New standardized cystatin C and creatinine GFR equations in children validated with inulin clearance

Pediatric Nephrology

Volumn 30, Issue 8, 2015, Pages 1317-1326

  Berg, Ulla B ^a   Nyman, Ulf ^b   Bäck, Rune ^a   Hansson, Magnus ^a   Monemi, Kajsa Åsling ^a   Herthelius, Maria ^a   Björk, Jonas ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Clearance of inulin; Creatinine; Cystatin C; Glomerular filtration rate; Renal dysfunction; Renal function

Indexed keywords

CREATININE; CYSTATIN C; INULIN; BIOLOGICAL MARKER; CST3 PROTEIN, HUMAN; INSULIN;

ADOLESCENT; ARITHMETIC; ARTICLE; CHILD; CREATININE BLOOD LEVEL; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; INULIN CLEARANCE; KIDNEY CLEARANCE; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TASK PERFORMANCE; VALIDATION STUDY; BLOOD; KIDNEY FUNCTION TEST; PRESCHOOL CHILD; PROCEDURES; STANDARDS;

ADOLESCENT; BIOMARKERS; CHILD; CHILD, PRESCHOOL; CREATININE; CYSTATIN C; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INSULIN; KIDNEY FUNCTION TESTS; MALE;

EID: 84933180658     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-015-3060-3     Document Type: Article

References (28)

1. Smith HT (1951) The reliability of inulin as a measure of glomerular filtration rate. The Kidney: structure and function in health and disease. Oxford University Press, New York, NY, pp 231–238
2. Schwartz GJ, Work DF (2009) Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol 4:1832–1843
3. Filler G, Lepage N (2003) Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula? Pediatr Nephrol 18:981–985
4. Grubb A, Nyman U, Björk J, Lindström V, Rippe B, Sterner G, Christensson A (2005) Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. Clin Chem 51:1420–1431
5. Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629–637
6. Gao A, Cachat F, Faouzi M, Bardy D, Mosig D, Meyrat BJ, Girardin E, Chehade H (2013) Comparison of the glomerular filtration rate in children by the new revised Schwartz formula and a new generalized formula. Kidney Int 83:524–530
7. Blirup-Jensen S, Grubb A, Lindström V, Schmidt C, Althaus H (2008) Standardization of Cystatin C: development of primary and secondary reference preparations. Scand J Clin Lab Invest Suppl 241:67–70
8. Grubb A, Blirup-Jensen S, Lindström V, Schmidt C, Althaus H, Zegers I, C IWGoSoC (2010) First certified reference material for cystatin C in human serum ERM-DA471/IFCC. Clin Chem Lab Med: CCLM / FESCC 48:1619–1621
9. Grubb A, Horio M, Hansson LO, Björk J, Nyman U, Flodin M, Larsson A, Bökenkamp A, Yasuda Y, Blufpand H, Lindström V, Zegers I, Althaus H, Blirup-Jensen S, Itoh Y, Sjöström P, Nordin G, Christensson A, Klima H, Sunde K, Hjort-Christensen P, Armbruster D, Ferrero C (2014) Generation of a new cystatin C-based estimating equation for glomerular filtration rate by use of 7 assays standardized to the international calibrator. Clin Chem 60:974–986
10. Chehade H, Cachat F, Jannot AS, Meyrat BJ, Mosig D, Bardy D, Parvex P, Girardin E (2014) New combined serum creatinine and cystatin C quadratic formula for GFR assessment in children. Clin J Am Soc Nephrol 9:54–63
11. Berg U (1981) Renal function in acute febrile urinary tract infection in children: pathophysiologic aspects on the reduced concentrating capacity. Kidney Int 20:753–758
12. Kuehnle HF, von Dahl K, Schmidt FH (1992) Fully enzymatic inulin determination in small volume samples without deproteinization. Nephron 62:104–107
13. Haycock GB, Schwartz GJ, Wisotsky DH (1978) Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J Pediatr 93:62–66
14. Björk J, Bäck SE, Sterner G, Carlson J, Lindström V, Bakoush O, Simonsson P, Grubb A, Nyman U (2007) Prediction of relative glomerular filtration rate in adults: new improved equations based on Swedish Caucasians and standardized plasma-creatinine assays. Scand J Clin Lab Invest 67:678–695
15. Spinler SA, Nawarskas JJ, Boyce EG, Connors JE, Charland SL, Goldfarb S (1998) Predictive performance of ten equations for estimating creatinine clearance in cardiac patients. Iohexol Cooperative Study Group. Ann Pharmacother 32:1275–1283
16. Earley A, Miskulin D, Lamb EJ, Levey AS, Uhlig K (2012) Estimating equations for glomerular filtration rate in the era of creatinine standardization: a systematic review. Ann Intern Med 156:785–795
17. National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Part 5. Evaluation of laboratory measurements for clinical assessment of kidney disease. Guideline 4. Estimation of GFR. Am J Kidney Dis 39:S 76–S 92
18. Soveri I, Berg UB, Björk J, Elinder CG, Grubb A, Mejare I, Sterner G, Bäck SE, Group SGR (2014) Measuring GFR: a systematic review. Am J Kidney Dis 64:411–424
19. Andersen TB, Jodal L, Boegsted M, Erlandsen EJ, Morsing A, Frokiaer J, Brochner-Mortensen J (2012) GFR prediction from cystatin C and creatinine in children: effect of including body cell mass. Am J Kidney Dis 59:50–57
20. Bacchetta J, Cochat P, Rognant N, Ranchin B, Hadj-Aissa A, Dubourg L (2011) Which creatinine and cystatin C equations can be reliably used in children? Clin J Am Soc Nephrol 6:552–560
21. Berg UB, Bäck R, Celsi G, Halling SE, Homberg I, Krmar RT, Åsling Monemi K, Öborn H, Herthelius M (2011) Comparison of plasma clearance of iohexol and urinary clearance of inulin for measurement of GFR in children. Am J Kidney Dis 57:55–61
22. Blufpand HN, Tromp J, Abbink FC, Stoffel-Wagner B, Bouman AA, Schouten-van Meeteren AY, van Wijk JA, Kaspers GJ, Bokenkamp A (2011) Cystatin C more accurately detects mildly impaired renal function than creatinine in children receiving treatment for malignancy. Pediatr Blood Cancer 57:262–267
23. Pottel H, Mottaghy FM, Zaman Z, Martens F (2010) On the relationship between glomerular filtration rate and serum creatinine in children. Pediatr Nephrol 25:927–934
24. Swedish Council on Health Technology Assessment Methods to Estimate and Measure Kidney Function (glomerular filtration rate). A Systematic Review. 2013. Report no. 214. Accessed January 31, 2014. http://www.sbu.se/upload/Publikationer/Content0/1/Njurfunktion/Njurfunktion.pdf
25. Nyman U, Björk J, Lindström V, Grubb A (2008) The Lund-Malmo creatinine-based glomerular filtration rate prediction equation for adults also performs well in children. Scand J Clin Lab Invest 68:568–576
26. Björk J, Grubb A, Larsson A, Hansson LO, Flodin M, Sterner G, Lindström V, Nyman U (2014) Accuracy of GFR estimating equations combining standardized cystatin C and creatinine assays: a cross-sectional study in Sweden. Clin Chem Lab Med. doi:10.1515/cclm-2014-0578
27. Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS, Investigators C-E (2012) Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 367:20–29
28. Nyman U, Grubb A, Sterner G, Björk J (2009) Different equations to combine creatinine and cystatin C to predict GFR. Arithmetic mean of existing equations performs as well as complex combinations. Scand J Clin Lab Invest 69:619–627