Vitamin D supplementation and testosterone concentrations in male human subjects

Clinical Endocrinology

Volumn 83, Issue 1, 2015, Pages 105-110

  Heijboer, Annemieke C ^a   Oosterwerff, Mirjam ^a   Schroten, Nicolas F ^b   Eekhoff, Elisabeth M W ^a   Chel, Victor G M ^c,d   De Boer, Rudolf A ^b   Blankenstein, Marinus A ^a   Lips, Paul ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c Overduin Katwijk   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; CALCIUM CARBONATE; COLECALCIFEROL; PLACEBO; TESTOSTERONE; VITAMIN D; 25-HYDROXYVITAMIN D; VITAMIN;

AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG EFFICACY; HEART FAILURE; HUMAN; IMMIGRANT; IMMUNOASSAY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; NURSING HOME PATIENT; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SERUM; TANDEM MASS SPECTROMETRY; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; TREATMENT OUTCOME; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; ADULT; ANALOGS AND DERIVATIVES; BLOOD; COHORT ANALYSIS; DIETARY SUPPLEMENT; MIDDLE AGED; MIGRANT; NURSING HOME; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; CHOLECALCIFEROL; COHORT STUDIES; DIETARY SUPPLEMENTS; EMIGRANTS AND IMMIGRANTS; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; NURSING HOMES; TESTOSTERONE; VITAMIN D; VITAMIN D DEFICIENCY; VITAMINS; YOUNG ADULT;

EID: 84932192551     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12711     Document Type: Article

References (32)

