Spread of imipenem-resistant Acinetobacter baumannii co-expressing OXA-23 and GES-11 carbapenemases in Lebanon

International Journal of Infectious Diseases

Volumn 36, Issue , 2015, Pages e56-e61

  Hammoudi, D ^a,b,c   Moubareck, C Ayoub ^a,b,d   Hakime, N ^e   Houmani, M ^f   Barakat, A ^g   Najjar, Z ^h   Suleiman, M ⁱ   Fayad, N ^j   Sarraf, R ^k   Sarkis, D Karam ^a,b  

^a SAINT JOSEPH UNIVERSITY   (Lebanon)

^b Rodolph Merieux Laboratory   (Lebanon)

^c LEBANESE INTERNATIONAL UNIVERSITY   (Lebanon)

^d ZAYED UNIVERSITY   (United Arab Emirates)

^e SAINT GEORGE HOSPITAL UNIVERSITY MEDICAL CENTER   (Lebanon)

^f Labib Medical Center   (Lebanon)

^g Bellevue Medical Center   (Lebanon)

^h Chtaura Hospital   (Lebanon)

ⁱ Farhat Hospital   (Lebanon)

^j Secours Populaire Libanais Hospital   (Lebanon)

^k Mounla Hospital   (Lebanon)

more..

Author keywords

ERIC PCR; GES 11; Imipenem resistant acinetobacter baumannii; OXA 23

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; BACTERIAL PROTEIN; BETA LACTAMASE; BETA LACTAMASE GES 11; BETA LACTAMASE OXA 23; BETA LACTAMASE OXA 24; CARBAPENEMASE; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEPHALOSPORINASE; CLAVULANIC ACID; CLOXACILLIN; EDETIC ACID; EXTENDED SPECTRUM BETA LACTAMASE; IMIPENEM; ISABA1 PROTEIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BACTERIUM ISOLATE; CLONAL SPECIES; CLONAL VARIATION; CONTROLLED STUDY; DNA FINGERPRINTING; DRUG POTENTIATION; ENTEROBACTERIACEAE; ENTEROBACTERIAL REPETITIVE INTERGENIC CONSENSUS POLYMERASE CHAIN REACTION; GENE EXPRESSION; GENE INSERTION SEQUENCE; GENETIC LINKAGE; GENOTYPE; HORIZONTAL GENE TRANSFER; HOSPITAL; IN VITRO STUDY; LEBANESE; LEBANON; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEIC ACID ANALYSIS; POLYMERASE CHAIN REACTION; PREVALENCE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; ISOLATION AND PURIFICATION;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CLOXACILLIN; DRUG RESISTANCE, BACTERIAL; HUMANS; IMIPENEM; LEBANON; POLYMERASE CHAIN REACTION;

EID: 84931266302     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2015.05.015     Document Type: Article

References (36)

