메뉴 건너뛰기




Volumn 24, Issue 3, 2015, Pages 155-163

Imaging genomics of glioblastoma: Biology, biomarkers, and breakthroughs

Author keywords

biomarkers; glioma; IDH1; imaging genomics; MGMT; radiogenomics; radiophenotypes

Indexed keywords

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARIC ACID; APOLIPOPROTEIN E; BEVACIZUMAB; BIOLOGICAL MARKER; CARMUSTINE; EPIDERMAL GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 8; ISOCITRATE DEHYDROGENASE 1; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MICRORNA; MICRORNA 219; ONCOLYTIC VIRUS; PROTEIN P53; TEMOZOLOMIDE; UNCLASSIFIED DRUG; TUMOR MARKER;

EID: 84931833137     PISSN: 08993459     EISSN: 15361004     Source Type: Journal    
DOI: 10.1097/RMR.0000000000000052     Document Type: Review
Times cited : (17)

References (103)
  • 1
    • 84931844531 scopus 로고    scopus 로고
    • National Expenditures for Cancer Care
    • Available at: Accessed March 5, 2014
    • National Expenditures for Cancer Care. Cancer Prevalence and Cost of Care Projections. 2010. Available at: http://costprojections.cancer.gov/expenditures.html. Accessed March 5, 2014.
    • (2010) Cancer Prevalence and Cost of Care Projections
  • 2
    • 0003397692 scopus 로고    scopus 로고
    • Atlanta, GA: American Cancer Society Inc
    • American Cancer Society. Cancer Facts & Figures 2011. Atlanta, GA: American Cancer Society Inc; 2011.
    • (2011) Cancer Facts & Figures 2011
  • 3
    • 84929620816 scopus 로고    scopus 로고
    • CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2007-2011
    • Ostrom QT, Gittleman H, Liao P, CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 2014; 16 (suppl 4): iv1-iv63.
    • (2014) Neuro Oncol , vol.16 , pp. iv1-iv63
    • Ostrom, Q.T.1    Gittleman, H.2    Liao, P.3
  • 4
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009; 10: 459-466.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 5
    • 84864560067 scopus 로고    scopus 로고
    • A novel volume-age-KPS (VAK) glioblastoma classification identifies a prognostic cognate microRNA-gene signature
    • Zinn PO, Sathyan P, Mahajan B, A novel volume-age-KPS (VAK) glioblastoma classification identifies a prognostic cognate microRNA-gene signature. PLoS One. 2012; 7: e41522.
    • (2012) PLoS One , vol.7 , pp. e41522
    • Zinn, P.O.1    Sathyan, P.2    Mahajan, B.3
  • 6
    • 34547432232 scopus 로고    scopus 로고
    • Incidence of gliomas by anatomic location
    • Larjavaara S, Mantyla R, Salminen T, Incidence of gliomas by anatomic location. Neuro Oncol. 2007; 9: 319-325.
    • (2007) Neuro Oncol , vol.9 , pp. 319-325
    • Larjavaara, S.1    Mantyla, R.2    Salminen, T.3
  • 8
    • 84960987433 scopus 로고
    • Neutron capture therapy with boron in the treatment of glioblastoma multiforme
    • Farr LE, Sweet WH, Robertson JS, Neutron capture therapy with boron in the treatment of glioblastoma multiforme. Am J Roentgenol Radium Ther Nucl Med. 1954; 71: 279-293.
    • (1954) Am J Roentgenol Radium Ther Nucl Med , vol.71 , pp. 279-293
    • Farr, L.E.1    Sweet, W.H.2    Robertson, J.S.3
  • 9
    • 77952555038 scopus 로고    scopus 로고
    • Exciting new advances in neuro-oncology: The avenue to a cure for malignant glioma
    • Van Meir EG, Hadjipanayis CG, Norden AD, Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma. CA Cancer J Clin. 2010; 60: 166-193.
    • (2010) CA Cancer J Clin , vol.60 , pp. 166-193
    • Van Meir, E.G.1    Hadjipanayis, C.G.2    Norden, A.D.3
  • 10
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005; 352: 987-996.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 11
    • 75149186046 scopus 로고    scopus 로고
    • Chemotherapy for glioblastoma: Current treatment and future perspectives for cytotoxic and targeted agents
    • Minniti G, Muni R, Lanzetta G, Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents. Anticancer Res. 2009; 29: 5171-5184.
    • (2009) Anticancer Res , vol.29 , pp. 5171-5184
    • Minniti, G.1    Muni, R.2    Lanzetta, G.3
  • 12
    • 84894194756 scopus 로고    scopus 로고
    • Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
    • Chinot OL, Wick W, Mason W, Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 2014; 370: 709-722.
    • (2014) N Engl J Med , vol.370 , pp. 709-722
    • Chinot, O.L.1    Wick, W.2    Mason, W.3
  • 13
    • 84894114159 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab for newly diagnosed glioblastoma
    • Gilbert MR, Dignam JJ, Armstrong TS, A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014; 370: 699-708.
