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Volumn 56, Issue 6, 2015, Pages 1718-1722

Lack of objective response of myelodysplastic syndromes and acute myeloid leukemia to decitabine after failure of azacitidine

Author keywords

Acute myeloid leukemia; Azacitidine; Decitabine; Myelodysplastic syndromes

Indexed keywords

AZACITIDINE; DECITABINE; ANTINEOPLASTIC ANTIMETABOLITE;

EID: 84932097658     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2014.966708     Document Type: Article
Times cited : (19)

References (32)
  • 1
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes:A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes:A randomised, open-label, phase III study. Lancet Oncol 2009; 10: 223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 2
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
    • Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B. J Clin Oncol 2002; 20: 2429-2440.
    • (2002) J Clin Oncol , vol.20 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3
  • 3
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
    • Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006; 106: 1794-1803.
    • (2006) Cancer , vol.106 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3
  • 4
    • 79956294708 scopus 로고    scopus 로고
    • Low-dose decitabine versus best supportive care in elderly patients with intermediate-or highrisk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy:final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group
    • Lubbert M, Suciu S, Baila L, et al. Low-dose decitabine versus best supportive care in elderly patients with intermediate-or highrisk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy:final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group. J Clin Oncol 2011; 29: 1987-1996.
    • (2011) J Clin Oncol , vol.29 , pp. 1987-1996
    • Lubbert, M.1    Suciu, S.2    Baila, L.3
  • 5
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010; 28: 562-569.
    • (2010) J Clin Oncol , vol.28 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 6
    • 77449149374 scopus 로고    scopus 로고
    • Multicenter, phase II study of decitabine for thefirst-line treatment of older patients with acute myeloid leukemia
    • Cashen AF, Schiller GJ, O' Donnell MRD, et al. Multicenter, phase II study of decitabine for thefirst-line treatment of older patients with acute myeloid leukemia. J Clin Oncol 2010; 28: 556-561.
    • (2010) J Clin Oncol , vol.28 , pp. 556-561
    • Cashen, A.F.1    Schiller, G.J.2    Donnell M R D O.'.3
  • 7
    • 84864063679 scopus 로고    scopus 로고
    • Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
    • Kantarjian HM, Th omas XG, Dmoszynska A, et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol 2012; 30: 2670-2677.
    • (2012) J Clin Oncol , vol.30 , pp. 2670-2677
    • Kantarjian, H.M.1    Th Omas, X.G.2    Dmoszynska, A.3
  • 8
    • 84897387993 scopus 로고    scopus 로고
    • Azacitidine in untreated acute myeloid leukemia: A report on 149 patients
    • Th epot S, Itzykson R, Seegers V, et al. Azacitidine in untreated acute myeloid leukemia: A report on 149 patients. Am J Hematol 2014; 89: 410-416.
    • (2014) Am J Hematol , vol.89 , pp. 410-416
    • Th Epot, S.1    Itzykson, R.2    Seegers, V.3
  • 9
    • 84903463772 scopus 로고    scopus 로고
    • Ten-day decitabine as initial therapy for newly diagnosed patients with acute myeloid leukemia unfit for intensive chemotherapy
    • Bhatnagar B, Duong VH, Gourdin TS, et al. Ten-day decitabine as initial therapy for newly diagnosed patients with acute myeloid leukemia unfit for intensive chemotherapy. Leuk Lymphoma 2014; 55: 1533-1537.
    • (2014) Leuk Lymphoma , vol.55 , pp. 1533-1537
    • Bhatnagar, B.1    Duong, V.H.2    Gourdin, T.S.3
  • 10
    • 84921436355 scopus 로고    scopus 로고
    • Results of a phase 3, multicenter, randomized, open-label study of azacitidine (AZA) vs conventional care regimens (CCR) in older patients with newly diagnosed acute myeloid leukemia (AML)
    • Abstract LB6212
    • Dombret H, Seymour JF, Butrym A, et al. Results of a phase 3, multicenter, randomized, open-label study of azacitidine (AZA) vs conventional care regimens (CCR) in older patients with newly diagnosed acute myeloid leukemia (AML). Haematologica 2014; 99(Suppl. 1): Abstract LB6212.
    • (2014) Haematologica , vol.99
    • Dombret, H.1    Seymour, J.F.2    Butrym, A.3
  • 11
    • 68949145132 scopus 로고    scopus 로고
    • Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: The alternative dosing for outpatient treatment (ADOPT) trial
    • Steensma D P, Baer M R, Slack J L, et al. M ulticenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: The alternative dosing for outpatient treatment (ADOPT) trial. J Clin Oncol 2009; 27: 3842-3848.
    • (2009) J Clin Oncol , vol.27 , pp. 3842-3848
    • Steensma, D.P.1    Baer, M.R.2    Slack, J.L.3
  • 12
    • 84879783893 scopus 로고    scopus 로고
    • Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia
    • Ritchie EK, Feldman EJ, Christos PJ, et al. Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia. Leuk Lymphoma 2013; 54: 2003-2007.
    • (2013) Leuk Lymphoma , vol.54 , pp. 2003-2007
    • Ritchie, E.K.1    Feldman, E.J.2    Christos, P.J.3
  • 13
    • 84891867775 scopus 로고    scopus 로고
    • Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML)
    • Tawfik B, Sliesoraitis S, Lyerly S, et al. Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML). Ann Hematol 2014; 93: 47-55.
    • (2014) Ann Hematol , vol.93 , pp. 47-55
    • Tawfik, B.1    Sliesoraitis, S.2    Lyerly, S.3
  • 14
    • 77952140672 scopus 로고    scopus 로고
    • Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
    • USA
    • Blum W, Garzon R, Klisovic RB, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci USA 2010; 107: 7473-7478.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 7473-7478
    • Blum, W.1    Garzon, R.2    Klisovic, R.B.3
  • 15
    • 84857747740 scopus 로고    scopus 로고
    • Amulticenter phase II trial of decitabine asfirst-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy
    • Lubbert M, Ruter BH, Claus R, et al. A multicenter phase II trial of decitabine asfirst-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy. Haematologica 2012; 97: 393-401.
    • (2012) Haematologica , vol.97 , pp. 393-401
    • Lubbert, M.1    Ruter, B.H.2    Claus, R.3
  • 16
    • 80051992418 scopus 로고    scopus 로고
    • Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure
    • Prebet T, Gore SD, Esterni B, et al. Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure. J Clin Oncol 2011; 29: 3322-3327.
    • (2011) J Clin Oncol , vol.29 , pp. 3322-3327
    • Prebet, T.1    Gore, S.D.2    Esterni, B.3
  • 17
    • 77956862198 scopus 로고    scopus 로고
    • Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy
    • Jabbour E, Garcia-Manero G, Batty N, et al. Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy. Cancer 2010; 116: 3830-3834.
    • (2010) Cancer , vol.116 , pp. 3830-3834
    • Jabbour, E.1    Garcia-Manero, G.2    Batty, N.3
  • 18
    • 84888008620 scopus 로고    scopus 로고
    • Poor outcome of patients with myelodysplastic syndrome after azacitidine treatment failure
    • Duong VH, Lin K, Reljic T, et al. Poor outcome of patients with myelodysplastic syndrome after azacitidine treatment failure. Clin Lymphoma Myeloma Leuk 2013; 13: 711-715.
    • (2013) Clin Lymphoma Myeloma Leuk , vol.13 , pp. 711-715
    • Duong, V.H.1    Lin, K.2    Reljic, T.3
  • 19
    • 0036902962 scopus 로고    scopus 로고
    • DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias
    • Leone G, Teofili L, Voso MT, et al. DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias. Haematologica 2002; 87: 1324-1341.
    • (2002) Haematologica , vol.87 , pp. 1324-1341
    • Leone, G.1    Teofili, L.2    Voso, M.T.3
  • 20
    • 77749302093 scopus 로고    scopus 로고
    • Acomparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
    • Hollenbach P W, Nguyen A N, Brady H, et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. PLoS One 2010; 5: e9001.
    • (2010) PLoS One , vol.5 , pp. e9001
    • Hollenbach, P.W.1    Nguyen, A.N.2    Brady, H.3
  • 21
    • 60249094793 scopus 로고    scopus 로고
    • Mechanisms of resistance to 5- Aza-2'-deoxycytidine in human cancer cell lines
    • Qin T, Jelinek J, Si J, et al. M echanisms of resistance to 5- Aza-2'-deoxycytidine in human cancer cell lines. Blood 2009; 113: 659-667.
    • (2009) Blood , vol.113 , pp. 659-667
    • Qin, T.1    Jelinek, J.2    Si, J.3
  • 22
    • 42049097308 scopus 로고    scopus 로고
    • Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine
    • Borthakur G, Ahdab SE, Ravandi F, et al. Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine. Leuk Lymphoma 2008; 49: 690-695.
    • (2008) Leuk Lymphoma , vol.49 , pp. 690-695
    • Borthakur, G.1    Ahdab, S.E.2    Ravandi, F.3
  • 23
