Oral oxycodone plus intravenous acetaminophen versus intravenous morphine sulfate in acute bone fracture pain control: a double-blind placebo-controlled randomized clinical trial

European Journal of Orthopaedic Surgery and Traumatology

Volumn 24, Issue 7, 2014, Pages 1305-1309

  Zare, Mohammad Amin ^a   Ghalyaie, Alireza Hassan ^a   Fathi, Marzieh ^a   Farsi, Davood ^a   Abbasi, Saeed ^a   Hafezimoghadam, Peyman ^a  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Fracture; Intravenous acetaminophen; Morphine; Oxycodone; Pain

Indexed keywords

MORPHINE SULFATE; OXYCODONE; PARACETAMOL; ANALGESIC AGENT; MORPHINE; NARCOTIC ANALGESIC AGENT;

ADULT; ARTICLE; CONSCIOUSNESS LEVEL; CONTROLLED STUDY; DEPRESSION; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; FEMALE; FRACTURE; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; OXYGEN DESATURATION; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SCORING SYSTEM; SEIZURE; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME; VOMITING; ACUTE DISEASE; ADVERSE EFFECTS; CHEMICALLY INDUCED; COMPARATIVE STUDY; COMPLICATION; DRUG COMBINATION; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PAIN MEASUREMENT; YOUNG ADULT;

ACETAMINOPHEN; ACUTE DISEASE; ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ADULT; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FRACTURES, BONE; HUMANS; MALE; MORPHINE; NAUSEA; OXYCODONE; PAIN; PAIN MEASUREMENT; PRURITUS; YOUNG ADULT;

EID: 84933515316     PISSN: 16338065     EISSN: 14321068     Source Type: Journal    
DOI: 10.1007/s00590-013-1392-x     Document Type: Article

References (24)

1. Fosnocht DE, Swanson ER, Barton ED (2009) Changing attitudes about pain and pain control in emergency medicine. Emerg Med Clin North Am 3:297–306
2. Garbez R, Puntillo K (2005) Acute musculoskeletal pain in the emergency department: a review of the literature and implications for the advanced practice nurse. AACN Clin Issues 16(3):310–319
3. Miner J, Biros MH, Trainor A, Hubbard D, Beltram M (2009) Patient and physician perceptions as risk factors for oligoanalgesia: a prospective observational study of the relief of pain in the emergency department. Current Opin Anaesthesiol 22:588–593
4. Rupp T, Delaney KA (2004) Inadequate analgesia in emergency medicine. Ann Emerg Med 43:494–503
5. Bijur PE, Kenny MK, Gallagher EJ (2005) Intravenous morphine at 0.1 mg/kg is not effective for controlling severe acute pain in the majority of patients. Ann Emerg Med 46:362–367
6. Buvanendran A, Kroin JS (2009) Multimodal analgesia for controlling acute postoperative pain. Current Opin Anaesthesiol 22:588–593
7. Holmer Pettersson P, Owall A, Jakobsson J (2004) Early bioavailability of paracetamol after oral and intravenous administration. Acta Anaesthesiol Scand 48(7):867–870
8. Bektas F, Eken C, Karadenız O, Goksu E, Cubuk M, Cete Y (2009) Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial. Ann Emerg Med 54(4):568–574
9. Lee SY, Lee WH, Lee EH, Han KC, Ko YK (2010) The effects of paracetamol, ketorolac, and paracetamol plus morphine on pain control after thyroidectomy. Korean J Pain 23(2):124–130
10. Remy C, Marret E, Bonnet F (2005) Effects of acetaminophen on morphine side effects and consumption after major surgery: meta-analysis of randomized controlled trials. Br J Anaesth 94(4):505–513
11. Yeh YC, Reddy P (2012) Clinical and economic evidence for intravenous acetaminophen. Pharmacotherapy 32(6):559–579
12. Kalso E (2005) Oxycodone. J Pain Symptom Manage 29:47–56
13. Gatti A, Sabato E, Di Paolo AR, Mammucari M, Sabato AF (2010) Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain. Drug Investig 30:3–14
14. DeBeer J, Winemaker M, Donnelly G, Miceli P, Reiz J, Harsanyi Z (2005) Efficacy and safety of controlled-release oxycodone and standard therapies for postoperative pain after knee or hip replacement. Can J Surg 48:277–283
15. Seaton SM, Reeves M (2009) Oxycodone as a Component of multimodal analgesia post-caesarean section in Australia and New Zealand. J Pharm Practuce Res 39(2):104–108
16. Edwards JE, Moore RA, McQuay HJ (2000) Single dose oxycodone and oxycodone plus paracetamol (acetominophen) for acute postoperative pain. Cochrane Database Syst Rev 4:CD002763
17. Gaskell H, Derry S, Moore RA, McQuay HJ (2009) Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults. Cochrane Database Syst Rev 3:CD002763
18. Miner JR, Moore J, Gray RO, Skinner L, Biros MH (2008) Oral versus intravenous opioid dosing for the initial treatment of acute musculoskeletal pain in the emergency department. Acad Emerg Med 15(12):1234–1240
19. Lovell SJ, Taira T, Rodriguez E, Wackett A, Gulla J, Singer AJ (2004) Comparison of valdecoxib and an oxycodone–acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. Acad Emerg Med 11(12):1278–1282
20. Anastasspoulos KP, Chow W, Ackerman SJ, Tapia C, Benson C, Kim MS (2011) Oxycodone-related side effects: impact on degree of bother, adherence, pain relief, satisfaction and quality of life. J Opioid Manag 7(3):203–215
21. Staahl C, Christrup LL, Anderson SD, Arendt-Nielsen L, Drewes AM (2006) A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model. Pain 123(1–2):28–36
22. Duellman TJ, Gaffigan C, Milbrandt JC, Allan DG (2009) Multi-modal, preemptive analgesia decreases the length of hospital stay following total joint arthroplasty. Orthopedics 32(3):167
23. Rothwell MP, Pearson D, Hunter JD, Mitchell PA, Graham-Woollard T, Goodwin L, Dunn G (2011) Oral oxycodone offers equivalent analgesia to intravenous patient-controlled analgesia after total hip replacement: a randomized, single-center, non-blinded, non-inferiority study. Br J Anesth 56(4):199–200
24. Gammaitoni AR, Galer BS, Bulloch S et al (2003) Randomized, double-blind, placebo-controlled comparison of the analgesic efficacy of oxycodone 10 mg/acetaminophen 325 versus controlled-release oxycodone 20 mg in postsurgical pain. J Clin Pharmacol 43:296–304