1. Abbott I., Cerqueira G.M., Bhuiyan S., Peleg A.Y. Carbapenem resistance in Acinetobacter baumannii: laboratory challenges, mechanistic insights and therapeutic strategies. Expert Rev Anti Infect Ther 2013, 11:395-409.
2. Poirel L., Nordmann P. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin Microbiol Infect 2006, 12:826-836.
3. Bonnin R.A., Potron A., Poirel L., Lecuyer H., Neri R., Nordmann P. PER-7, an extended-spectrum beta-lactamase with increased activity toward broad-spectrum cephalosporins in Acinetobacter baumannii. Antimicrob Agents Chemother 2011, 55:2424-2427.
4. Cicek A.C., Saral A., Iraz M., Ceylan A., Duzgun A.O., Peleg A.Y., et al. OXA- and GES-type β-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital. Clin Microbiol Infect 2014, 20:410-415.
5. Farajnia S., Azhari F., Alikhani M.Y., Hosseini M.K., Peymani A., Sohrabi N. Prevalence of PER and VEB type extended spectrum betalactamases among multidrug resistant Acinetobacter baumannii isolates in north-west of Iran. Iran J Basic Med Sci 2013, 16:751-755.
6. Manchanda V., Sanchaita S., Singh N. Multidrug resistant Acinetobacter. J Glob Infect Dis 2010, 2:291-304.
7. Bonnin R.A., Nordmann P., Poirel L. Screening and deciphering antibiotic resistance in Acinetobacter baumannii: a state of the art. Expert Rev Anti Infect Ther 2013, 11:571-583.
8. Moubareck C., Brémont S., Conroy M.C., Courvalin P., Lambert T. GES-11, a novel integron-associated GES variant in Acinetobacter baumannii. Antimicrob Agents Chemother 2009, 53:3579-3581.
9. Robledo I.E., Aquino E.E., Santé M.I., Santana J.L., Otero D.M., León C.F., et al. Detection of KPC in Acinetobacter spp. in Puerto Rico. Antimicrob Agents Chemother 2010, 54:1354-1357.
10. Gupta V., Garg R., Garg S., Chander J., Attri A.K. Coexistence of extended spectrum beta-lactamases, AmpC beta-lactamases and metallo-beta-lactamases in Acinetobacter baumannii from burns patients: a report from a tertiary care centre of India. Ann Burns Fire Disasters 2013, 26:189-192.
11. Corvec S., Caroff N., Espaze E., Giraudeau C., Drugeon H., Reynaud A. AmpC cephalosporinase hyperproduction in Acinetobacter baumannii clinical strains. J Antimicrob Chemother 2003, 52:629-635.
12. Segal H., Nelson E.C., Elisha B.G. Genetic environment and transcription of ampC in an Acinetobacter baumannii clinical isolate. Antimicrob Agents Chemother 2004, 48:612-614.
13. Figueiredo S., Poirel L., Papa A., Koulourida V., Nordmann P. Overexpression of the naturally occurring blaOXA-51 gene in Acinetobacter baumannii mediated by novel insertion sequence ISAba9. Antimicrob Agents Chemother 2009, 53:4045-4047.
14. Turton J.F., Ward M.E., Woodford N., Kaufmann M.E., Pike R., Livermore D.M., et al. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol Lett 2006, 258:72-77.
15. Mugnier P.D., Poirel L., Naas T., Nordmann P. Worldwide dissemination of the blaOXA-23 carbapenemase gene of Acinetobacter baumannii. Emerg Infect Dis 2010, 16:35-40.
16. Bogaerts P., Naas T., El Garch F., Cuzon G., Deplano A., Delaire T., et al. GES extended-spectrum β-lactamases in Acinetobacter baumannii isolates in Belgium. Antimicrob Agents Chemother 2010, 54:4872-4878.
17. Zarrilli R., Vitale D., Di Popolo A., Bagattini M., Daoud Z., Khan A.U., et al. A plasmid-borne blaOXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital. Antimicrob Agents Chemother 2008, 52:4115-4120.
18. Rafei R., Dabboussi F., Hamze M., Eveillard M., Lemarié C., Mallat H., et al. First report of blaNDM-1-producing Acinetobacter baumannii isolated in Lebanon from civilians wounded during the Syrian war. Int J Infect Dis 2014, 21:21-23.
