Nebulized colistin for treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: We still need to straighten out the dose!

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Honore, Patrick M ^a   Jacobs, Rita ^a   Hendrickx, Inne ^a   Waele, Elisabeth ^a   Regt, Jouke ^a   Spapen, Herbert D ^a  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; COLISTIMETHATE; COLISTIN; ANTIINFECTIVE AGENT;

DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; GRAM NEGATIVE BACTERIUM; HIGH RISK PATIENT; HUMAN; KIDNEY INJURY; LETTER; LUNG INFECTION; MONOTHERAPY; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; VENTILATOR ASSOCIATED PNEUMONIA; ADVERSE EFFECTS; ARTIFICIAL VENTILATION; NEBULIZER; PNEUMONIA, VENTILATOR-ASSOCIATED;

ANTI-BACTERIAL AGENTS; HUMANS; NEBULIZERS AND VAPORIZERS; PNEUMONIA, VENTILATOR-ASSOCIATED; RESPIRATION, ARTIFICIAL;

EID: 84933042413     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-0966-x     Document Type: Letter

References (5)

1. Zampieri FG, Nassar Jr AP, Gusmao-Flores D, Taniguchi LU, Torres A, Ranzani OT. Nebulized antibiotics for ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care. 2015;19:150.
2. Ratjen F, Rietschel E, Kasel D, Schwiertz R, Starke K, Beier H, et al. Pharmacokinetics of inhaled colistin in patients with cystic fibrosis. J Antimicrob Chemother. 2006;57:306-11.
3. Athanassa ZE, Markantonis SL, Fousteri MZ, Myrianthefs PM, Boutzouka EG, Tsakris A, et al. Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients. Intensive Care Med. 2012;38:1779-86.
4. Gurjar M. Colistin for lung infection: an update. J Intensive Care. 2015;3:3.
5. Lu Q, Luo R, Bodin L, Yang J, Zahr N, Aubry A, et al. Efficacy of high-dose nebulized colistin in ventilator-associated pneumonia caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. Anesthesiology. 2012;117:1335-47.