-
1
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes:A randomised, open-label, phase III study
-
Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes:A randomised, open-label, phase III study. Lancet Oncol 2009; 10: 223-232.
-
(2009)
Lancet Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
-
2
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
-
Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B. J Clin Oncol 2002; 20: 2429-2440.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2429-2440
-
-
Silverman, L.R.1
Demakos, E.P.2
Peterson, B.L.3
-
3
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
-
Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006; 106: 1794-1803.
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
Issa, J.P.2
Rosenfeld, C.S.3
-
4
-
-
79956294708
-
Low-dose decitabine versus best supportive care in elderly patients with intermediate-or highrisk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy:final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group
-
Lubbert M, Suciu S, Baila L, et al. Low-dose decitabine versus best supportive care in elderly patients with intermediate-or highrisk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy:final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group. J Clin Oncol 2011; 29: 1987-1996.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1987-1996
-
-
Lubbert, M.1
Suciu, S.2
Baila, L.3
-
5
-
-
77449149373
-
Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
-
Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010; 28: 562-569.
-
(2010)
J Clin Oncol
, vol.28
, pp. 562-569
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
-
6
-
-
77449149374
-
Multicenter, phase II study of decitabine for thefirst-line treatment of older patients with acute myeloid leukemia
-
Cashen AF, Schiller GJ, O' Donnell MRD, et al. Multicenter, phase II study of decitabine for thefirst-line treatment of older patients with acute myeloid leukemia. J Clin Oncol 2010; 28: 556-561.
-
(2010)
J Clin Oncol
, vol.28
, pp. 556-561
-
-
Cashen, A.F.1
Schiller, G.J.2
Donnell M R D O.'.3
-
7
-
-
84864063679
-
Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
-
Kantarjian HM, Th omas XG, Dmoszynska A, et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol 2012; 30: 2670-2677.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2670-2677
-
-
Kantarjian, H.M.1
Th Omas, X.G.2
Dmoszynska, A.3
-
8
-
-
84897387993
-
Azacitidine in untreated acute myeloid leukemia: A report on 149 patients
-
Th epot S, Itzykson R, Seegers V, et al. Azacitidine in untreated acute myeloid leukemia: A report on 149 patients. Am J Hematol 2014; 89: 410-416.
-
(2014)
Am J Hematol
, vol.89
, pp. 410-416
-
-
Th Epot, S.1
Itzykson, R.2
Seegers, V.3
-
9
-
-
84903463772
-
Ten-day decitabine as initial therapy for newly diagnosed patients with acute myeloid leukemia unfit for intensive chemotherapy
-
Bhatnagar B, Duong VH, Gourdin TS, et al. Ten-day decitabine as initial therapy for newly diagnosed patients with acute myeloid leukemia unfit for intensive chemotherapy. Leuk Lymphoma 2014; 55: 1533-1537.
-
(2014)
Leuk Lymphoma
, vol.55
, pp. 1533-1537
-
-
Bhatnagar, B.1
Duong, V.H.2
Gourdin, T.S.3
-
10
-
-
84921436355
-
Results of a phase 3, multicenter, randomized, open-label study of azacitidine (AZA) vs conventional care regimens (CCR) in older patients with newly diagnosed acute myeloid leukemia (AML)
-
Abstract LB6212
-
Dombret H, Seymour JF, Butrym A, et al. Results of a phase 3, multicenter, randomized, open-label study of azacitidine (AZA) vs conventional care regimens (CCR) in older patients with newly diagnosed acute myeloid leukemia (AML). Haematologica 2014; 99(Suppl. 1): Abstract LB6212.
-
(2014)
Haematologica
, vol.99
-
-
Dombret, H.1
Seymour, J.F.2
Butrym, A.3
-
11
-
-
68949145132
-
Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: The alternative dosing for outpatient treatment (ADOPT) trial
-
Steensma D P, Baer M R, Slack J L, et al. M ulticenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: The alternative dosing for outpatient treatment (ADOPT) trial. J Clin Oncol 2009; 27: 3842-3848.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3842-3848
-
-
Steensma, D.P.1
Baer, M.R.2
Slack, J.L.3
-
12
-
-
84879783893
-
Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia
-
Ritchie EK, Feldman EJ, Christos PJ, et al. Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia. Leuk Lymphoma 2013; 54: 2003-2007.