    • (2014) N Engl J Med , vol.370 , pp. 699-708
    • Gilbert, M.R.1    Dignam, J.J.2    Armstrong, T.S.3
  • 14
    • 0032508734 scopus 로고    scopus 로고
    • Gliadel wafers for treatment of brain tumors
    • Gliadel wafers for treatment of brain tumors. Med Lett Drugs Ther. 1998; 40: 92.
    • (1998) Med Lett Drugs Ther , vol.40 , pp. 92
  • 15
    • 84865790609 scopus 로고    scopus 로고
    • Magnetic resonance imaging appearance and changes on intracavitary Gliadel wafer placement: A pilot study
    • Colen RR, Zinn PO, Hazany S, Magnetic resonance imaging appearance and changes on intracavitary Gliadel wafer placement: a pilot study. World J Radiol. 2011; 3: 266-272.
    • (2011) World J Radiol , vol.3 , pp. 266-272
    • Colen, R.R.1    Zinn, P.O.2    Hazany, S.3
  • 16
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010; 17: 98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3
  • 17
    • 84857820489 scopus 로고    scopus 로고
    • Tumor heterogeneity and personalized medicine
    • Longo DL,. Tumor heterogeneity and personalized medicine. N Engl J Med. 2012; 366: 956-957.
    • (2012) N Engl J Med , vol.366 , pp. 956-957
    • Longo, D.L.1
  • 18
    • 84930665805 scopus 로고    scopus 로고
    • First-in-human phase i clinical trial of oncolytic Delta-24-RGD (DNX-2401) with biological endpoints: Implications for viro-immunotherapy
    • Lang FF, Conrad C, Gomez-Manzano C, First-in-human phase I clinical trial of oncolytic Delta-24-RGD (DNX-2401) with biological endpoints: implications for viro-immunotherapy. Neuro Oncol. 2014; 16 (suppl 3): iii39.
    • (2014) Neuro Oncol , vol.16 , pp. iii39
    • Lang, F.F.1    Conrad, C.2    Gomez-Manzano, C.3
  • 19
    • 84864353632 scopus 로고    scopus 로고
    • Imaging and genomics: Is there a synergy?
    • Jaffe CC,. Imaging and genomics: is there a synergy? Radiology. 2012; 264: 329-331.
    • (2012) Radiology , vol.264 , pp. 329-331
    • Jaffe, C.C.1
  • 20
    • 63449086968 scopus 로고    scopus 로고
    • Epigenetic mechanisms in glioblastoma multiforme
    • Nagarajan RP, Costello JF,. Epigenetic mechanisms in glioblastoma multiforme. Semin Cancer Biol. 2009; 19: 188-197.
    • (2009) Semin Cancer Biol , vol.19 , pp. 188-197
    • Nagarajan, R.P.1    Costello, J.F.2
  • 21
    • 84875340771 scopus 로고    scopus 로고
    • Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner
    • Stricker SH, Feber A, Engstrom PG, Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev. 2013; 27: 654-669.
    • (2013) Genes Dev , vol.27 , pp. 654-669
    • Stricker, S.H.1    Feber, A.2    Engstrom, P.G.3
  • 22
    • 84881014802 scopus 로고    scopus 로고
    • Epigenetic pathways and glioblastoma treatment
    • Clarke J, Penas C, Pastori C, Epigenetic pathways and glioblastoma treatment. Epigenetics. 2013; 8: 785-795.
    • (2013) Epigenetics , vol.8 , pp. 785-795
    • Clarke, J.1    Penas, C.2    Pastori, C.3
  • 23
    • 0034051902 scopus 로고    scopus 로고
    • Genomic-scale gene expression profiling of normal and malignant immune cells
    • Alizadeh AA, Staudt LM,. Genomic-scale gene expression profiling of normal and malignant immune cells. Curr Opin Immunol. 2000; 12: 219-225.
    • (2000) Curr Opin Immunol , vol.12 , pp. 219-225
    • Alizadeh, A.A.1    Staudt, L.M.2
  • 24
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008; 455: 1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 25
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, An integrated genomic analysis of human glioblastoma multiforme. Science. 2008; 321: 1807-1812.
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 26
    • 84885755228 scopus 로고    scopus 로고
    • Imaging genomic mapping in glioblastoma
    • Zinn PO, Colen RR,. Imaging genomic mapping in glioblastoma. Neurosurgery. 2013; 60 (suppl 1): 126-130.
    • (2013) Neurosurgery , vol.60 , pp. 126-130
    • Zinn, P.O.1    Colen, R.R.2
  • 27
    • 74049098972 scopus 로고    scopus 로고
    • Clinical trial designs for evaluating the medical utility of prognostic and predictive biomarkers in oncology
    • Simon R,. Clinical trial designs for evaluating the medical utility of prognostic and predictive biomarkers in oncology. Per Med. 2010; 7: 33-47.
    • (2010) Per Med , vol.7 , pp. 33-47
    • Simon, R.1
  • 28
    • 0034028030 scopus 로고    scopus 로고
    • Repair of O(6)-alkylguanine by alkyltransferases
    • Pegg AE,. Repair of O(6)-alkylguanine by alkyltransferases. Mutat Res. 2000; 462: 83-100.
