Association of FCGR2A-R/H131 polymorphism with susceptibility to systemic lupus erythematosus among Asian population: a meta-analysis of 20 studies

Archives of Dermatological Research

Volumn 306, Issue 9, 2014, Pages 781-791

  Li, Rui ^a   Peng, Hui ^b   Chen, Gui Mei ^a   Feng, Chen Chen ^a   Zhang, Yu Jing ^a   Wen, Peng Fei ^a   Qiu, Li Juan ^a   Leng, Rui Xue ^a   Pan, Hai Feng ^a   Ye, Dong Qing ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b WANNAN MEDICAL COLLEGE   (China)

Author keywords

FCGR2A; Meta analysis; Polymorphism; Systemic lupus erythematosus

Indexed keywords

FC RECEPTOR; FCGR2A PROTEIN, HUMAN;

ASIA; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; EPIDEMIOLOGY; ETHNOLOGY; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOLOGY; LUPUS ERYTHEMATOSUS NEPHRITIS; META ANALYSIS; PHENOTYPE; RISK; RISK FACTOR; SYSTEMIC LUPUS ERYTHEMATOSUS;

ASIA; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; ODDS RATIO; PHENOTYPE; POLYMORPHISM, GENETIC; RECEPTORS, IGG; RISK FACTORS;

EID: 84931837281     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-014-1483-5     Document Type: Article

References (55)

