Left atrial remodeling and function in advanced heart failure with preserved or reduced ejection fraction

Circulation: Heart Failure

Volumn 8, Issue 2, 2015, Pages 295-303

  Melenovsky, Vojtech ^a,b   Hwang, Seok Jae ^a   Redfield, Margaret M ^a   Zakeri, Rosita ^a   Lin, Grace ^a   Borlaug, Barry A ^a  

^a MAYO CLINIC   (United States)

^b INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

atrial fibrillation; heart failure; left atrial function; pulmonary hypertension; right ventricle

Indexed keywords

ADULT; AGED; ARTICLE; ATRIAL FIBRILLATION; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FEMALE; HEART ATRIUM REMODELING; HEART CATHETERIZATION; HEART FAILURE; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART FAILURE WITH REDUCED EJECTION FRACTION; HEART LEFT ATRIUM PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE FAILURE; HEART VOLUME; HUMAN; LUNG VASCULAR RESISTANCE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MITRAL VALVE REGURGITATION; MORTALITY; OUTCOME ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; WALL STRESS; ARTERIAL STIFFNESS; HEART ATRIUM FUNCTION; HEART RIGHT VENTRICLE FUNCTION; HEART STROKE VOLUME; PATHOPHYSIOLOGY; PHYSIOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; VASCULAR RESISTANCE;

AGED; ATRIAL FUNCTION, LEFT; ATRIAL REMODELING; FEMALE; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; PROGNOSIS; RETROSPECTIVE STUDIES; STROKE VOLUME; VASCULAR RESISTANCE; VASCULAR STIFFNESS; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 84933677596     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.114.001667     Document Type: Article

References (47)