    • (2000) Mutat Res , vol.462 , pp. 83-100
    • Pegg, A.E.1
  • 29
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Esteller M, Garcia-Foncillas J, Andion E, Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med. 2000; 343: 1350-1354.
    • (2000) N Engl J Med , vol.343 , pp. 1350-1354
    • Esteller, M.1    Garcia-Foncillas, J.2    Andion, E.3
  • 30
    • 75149166496 scopus 로고    scopus 로고
    • MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?
    • Weller M, Stupp R, Reifenberger G, MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol. 2010; 6: 39-51.
    • (2010) Nat Rev Neurol , vol.6 , pp. 39-51
    • Weller, M.1    Stupp, R.2    Reifenberger, G.3
  • 31
    • 47549101044 scopus 로고    scopus 로고
    • Molecular predictors in glioblastoma: Toward personalized therapy
    • Colman H, Aldape K,. Molecular predictors in glioblastoma: toward personalized therapy. Arch Neurol. 2008; 65: 877-883.
    • (2008) Arch Neurol , vol.65 , pp. 877-883
    • Colman, H.1    Aldape, K.2
  • 32
    • 12144291692 scopus 로고    scopus 로고
    • Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
    • Hegi ME, Diserens AC, Godard S, Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res. 2004; 10: 1871-1874.
    • (2004) Clin Cancer Res , vol.10 , pp. 1871-1874
    • Hegi, M.E.1    Diserens, A.C.2    Godard, S.3
  • 33
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005; 352: 997-1003.
    • (2005) N Engl J Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 34
    • 78149471362 scopus 로고    scopus 로고
    • Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells
    • Kato T, Natsume A, Toda H, Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells. Gene Ther. 2010; 17: 1363-1371.
    • (2010) Gene Ther , vol.17 , pp. 1363-1371
    • Kato, T.1    Natsume, A.2    Toda, H.3
  • 35
    • 73649145880 scopus 로고    scopus 로고
    • IDH1 mutations in gliomas: When an enzyme loses its grip
    • Frezza C, Tennant DA, Gottlieb E,. IDH1 mutations in gliomas: when an enzyme loses its grip. Cancer Cell. 2010; 17: 7-9.
    • (2010) Cancer Cell , vol.17 , pp. 7-9
    • Frezza, C.1    Tennant, D.A.2    Gottlieb, E.3
  • 36
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G, IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009; 360: 765-773.
    • (2009) N Engl J Med , vol.360 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 37
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang L, White DW, Gross S, Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009; 462: 739-U752.
    • (2009) Nature , vol.462 , pp. 739-U752
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 38
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    • Zhao S, Lin Y, Xu W, Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009; 324: 261-265.
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1    Lin, Y.2    Xu, W.3
  • 39
    • 70249097408 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas
    • Sanson M, Marie Y, Paris S, Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J Clin Oncol. 2009; 27: 4150-4154.
    • (2009) J Clin Oncol , vol.27 , pp. 4150-4154
    • Sanson, M.1    Marie, Y.2    Paris, S.3
  • 40
    • 78650018623 scopus 로고    scopus 로고
    • The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and IDH1 mutations
    • von Deimling A, Korshunov A, Hartmann C,. The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and IDH1 mutations. Brain Pathol. 2011; 21: 74-87.
    • (2011) Brain Pathol , vol.21 , pp. 74-87
    • Von Deimling, A.1    Korshunov, A.2    Hartmann, C.3
  • 41
    • 77649122144 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: A report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
    • van den Bent MJ, Dubbink HJ, Marie Y, IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. Clin Cancer Res. 2010; 16: 1597-1604.
    • (2010) Clin Cancer Res , vol.16 , pp. 1597-1604
    • Van Den Bent, M.J.1    Dubbink, H.J.2    Marie, Y.3
  • 42
    • 84856466311 scopus 로고    scopus 로고
    • IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma
    • SongTao Q, Lei Y, Si G, IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma. Cancer Sci. 2012; 103: 269-273.
    • (2012) Cancer Sci , vol.103 , pp. 269-273
    • Songtao, Q.1    Lei, Y.2    Si, G.3
  • 43
    • 84867205193 scopus 로고    scopus 로고
    • Biology, genetic and imaging of glial cell tumours
    • Walker C, Baborie A, Crooks D, Biology, genetic and imaging of glial cell tumours. Br J Radiol. 2011; 84 (spec iss 2): S090-S106.
    • (2011) Br J Radiol , vol.84 , pp. S090-S106
    • Walker, C.1    Baborie, A.2    Crooks, D.3
  • 44
    • 16444368462 scopus 로고    scopus 로고
    • Genetic pathways to glioblastomas
    • Ohgaki H,. Genetic pathways to glioblastomas. Neuropathology. 2005; 25: 1-7.