19. Performance standards for antimicrobial susceptibility testing. Twenty-second informational supplement M100-S22 2012, Clinical and Laboratory and Standards Institute, CLSI, Wayne, PA.
20. Turton J.F., Woodford N., Glover J., Yarde S., Kaufmann M.E., Pitt T.L. Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species. J Clin Microbiol 2006, 44:2974-2976.
21. Thomson K.S. Extended-spectrum-beta-lactamase, AmpC, and carbapenemase issues. J Clin Microbiol 2010, 48:1019-1025.
22. Antibiotic resistance techniques 2010, Unité des Agents Antibactériens, Institut Pasteur, Paris, France. Sixth edition.
23. Ferreira A.E., Marchetti D.P., da Cunha G.R., de Oliveira L.M., Fuentefria D.B., Dall Bello A.G., et al. Molecular characterization of clinical multiresistant isolates of Acinetobacter sp. from hospitals in Porto Alegre, State of Rio Grande do Sul, Brazil. Rev Soc Bras Med Trop 2011, 44:725-730.
24. Al-Agamy M.H., Khalaf N.G., Tawfick M.M., Shibl A.M., El Kholy A. Molecular characterization of carbapenem-insensitive Acinetobacter baumannii in Egypt. Int J Infect Dis 2014, 22:49-54.
25. Ciftci I.H., Aşik G., Karakeçe E., Oksüz L., Yağci S., Sesli Çetin E., et al. [Distribution of blaOXA genes in Acinetobacter baumannii strains: a multicenter study]. Mikrobiyol Bul 2013, 47:592-602.
26. Villalón P., Valdezate S., Medina-Pascual M.J., Carrasco G., Vindel A., Saez-Nieto J.A. Epidemiology of the Acinetobacter-derived cephalosporinase, carbapenem-hydrolysing oxacillinase and metallo-β-lactamase genes, and of common insertion sequences, in epidemic clones of Acinetobacter baumannii from Spain. J Antimicrob Chemother 2013, 68:550-553.
27. Principe L., Piazza A., Giani T., Bracco S., Caltagirone M.S., Arena F., et al. Epidemic diffusion of OXA-23-producing Acinetobacter baumannii isolates in Italy: results of the first cross-sectional countrywide survey. J Clin Microbiol 2014, 52:3004-3010.
28. Calhoun J.H., Murray C.K., Manring M.M. Multidrug-resistant organisms in military wounds from Iraq and Afghanistan. Clin Orthop 2008, 466:1356-1362.
29. Peymani A., Higgins P.G., Nahaei M.R., Farajnia S., Seifert H. Characterisation and clonal dissemination of OXA-23-producing Acinetobacter baumannii in Tabriz, northwest Iran. Int J Antimicrob Agents 2012, 39:526-528.
30. Mugnier P., Poirel L., Pitout M., Nordmann P. Carbapenem-resistant and OXA-23-producing Acinetobacter baumannii isolates in the United Arab Emirates. Clin Microbiol Infect 2008, 14:879-882.
31. Bonnin R.A., Rotimi V.O., Al Hubail M., Gasiorowski E., Al Sweih N., Nordmann P., et al. Wide dissemination of GES-type carbapenemases in Acinetobacter baumannii isolates in Kuwait. Antimicrob Agents Chemother 2013, 57:183-188.
32. Charfi-Kessis K., Mansour W., Ben Haj Khalifa A., Mastouri M., Nordmann P., Aouni M., et al. Multidrug-resistant Acinetobacter baumannii strains carrying the blaOxA-23 and the blaGES-11 genes in a neonatology center in Tunisia. Microb Pathog 2014, 74:20-24.
33. Sari A.N., Biçmen M., Gülay Z. The first report on the outbreak of OXA-24/40-like carbapenemase-producing Acinetobacter baumannii in Turkey. Jpn J Infect Dis 2013, 66:439-442.
34. Di Popolo A., Giannouli M., Triassi M., Brisse S., Zarrilli R. Molecular epidemiological investigation of multidrug-resistant Acinetobacter baumannii strains in four Mediterranean countries with a multilocus sequence typing scheme. Clin Microbiol Infect 2011, 17:197-201.
35. Poirel L., Bonnin R.A., Boulanger A., Schrenzel J., Kaase M., Nordmann P. Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii. Antimicrob Agents Chemother 2012, 56:1087-1089.
36. Rodríguez-Martínez J.M., Nordmann P., Ronco E., Poirel L. Extended-spectrum cephalosporinase in Acinetobacter baumannii. Antimicrob Agents Chemother 2010, 54:3484-3488.