1. Braunwald E, Frahm CJ. Studies on starling's law of the heart: IV. Observations on the hemodynamic functions of the left atrium in man. Circulation. 1961;24:633-642.
2. Donal E, Raud-Raynier P, De Place C, Gervais R, Rosier A, Roulaud M, Ingels A, Carre F, Daubert JC, Denjean A. Resting echocardiographic assessments of left atrial function and filling pressure interest in the understanding of exercise capacity in patients with chronic congestive heart failure. J Am Soc Echocardiogr. 2008;21:703-710. doi: 10.1016/j. echo.2007.10.002.
3. Welles CC, Ku IA, Kwan DM, Whooley MA, Schiller NB, Turakhia MP. Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. J Am Coll Cardiol. 2012;59:673-680. doi: 10.1016/j.jacc.2011.11.012.
4. Tan YT, Wenzelburger F, Lee E, Nightingale P, Heatlie G, Leyva F, Sanderson JE. Reduced left atrial function on exercise in patients with heart failure and normal ejection fraction. Heart. 2010;96:1017-1023. doi: 10.1136/hrt.2009.189118.
5. Melenovsky V, Borlaug BA, Rosen B, Hay I, Ferruci L, Morell CH, Lakatta EG, Najjar SS, Kass DA. Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction. J Am Coll Cardiol. 2007;49:198-207. doi: 10.1016/j.jacc.2006.08.050.
6. Gottdiener JS, Kitzman DW, Aurigemma GP, Arnold AM, Manolio TA. Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons > or =65 years of age (the cardiovascular health study). Am J Cardiol. 2006;97:83-89. doi: 10.1016/j.amjcard.2005.07.126.
7. Hoit BD. Left atrial size and function: role in prognosis. J Am Coll Cardiol. 2014;63:493-505. doi: 10.1016/j.jacc.2013.10.055.
8. Olsson LG, Swedberg K, Ducharme A, Granger CB, Michelson EL, McMurray JJ, Puu M, Yusuf S, Pfeffer MA; CHARM Investigators. Atrial fibrillation and risk of clinical events in chronic heart failure with and without left ventricular systolic dysfunction: results from the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) program. J Am Coll Cardiol. 2006;47:1997-2004. doi: 10.1016/j.jacc.2006.01.060.
9. Schwammenthal E, Vered Z, Agranat O, Kaplinsky E, Rabinowitz B, Feinberg MS. Impact of atrioventricular compliance on pulmonary artery pressure in mitral stenosis: an exercise echocardiographic study. Circulation. 2000;102:2378-2384.
10. Stefanadis C, Dernellis J, Stratos C, Tsiamis E, Vlachopoulos C, Toutouzas K, Lambrou S, Pitsavos C, Toutouzas P. Effects of balloon mitral valvuloplasty on left atrial function in mitral stenosis as assessed by pressure-area relation. J Am Coll Cardiol. 1998;32:159-168.
11. Guazzi M, Borlaug BA. Pulmonary hypertension due to left heart disease. Circulation. 2012;126:975-990. doi: 10.1161/CIRCULATIONAHA.111.085761.
12. Butler J, Chomsky DB, Wilson JR. Pulmonary hypertension and exercise intolerance in patients with heart failure. J Am Coll Cardiol. 1999;34:1802-1806.
13. Lam CS, Roger VL, Rodeheffer RJ, Borlaug BA, Enders FT, Redfield MM. Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol. 2009;53:1119-1126. doi: 10.1016/j.jacc.2008.11.051.
14. Tedford RJ, Hassoun PM, Mathai SC, Girgis RE, Russell SD, Thiemann DR, Cingolani OH, Mudd JO, Borlaug BA, Redfield MM, Lederer DJ, Kass DA. Pulmonary capillary wedge pressure augments right ventricular pulsatile loading. Circulation. 2012;125:289-297. doi: 10.1161/CIRCULATIONAHA.111.051540.
15. Dupont M, Mullens W, Skouri HN, Abrahams Z, Wu Y, Taylor DO, Starling RC, Tang WH. Prognostic role of pulmonary arterial capacitance in advanced heart failure. Circ Heart Fail. 2012;5:778-785. doi: 10.1161/CIRCHEARTFAILURE.112.968511.
16. Borlaug BA, Nishimura RA, Sorajja P, Lam CS, Redfield MM. Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail. 2010;3:588-595. doi: 10.1161/CIRCHEARTFAILURE.109.930701.
17. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise J, Solomon S, Spencer KT, St John Sutton M, Stewart W; American Society of Echocardiography's Nomenclature and Standards Committee; Task Force on Chamber Quantification; American College of Cardiology Echocardiography Committee; American Heart Association; European Association of Echocardiography, European Society of Cardiology. Recommendations for chamber quantification. Eur J Echocardiogr. 2006;7:79-108. doi: 10.1016/j.euje.2005.12.014.
18. Redfield MM, Jacobsen SJ, Burnett JC Jr, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA. 2003;289:194-202.
19. Zoghbi WA, Enriquez-Sarano M, Foster E, Grayburn PA, Kraft CD, Levine RA, Nihoyannopoulos P, Otto CM, Quinones MA, Rakowski H, Stewart WJ, Waggoner A, Weissman NJ; American Society of Echocardiography. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr. 2003;16:777-802. doi: 10.1016/S0894-7317(03)00335-3.
20. Quinones MA, Waggoner AD, Reduto LA, Nelson JG, Young JB, Winters WL Jr, Ribeiro LG, Miller RR. A new, simplified and accurate method for determining ejection fraction with two-dimensional echocardiography. Circulation. 1981;64:744-753.
21. Rosca M, Lancellotti P, Popescu BA, Piérard LA. Left atrial function: pathophysiology, echocardiographic assessment, and clinical applications. Heart. 2011;97:1982-1989. doi: 10.1136/heartjnl-2011-300069.
22. Dernellis JM, Stefanadis CI, Zacharoulis AA, Toutouzas PK. Left atrial mechanical adaptation to long-standing hemodynamic loads based on pressure-volume relations. Am J Cardiol. 1998;81:1138-1143.
23. Barbier P, Solomon SB, Schiller NB, Glantz SA. Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function. Circulation. 1999;100:427-436.
24. John Sutton MG, Plappert TA, Hirshfeld JW, Reichek N. Assessment of left ventricular mechanics in patients with asymptomatic aortic regurgitation: a two-dimensional echocardiographic study. Circulation. 1984;69:259-268.
