Risk factors for recurrent urinary tract infection and renal scarring

Pediatrics

Volumn 136, Issue 1, 2015, Pages e13-e21

  Keren, Ron ^a,b   Shaikh, Nader ^c   Pohl, Hans ^d   Gravens Mueller, Lisa ^e   Ivanova, Anastasia ^a   Zaoutis, Lisa ^a   Patel, Melissa ^a   De Berardinis, Rachel ^a   Parker, Allison ^a   Bhatnagar, Sonika ^c   Haralam, Mary Ann ^c   Pope, Marcia ^c   Kearney, Diana ^c   Sprague, Bruce ^d   Barrera, Raquel ^d   Viteri, Bernarda ^d   Egigueron, Martina ^d   Shah, Neha ^d   Hoberman, Alejandro ^c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TECHNETIUM 99M; ANTIINFECTIVE AGENT;

AGE; ARTICLE; BLADDER AND BOWEL DYSFUNCTION; BLADDER DYSFUNCTION; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DIGESTIVE SYSTEM DISEASE; FEMALE; FEVER; FOLLOW UP; HUMAN; INFANT; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RACE; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; RENAL SCARRING; RISK FACTOR; URINARY TRACT INFECTION; VESICOURETERAL REFLUX; ANTIBIOTIC PROPHYLAXIS; CICATRIX; CLINICAL TRIAL; COMPLICATION; INCIDENCE; KIDNEY; MULTICENTER STUDY; PATHOLOGY; PROCEDURES; RISK ASSESSMENT; UNITED STATES; URINARY TRACT INFECTIONS; VESICO-URETERAL REFLUX;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; CHILD, PRESCHOOL; CICATRIX; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; INFANT; KIDNEY; MALE; PROSPECTIVE STUDIES; RECURRENCE; RISK ASSESSMENT; RISK FACTORS; UNITED STATES; URINARY TRACT INFECTIONS; VESICO-URETERAL REFLUX;

EID: 84934280790     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2015-0409     Document Type: Article

References (35)