    • (2005) Neuropathology , vol.25 , pp. 1-7
    • Ohgaki, H.1
  • 45
    • 84885356671 scopus 로고    scopus 로고
    • EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
    • Fan QW, Cheng CK, Gustafson WC, EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013; 24: 438-449.
    • (2013) Cancer Cell , vol.24 , pp. 438-449
    • Fan, Q.W.1    Cheng, C.K.2    Gustafson, W.C.3
  • 46
    • 84885347725 scopus 로고    scopus 로고
    • EGFR and EGFRvIII in glioblastoma: Partners in crime
    • Zadeh G, Bhat KP, Aldape K,. EGFR and EGFRvIII in glioblastoma: partners in crime. Cancer Cell. 2013; 24: 403-404.
    • (2013) Cancer Cell , vol.24 , pp. 403-404
    • Zadeh, G.1    Bhat, K.P.2    Aldape, K.3
  • 47
    • 0035479296 scopus 로고    scopus 로고
    • EGFR overexpression and radiation response in glioblastoma multiforme
    • Barker FG 2nd, Simmons ML, Chang SM, EGFR overexpression and radiation response in glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2001; 51: 410-418.
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , pp. 410-418
    • Barker, G.F.1    Simmons, M.L.2    Chang, S.M.3
  • 48
    • 14644412873 scopus 로고    scopus 로고
    • Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
    • Heimberger AB, Hlatky R, Suki D, Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients. Clin Cancer Res. 2005; 11: 1462-1466.
    • (2005) Clin Cancer Res , vol.11 , pp. 1462-1466
    • Heimberger, A.B.1    Hlatky, R.2    Suki, D.3
  • 49
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff IK, Wang MY, Vivanco I, Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005; 353: 2012-2024.
    • (2005) N Engl J Med , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 50
    • 84890677609 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) mutation status and Rad51 determine the response of glioblastoma (GBM) to multimodality therapy with cetuximab, temozolomide and radiation
    • Wachsberger PR, Lawrence RY, Liu Y, Epidermal growth factor receptor (EGFR) mutation status and Rad51 determine the response of glioblastoma (GBM) to multimodality therapy with cetuximab, temozolomide and radiation. Front Oncol. 2013; 3: 13.
    • (2013) Front Oncol , vol.3 , pp. 13
    • Wachsberger, P.R.1    Lawrence, R.Y.2    Liu, Y.3
  • 51
    • 77953005998 scopus 로고    scopus 로고
    • Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors
    • Yang RY, Yang KS, Pike LJ, Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors. Chem Biol Drug Des. 2010; 76: 1-9.
    • (2010) Chem Biol Drug des , vol.76 , pp. 1-9
    • Yang, R.Y.1    Yang, K.S.2    Pike, L.J.3
  • 52
    • 84884203467 scopus 로고    scopus 로고
    • Ionizing radiation-induced gene expression changes in TP53 proficient and deficient glioblastoma cell lines
    • Godoy PR, Mello SS, Magalhaes DA, Ionizing radiation-induced gene expression changes in TP53 proficient and deficient glioblastoma cell lines. Mutat Res. 2013; 756: 46-55.
    • (2013) Mutat Res , vol.756 , pp. 46-55
    • Godoy, P.R.1    Mello, S.S.2    Magalhaes, D.A.3
  • 53
    • 84874091180 scopus 로고    scopus 로고
    • The definition of primary and secondary glioblastoma
    • Ohgaki H, Kleihues P,. The definition of primary and secondary glioblastoma. Clin Cancer Res. 2013; 19: 764-772.
    • (2013) Clin Cancer Res , vol.19 , pp. 764-772
    • Ohgaki, H.1    Kleihues, P.2
  • 54
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R, Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell. 2006; 9: 157-173.
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3
  • 55
    • 84876887800 scopus 로고    scopus 로고
    • MR imaging predictors of molecular profile and survival: Multi-institutional study of the TCGA glioblastoma data set
    • Gutman DA, Cooper LA, Hwang SN, MR imaging predictors of molecular profile and survival: multi-institutional study of the TCGA glioblastoma data set. Radiology. 2013; 267: 560-569.
    • (2013) Radiology , vol.267 , pp. 560-569
    • Gutman, D.A.1    Cooper, L.A.2    Hwang, S.N.3
  • 56
    • 84897994935 scopus 로고    scopus 로고
    • SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients
    • Feng Y, Wang Z, Bao Z, SOCS3 promoter hypermethylation is a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients. PLoS One. 2014; 9: e91829.
    • (2014) PLoS One , vol.9 , pp. e91829
    • Feng, Y.1    Wang, Z.2    Bao, Z.3
  • 57
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr H, Weisenberger DJ, Diefes K, Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 2010; 17: 510-522.
    • (2010) Cancer Cell , vol.17 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3
  • 58
    • 34247503858 scopus 로고    scopus 로고
    • Advanced MR imaging techniques in the diagnosis of intraaxial brain tumors in adults
    • Al-Okaili RN, Krejza J, Wang S, Advanced MR imaging techniques in the diagnosis of intraaxial brain tumors in adults. Radiographics. 2006; 26 (suppl 1): S173-S189.