25. Beinart R, Abbara S, Blum A, Ferencik M, Heist K, Ruskin J, Mansour M. Left atrial wall thickness variability measured by CT scans in patients undergoing pulmonary vein isolation. J Cardiovasc Electrophysiol. 2011;22:1232-1236. doi: 10.1111/j.1540-8167.2011.02100.x.
26. Melenovsky V, Hwang SJ, Lin G, Redfield MM, Borlaug BA. Right heart dysfunction in heart failure with preserved ejection fraction. Eur Heart J. 2014;35:3452-3462. doi: 10.1093/eurheartj/ehu193.
27. Peluso D, Badano LP, Muraru D, Dal Bianco L, Cucchini U, Kocabay G, Kovàcs A, Casablanca S, Iliceto S. Right atrial size and function assessed with three-dimensional and speckle-tracking echocardiography in 200 healthy volunteers. Eur Heart J Cardiovasc Imaging. 2013;14:1106-1114. doi: 10.1093/ehjci/jet024.
28. Lee DS, Gona P, Vasan RS, Larson MG, Benjamin EJ, Wang TJ, Tu JV, Levy D. Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute. Circulation. 2009;119:3070-3077. doi: 10.1161/CIRCULATIONAHA.108.815944.
29. Lam CS, Carson PE, Anand IS, Rector TS, Kuskowski M, Komajda M, McKelvie RS, McMurray JJ, Zile MR, Massie BM, Kitzman DW. Sex differences in clinical characteristics and outcomes in elderly patients with heart failure and preserved ejection fraction: the Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) trial. Circ Heart Fail. 2012;5:571-578. doi: 10.1161/CIRCHEARTFAILURE.112.970061.
30. Kurt M, Wang J, Torre-Amione G, Nagueh SF. Left atrial function in diastolic heart failure. Circ Cardiovasc Imaging. 2009;2:10-15. doi: 10.1161/CIRCIMAGING.108.813071.
31. Triposkiadis F, Harbas C, Kelepeshis G, Sitafidis G, Skoularigis J, Demopoulos V, Tsilimingas N. Left atrial remodeling in patients younger than 70 years with diastolic and systolic heart failure. J Am Soc Echocardiogr. 2007;20:177-185. doi: 10.1016/j.echo.2006.08.013.
32. Borlaug BA, Redfield MM. Diastolic and systolic heart failure are distinct phenotypes within the heart failure spectrum. Circulation. 2011;123:2006-2013; discussion 2014. doi: 10.1161/CIRCULATIONAHA.110.954388.
33. Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013;62:263-271. doi: 10.1016/j.jacc.2013.02.092.
34. Aldhoon B, Melenovský V, Peichl P, Kautzner J. New insights into mechanisms of atrial fibrillation. Physiol Res. 2010;59:1-12.
35. Phan TT, Abozguia K, Shivu GN, Ahmed I, Leyva F, Patel K, Frenneaux M. Increased atrial contribution to left ventricular filling compensates for impaired early filling during exercise in heart failure with preserved ejection fraction. J Card Fail. 2009;15:890-897. doi: 10.1016/j. cardfail.2009.06.440.
36. Kono T, Sabbah HN, Rosman H, Alam M, Stein PD, Goldstein S. Left atrial contribution to ventricular filling during the course of evolving heart failure. Circulation. 1992;86:1317-1322.
37. Hoit BD, Shao Y, Gabel M. Left atrial systolic and diastolic function accompanying chronic rapid pacing-induced atrial failure. Am J Physiol. 1998;275(1 Pt 2):H183-H189.
38. Khan A, Moe GW, Nili N, Rezaei E, Eskandarian M, Butany J, Strauss BH. The cardiac atria are chambers of active remodeling and dynamic collagen turnover during evolving heart failure. J Am Coll Cardiol. 2004;43:68-76.
39. Obokata M, Negishi K, Kurosawa K, Arima H, Tateno R, Ui G, Tange S, Arai M, Kurabayashi M. Incremental diagnostic value of la strain with leg lifts in heart failure with preserved ejection fraction. JACC Cardiovasc Imaging. 2013;6:749-758. doi: 10.1016/j.jcmg.2013.04.006.
40. Plehn JF, Southworth J, Cornwell GG III. Brief report: atrial systolic failure in primary amyloidosis. N Engl J Med. 1992;327:1570-1573. doi: 10.1056/NEJM199211263272205.
41. Gupta DK, Shah AM, Giugliano RP, Ruff CT, Antman EM, Grip LT, Deenadayalu N, Hoffman E, Patel I, Shi M, Mercuri M, Mitrovic V, Braunwald E, Solomon SD; Effective aNticoaGulation with factor xA next GEneration in AF-Thrombolysis In Myocardial Infarction 48 Echocardiographic Study Investigators. Left atrial structure and function in atrial fibrillation: ENGAGE AF-TIMI 48. Eur Heart J. 2014;35:1457-1465. doi: 10.1093/eurheartj/eht500.
42. Santos AB, Kraigher-Krainer E, Gupta DK, Claggett B, Zile MR, Pieske B, Voors AA, Lefkowitz M, Bransford T, Shi V, Packer M, McMurray JJ, Shah AM, Solomon SD; PARAMOUNT Investigators. Impaired left atrial function in heart failure with preserved ejection fraction. Eur J Heart Fail. 2014;16:1096-1103. doi: 10.1002/ejhf.147.
43. Shibata S, Hastings JL, Prasad A, Fu Q, Bhella PS, Pacini E, Krainski F, Palmer MD, Zhang R, Levine BD. Congestive heart failure with preserved ejection fraction is associated with severely impaired dynamic Starling mechanism. J Appl Physiol (1985). 2011;110:964-971. doi: 10.1152/japplphysiol.00826.2010.
44. Rosenberg MA, Manning WJ. Diastolic dysfunction and risk of atrial fibrillation: a mechanistic appraisal. Circulation. 2012;126:2353-2362. doi: 10.1161/CIRCULATIONAHA.112.113233.
45. Mehta S, Charbonneau F, Fitchett DH, Marpole DG, Patton R, Sniderman AD. The clinical consequences of a stiff left atrium. Am Heart J. 1991;122(4 Pt 1):1184-1191.
46. Ghio S, Gavazzi A, Campana C, Inserra C, Klersy C, Sebastiani R, Arbustini E, Recusani F, Tavazzi L. Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure. J Am Coll Cardiol. 2001;37:183-188.
47. Gibson DN, Di Biase L, Mohanty P, Patel JD, Bai R, Sanchez J, Burkhardt JD, Heywood JT, Johnson AD, Rubenson DS, Horton R, Gallinghouse GJ, Beheiry S, Curtis GP, Cohen DN, Lee MY, Smith MR, Gopinath D, Lewis WR, Natale A. Stiff left atrial syndrome after catheter ablation for atrial fibrillation: clinical characterization, prevalence, and predictors. Heart Rhythm. 2011;8:1364-1371. doi: 10.1016/j.hrthm.2011.02.026.