1. Arnett FC, Reveille JD (1992) Genetics of systemic lupus erythematosus. Rheum Dis Clin North Am 18(4):865–892
2. Botto M, Theodoridis E, Thompson EM, Beynon HL, Briggs D, Isenberg DA, Walport MJ, Davies KA (1996) Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease. Clin Exp Immunol 104(2):264–268
3. Chen JY, Wang CM, Tsao KC, Chow YH, Wu JM, Li CL, Ho HH, Wu YJ, Luo SF (2004) Fcgamma receptor IIa, IIIa, and IIIb polymorphisms of systemic lupus erythematosus in Taiwan. Ann Rheum Dis 63(7):877–880
4. Chu ZT, Tsuchiya N, Kyogoku C, Ohashi J, Qian YP, Xu SB, Mao CZ, Chu JY, Tokunaga K (2004) Association of Fcgamma receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations. Tissue Antigens 63(1):21–27
5. Clark MR, Stuart SG, Kimberly RP, Ory PA, Goldstein IM (1991) A single amino acid distinguishes the high-responder from low responder form of Fc receptor II on human monocytes. Eur J Immunol 21(8):1911–1916
6. Davies KA, Peters AM, Beynon HL, Walport MJ (1992) Immune complex processing in patients with systemic lupus erythematosus. In vivo imaging and clearance studies. J Clin Invest 90(5):2075–2083
7. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188
8. Dijstelbloem HM, Bijl M, Fijnheer R, Scheepers RH, Oost WW, Jansen MD, Sluiter WJ, Limburg PC, Derksen RH, van de Winkel JG, Kallenberg CG (2000) Fcgamma receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes. Arthritis Rheum 43(12):2793–2800
9. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634
10. Fernando MM, Freudenberg J, Lee A, Morris DL, Boteva L, Rhodes B, Gonzalez-Escribano MF, Lopez-Nevot MA, Navarra SV, Gregersen PK, Martin J, IMAGEN, Vyse TJ (2012) Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G. Ann Rheum Dis 71(5):777–784
11. Frank MM, Hamburger MI, Lawley TJ, Kimberly RP, Plotz PH (1979) Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med 300(10):518–523
12. Han JW, Zheng HF, Ye Cui et al (2009) Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 41(11):1234–1237
13. Harley JB, Alarcón-Riquelme ME, Criswell LA et al (2008) Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 40(2):204–210
14. Hatta Y, Tsuchiya N, Ohashi J, Matsushita M, Fujiwara K, Hagiwara K, Juji T, Tokunaga K (1999) Association of Fc gamma receptor IIIB, but not of Fc gamma receptor IIA and IIIA polymorphisms with systemic lupus erythematosus in Japanese. Genes Immun 1(1):53–60
15. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558
16. Hirankarn N, Wongpiyabovorn J, Hanvivatvong O, Netsawang J, Akkasilpa S, Wongchinsri J, Hanvivadhanakul P, Korkit W, Avihingsanon Y (2006) The synergistic effect of FC gamma receptor IIa and interleukin-10 genes on the risk to develop systemic lupus erythematosus in Thai population. Tissue Antigens 68(5):399–406
17. Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlqvist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen AC, Criswell LA, Gregersen PK, Behrens TW (2008) Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 358(9):900–909
18. Jönsen A, Bengtsson AA, Sturfelt G, Truedsson L (2004) Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcgammaRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility. Arthritis Res Ther 6(6):R557–R562
19. Karassa FB, Trikalinos TA, Ioannidis JP, FcgammaRIIa-SLE Meta-Analysis Investigators (2002) Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. Arthritis Rheum 46(6):1563–1571
20. Kelly JA, Kelley JM, Kaufman KM, Kilpatrick J, Bruner GR, Merrill JT, James JA, Frank SG, Reams E, Brown EE, Gibson AW, Marion MC, Langefeld CD, Li QZ, Karp DR, Wakeland EK, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Alarcón GS, Kimberly RP, Harley JB, Edberg JC (2008) Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans. Genes Immun 9(3):187–194
21. Khoa PD, Sugiyama T, Yokochi T (2003) Fc gamma receptor II polymorphism in Vietnamese patients with systemic lupus erythematosus. Lupus 12(9):704–706
22. Kimberly RP, Salmon JE, Edberg JC (1995) Receptors for immunoglobulin G. Molecular diversity and implications for disease. Arthritis Rheum 38(3):306–314
23. Kobayashi T, Ito S, Yasuda K, Kuroda T, Yamamoto K, Sugita N, Tai H, Narita I, Gejyo F, Yoshie H (2007) The combined genotypes of stimulatory and inhibitory Fc gamma receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults. J Periodontol 78(3):467–474
24. Kobayashi T, Ito S, Yamamoto K, Hasegawa H, Sugita N, Kuroda T, Kaneko S, Narita I, Yasuda K, Nakano M, Gejyo F, Yoshie H (2003) Risk of periodontitis in systemic lupus erythematosus is associated with Fcgamma receptor polymorphisms. J Periodontol 74(3):378–384
25. Kozyrev SV, Abelson AK, Wojcik J, Zaghlool A, Linga Reddy MV, Sanchez E, Gunnarsson I, Svenungsson E, Sturfelt G, Jönsen A, Truedsson L, Pons-Estel BA, Witte T, D’Alfonso S, Barizzone N, Danieli MG, Gutierrez C, Suarez A, Junker P, Laustrup H, González-Escribano MF, Martin J, Abderrahim H, Alarcón-Riquelme ME (2008) Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. Nat Genet 40(2):211–216
26. Kyogoku C, Dijstelbloem HM, Tsuchiya N, Hatta Y, Kato H, Yamaguchi A, Fukazawa T, Jansen MD, Hashimoto H, van de Winkel JG, Kallenberg CG, Tokunaga K (2002) Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum 46(5):1242–1254
27. Lee HS, Chung YH, Kim TG, Kim TH, Jun JB, Jung S, Bae SC, Yoo DH (2003) Independent association of HLA-DR and FCgamma receptor polymorphisms in Korean patients with systemic lupus erythematosus. Rheumatology (Oxford) 42(12):1501–1507
28. Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4):719–748
