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Volumn 63, Issue 1, 2015, Pages 13-19

Decades after recovery from hepatitis B and HBsAg clearance the CD8+ T cell response against HBV core is nearly undetectable

Author keywords

Anti HBs; CD8+ T cell response; HBcAg; HBsAg; HBV core

Indexed keywords

CORE PROTEIN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; HLA ANTIGEN CLASS 1; INTERLEUKIN 7 RECEPTOR; VIRUS DNA; HEPATITIS B ANTIBODY;

EID: 84931567803     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.01.030     Document Type: Article
Times cited : (15)

References (36)
  • 1
    • 0032754504 scopus 로고    scopus 로고
    • Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection
    • M.K. Maini, C. Boni, G.S. Ogg, A.S. King, S. Reignat, and C.K. Lee Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection Gastroenterology 117 1999 1386 1396
    • (1999) Gastroenterology , vol.117 , pp. 1386-1396
    • Maini, M.K.1    Boni, C.2    Ogg, G.S.3    King, A.S.4    Reignat, S.5    Lee, C.K.6
  • 2
    • 0037213545 scopus 로고    scopus 로고
    • CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • R. Thimme, S. Wieland, C. Steiger, J. Ghrayeb, K.A. Reimann, and R.H. Purcell CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection J Virol 77 2003 68 76
    • (2003) J Virol , vol.77 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3    Ghrayeb, J.4    Reimann, K.A.5    Purcell, R.H.6
  • 3
    • 84879412047 scopus 로고    scopus 로고
    • Kinetics of peripheral hepatitis B virus-specific CD8+ T cells in patients with onset of viral reactivation
    • J. Aoki, Y. Kowazaki, T. Ohtsuki, R. Okamoto, K. Ohashi, and S. Hayashi Kinetics of peripheral hepatitis B virus-specific CD8+ T cells in patients with onset of viral reactivation J Gastroenterol 48 2013 728 737
    • (2013) J Gastroenterol , vol.48 , pp. 728-737
    • Aoki, J.1    Kowazaki, Y.2    Ohtsuki, T.3    Okamoto, R.4    Ohashi, K.5    Hayashi, S.6
  • 4
    • 0028925535 scopus 로고
    • The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis
    • B. Rehermann, P. Fowler, J. Sidney, J. Person, A. Redeker, and M. Brown The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis J Exp Med 181 1995 1047 1058
    • (1995) J Exp Med , vol.181 , pp. 1047-1058
    • Rehermann, B.1    Fowler, P.2    Sidney, J.3    Person, J.4    Redeker, A.5    Brown, M.6
  • 5
    • 0029838758 scopus 로고    scopus 로고
    • The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response
    • B. Rehermann, C. Ferrari, C. Pasquinelli, and F.V. Chisari The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response Nat Med 2 1996 1104 1108
    • (1996) Nat Med , vol.2 , pp. 1104-1108
    • Rehermann, B.1    Ferrari, C.2    Pasquinelli, C.3    Chisari, F.V.4
  • 6
    • 0025719119 scopus 로고
    • Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen
    • A. Penna, F.V. Chisari, A. Bertoletti, G. Missale, P. Fowler, and T. Giuberti Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen J Exp Med 174 1991 1565 1570
    • (1991) J Exp Med , vol.174 , pp. 1565-1570
    • Penna, A.1    Chisari, F.V.2    Bertoletti, A.3    Missale, G.4    Fowler, P.5    Giuberti, T.6
  • 7
    • 6944244922 scopus 로고    scopus 로고
    • A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen
    • M.T. Chen, J.N. Billaud, M. Sallberg, L.G. Guidotti, F.V. Chisari, and J. Jones A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen Proc Natl Acad Sci U S A 101 2004 14913 14918
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14913-14918
    • Chen, M.T.1    Billaud, J.N.2    Sallberg, M.3    Guidotti, L.G.4    Chisari, F.V.5    Jones, J.6
