Subzero temperature chromatography and top-down mass spectrometry for protein higher-order structure characterization: method validation and application to therapeutic antibodies

Journal of the American Chemical Society

Volumn 136, Issue 37, 2014, Pages 13065-13071

  Pan, Jingxi ^a   Zhang, Suping ^a   Parker, Carol E ^a   Borchers, Christoph H ^a  

^a UNIVERSITY OF VICTORIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CALMODULIN; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; TRASTUZUMAB;

CHEMICAL STRUCTURE; CHEMISTRY; COLD; DEUTERIUM HYDROGEN EXCHANGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; PROCEDURES; PROTEIN CONFORMATION; VALIDATION STUDY;

AMIDES; ANTIBODIES, MONOCLONAL, HUMANIZED; CALMODULIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLD TEMPERATURE; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 84932611102     PISSN: None     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja507880w     Document Type: Article

References (0)