-
(2013)
Leuk Lymphoma
, vol.54
, pp. 2003-2007
-
-
Ritchie, E.K.1
Feldman, E.J.2
Christos, P.J.3
-
13
-
-
84891867775
-
Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML)
-
Tawfik B, Sliesoraitis S, Lyerly S, et al. Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML). Ann Hematol 2014; 93: 47-55.
-
(2014)
Ann Hematol
, vol.93
, pp. 47-55
-
-
Tawfik, B.1
Sliesoraitis, S.2
Lyerly, S.3
-
14
-
-
77952140672
-
Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
-
USA
-
Blum W, Garzon R, Klisovic RB, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci USA 2010; 107: 7473-7478.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 7473-7478
-
-
Blum, W.1
Garzon, R.2
Klisovic, R.B.3
-
15
-
-
84857747740
-
Amulticenter phase II trial of decitabine asfirst-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy
-
Lubbert M, Ruter BH, Claus R, et al. A multicenter phase II trial of decitabine asfirst-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy. Haematologica 2012; 97: 393-401.
-
(2012)
Haematologica
, vol.97
, pp. 393-401
-
-
Lubbert, M.1
Ruter, B.H.2
Claus, R.3
-
16
-
-
80051992418
-
Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure
-
Prebet T, Gore SD, Esterni B, et al. Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure. J Clin Oncol 2011; 29: 3322-3327.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3322-3327
-
-
Prebet, T.1
Gore, S.D.2
Esterni, B.3
-
17
-
-
77956862198
-
Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy
-
Jabbour E, Garcia-Manero G, Batty N, et al. Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy. Cancer 2010; 116: 3830-3834.
-
(2010)
Cancer
, vol.116
, pp. 3830-3834
-
-
Jabbour, E.1
Garcia-Manero, G.2
Batty, N.3
-
18
-
-
84888008620
-
Poor outcome of patients with myelodysplastic syndrome after azacitidine treatment failure
-
Duong VH, Lin K, Reljic T, et al. Poor outcome of patients with myelodysplastic syndrome after azacitidine treatment failure. Clin Lymphoma Myeloma Leuk 2013; 13: 711-715.
-
(2013)
Clin Lymphoma Myeloma Leuk
, vol.13
, pp. 711-715
-
-
Duong, V.H.1
Lin, K.2
Reljic, T.3
-
19
-
-
0036902962
-
DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias
-
Leone G, Teofili L, Voso MT, et al. DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias. Haematologica 2002; 87: 1324-1341.
-
(2002)
Haematologica
, vol.87
, pp. 1324-1341
-
-
Leone, G.1
Teofili, L.2
Voso, M.T.3
-
20
-
-
77749302093
-
Acomparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
-
Hollenbach P W, Nguyen A N, Brady H, et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. PLoS One 2010; 5: e9001.
-
(2010)
PLoS One
, vol.5
, pp. e9001
-
-
Hollenbach, P.W.1
Nguyen, A.N.2
Brady, H.3
-
21
-
-
60249094793
-
Mechanisms of resistance to 5- Aza-2'-deoxycytidine in human cancer cell lines
-
Qin T, Jelinek J, Si J, et al. M echanisms of resistance to 5- Aza-2'-deoxycytidine in human cancer cell lines. Blood 2009; 113: 659-667.
-
(2009)
Blood
, vol.113
, pp. 659-667
-
-
Qin, T.1
Jelinek, J.2
Si, J.3
-
22
-
-
42049097308
-
Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine
-
Borthakur G, Ahdab SE, Ravandi F, et al. Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine. Leuk Lymphoma 2008; 49: 690-695.
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 690-695
-
-
Borthakur, G.1
Ahdab, S.E.2
Ravandi, F.3
-
23
-
-
84932126773
-
Treatment with decitabine (DAC) after azacitidine (AZA) failure in high risk myelodysplastic syndrome (MDS) and advanced chronic myelomonocytic leukemia (CMML)
-
Abstract 2796
-
Braun T, Cherait A, Berthon C, et al. T reatment with decitabine (DAC) after azacitidine (AZA) failure in high risk myelodysplastic syndrome (MDS) and advanced chronic myelomonocytic leukemia (CMML). Blood 2013; 122(Suppl. 1): Abstract 2796.