  • 8
    • 75149117314 scopus 로고    scopus 로고
    • Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B
    • 693, e681-e684
    • P. Fisicaro, C. Valdatta, M. Massari, E. Loggi, E. Biasini, and L. Sacchelli Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B Gastroenterology 138 2010 682 693 693, e681-e684
    • (2010) Gastroenterology , vol.138 , pp. 682-693
    • Fisicaro, P.1    Valdatta, C.2    Massari, M.3    Loggi, E.4    Biasini, E.5    Sacchelli, L.6
  • 9
    • 84921332527 scopus 로고    scopus 로고
    • Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation
    • B. Bengsch, B. Martin, and R. Thimme Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation J Hepatol 61 2014 1212 1219
    • (2014) J Hepatol , vol.61 , pp. 1212-1219
    • Bengsch, B.1    Martin, B.2    Thimme, R.3
  • 10
    • 79955112364 scopus 로고    scopus 로고
    • Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection
    • A. Schurich, P. Khanna, A.R. Lopes, K.J. Han, D. Peppa, and L. Micco Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection Hepatology 53 2011 1494 1503
    • (2011) Hepatology , vol.53 , pp. 1494-1503
    • Schurich, A.1    Khanna, P.2    Lopes, A.R.3    Han, K.J.4    Peppa, D.5    Micco, L.6
  • 11
    • 43049112084 scopus 로고    scopus 로고
    • Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection
    • A.R. Lopes, P. Kellam, A. Das, C. Dunn, A. Kwan, and J. Turner Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection J Clin Invest 118 2008 1835 1845
    • (2008) J Clin Invest , vol.118 , pp. 1835-1845
    • Lopes, A.R.1    Kellam, P.2    Das, A.3    Dunn, C.4    Kwan, A.5    Turner, J.6
  • 12
    • 84866705034 scopus 로고    scopus 로고
    • Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues
    • C. Boni, D. Laccabue, P. Lampertico, T. Giuberti, M. Vigano, and S. Schivazappa Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues Gastroenterology 143 2012 e969
    • (2012) Gastroenterology , vol.143 , pp. e969
    • Boni, C.1    Laccabue, D.2    Lampertico, P.3    Giuberti, T.4    Vigano, M.5    Schivazappa, S.6
  • 13
    • 84879549459 scopus 로고    scopus 로고
    • Combination of DNA prime-adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model
    • A.D. Kosinska, E. Zhang, L. Johrden, J. Liu, P.L. Seiz, and X. Zhang Combination of DNA prime-adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model PLoS Pathog 9 2013 e1003391
    • (2013) PLoS Pathog , vol.9
    • Kosinska, A.D.1    Zhang, E.2    Johrden, L.3    Liu, J.4    Seiz, P.L.5    Zhang, X.6
  • 14
    • 84893805242 scopus 로고    scopus 로고
    • Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection
    • J. Liu, E. Zhang, Z. Ma, W. Wu, A. Kosinska, and X. Zhang Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection PLoS Pathog 10 2014 e1003856
    • (2014) PLoS Pathog , vol.10
    • Liu, J.1    Zhang, E.2    Ma, Z.3    Wu, W.4    Kosinska, A.5    Zhang, X.6
  • 15
    • 84905662172 scopus 로고    scopus 로고
    • Protective immunity against hepatitis C: many shades of gray
    • M.S. Abdel-Hakeem, and N.H. Shoukry Protective immunity against hepatitis C: many shades of gray Front Immunol 5 2014 274
    • (2014) Front Immunol , vol.5 , pp. 274
    • Abdel-Hakeem, M.S.1    Shoukry, N.H.2
  • 16
    • 0034030136 scopus 로고    scopus 로고
    • Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
    • A. Takaki, M. Wiese, G. Maertens, E. Depla, U. Seifert, and A. Liebetrau Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C Nat Med 6 2000 578 582
    • (2000) Nat Med , vol.6 , pp. 578-582
    • Takaki, A.1    Wiese, M.2    Maertens, G.3    Depla, E.4    Seifert, U.5    Liebetrau, A.6
