Mechanical stress promotes maturation of human myocardium from pluripotent stem cell-derived progenitors

Stem Cells

Volumn 33, Issue 7, 2015, Pages 2148-2157

  Ruan, Jia Ling ^a,b   Tulloch, Nathaniel L ^b   Saiget, Mark ^b   Paige, Sharon L ^b   Razumova, Maria V ^a,b   Regnier, Michael ^a,b   Tung, Kelvin Chan ^d   Keller, Gordon ^d   Pabon, Lil ^b   Reinecke, Hans ^b   Murry, Charles E ^a,b,c  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Cardiac; Cardiovascular progenitor; Cardiovascular tissue engineering; Differentiation; Embryonic stem cells; Induced pluripotent stem cells; Progenitor cells; Vascular development

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALCIUM; COLLAGEN; MYOSIN HEAVY CHAIN BETA; TROPONIN T;

ARTICLE; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; DISEASE MARKER; DYNAMICS; HEART MUSCLE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEL; MECHANICAL STRESS; MICROENVIRONMENT; MORPHOGENESIS; PLURIPOTENT STEM CELL; SMOOTH MUSCLE; STEM CELL; ANIMAL; CARDIAC MUSCLE; CYTOLOGY; METABOLISM; TISSUE ENGINEERING;

ANIMALS; CELL DIFFERENTIATION; HUMANS; MYOCARDIUM; PLURIPOTENT STEM CELLS; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 84931576665     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2036     Document Type: Article

References (24)

1. Nourse MB, Halpin DE, Scatena M, et al., VEGF induces differentiation of functional endothelium from human embryonic stem cells: Implications for tissue engineering. Arterioscler Thromb Vasc Biol 2010; 30: 80-89.
2. Laflamme MA, Chen KY, Naumova AV, et al., Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 2007; 25: 1015-1024.
3. Yang L, Soonpaa MH, Adler ED, et al., Human cardiovascular progenitor cells develop from a kdr+ embryonic-stem-cell-derived population. Nature 2008; 453: 524-528.
4. Kattman SJ, Huber TL, Keller GM,. Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell 2006; 11: 723-732.
5. Kattman SJ, Witty AD, Gagliardi M, et al., Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 2011; 8: 228-240.
6. Tulloch NL, Muskheli V, Razumova MV, et al., Growth of engineered human myocardium with mechanical loading and vascular coculture. Circ Res 2011; 109: 47-59.
7. Caspi O, Lesman A, Basevitch Y, et al., Tissue engineering of vascularized cardiac muscle from human embryonic stem cells. Circ Res 2007; 100: 263-272.
8. Zimmermann W, Schneiderbanger K, Schubert P, et al., Tissue engineering of a differentiated cardiac muscle construct. Circ Res 2001; 90: 223-230.
9. Eschenhagen T, Didié M, Münzel F, et al., 3D engineered heart tissue for replacement therapy. Basic Res Cardiol 2002; 97: I146-I152.
10. Zimmermann W, Didié M, Wasmeier G,. Cardiac grafting of engineered heart tissue in syngenic rats. Circulation 2002: 151-157.
11. Zimmermann W-H, Melnychenko I, Wasmeier G, et al., Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nat Med 2006; 12: 452-458.
12. Naito H, Melnychenko I, Didié M, et al., Optimizing engineered heart tissue for therapeutic applications as surrogate heart muscle. Circulation 2006; 114: I72-I78.
13. Radisic M, Park H,. Pre-treatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue. J Biomed Mater Res A 2008; 86: 713-724.
14. Stevens KR, Kreutziger KL, Dupras SK, et al., Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue. Proc Natl Acad Sci USA 2009; 106: 16568-16573.
15. Paige SL, Osugi T, Afanasiev OK, et al., Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS One 2010; 5: e11134.
16. Paige SL, Thomas S, Stoick-Cooper CL, et al., A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell 2012; 151: 221-232.
17. Korte FS, Dai J, Buckley K, et al., Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation. J Mol Cell Cardiol 2011; 51: 894-901.
18. Herron TJ, Vandenboom R, Fomicheva E, et al., Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes. Circ Res 2007; 100: 1182-1190.
19. Kennedy M, D'Souza SL, Lynch-Kattman M, et al., Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 2007; 109: 2679-2687.
20. Reiser PJ, Portman MA, Ning XH, et al., Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles. Am J Physiol Heart Circ Physiol 2001; 280: H1814-H1820.
21. Gwak S-J, Bhang SH, Kim I-K, et al., The effect of cyclic strain on embryonic stem cell-derived cardiomyocytes. Biomaterials 2008; 29: 844-856.
22. Heo JS, Lee J-C,. β-Catenin mediates cyclic strain-stimulated cardiomyogenesis in mouse embryonic stem cells through ROS-dependent and integrin-mediated PI3K/Akt pathways. J Cell Biochem 2011; 112: 1880-1889.
23. Schmelter M, Ateghang B, Helmig S, et al., Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation. FASEB J 2006; 20: 1182-1184.
24. Haddad F, Qin AX, Bodell PW, et al., Intergenic transcription and developmental regulation of cardiac myosin heavy chain genes. Am J Physiol Heart Circ Physiol 2008; 294: H29-H40.