A Randomized Case-Controlled Study of Recombinant Human Granulocyte Colony Stimulating Factor for the Treatment of Sepsis in Preterm Neutropenic Infants

Pediatrics and Neonatology

Volumn 56, Issue 3, 2015, Pages 171-175

  Aktaş, Doʇukan ^a   Demirel, Bilge ^a   Gürsoy, Tuʇba ^a   Ovali, Fahri ^a  

^a Zeynep Kamil Training and Education Hospital   (Turkey)

Author keywords

colony stimulating factor; neutropenia, sepsis; preterm

Indexed keywords

ANTIBIOTIC AGENT; FILGRASTIM; ANTIINFECTIVE AGENT; HEMATOLOGIC AGENT;

ABSENCE OF SIDE EFFECTS; ANTIBIOTIC THERAPY; ARTICLE; BLOOD CULTURE; BLOOD SAMPLING; BRAIN HEMORRHAGE; CLINICAL FEATURE; CONTROLLED STUDY; DATA ANALYSIS SOFTWARE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; INFANT; INFANT DISEASE; LUNG DYSPLASIA; MAJOR CLINICAL STUDY; MALE; MENINGITIS; NECROTIZING ENTEROCOLITIS; NEUTROPENIA; NEUTROPHIL COUNT; OUTCOME ASSESSMENT; PATENT DUCTUS ARTERIOSUS; PNEUMONIA; PREMATURITY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS SYNDROME; SEPSIS; TURKEY (REPUBLIC); BLOOD; BLOOD CELL COUNT; INFANT, PREMATURE, DISEASES; NEWBORN; TURKEY;

ANTI-BACTERIAL AGENTS; BLOOD CELL COUNT; FEMALE; FILGRASTIM; HEMATOLOGIC AGENTS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; MALE; NEUTROPENIA; SEPSIS; TURKEY;

EID: 84931562372     PISSN: 18759572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pedneo.2014.06.007     Document Type: Article

References (28)