  • 17
    • 0036337681 scopus 로고    scopus 로고
    • Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections
    • K. Kakimi, M. Isogawa, J. Chung, A. Sette, and F.V. Chisari Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections J Virol 76 2002 8609 8620
    • (2002) J Virol , vol.76 , pp. 8609-8620
    • Kakimi, K.1    Isogawa, M.2    Chung, J.3    Sette, A.4    Chisari, F.V.5
  • 18
    • 2442682870 scopus 로고    scopus 로고
    • Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy
    • G.J. Webster, S. Reignat, D. Brown, G.S. Ogg, L. Jones, and S.L. Seneviratne Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy J Virol 78 2004 5707 5719
    • (2004) J Virol , vol.78 , pp. 5707-5719
    • Webster, G.J.1    Reignat, S.2    Brown, D.3    Ogg, G.S.4    Jones, L.5    Seneviratne, S.L.6
  • 19
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • S.M. Kaech, J.T. Tan, E.J. Wherry, B.T. Konieczny, C.D. Surh, and R. Ahmed Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells Nat Immunol 4 2003 1191 1198
    • (2003) Nat Immunol , vol.4 , pp. 1191-1198
    • Kaech, S.M.1    Tan, J.T.2    Wherry, E.J.3    Konieczny, B.T.4    Surh, C.D.5    Ahmed, R.6
  • 20
    • 0030008076 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection
    • B. Rehermann, D. Lau, J.H. Hoofnagle, and F.V. Chisari Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection J Clin Invest 97 1996 1655 1665
    • (1996) J Clin Invest , vol.97 , pp. 1655-1665
    • Rehermann, B.1    Lau, D.2    Hoofnagle, J.H.3    Chisari, F.V.4
  • 21
    • 69549113042 scopus 로고    scopus 로고
    • HLA genotyping and antibody characterization using the luminex multiplex technology
    • F.M. Heinemann HLA genotyping and antibody characterization using the luminex multiplex technology Transfus Med Hemother 36 2009 273 278
    • (2009) Transfus Med Hemother , vol.36 , pp. 273-278
    • Heinemann, F.M.1
  • 22
    • 84869500628 scopus 로고    scopus 로고
    • Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1
    • G. Ren, S. Esser, C. Jochum, J.F. Schlaak, G. Gerken, and D. Schadendorf Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1 Aids 26 2012 2145 2153
    • (2012) Aids , vol.26 , pp. 2145-2153
    • Ren, G.1    Esser, S.2    Jochum, C.3    Schlaak, J.F.4    Gerken, G.5    Schadendorf, D.6
  • 23
    • 70349241721 scopus 로고    scopus 로고
    • Degree of cross-genotype reactivity of hepatitis C virus-specific CD8+ T cells directed against NS3
    • S. Giugliano, F. Oezkan, M. Bedrejowski, M. Kudla, M. Reiser, and S. Viazov Degree of cross-genotype reactivity of hepatitis C virus-specific CD8+ T cells directed against NS3 Hepatology 50 2009 707 716
    • (2009) Hepatology , vol.50 , pp. 707-716
    • Giugliano, S.1    Oezkan, F.2    Bedrejowski, M.3    Kudla, M.4    Reiser, M.5    Viazov, S.6
  • 24
    • 4444354594 scopus 로고    scopus 로고
    • High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection
    • G.M. Lauer, E. Barnes, M. Lucas, J. Timm, K. Ouchi, and A.Y. Kim High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection Gastroenterology 127 2004 924 936
    • (2004) Gastroenterology , vol.127 , pp. 924-936
    • Lauer, G.M.1    Barnes, E.2    Lucas, M.3    Timm, J.4    Ouchi, K.5    Kim, A.Y.6
  • 25
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • E.J. Wherry T cell exhaustion Nat Immunol 12 2011 492 499
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 26
    • 78649625973 scopus 로고    scopus 로고
    • The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function
