Spanish version of the Strauss and Carpenter Prognostic Scale for Schizophrenia. Rev Psiquiatr Salud Ment 2009, 2:150-159. 10.1016/S1888-9891(09)73233-1.
38. American Psychiatric Association (APA): Diagnostic and Statistical Manual of Mental Disorders (4th edition, text revision) (DSM IV-TR). Washington DC: American Psychiatric Press; 2000.
39. Jones SH, Thornicroft G, Coffey M, Dunn G: A brief mental health outcome scale-reliability and validity of the Global Assessment of Functioning (GAF). Br J Psychiatry 1995, 166:654-659. 10.1192/bjp.166.5.654.
40. Reisberg B: Functional assessment staging (FAST). Psychopharmacol Bull 1988, 24:653-659.
41. González-Ortega I, Rosa A, Alberich S, Barbeito S, Vega P, Echeburúa E, Vieta E, González-Pinto A: Validation and use of the functioning assessment short test in first psychotic episodes. J Nerv Ment Dis 2010, 198:836-840. 10.1097/NMD.0b013e3181f97bf9.
42. Morisky DE, Green LW, Levine DM: Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986, 24:67-74. 10.1097/00005650-198601000-00007.
43. Val A, Amorós G, Martínez P, Fernández ML, León M: Descriptive study of patient compliance in pharmacologic antihypertensive treatment and validation of the Morisky and Green test [in Spanish]. Aten Primaria 1992, 10:767-770.
44. WHOQOL GROUP: Study protocol for the World Health Organization Project to develop a Quality of Life Assessment Instrument (WHOQOL). Qual Life Res 1993, 2:153-159.
45. Lucas-Carrasco R: The WHO quality of life (WHOQOL) questionnaire: Spanish development and validation studies. Qual Life Res 2012, 21:161-165. 10.1007/s11136-011-9926-3.
46. Group EQ: EuroQol - a new facility for the measurement of health-related quality of life. Health Policy 1990, 16:199-208.
47. Badia X, Roset M, Montserrat S, Herdman M, Segura A: The Spanish version of EuroQol: a description and its applications. European Quality of Life scale. Med Clin cBarc) 1999,112(Suppl 1):79-85.
48. Stafford MR, Jackson H, Mayo-Wilson E, Morrison AP, Kendall T: Early interventions to prevent psychosis: systematic review and meta-analysis. BMJ 2013, 346:f762.