1. B.J. Stoll, N. Hansen, A.A. Fanaroff, L.L. Wright, W.A. Carlo, and R.A. Ehrenkranz Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network Pediatrics 110 2002 285 291
2. B.J. Stoll, N.I. Hansen, I. Adams-Chapman, A.A. Fanaroff, S.R. Hintz, and B. Vohr Neurodevelopmental and growth impairment among extremely low-birthweight infants with neonatal infection JAMA 292 2004 2357 2365
3. I. Adams-Chapman Long-term impact of infection on the preterm neonate Semin Perinatol 36 2012 462 470
4. M.M. Lahra, P.J. Beeby, and H.E. Jeffery Intrauterine inflammation, neonatal sepsis, and chronic lung disease: a 13-year hospital cohort study Pediatrics 123 2009 1314 1319
5. J.D. Siegel, and G.H. McCracken Jr. Sepsis neonatorum N Engl J Med 304 1981 642 647
6. E.F. La Gamma, L.M. Drusin, A.W. Mackles, S. Machalek, and P.A. Auld Neonatal infections. An important determinant of late NICU mortality in infants less than 1000 g at birth Am J Dis Child 137 1983 838 841
7. M.C. Banerjea, and C.P. Speer The current role of colony-stimulating factors in prevention and treatment of neonatal sepsis Semin Neonatol 7 2002 335 349
8. M. Ballow, K.L. Cates, J.C. Rowe, C. Goetz, and C. Desbonnet Development of the immune system in very low birth weight (less than 1500g) premature infants: concentration of plasma immunoglobulins and patterns of infections Pediatr Res 20 1986 899 904
9. H.R. Hill Biochemical, structural, and functional abnormalities of polymorphonuclear leukocytes in the neonate Pediatr Res 22 1987 375 382
10. P. Gessler, T. Nebe, A. Birle, N. Haas, and W. Kachel Neutrophil respiratory burst in term and preterm neonates without signs of infection and in those with increased levels of C-reactive protein Pediatr Res 39 1996 843 848
11. R.L. Rodwell, K.M. Taylor, D.I. Tudehope, and P.H. Gray Hematologic scoring system in early diagnosis of sepsis in neutropenic newborns Pediatr Infect Dis J 12 1993 372 376
12. E.F. La Gamma, and M.H. De Castro What is the rationale for the use of granulocyte and granulocyte-macrophage colony-stimulating factors in the neonatal intensive care unit? Acta Paediatr Suppl 91 2002 109 116
13. P. Lanzkowski Disorders of white blood cells P. Lanzkowski, A manual of pediatric hematology and oncology 4th ed. 2010 Elsevier Academic Press London 214
14. S. Bektas, B. Goetze, and C.P. Speer Decreased adherence, chemotaxis and phagocytic activities of neutrophils from preterm neonates Acta Paediatr Scand 79 1990 1031 1038
15. C.P. Speer, and R.B. Johnston Neutrophil function in newborn infants R.A. Polin, W.W. Fox, Fetal and neonatal physiology 2nd ed. 1998 WB Saunders Philadelphia 1954 1960
16. W.A. Engle, R.L. Schreiner, and R.L. Baehner Neonatal white blood cell disorders Semin Perinatol 7 1983 184 200
17. K. Iguchi, S. Inoue, and A. Kumar Effect of recombinant human granulocyte colony-stimulating factor administration in normal and experimentally infected newborn rats Exp Hematol 19 1991 352 358
18. M.S. Cairo, J.M. Plunkett, D. Mauss, and C. Van der Ven Seven-day administration of recombinant human granulocyte colony-stimulating factor to newborn rats: modulation of neonatal neutrophilia, myelopoiesis, and group B streptococcal sepsis Blood 76 1990 1788 1794
19. M. Gahr, R. Blanke, and C.P. Speer Polymorphonuclear leukocyte function in term and preterm newborn infants Biol Neonate 48 1985 15 20
20. A.R. Russell, E.G. Davies, S.E. Ball, and E. Gordon-Smith Granulocyte colony stimulating factor treatment for neonatal neutropenia Arch Dis Child Fetal Neonatal Ed 72 1995 53 54
21. V. Drossou-Agakidou, F. Kanakoudi-Tsakalidou, K. Sarafidis, A. Taparkou, V. Tzimouli, and H. Tsandali Administration of recombinant human granulocyte-colony stimulating factor to septic neonates induces neutrophilia and enhances the neutrophil respiratory burst and beta2 integrin expression. Results of a randomized controlled trial Eur J Pediatr 157 1998 583 588
22. R. Carr, N. Modi, and C. Doré G-CSF and GM-CSF for treating or preventing neonatal infections Cochrane Database Syst Rev 3 2003 CD003066
23. M. Weiss, S. Voglic, B. Harms-Schirra, I. Lorenz, B. Lasch, and K. Dumon Effects of exogenous recombinant human granulocyte colony-stimulating factor (filgrastim, rhG-CSF) on neutrophils of critically ill patients with systemic inflammatory response syndrome depend on endogenous G-CSF plasma concentrations on admission Intensive Care Med 29 2003 904 914
24. K. Bilgin, A. Yaramiş, K. Haspolat, M.A. Taş, S. Günbey, and O. Derman A randomized trial of granulocyte-macrophage colony-stimulating factor in neonates with sepsis and neutropenia Pediatrics 107 2001 36 41
25. A. Ahmad, G. Laborada, J. Bussel, and M. Nesin Comparison of recombinant granulocyte colony-stimulating factor, recombinant human granulocyte-macrophage colony-stimulating factor and placebo for treatment of septic preterm infants Pediatr Infect Dis J 21 2002 1061 1065
26. E.R. Gillan, R.D. Christensen, Y. Suen, R. Ellis, C. van de Ven, and M.S. Cairo A randomized, placebo-controlled trial of recombinant human granulocyte colony-stimulating factor administration in newborn infants with presumed sepsis: significant induction of peripheral and bone marrow neutrophilia Blood 84 1994 1427 1433
27. K.R. Schibler, K.A. Osborne, L.Y. Leung, T.V. Le, S.I. Baker, and D.D. Thompson A randomized, placebo-controlled trial of granulocyte colony-stimulating factor administration to newborn infants with neutropenia and clinical signs of early-onset sepsis Pediatrics 102 1998 6 13
28. P. Kocherlakota, and E.F. La Gamma Human granulocyte colony-stimulating factor may improve outcome attributable to neonatal sepsis complicated by neutropenia Pediatrics 100 1997 E6