    • (2006) Radiographics , vol.26 , pp. S173-S189
    • Al-Okaili, R.N.1    Krejza, J.2    Wang, S.3
  • 60
    • 0026472997 scopus 로고
    • Diffusion and perfusion magnetic resonance imaging in brain tumors
    • Le Bihan D, Douek P, Argyropoulou M, Diffusion and perfusion magnetic resonance imaging in brain tumors. Top Magn Reson Imaging. 1993; 5: 25-31.
    • (1993) Top Magn Reson Imaging , vol.5 , pp. 25-31
    • Le Bihan, D.1    Douek, P.2    Argyropoulou, M.3
  • 61
    • 84876013157 scopus 로고    scopus 로고
    • ADC values and prognosis of malignant astrocytomas: Does lower ADC predict a worse prognosis independent of grade of tumor? A meta-analysis
    • Zulfiqar M, Yousem DM, Lai H,. ADC values and prognosis of malignant astrocytomas: does lower ADC predict a worse prognosis independent of grade of tumor? A meta-analysis. AJR Am J Roentgenol. 2013; 200: 624-629.
    • (2013) AJR Am J Roentgenol , vol.200 , pp. 624-629
    • Zulfiqar, M.1    Yousem, D.M.2    Lai, H.3
  • 63
    • 76749097367 scopus 로고    scopus 로고
    • Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging
    • Barajas RF, Chang JS, Segal MR, Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology. 2009; 253: 486-496.
    • (2009) Radiology , vol.253 , pp. 486-496
    • Barajas, R.F.1    Chang, J.S.2    Segal, M.R.3
  • 64
    • 0345254996 scopus 로고    scopus 로고
    • Glioma grading: Sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging
    • Law M, Yang S, Wang H, Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol. 2003; 24: 1989-1998.
    • (2003) AJNR Am J Neuroradiol , vol.24 , pp. 1989-1998
    • Law, M.1    Yang, S.2    Wang, H.3
  • 65
    • 84875476605 scopus 로고    scopus 로고
    • Genomic mapping and survival prediction in glioblastoma: Molecular subclassification strengthened by hemodynamic imaging biomarkers
    • Jain R, Poisson L, Narang J, Genomic mapping and survival prediction in glioblastoma: molecular subclassification strengthened by hemodynamic imaging biomarkers. Radiology. 2013; 267: 212-220.
    • (2013) Radiology , vol.267 , pp. 212-220
    • Jain, R.1    Poisson, L.2    Narang, J.3
  • 66
    • 84862907876 scopus 로고    scopus 로고
    • Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion
    • Sorensen AG, Emblem KE, Polaskova P, Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Res. 2012; 72: 402-407.
    • (2012) Cancer Res , vol.72 , pp. 402-407
    • Sorensen, A.G.1    Emblem, K.E.2    Polaskova, P.3
  • 67
    • 64649086978 scopus 로고    scopus 로고
    • Cerebral blood volume measurements by perfusion-weighted MR imaging in gliomas: Ready for prime time in predicting short-term outcome and recurrent disease?
    • Bisdas S, Kirkpatrick M, Giglio P, Cerebral blood volume measurements by perfusion-weighted MR imaging in gliomas: ready for prime time in predicting short-term outcome and recurrent disease? Am J Neuroradiol. 2009; 30: 681-688.
    • (2009) Am J Neuroradiol , vol.30 , pp. 681-688
    • Bisdas, S.1    Kirkpatrick, M.2    Giglio, P.3
  • 68
    • 0042828981 scopus 로고    scopus 로고
    • (1)H-MRS metabolic patterns for distinguishing between meningiomas and other brain tumors
    • Cho YD, Choi GH, Lee SP, (1)H-MRS metabolic patterns for distinguishing between meningiomas and other brain tumors. Magn Reson Imaging. 2003; 21: 663-672.
    • (2003) Magn Reson Imaging , vol.21 , pp. 663-672
    • Cho, Y.D.1    Choi, G.H.2    Lee, S.P.3
  • 69
    • 77952407905 scopus 로고    scopus 로고
    • Texture analysis: A review of neurologic MR imaging applications
    • Kassner A, Thornhill RE,. Texture analysis: a review of neurologic MR imaging applications. AJNR Am J Neuroradiol. 2010; 31: 809-816.
    • (2010) AJNR Am J Neuroradiol , vol.31 , pp. 809-816
    • Kassner, A.1    Thornhill, R.E.2
  • 71
    • 67349122032 scopus 로고    scopus 로고
    • Radiogenomics: Creating a link between molecular diagnostics and diagnostic imaging
    • Rutman AM, Kuo MD,. Radiogenomics: creating a link between molecular diagnostics and diagnostic imaging. Eur J Radiol. 2009; 70: 232-241.
    • (2009) Eur J Radiol , vol.70 , pp. 232-241
    • Rutman, A.M.1    Kuo, M.D.2
  • 72
    • 84964247537 scopus 로고    scopus 로고
    • Imaging genomics of Glioblastoma: State of the art bridge between genomics and neuroradiology
    • ElBanan MG, Amer AM, Zinn PO, Imaging genomics of Glioblastoma: state of the art bridge between genomics and neuroradiology. Neuroimaging Clin N Am. 2015; 25: 141-153.