29. Mavridis D, Salanti G (2014) How to assess publication bias: funnel plot, trim-and-fill method and selection models. Evid Based Ment Health 17(1):30
30. Moser KL, Neas BR, Salmon JE, Yu H, Gray-McGuire C, Asundi N, Bruner GR, Fox J, Kelly J, Henshall S, Bacino D, Dietz M, Hogue R, Koelsch G, Nightingale L, Shaver T, Abdou NI, Albert DA, Carson C, Petri M, Treadwell EL, James JA, Harley JB (1998) Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci USA 95(25):14869–14874
31. Ni PS, Shen FM, Meng W, Jiang F, Feng SF (2000) The association and linkage analysis between the FcγRIIa-131 and systemic lupus erythematosus. Chin J Med Genet 17(6):409–412 (in Chinese)
32. Norsworthy P, Theodoridis E, Botto M, Athanassiou P, Beynon H, Gordon C, Isenberg D, Walport MJ, Davies KA (1999) Overrepresentation of the Fcgamma receptor type IIA R131/R131 genotype in caucasoid systemic lupus erythematosus patients with autoantibodies to C1q and glomerulonephritis. Arthritis Rheum 42(9):1828–1832
33. Pan HF, Ye DQ, Li XP (2008) Type 17 T-helper cells might be a promising therapeutic target for systemic lupus erythematosus. Nat Clin Pract Rheumatol 4(7):352–353
34. Qiu MT, Li XP, Mao CZ, Yang HY (2005) Study on the correlation between polymorphism distribution of FcγRIIA and SLE susceptibility. South China J Derm Venereol 12(2):82–87 (in Chinese)
35. Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW, de Bakker PI, Le JM, Lee HS, Batliwalla F, Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos CI, Criswell LA, Seldin MF, Kastner DL, Gregersen PK (2007) STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 357(10):977–986
36. Sammaritano LR, Ng S, Sobel R, Lo SK, Simantov R, Furie R, Kaell A, Silverstein R, Salmon JE (1997) Anticardiolipin IgG subclasses: association of IgG2 with arterial and/or venous thrombosis. Arthritis Rheum 40(11):1998–2006
37. Salmon JE, Millard S, Schachter LA, Arnett FC, Ginzler EM, Gourley MF, Ramsey-Goldman R, Peterson MG, Kimberly RP (1996) Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. J Clin Invest 97(5):1348–1354
38. Salmon JE, Pricop L (2001) Human receptors for immunoglobulin G: key elements in the pathogenesis of rheumatic disease. Arthritis Rheum 44(4):739–750
39. Sánchez E, Comeau ME, Freedman BI et al (2011) Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum 63(11):3493–3501
40. Sato H, Iwano M, Akai Y, Nishino T, Fujimoto T, Shiiki H, Dohi K (2001) FcgammaRIIa polymorphism in Japanese patients with systemic lupus erythematosus. Lupus 10(2):97–101
41. Schur PH (1995) The genetics of systemic lupus erythematosus. Lupus 4(6):425–437
42. Shen SK, Ren W, Han JW, Zhang X, Gao M, Cui Y, Sun LD, Zhou FS, Zheng HF, Yang JQ, Yang S, Zhang XJ (2009) Association between polymorphism of FCGR2A gene and systemic lupus erythematosus susceptibility in Chinese Han population. Acta Univ Med Anhui 44(3):334–336 (in Chinese)
43. Sigurdsson S, Nordmark G, Göring HH, Lindroos K, Wiman AC, Sturfelt G, Jönsen A, Rantapää-Dahlqvist S, Möller B, Kere J, Koskenmies S, Widén E, Eloranta ML, Julkunen H, Kristjansdottir H, Steinsson K, Alm G, Rönnblom L, Syvänen AC (2005) Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet 76(3):528–537
44. Siriboonrit U, Tsuchiya N, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Fujiwara K, Chandanayingyong D, Tokunaga K (2003) Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens 61(5):374–383
45. Song YW, Han CW, Kang SW, Baek HJ, Lee EB, Shin CH, Hahn BH, Tsao BP (1998) Abnormal distribution of Fc gamma receptor type IIa polymorphisms in Korean patients with systemic lupus erythematosus. Arthritis Rheum 41(3):421–426
46. Sun L, Shen N, Wang Y, Qian J, Bao CD, Gu YY, Chen SL (2004) Association between FCGR2A polymorphism and systemic lupus erythematosus. Chin J Rheumatol 8(1):1–3 (in Chinese)
47. Tsao BP (2000) Lupus susceptibility genes on human chromosome 1. Int Rev Immunol 19(4–5):319–334
48. Warmerdam PA, van de Winkel JG, Vlug A, Westerdaal NA, Capel PJ (1991) A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding. J Immunol 147(4):1338–1343
49. Wisnieski JJ, Jones SM (1992) Comparison of autoantibodies to the collagen-like region of C1q in hypocomplementemic urticarial vasculitis syndrome and systemic lupus erythematosus. J Immunol 148(5):1396–1403
50. Yang W, Shen N, Ye DQ et al (2010) Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet 6(2):e1000841
51. Yap SN, Phipps ME, Manivasagar M, Tan SY, Bosco JJ (1999) Human Fc gamma receptor IIA (FcgammaRIIA) genotyping and association with systemic lupus erythematosus (SLE) in Chinese and Malays in Malaysia. Lupus 8(4):305–310
52. Yuan H, Pan HF, Li LH, Feng JB, Li WX, Li XP, Ye DQ (2009) Meta analysis on the association between FccRIIa-R/H131 polymorphisms and systemic lupus erythematosus. Mol Biol Rep 36(5):1053–1058
53. Yun HR, Koh HK, Kim SS, Chung WT, Kim DW, Hong KP, Song GG, Chang HK, Choe JY, Bae SC, Salmon JE, Yoo DH, Kim TY, Kim SY (2001) FcgammaRIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients. Lupus 10(7):466–472
54. Zhou XJ, Lv JC, Qin LX, Yang HZ, Yu F, Zhao MH, Zhang H (2011) Is FCGR2A a susceptibility gene to systemic lupus erythematosus in Chinese? Lupus 20(11):1198–1202
55. Zuñiga R, Ng S, Peterson MG, Reveille JD, Baethge BA, Alarcón GS, Salmon JE (2001) Low-binding alleles of Fcgamma receptor types IIA and IIIA are inherited independently and are associated with systemic lupus erythematosus in Hispanic patients. Arthritis Rheum 44(2):361–367