1. Hellström A, Hanson E, Hansson S, Hjälmås K, Jodal U. Association between urinary symptoms at 7 years old and previous urinary tract infection. Arch Dis Child. 1991;66(2):232-234
2. Hoberman A, Charron M, Hickey RW, Baskin M, Kearney DH, Wald ER. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med. 2003;348(3):195-202
3. Rushton HG, Majd M, Jantausch B, Wiedermann BL, Belman AB. Renal scarring following reflux and nonreflux pyelonephritis in children: evaluation with 99mtechnetium-dimercaptosuccinic acid scintigraphy. J Urol. 1992;147(5): 1327-1332
4. Wennerström M, Hansson S, Jodal U, Stokland E. Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr. 2000;136(1): 30-34
5. Camacho V, Estorch M, Fraga G, et al. DMSA study performed during febrile urinary tract infection: a predictor of patient outcome? Eur J Nucl Med Mol Imaging. 2004;31(6):862-866
6. Conway PH, Cnaan A, Zaoutis T, Henry BV, Grundmeier RW, Keren R. Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. JAMA. 2007; 298(2):179-186
7. Panaretto K, Craig J, Knight J, Howman-Giles R, Sureshkumar P, Roy L. Risk factors for recurrent urinary tract infection in preschool children. J Paediatr Child Health. 1999;35(5): 454-459
8. Dias CS, Silva JM, Diniz JS, et al. Risk factors for recurrent urinary tract infections in a cohort of patients with primary vesicoureteral reflux. Pediatr Infect Dis J. 2010;29(2):139-144
9. Downs SM; The Urinary Tract Subcommittee of the American Academy of Pediatrics Committee on Quality Improvement. Technical report: urinary tract infections in febrile infants and young children. Pediatrics. 1999;103(4). Available at: www.pediatrics.org/cgi/content/full/103/4/e54
10. Bisset GS III, Strife JL, Dunbar JS. Urography and voiding cystourethrography: findings in girls with urinary tract infection. AJR Am J Roentgenol. 1987;148(3):479-482
11. Gleeson FV, Gordon I. Imaging in urinary tract infection. Arch Dis Child. 1991; 66(11):1282-1283
12. McKerrow W, Davidson-Lamb N, Jones PF. Urinary tract infection in children. Br Med J (Clin Res Ed). 1984;289(6440): 299-303
13. Benador D, Benador N, Slosman DO, Nusslé D, Mermillod B, Girardin E. Cortical scintigraphy in the evaluation of renal parenchymal changes in children with pyelonephritis. J Pediatr. 1994; 124(1):17-20
14. Jakobsson B, Berg U, Svensson L. Renal scarring after acute pyelonephritis. Arch Dis Child. 1994;70(2):111-115
15. Rosenberg AR, Rossleigh MA, Brydon MP, Bass SJ, Leighton DM, Farnsworth RH. Evaluation of acute urinary tract infection in children by dimercaptosuccinic acid scintigraphy: a prospective study. J Urol. 1992; 148(5 pt 2):1746-1749
16. Tappin DM, Murphy AV, Mocan H, et al. A prospective study of children with first acute symptomatic E. coli urinary tract infection. Early 99mtechnetium dimercaptosuccinic acid scan appearances. Acta Paediatr Scand. 1989; 78(6):923-929
17. Garin EH, Olavarria F, Garcia Nieto V, Valenciano B, Campos A, Young L. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics. 2006;117(3):626-632
18. Shaikh N, Hoberman A, Wise B, et al. Dysfunctional elimination syndrome: is it related to urinary tract infection or vesicoureteral reflux diagnosed early in life? Pediatrics. 2003;112(5):1134-1137
19. Svanborg C. Urinary tract infections in children: microbial virulence versus host susceptibility. Adv Exp Med Biol. 2013;764: 205-210
20. Ragnarsdóttir B, Svanborg C. Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: host-pathogen interaction in urinary tract infections. Pediatr Nephrol. 2012;27(11): 2017-2029
21. Koff SA, Wagner TT, Jayanthi VR. The relationship among dysfunctional elimination syndromes, primary vesicoureteral reflux and urinary tract infections in children. J Urol. 1998;160(3 pt 2):1019-1022
22. Seruca H. Vesicoureteral reflux and voiding dysfunction: a prospective study. J Urol. 1989;142(2 pt 2):494-498, discussion 501
23. van Gool JD, Hjälmås K, Tamminen-Möbius T, Olbing H; The International Reflux Study in Children. Historical clues to the complex of dysfunctional voiding, urinary tract infection and vesicoureteral reflux. J Urol. 1992;148(5 pt 2):1699-1702
24. Naseer SR, Steinhardt GF. New renal scars in children with urinary tract infections, vesicoureteral reflux and voiding dysfunction: a prospective evaluation. J Urol. 1997;158(2):566-568
25. Snodgrass W. Relationship of voiding dysfunction to urinary tract infection and vesicoureteral reflux in children. Urology. 1991;38(4):341-344
26. Hoberman A, Chesney RW; RIVUR Trial Investigators. Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med. 2014;371(11):1072-1073
27. Majd M, Rushton HG, Chandra R, Andrich MP, Tardif CP, Rashti F. Technetium-99m-DMSA renal cortical scintigraphy to detect experimental acute pyelonephritis in piglets: comparison of planar (pinhole) and SPECT imaging. J Nucl Med. 1996; 37(10):1731-1734
28. Rushton HG, Majd M, Chandra R, Yim D. Evaluation of 99mtechnetium-dimercapto-succinic acid renal scans in experimental acute pyelonephritis in piglets. J Urol. 1988;140(5 pt 2):1169-1174
29. Medical versus surgical treatment of primary vesicoureteral reflux: report of the International Reflux Study Committee. Pediatrics. 1981;67(3): 392-400
30. Farhat W, Bägli DJ, Capolicchio G, et al. The dysfunctional voiding scoring system: quantitative standardization of dysfunctional voiding symptoms in children. J Urol. 2000;164(3 pt 2): 1011-1015
31. Breiman L, Friedman JH, Olshen RA, Stone CJ. Classification and Regression Trees. Belmont, CA: Wadsworth; 1984
32. Conway JJ. The role of scintigraphy in urinary tract infection. Semin Nucl Med. 1988;18(4):308-319
33. Shim YH, Lee JW, Lee SJ. The risk factors of recurrent urinary tract infection in infants with normal urinary systems. Pediatr Nephrol. 2009;24(2):309-312
34. Hoberman A, Keren R. Antimicrobial prophylaxis for urinary tract infection in children. N Engl J Med. 2009;361(18): 1804-1806
35. Craig JC, Simpson JM, Williams GJ, et al; Prevention of Recurrent Urinary Tract Infection in Children with Vesicoureteric Reflux and Normal Renal Tracts (PRIVENT) Investigators. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med. 2009; 361(18):1748-1759