Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies

Journal of Immunology

Volumn 195, Issue 1, 2015, Pages 8-16

  Schellekens, Gerard A ^a   De Jong, Ben A W ^a   Van Den Hoogen, Frank H J ^a   Van De Putte, Leo B A ^a   Van Venrooij, Walther J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Antikeratin antibodies; Antiperinuclear factor; Autoantigen; Autoimmunity; Filaggrin; Rheumatoid factor

Indexed keywords

ANTIPERINUCLEAR FACTOR; AUTOANTIBODY; CITRULLINE; EPITOPE; FILAGGRIN; IMMUNOGLOBULIN G; KERATIN ANTIBODY; SYNTHETIC PEPTIDE; AUTOANTIGEN;

ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOFLUORESCENCE TEST; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY; AUTOIMMUNITY; HISTORY; IMMUNOLOGY; PATHOLOGY;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; CITRULLINE; HISTORY, 20TH CENTURY; HUMANS;

EID: 84932162250     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Smolen, J.S. 1996. Autoantibodies in rheumatoid arthritis. In Manual of Biological Markers of Disease. W J. van Venrooij and R.N. Maini, editors. Kluwer Academic Publishers, Dordrecht, The Netherlands. Cl.l/l-Cl.1/18.
2. Nienhuis, R.L.F., and E.A. Mandema. 1964. A new serum factor in patients with rheumatoid arthritis. The antiperinuclear factor. Ann. Rheum. Dis. 23:302-305.
3. Hoet, R.M., and W.J. Van Venrooij. 1992. The antiperinuclear factor and antikeratin antibodies in rheumatoid arthritis. In Rheumatoid Arthritis. J. Smolen, J. Kalden, and R.N. Maini, editors. Springer-Verlag, Berlin. 299-318.
4. Young, B.J.J., R.K. Mallya, R.DJ. Leslie, CJ.M. Clark, and T.J. Ham-blin. 1979. Anti-keratin antibodies in rheumatoid arthritis. Br. Med. J. 2:97-99.
5. Hoet, R.M., A.M.Th. Boerbooms, M. Arends, DJ. Ruiter, and WJ. Van Venrooij. 1991. Antiperinuclear factor, a marker autoantibody for rheumatoid arthritis: colocalisation of the perinuclear factor and profilaggrin. Ann. Rheum. Dis. 50:611-618.
6. Simon, M., E. Girbal, M. Sebbag, V. Gomes-Daudrix, C. Vincent, G. Sa-lema, and G. Serre. 1993. The cytokeratin filament-aggregating protein filag-grin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis. J. Clin. Invest. 92:1387-1393.
7. Sebbag, M., M. Simon, C. Vincent, C. Masson-Bessiere, E. Girbal, JJ. Durieux, and G. Serre. 1995. The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies. J. Clin. Invest. 95:2672-2679.
8. Faimela, L., M. Gripenberg, P. Kurki, and M. Leirisalo-Repo. 1992. Antikeratin antibodies: diagnostic and prognostic markers for early rheumatoid arthritis. Ann. Rheum. Dis. 51:743-746.
9. Kurki, P., K. Aho, T. Palosuo, and M. Heliovaara. 1992. Immunopathol-ogy of rheumatoid arthritis: antikeratin antibodies precede the clinical disease. Arthritis Rheum. 35:914-917.
10. McKinley-Grant, L.J., W.W. Idler, I.A. Bernstein, D.A.D. Parry, L. Cannizzaro, CM. Croce, K. Huebner, S.R. Lessin, and P.M. Steinert. 1989. Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region lq21. Proc. Natl Acad. Sci. USA. 86:4848-4852.
11. Gan, S.Q., O.W. McBride, W.W. Idler, M. Nedialka, and P.M. Steinert. 1990. Organization, structure, and polymorphisms of the human profilaggrin gene. Biochemistry. 29:9432-9440.
12. Arnett, F.C., S.M. Edworthy, D.A. Bloch, D.J. McShane, J.F. Fries, N.S. Cooper, L.A. Healey, S.R. Kaplan, M.H. Liang, H.S. Luthra, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315-324.
13. Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Lab., Cold Spring Harbor, NY.
14. Jameson, B.A., and H. Wolf. 1988. The antigenic index: a novel algorithm for predicting antigenic determinants. Comput. Appl. Biosci. 4:181-186.
15. Gamier, J., D.J. Osguthorpe, and B. Robson. 1978. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J. Mol. Biol. 120:97-120.
16. Schellekens, G.A., E. Lasonder, M. Feijlbrief, D.G.A.M. Koedijk, J.W. Drijfhout, A.J. Scheffer, S. Welling-Wester, and G.W. Welling. 1994. Identification of the core residues of the epitope of a monoclonal antibody raised against glycoprotein D of herpes simplex virus 1 by screening of a random peptide library. Eur. J. Immunol. 24:3188-3193.
17. Vincent, C, G. Serre, F. Lapeyre, B. Fournie, C. Ayrolles, A. Fournie, and J.P. Soleilhavoup. 1989. High diagnostic value in rheumatoid arthritis of antibodies to the stratum corneum of rat oesophagus epithelium, so-called "antikeratin antibodies." Ann. Rheum. Dis. 48:712-722.
18. Utz, P.J., M. Hottelet, P.H. Schur, and P. Anderson. 1997. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. J. Exp. Med 185:843-854.
19. Gregerson, P.K., J. Silver, and RJ. Winchester. 1987. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30:1205-1213.
20. Williamson, M.P., M.J. Hall, and B.K. Handa. 1986. Secondary structure of a herpes simplex virus glycoprotein D antigenic domain. Int. J. Pept. Protein Res. 27:562-568.
21. Dyson, H.J., and P.E. Wright. 1995. Antigenic peptides. FASEB J. 9:37-42.
22. Tarcsa, E., L.N. Marekov, G. Mei, G. Melino, S.C. Lee, and P.M. Stein-ert. 1996. Protein unfolding by peptidylarginine deiminase; substrate specificity and structural relationship of the natural substrates trichohyalin and filaggrin. J. Biol. Chem. 271:30709-30716.
23. Mack, J.W., A.C. Steven, and P.M. Steinert. 1993. The mechanism of interaction of filaggrin with intermediate filaments. J. Mol. Biol. 232:50-66.
24. Nagata, S., and T. Senshu. 1990. Peptidylarginine deiminase in rat and mouse hemopoietic cells. Experientia. 64:72-74.
25. Harding, C.R., and I.R. Scott. 1983. Histidine rich proteins (fjlaggrins): structural and functional heterogeneity during epidermal differentiation. J. Mol Biol 170:651-673.
26. Westgeest, A.A.A., A.M.Th. Boerbooms, M. Jongmans, J.P. Vanden-broucke, G. Vierwinden, and L.B.A. van de Putte. 1987. Antiperinuclear factor: indicator of more severe disease in seronegative rheumatoid arthritis. J. Rheumatol 14:893-897.
27. Boers, M., A.C. Verhoeven, H.M. Markusse, M.A.FJ. van de Laar, R. Westhovens, J.C. van Denderen, D. van Zebben, B.A.C. Dijkmans, A.J. Peeters, P. Jacobs, et al. 1997. Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalasine alone in early rheumatoid arthritis. Lancet. 350:309-318.