    • 84932126773 scopus 로고    scopus 로고
    • Treatment with decitabine (DAC) after azacitidine (AZA) failure in high risk myelodysplastic syndrome (MDS) and advanced chronic myelomonocytic leukemia (CMML)
    • Abstract 2796
    • Braun T, Cherait A, Berthon C, et al. T reatment with decitabine (DAC) after azacitidine (AZA) failure in high risk myelodysplastic syndrome (MDS) and advanced chronic myelomonocytic leukemia (CMML). Blood 2013; 122(Suppl. 1): Abstract 2796.
    • (2013) Blood , vol.122
    • Braun, T.1    Cherait, A.2    Berthon, C.3
  • 24
    • 84915741561 scopus 로고    scopus 로고
    • Evidence for selective benefit of sequential treatment with azanucleosides in patients with myelodysplastic syndromes (MDS)
    • Abstract 7113
    • Komrokji R S, A puri S, A l Ali N, et al. E vidence for selective benefit of sequential treatment with azanucleosides in patients with myelodysplastic syndromes (MDS). J Clin Oncol 2013; 31(Suppl.): Abstract 7113.
    • (2013) J Clin Oncol , vol.31
    • Komrokji, R.S.1    Apuri, S.2    Al Ali, N.3
  • 25
    • 84866621729 scopus 로고    scopus 로고
    • Revised international prognostic scoring system for myelodysplastic syndromes
    • Greenberg P L, Tuechler H, Schanz J, et al. R evised international prognostic scoring system for myelodysplastic syndromes. Blood 2012; 120: 2454-2465.
    • (2012) Blood , vol.120 , pp. 2454-2465
    • Greenberg, P.L.1    Tuechler, H.2    Schanz, J.3
  • 26
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115: 453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3
  • 27
    • 33745968917 scopus 로고    scopus 로고
    • Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia
    • Cheson B D, Greenberg P L, Bennett J M, et al. C linical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood 2006; 108: 419-425.
    • (2006) Blood , vol.108 , pp. 419-425
    • Cheson, B.D.1    Greenberg, P.L.2    Bennett, J.M.3
  • 28
    • 84879565439 scopus 로고    scopus 로고
    • Amultivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial
    • Gore SD, Fenaux P, Santini V, et al. A multivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial. Haematologica 2013; 98: 1067-1072.
    • (2013) Haematologica , vol.98 , pp. 1067-1072
    • Gore, S.D.1    Fenaux, P.2    Santini, V.3
  • 29
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman L R. F urther analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 2006; 24: 3895-3903.
    • (2006) J Clin Oncol , vol.24 , pp. 3895-3903
    • Silverman, L.R.1
  • 30
    • 79952667434 scopus 로고    scopus 로고
    • Continued azacitidine therapy beyond time offirst response improves quality of response in patients with higher-risk myelodysplastic syndromes
    • Silverman L R, Fenaux P, Mufti G J, et al. C ontinued azacitidine therapy beyond time offirst response improves quality of response in patients with higher-risk myelodysplastic syndromes. Cancer 2011; 117: 2697-2702.
    • (2011) Cancer , vol.117 , pp. 2697-2702
    • Silverman, L.R.1    Fenaux, P.2    Mufti, G.J.3
  • 31
    • 84875626317 scopus 로고    scopus 로고
    • Results from the dose escalation phase of a randomized phase 1-2first-in-human (FIH) study of SGI-110, a novel low volume stable subcutaneous (SQ) second generation hypomethylating agent (HMA) in patients with relapsed/ refractory MDS and AML
    • Abstract 414
    • Kantarjian HM, Roboz GJ, Rizzieri DA, et al. Results from the dose escalation phase of a randomized phase 1-2first-in-human (FIH) study of SGI-110, a novel low volume stable subcutaneous (SQ) second generation hypomethylating agent (HMA) in patients with relapsed/ refractory MDS and AML. Blood 2012; 120(Suppl. 1): Abstract 414.
    • (2012) Blood , vol.120
    • Kantarjian, H.M.1    Roboz, G.J.2    Rizzieri, D.A.3
  • 32
    • 84905915357 scopus 로고    scopus 로고
    • Outcomes of intermediate or high risk myelodysplastic syndromes (MDS) patients post azacitidine and/or decitabine treatment failures with SGI-110, a novel second generation hypomethylating agent (HMA)
    • O' Connell C, Tibes R, Walsh K, et al. Outcomes of intermediate or high risk myelodysplastic syndromes (MDS) patients post azacitidine and/or decitabine treatment failures with SGI-110, a novel second generation hypomethylating agent (HMA). Haematologica 2013; 98: 81-82.
    • (2013) Haematologica , vol.98 , pp. 81-82
    • Connell C O.'.1    Tibes, R.2    Walsh, K.3


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