    • B. Raziorrouh, W. Schraut, T. Gerlach, D. Nowack, N.H. Gruner, and A. Ulsenheimer The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function Hepatology 52 2010 1934 1947
    • (2010) Hepatology , vol.52 , pp. 1934-1947
    • Raziorrouh, B.1    Schraut, W.2    Gerlach, T.3    Nowack, D.4    Gruner, N.H.5    Ulsenheimer, A.6
  • 27
    • 84868159278 scopus 로고    scopus 로고
    • Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection
    • G. Nebbia, D. Peppa, A. Schurich, P. Khanna, H.D. Singh, and Y. Cheng Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection PLoS One 7 2012 e47648
    • (2012) PLoS One , vol.7
    • Nebbia, G.1    Peppa, D.2    Schurich, A.3    Khanna, P.4    Singh, H.D.5    Cheng, Y.6
  • 28
    • 34247117935 scopus 로고    scopus 로고
    • Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
    • C. Boni, P. Fisicaro, C. Valdatta, B. Amadei, P. Di Vincenzo, and T. Giuberti Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection J Virol 81 2007 4215 4225
    • (2007) J Virol , vol.81 , pp. 4215-4225
    • Boni, C.1    Fisicaro, P.2    Valdatta, C.3    Amadei, B.4    Di Vincenzo, P.5    Giuberti, T.6
  • 29
    • 84862664371 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: management of chronic hepatitis B virus infection
    • European Association for the Study of the Liver EASL clinical practice guidelines: management of chronic hepatitis B virus infection J Hepatol 57 2012 167 185
    • (2012) J Hepatol , vol.57 , pp. 167-185
    • European Association for the Study of the Liver1
  • 31
  • 32
    • 77949330147 scopus 로고    scopus 로고
    • Reactivation of hepatitis B virus following rituximab-based regimens: a serious complication in both HBsAg-positive and HBsAg-negative patients
    • S.N. Pei, C.H. Chen, C.M. Lee, M.C. Wang, M.C. Ma, and T.H. Hu Reactivation of hepatitis B virus following rituximab-based regimens: a serious complication in both HBsAg-positive and HBsAg-negative patients Ann Hematol 89 2010 255 262
    • (2010) Ann Hematol , vol.89 , pp. 255-262
    • Pei, S.N.1    Chen, C.H.2    Lee, C.M.3    Wang, M.C.4    Ma, M.C.5    Hu, T.H.6
  • 33
    • 84874543706 scopus 로고    scopus 로고
    • Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion
    • D. Peppa, U.S. Gill, G. Reynolds, N.J. Easom, L.J. Pallett, and A. Schurich Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion J Exp Med 210 2013 99 114
    • (2013) J Exp Med , vol.210 , pp. 99-114
    • Peppa, D.1    Gill, U.S.2    Reynolds, G.3    Easom, N.J.4    Pallett, L.J.5    Schurich, A.6
  • 34
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • B. Rehermann, and M. Nascimbeni Immunology of hepatitis B virus and hepatitis C virus infection Nat Rev Immunol 5 2005 215 229
    • (2005) Nat Rev Immunol , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 35
    • 84902651736 scopus 로고    scopus 로고
    • Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity
    • H.C. Xu, M. Grusdat, A.A. Pandyra, R. Polz, J. Huang, and P. Sharma Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity Immunity 40 2014 949 960
    • (2014) Immunity , vol.40 , pp. 949-960
    • Xu, H.C.1    Grusdat, M.2    Pandyra, A.A.3    Polz, R.4    Huang, J.5    Sharma, P.6
  • 36
    • 84902654063 scopus 로고    scopus 로고
    • Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1
    • J. Crouse, G. Bedenikovic, M. Wiesel, M. Ibberson, I. Xenarios, and D. Von Laer Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1 Immunity 40 2014 961 973
    • (2014) Immunity , vol.40 , pp. 961-973
    • Crouse, J.1    Bedenikovic, G.2    Wiesel, M.3    Ibberson, M.4    Xenarios, I.5    Von Laer, D.6


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