Cannabinoid receptor 1 antagonism in hepatocellular carcinoma: Killing two birds with one stone

European Journal of Gastroenterology and Hepatology

Volumn 27, Issue 6, 2015, Pages 747-748

  Bifulco, Maurizio ^a,b   Ciaglia, Elena ^a,b  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR ANTAGONIST; EPIDERMAL GROWTH FACTOR RECEPTOR 2; INDOLEAMINE 2,3 DIOXYGENASE;

DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; HUMAN; IMMUNOLOGICAL TOLERANCE; LETTER; LIVER CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TARGET CELL DESTRUCTION; TUMOR MICROENVIRONMENT; ANIMAL; CARCINOMA, HEPATOCELLULAR; LIVER NEOPLASMS; PHYSIOLOGY;

ANIMALS; CARCINOMA, HEPATOCELLULAR; HUMANS; LIVER NEOPLASMS; RECEPTOR, CANNABINOID, CB1;

EID: 84932120214     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0000000000000337     Document Type: Letter

References (5)

1. Mukhopadhyay B, Schuebel K, Mukhopadhyay P, Cinar R, Godlewski G, Xiong K, et al. Cannabinoid receptor promotes hepatocellular carcinoma initiation and progression via multiple mechanisms. Hepatology 2015. [Epub ahead of print].
2. Pisanti S, Picardi P, D'Alessandro A, Laezza C, Bifulco M. The endocannabinoid signaling system in cancer. Trends Pharmacol Sci 2013; 34:273-282.
3. Di Marzo V, Bifulco M, De Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 2004; 3: 771-784.
4. Pardee AD, Butterfield LH. Immunotherapy of hepatocellular carcinoma: unique challenges and clinical opportunities. Oncoimmunology 2012; 1:48-55.
5. Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, et al. CXCR4 inhibition in tumor microenvironment facilitates anti-PD-1 immunotherapy in sorafenib-treated HCC in mice. Hepatology 2014. [Epub ahead of print].