-
(2013)
Blood
, vol.122
-
-
Braun, T.1
Cherait, A.2
Berthon, C.3
-
24
-
-
84915741561
-
Evidence for selective benefit of sequential treatment with azanucleosides in patients with myelodysplastic syndromes (MDS)
-
Abstract 7113
-
Komrokji R S, A puri S, A l Ali N, et al. E vidence for selective benefit of sequential treatment with azanucleosides in patients with myelodysplastic syndromes (MDS). J Clin Oncol 2013; 31(Suppl.): Abstract 7113.
-
(2013)
J Clin Oncol
, vol.31
-
-
Komrokji, R.S.1
Apuri, S.2
Al Ali, N.3
-
25
-
-
84866621729
-
Revised international prognostic scoring system for myelodysplastic syndromes
-
Greenberg P L, Tuechler H, Schanz J, et al. R evised international prognostic scoring system for myelodysplastic syndromes. Blood 2012; 120: 2454-2465.
-
(2012)
Blood
, vol.120
, pp. 2454-2465
-
-
Greenberg, P.L.1
Tuechler, H.2
Schanz, J.3
-
26
-
-
77449159028
-
Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel, on behalf of the European LeukemiaNet
-
Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115: 453-474.
-
(2010)
Blood
, vol.115
, pp. 453-474
-
-
Dohner, H.1
Estey, E.H.2
Amadori, S.3
-
27
-
-
33745968917
-
Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia
-
Cheson B D, Greenberg P L, Bennett J M, et al. C linical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood 2006; 108: 419-425.
-
(2006)
Blood
, vol.108
, pp. 419-425
-
-
Cheson, B.D.1
Greenberg, P.L.2
Bennett, J.M.3
-
28
-
-
84879565439
-
Amultivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial
-
Gore SD, Fenaux P, Santini V, et al. A multivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial. Haematologica 2013; 98: 1067-1072.
-
(2013)
Haematologica
, vol.98
, pp. 1067-1072
-
-
Gore, S.D.1
Fenaux, P.2
Santini, V.3
-
29
-
-
33748474416
-
Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
-
Silverman L R. F urther analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 2006; 24: 3895-3903.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3895-3903
-
-
Silverman, L.R.1
-
30
-
-
79952667434
-
Continued azacitidine therapy beyond time offirst response improves quality of response in patients with higher-risk myelodysplastic syndromes
-
Silverman L R, Fenaux P, Mufti G J, et al. C ontinued azacitidine therapy beyond time offirst response improves quality of response in patients with higher-risk myelodysplastic syndromes. Cancer 2011; 117: 2697-2702.
-
(2011)
Cancer
, vol.117
, pp. 2697-2702
-
-
Silverman, L.R.1
Fenaux, P.2
Mufti, G.J.3
-
31
-
-
84875626317
-
Results from the dose escalation phase of a randomized phase 1-2first-in-human (FIH) study of SGI-110, a novel low volume stable subcutaneous (SQ) second generation hypomethylating agent (HMA) in patients with relapsed/ refractory MDS and AML
-
Abstract 414
-
Kantarjian HM, Roboz GJ, Rizzieri DA, et al. Results from the dose escalation phase of a randomized phase 1-2first-in-human (FIH) study of SGI-110, a novel low volume stable subcutaneous (SQ) second generation hypomethylating agent (HMA) in patients with relapsed/ refractory MDS and AML. Blood 2012; 120(Suppl. 1): Abstract 414.
-
(2012)
Blood
, vol.120
-
-
Kantarjian, H.M.1
Roboz, G.J.2
Rizzieri, D.A.3
-
32
-
-
84905915357
-
Outcomes of intermediate or high risk myelodysplastic syndromes (MDS) patients post azacitidine and/or decitabine treatment failures with SGI-110, a novel second generation hypomethylating agent (HMA)
-
O' Connell C, Tibes R, Walsh K, et al. Outcomes of intermediate or high risk myelodysplastic syndromes (MDS) patients post azacitidine and/or decitabine treatment failures with SGI-110, a novel second generation hypomethylating agent (HMA). Haematologica 2013; 98: 81-82.
-
(2013)
Haematologica
, vol.98
, pp. 81-82
-
-
Connell C O.'.1
Tibes, R.2
Walsh, K.3
|