Biomarkers in Parkinson disease: It's time to combine

Neurology

Volumn 84, Issue 24, 2015, Pages 2392-2393

  McKeown, Martin J ^a   Peavy, Guerry M ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; SYNUCLEIN; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; PEPTIDE FRAGMENT;

FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; NERVE CELL; PARKINSON DISEASE; PRIORITY JOURNAL; RESTING STATE NETWORK; REVIEW; BRAIN; CEREBROSPINAL FLUID; FEMALE; MALE; PATHOPHYSIOLOGY;

ALPHA-SYNUCLEIN; AMYLOID BETA-PEPTIDES; BRAIN; FEMALE; HUMANS; MALE; PARKINSON DISEASE; PEPTIDE FRAGMENTS;

EID: 84931085779     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000001692     Document Type: Review

References (10)

1. Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001;69:89-95.
2. Antoniades C, Barker R. The search for biomarkers in Parkinson's disease: a critical review. Expert Rev Neurother 2008;8:1841-1852.
3. Whone AL, Watts RL, Stoessl AJ, et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: the REAL-PET Study. Ann Neurol 2003;54:93-101.
4. Ross CA, Poirier MA. Protein aggregation and neurode-generative disease. Nat Med 2004;10(suppl):S10-S17.
5. Hirsch E. Biochemistry of Parkinson's disease with special reference to the dopaminergic systems. Mol Neurobiol 1994;9:135-142.
6. Brown P. Abnormal oscillatory synchronisation in the motor system leads to impaired movement. Curr Opin Neurobiol 2007;17:656-664.
7. Appel-Cresswell S, de la Fuente-Fernandez R, Galley S, McKeown MJ. Imaging of compensatory mechanisms in Parkinson's disease. Curr Opin Neurol 2010;23:407-412.
8. McKeown MJ, Uthama A, Abugharbieh R, Palmer S, Lewis M, Huang X. Shape (but not volume) changes in the thalami in Parkinson disease. BMC Neurol 2008;8:8.
9. Campbell MC, Koller JM, Snyder AZ, Buddhala C, Kotzbauer PT, Perlmutter JS. CSF proteins and resting-state functional connectivity in Parkinson disease. Neurology 2015;84:2413-2421.
10. Sejnowski TJ, Churchland PS, Movshon JA. Putting big data to good use in neuroscience. Nat Neurosci 2014;17:1440-1441.