    • (2015) Neuroimaging Clin N Am , vol.25 , pp. 141-153
    • Elbanan, M.G.1    Amer, A.M.2    Zinn, P.O.3
  • 73
    • 77449124033 scopus 로고    scopus 로고
    • Glioblastoma multiforme regional genetic and cellular expression patterns: Influence on anatomic and physiologic MR imaging
    • Barajas RF Jr, Hodgson JG, Chang JS, Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imaging. Radiology. 2010; 254: 564-576.
    • (2010) Radiology , vol.254 , pp. 564-576
    • Barajas, R.F.1    Hodgson, J.G.2    Chang, J.S.3
  • 74
    • 0034680078 scopus 로고    scopus 로고
    • Patterns of brain activation in people at risk for Alzheimer's disease
    • Bookheimer SY, Strojwas MH, Cohen MS, Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med. 2000; 343: 450-456.
    • (2000) N Engl J Med , vol.343 , pp. 450-456
    • Bookheimer, S.Y.1    Strojwas, M.H.2    Cohen, M.S.3
  • 75
    • 42449156691 scopus 로고    scopus 로고
    • Identification of noninvasive imaging surrogates for brain tumor gene-expression modules
    • Diehn M, Nardini C, Wang DS, Identification of noninvasive imaging surrogates for brain tumor gene-expression modules. Proc Natl Acad Sci USA. 2008; 105: 5213-5218.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 5213-5218
    • Diehn, M.1    Nardini, C.2    Wang, D.S.3
  • 76
    • 29344453338 scopus 로고    scopus 로고
    • Magnetic resonance imaging characteristics predict epidermal growth factor receptor amplification status in glioblastoma
    • Aghi M, Gaviani P, Henson JW, Magnetic resonance imaging characteristics predict epidermal growth factor receptor amplification status in glioblastoma. Clin Cancer Res. 2005; 11 (24 pt 1): 8600-8605.
    • (2005) Clin Cancer Res , vol.11 , Issue.24 , pp. 8600-8605
    • Aghi, M.1    Gaviani, P.2    Henson, J.W.3
  • 77
    • 70749119866 scopus 로고    scopus 로고
    • An analysis of image texture, tumor location, and MGMT promoter methylation in glioblastoma using magnetic resonance imaging
    • Drabycz S, Roldan G, de Robles P, An analysis of image texture, tumor location, and MGMT promoter methylation in glioblastoma using magnetic resonance imaging. Neuroimage. 2010; 49: 1398-1405.
    • (2010) Neuroimage , vol.49 , pp. 1398-1405
    • Drabycz, S.1    Roldan, G.2    De Robles, P.3
  • 78
    • 53749087689 scopus 로고    scopus 로고
    • Relationship between gene expression and enhancement in glioblastoma multiforme: Exploratory DNA microarray analysis
    • Pope WB, Chen JH, Dong J, Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis. Radiology. 2008; 249: 268-277.
    • (2008) Radiology , vol.249 , pp. 268-277
    • Pope, W.B.1    Chen, J.H.2    Dong, J.3
  • 79
    • 34247278764 scopus 로고    scopus 로고
    • Neuroimaging characteristics in subgroup of GBMs with p53 overexpression
    • Mut M, Turba UC, Botella AC, Neuroimaging characteristics in subgroup of GBMs with p53 overexpression. J Neuroimaging. 2007; 17: 168-174.
    • (2007) J Neuroimaging , vol.17 , pp. 168-174
    • Mut, M.1    Turba, U.C.2    Botella, A.C.3
  • 80
    • 34249021494 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase and loss of heterozygosity on 19q and/or 17p are overlapping features of secondary glioblastomas with prolonged survival
    • 6-methylguanine DNA methyltransferase and loss of heterozygosity on 19q and/or 17p are overlapping features of secondary glioblastomas with prolonged survival. Clin Cancer Res. 2007; 13: 2606-2613.
    • (2007) Clin Cancer Res , vol.13 , pp. 2606-2613
    • Eoli, M.1    Menghi, F.2    Bruzzone, M.G.3
  • 81
    • 84862880290 scopus 로고    scopus 로고
    • Imaging parameters of high grade gliomas in relation to the MGMT promoter methylation status: The CT, diffusion tensor imaging, and perfusion MR imaging
    • Moon WJ, Choi JW, Roh HG, Imaging parameters of high grade gliomas in relation to the MGMT promoter methylation status: the CT, diffusion tensor imaging, and perfusion MR imaging. Neuroradiology. 2012; 54: 555-563.
    • (2012) Neuroradiology , vol.54 , pp. 555-563
    • Moon, W.J.1    Choi, J.W.2    Roh, H.G.3
  • 82
    • 0035884185 scopus 로고    scopus 로고
    • Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms
    • Zlatescu MC, TehraniYazdi A, Sasaki H, Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms. Cancer Res. 2001; 61: 6713-6715.
