A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs

Journal of Immunology

Volumn 194, Issue 12, 2015, Pages 6144-6154

  Nicholas, Ben ^a,b   Staples, Karl J ^a,b   Moese, Stefan ^c   Meldrum, Eric ^c   Ward, Jon ^a   Dennison, Patrick ^a,b   Havelock, Tom ^a,b   Hinks, Timothy S C ^a,b   Amer, Khalid ^d   Woo, Edwin ^d   Chamberlain, Martin ^d   Singh, Neeta ^d   North, Malcolm ^b   Pink, Sandy ^b   Wilkinson, Tom M A ^a,b   Djukanović, Ratko ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b University Hospital Southampton NHS Foundation Trust   (United Kingdom)

^c 3 V Biosciences Inc   (United States)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; ANTIVIRUS AGENT; AUTACOID; OSELTAMIVIR; TVB 024; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG RESEARCH; DRUG TARGETING; EX VIVO STUDY; EXPLANT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFECTION RATE; INFLUENZA A (H3N2); INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; VIRUS INHIBITION; VIRUS RELEASE; VIRUS REPLICATION; VIRUS SHEDDING; DRUG EFFECTS; DRUG SCREENING; IMMUNOPHENOTYPING; INFLUENZA A VIRUS; INFLUENZA, HUMAN; LUNG; ORGAN CULTURE TECHNIQUE; PHENOTYPE; PHYSIOLOGY; PROCEDURES; VIROLOGY;

ANTIVIRAL AGENTS; DRUG EVALUATION, PRECLINICAL; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INFLUENZA A VIRUS; INFLUENZA, HUMAN; LUNG; ORGAN CULTURE TECHNIQUES; PHENOTYPE;

EID: 84931368635     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402283     Document Type: Article

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