1. van Schoor, N.M., &, Lips, P., (2011) Worldwide vitamin D status. Best Practice & Research. Clinical Endocrinology & Metabolism, 25, 671-680.
2. Wolden-Kirk, H., Gysemans, C., Verstuyf, A., et al,. (2012) Extraskeletal effects of vitamin D. Endocrinology and Metabolism Clinics of North America, 41, 571-594.
3. Lerchbaum, E., &, Obermayer-Pietsch, B., (2012) Vitamin D and fertility: a systematic review. European Journal of Endocrinology, 166, 765-778.
4. Lerchbaum, E., Pilz, S., Trummer, C., et al,. (2014) Serum vitamin D levels and hypogonadism in men. Andrology, 2, 748-754.
5. Blomberg, J.M., Nielsen, J.E., Jorgensen, A., et al,. (2010) Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Human Reproduction, 25, 1303-1311.
6. Hofer, D., Munzker, J., Schwetz, V., et al,. (2014) Testicular synthesis and vitamin D action. Journal of Clinical Endocrinology and Metabolism, 99, 3766-3773.
7. Kinuta, K., Tanaka, H., Moriwake, T., et al,. (2000) Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology, 141, 1317-1324.
8. Wehr, E., Pilz, S., Boehm, B.O., et al,. (2010) Association of vitamin D status with serum androgen levels in men. Clinical Endocrinology (Oxf), 73, 243-248.
9. Lee, D.M., Tajar, A., Pye, S.R., et al,. (2012) Association of hypogonadism with vitamin D status: the European Male Ageing Study. European Journal of Endocrinology, 166, 77-85.
10. Nimptsch, K., Platz, E.A., Willett, W.C., et al,. (2012) Association between plasma 25-OH vitamin D and testosterone levels in men. Clinical Endocrinology (Oxf), 77, 106-112.
11. Svartberg, J., Jorde, R., Sundsfjord, J., et al,. (2003) Seasonal variation of testosterone and waist to hip ratio in men: the Tromso study. Journal of Clinical Endocrinology and Metabolism, 88, 3099-3104.
12. Andersson, A.M., Carlsen, E., Petersen, J.H., et al,. (2003) Variation in levels of serum inhibin B, testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin in monthly samples from healthy men during a 17-month period: possible effects of seasons. Journal of Clinical Endocrinology and Metabolism, 88, 932-937.
13. Yang, B., Sun, H., Wan, Y., et al,. (2012) Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. International Journal of Andrology, 35, 783-792.
14. Tancredi, A., Reginster, J.Y., Luyckx, F., et al,. (2005) No major month to month variation in free testosterone levels in aging males. Minor impact on the biological diagnosis of 'andropause'. Psychoneuroendocrinology, 30, 638-646.
15. Rojansky, N., Brzezinski, A., &, Schenker, J.G., (1992) Seasonality in human reproduction: an update. Human Reproduction, 7, 735-745.
16. Pilz, S., Frisch, S., Koertke, H., et al,. (2011) Effect of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research, 43, 223-225.
17. Jorde, R., Grimnes, G., Hutchinson, M.S., et al,. (2013) Supplementation with vitamin D does not increase serum testosterone levels in healthy males. Hormone and Metabolic Research, 45, 675-681.
18. Schroten, N.F., Ruifrok, W.P., Kleijn, L., et al,. (2013) Short-term vitamin D3 supplementation lowers plasma renin activity in patients with stable chronic heart failure: an open-label, blinded end point, randomized prospective trial (VitD-CHF trial). American Heart Journal, 166, 357-364.
19. Chel, V., Wijnhoven, H.A., Smit, J.H., et al,. (2008) Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents. Osteoporosis International, 19, 663-671.
20. Oosterwerff, M.M., Eekhoff, E.M., van Schoor, N.M., et al,. (2014) Effect of moderate-dose vitamin D supplementation on insulin sensitivity in vitamin D-deficient non-Western immigrants in the Netherlands: a randomized placebo-controlled trial. American Journal of Clinical Nutrition, 100, 152-160.
21. Heijboer, A.C., Blankenstein, M.A., Kema, I.P., et al,. (2012) Accuracy of 6 routine 25-hydroxyvitamin D assays: influence of vitamin D binding protein concentration. Clinical Chemistry, 58, 543-548.
22. Janssen, M.J., Wielders, J.P., Bekker, C.C., et al,. (2012) Multicenter comparison study of current methods to measure 25-hydroxyvitamin D in serum. Steroids, 77, 1366-1372.
23. Groenestege, W.M., Bui, H.N., ten Kate, J., et al,. (2012) Accuracy of first and second generation testosterone assays and improvement through sample extraction. Clinical Chemistry, 58, 1154-1156.
24. Bui, H.N., Sluss, P.M., Blincko, S., et al,. (2013) Dynamics of serum testosterone during the menstrual cycle evaluated by daily measurements with an ID-LC-MS/MS method and a 2nd generation automated immunoassay. Steroids, 78, 96-101.
25. Janssen, H.C., Emmelot-Vonk, M.H., Verhaar, H.J., et al,. (2013) Determinants of vitamin D status in healthy men and women aged 40-80 years. Maturitas, 74, 79-83.
26. Yeap, B.B., Almeida, O.P., Hyde, Z., et al,. (2009) Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men Study. Clinical Endocrinology (Oxf), 70, 455-463.
27. Lerchbaum, E., Pilz, S., Boehm, B.O., et al,. (2012) Combination of low free testosterone and low vitamin D predicts mortality in older men referred for coronary angiography. Clinical Endocrinology (Oxf), 77, 475-483.
28. Taieb, J., Mathian, B., Millot, F., et al,. (2003) Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children. Clinical Chemistry, 49, 1381-1395.
29. Chapuy, M.C., Preziosi, P., Maamer, M., et al,. (1997) Prevalence of vitamin D insufficiency in an adult normal population. Osteoporosis International, 7, 439-443.
30. Durup, D., Jorgensen, H.L., Christensen, J., et al,. (2012) A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study. Journal of Clinical Endocrinology and Metabolism, 97, 2644-2652.
31. Carter, G.D., (2012) 25-hydroxyvitamin D: a difficult analyte. Clinical Chemistry, 58, 486-488.
32. Rosner, W., &, Vesper, H., (2010) Toward excellence in testosterone testing: a consensus statement. Journal of Clinical Endocrinology and Metabolism, 95, 4542-4548.