    • (2001) Cancer Res , vol.61 , pp. 6713-6715
    • Zlatescu, M.C.1    Tehraniyazdi, A.2    Sasaki, H.3
  • 83
    • 83055176496 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: A radiographic study in 358 de novo human glioblastomas
    • 6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas. Neuroimage. 2012; 59: 908-916.
    • (2012) Neuroimage , vol.59 , pp. 908-916
    • Ellingson, B.M.1    Cloughesy, T.F.2    Pope, W.B.3
  • 84
    • 84876514587 scopus 로고    scopus 로고
    • Probabilistic radiographic atlas of glioblastoma phenotypes
    • Ellingson BM, Lai A, Harris RJ, Probabilistic radiographic atlas of glioblastoma phenotypes. AJNR Am J Neuroradiol. 2013; 34: 533-540.
    • (2013) AJNR Am J Neuroradiol , vol.34 , pp. 533-540
    • Ellingson, B.M.1    Lai, A.2    Harris, R.J.3
  • 85
    • 84865291187 scopus 로고    scopus 로고
    • Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma
    • Carrillo JA, Lai A, Nghiemphu PL, Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma. AJNR Am J Neuroradiol. 2012; 33: 1349-1355.
    • (2012) AJNR Am J Neuroradiol , vol.33 , pp. 1349-1355
    • Carrillo, J.A.1    Lai, A.2    Nghiemphu, P.L.3
  • 86
    • 84911005872 scopus 로고    scopus 로고
    • Anatomical localization of p53 mutated tumors: A radiographic study of human glioblastomas
    • Zhang T, Wang Y, Fan X, Anatomical localization of p53 mutated tumors: a radiographic study of human glioblastomas. J Neurol Sci. 2014; 346: 94-98.
    • (2014) J Neurol Sci , vol.346 , pp. 94-98
    • Zhang, T.1    Wang, Y.2    Fan, X.3
  • 87
    • 80053599063 scopus 로고    scopus 로고
    • Radiogenomic mapping of edema/cellular invasion MRI-phenotypes in glioblastoma multiforme
    • Zinn PO, Mahajan B, Sathyan P, Radiogenomic mapping of edema/cellular invasion MRI-phenotypes in glioblastoma multiforme. PLoS One. 2011; 6: e25451.
    • (2011) PLoS One , vol.6 , pp. e25451
    • Zinn, P.O.1    Mahajan, B.2    Sathyan, P.3
  • 88
    • 84877100753 scopus 로고    scopus 로고
    • Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images
    • Naeini KM, Pope WB, Cloughesy TF, Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images. Neuro Oncol. 2013; 15: 626-634.
    • (2013) Neuro Oncol , vol.15 , pp. 626-634
    • Naeini, K.M.1    Pope, W.B.2    Cloughesy, T.F.3
  • 89
    • 84926429639 scopus 로고    scopus 로고
    • Glioblastoma: Imaging genomic mapping reveals sex-specific oncogenic associations of cell death
    • Colen RR, Wang J, Singh SK, Glioblastoma: imaging genomic mapping reveals sex-specific oncogenic associations of cell death. Radiology. 2015; 275: 215-227.
    • (2015) Radiology , vol.275 , pp. 215-227
    • Colen, R.R.1    Wang, J.2    Singh, S.K.3
  • 90
    • 84862897099 scopus 로고    scopus 로고
    • Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging
    • Barajas RF, Phillips JJ, Parvataneni R, Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. Neuro Oncol. 2012; 14: 942-954.
    • (2012) Neuro Oncol , vol.14 , pp. 942-954
    • Barajas, R.F.1    Phillips, J.J.2    Parvataneni, R.3
  • 91
    • 84904663488 scopus 로고    scopus 로고
    • The potential role of magnetic resonance spectroscopy in image-guided radiotherapy
    • Nguyen ML, Willows B, Khan R, The potential role of magnetic resonance spectroscopy in image-guided radiotherapy. Front Oncol. 2014; 4: 91.
    • (2014) Front Oncol , vol.4 , pp. 91
    • Nguyen, M.L.1    Willows, B.2    Khan, R.3
  • 92
    • 84862527095 scopus 로고    scopus 로고
    • Differential gene expression in glioblastoma defined by ADC histogram analysis: Relationship to extracellular matrix molecules and survival
    • Pope WB, Mirsadraei L, Lai A, Differential gene expression in glioblastoma defined by ADC histogram analysis: relationship to extracellular matrix molecules and survival. AJNR Am J Neuroradiol. 2012; 33: 1059-1064.
    • (2012) AJNR Am J Neuroradiol , vol.33 , pp. 1059-1064
    • Pope, W.B.1    Mirsadraei, L.2    Lai, A.3
  • 93
    • 84931844533 scopus 로고    scopus 로고
    • Diffusion imaging genomic mapping identifies genomic targets involved in invasion and poor prognosis
    • November 21-24, 2013; San Francisco, California
    • Colen R, Jaafrani R, Zinn P,. Diffusion imaging genomic mapping identifies genomic targets involved in invasion and poor prognosis. Paper presented at the Annual Meeting of the Society of Neuro-Oncology; November 21-24, 2013; San Francisco, California.
    • Paper Presented at the Annual Meeting of the Society of Neuro-Oncology
    • Colen, R.1    Jaafrani, R.2    Zinn, P.3
  • 94
    • 84931831319 scopus 로고    scopus 로고
    • Pretreatment dynamic susceptibility contrast MRI perfusion in glioblastoma: Prediction of EGFR gene amplification
    • Gupta A, Young RJ, Shah AD, Pretreatment dynamic susceptibility contrast MRI perfusion in glioblastoma: prediction of EGFR gene amplification. Clin Neuroradiol. 2014: 1-8.
    • (2014) Clin Neuroradiol , pp. 1-8
    • Gupta, A.1    Young, R.J.2    Shah, A.D.3
  • 95
    • 27944459893 scopus 로고    scopus 로고
    • MR cerebral blood volume maps correlated with vascular endothelial growth factor expression and tumor grade in nonenhancing gliomas
    • Maia AC Jr, Malheiros SM, da Rocha AJ, MR cerebral blood volume maps correlated with vascular endothelial growth factor expression and tumor grade in nonenhancing gliomas. AJNR Am J Neuroradiol. 2005; 26: 777-783.
    • (2005) AJNR Am J Neuroradiol , vol.26 , pp. 777-783
    • Maia, A.C.1    Malheiros, S.M.2    Da Rocha, A.J.3
  • 96
    • 84931844534 scopus 로고    scopus 로고
    • Perfusion imaging genomic mapping uncovers potential genomic targets involved in angiogenesis and invasion
    • November 21-24, 2013; San Francisco, California
    • Colen R, TCGA Phenotype Group, Zinn P,. Perfusion imaging genomic mapping uncovers potential genomic targets involved in angiogenesis and invasion. Annual Meeting of the Society of Neuro-Oncology; November 21-24, 2013; San Francisco, California.
    • Annual Meeting of the Society of Neuro-Oncology
    • Colen, R.1    Tcga, P.G.2    Zinn, P.3
  • 97
    • 84883509554 scopus 로고    scopus 로고
    • Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate
    • Andronesi OC, Rapalino O, Gerstner E, Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate. J Clin Invest. 2013; 123: 3659-3663.
    • (2013) J Clin Invest , vol.123 , pp. 3659-3663
    • Andronesi, O.C.1    Rapalino, O.2    Gerstner, E.3
  • 98
    • 84858603856 scopus 로고    scopus 로고
    • Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
    • Pope WB, Prins RM, Thomas MA, Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. J Neurooncol. 2012; 107: 197-205.
    • (2012) J Neurooncol , vol.107 , pp. 197-205
    • Pope, W.B.1    Prins, R.M.2    Thomas, M.A.3
  • 99
    • 84862776826 scopus 로고    scopus 로고
    • 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
    • Choi C, Ganji SK, DeBerardinis RJ, 2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med. 2012; 18: 624-629.
    • (2012) Nat Med , vol.18 , pp. 624-629
    • Choi, C.1    Ganji, S.K.2    Deberardinis, R.J.3
  • 100
    • 84867311221 scopus 로고    scopus 로고
    • Detection of "oncometabolite" 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma
    • Kalinina J, Carroll A, Wang L, Detection of "oncometabolite" 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma. J Mol Med (Berlin, Germany). 2012; 90: 1161-1171.
    • (2012) J Mol Med (Berlin, Germany) , vol.90 , pp. 1161-1171
    • Kalinina, J.1    Carroll, A.2    Wang, L.3
  • 101
    • 84863243619 scopus 로고    scopus 로고
    • Predicting MGMT methylation status of glioblastomas from MRI texture
    • Levner I, Drabycz S, Roldan G, Predicting MGMT methylation status of glioblastomas from MRI texture. Med Image Comput Comput Assist Interv. 2009; 12 (pt 2): 522-530.
    • (2009) Med Image Comput Comput Assist Interv , vol.12 , pp. 522-530
    • Levner, I.1    Drabycz, S.2    Roldan, G.3
  • 102
    • 67650459914 scopus 로고    scopus 로고
    • Glioma grading: Sensitivity, specificity, positive and negative predictive values of diffusion and perfusion imaging
    • Arvinda HR, Kesavadas C, Sarma PS, Glioma grading: sensitivity, specificity, positive and negative predictive values of diffusion and perfusion imaging. J Neurooncol. 2009; 94: 87-96.
    • (2009) J Neurooncol , vol.94 , pp. 87-96
    • Arvinda, H.R.1    Kesavadas, C.2    Sarma, P.S.3
  • 103
    • 84964264742 scopus 로고    scopus 로고
    • Genomics of brain tumor imaging
    • Pope WB,. Genomics of brain tumor imaging. Neuroimaging Clin N Am. 2015; 25: 105-119.
    • (2015) Neuroimaging Clin N Am , vol.25 , pp. 105-119
    • Pope, W.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.