Acne treatment based on selective photothermolysis of sebaceous follicles with topically delivered light-absorbing gold microparticles

Journal of Investigative Dermatology

Volumn 135, Issue 7, 2015, Pages 1727-1734

  Paithankar, Dilip Y ^a   Sakamoto, Fernanda H ^b   Farinelli, William A ^b   Kositratna, Garuna ^b   Blomgren, Richard D ^a   Meyer, Todd J ^a   Faupel, Linda J ^a   Kauvar, Arielle N B ^c   Lloyd, Jenifer R ^d   Cheung, Wang L ^e   Owczarek, Witold D ^f   Suwalska, Anna M ^f   Kochanska, Katarzyna B ^f   Nawrocka, Agnieszka K ^f   Paluchowska, Elwira B ^f   Podolec, Katarzyna M ^g   Pirowska, Magdalena M ^g   Wojas Pelc, Anna B ^g   Anderson, R Rox ^b  

^a Sebacia   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c New York Laser and Skin Care   (United States)

^d Lloyd Dermatology and Laser Center   (United States)

^e UNIVERSITY OF ARKANSAS AT LITTLE ROCK   (United States)

^f MILITARY INSTITUTE OF MEDICINE   (Poland)

^g JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

GOLD; GOLD MICROPARTICLE; SILICON DIOXIDE; UNCLASSIFIED DRUG; PHOTOSENSITIZING AGENT;

ACNE VULGARIS; ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; DIODE LASER; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LASER; LIGHT ABSORPTION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OPTICS; PHOTOLYSIS; PHOTOTHERMOLYSIS; PIG; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEBACEOUS FOLLICLE; SEBACEOUS GLAND; SHAM PROCEDURE; THERMAL INJURY; TREATMENT DURATION; ANIMAL; DISEASE MODEL; DRUG EFFECTS; FOLLOW UP; HAIR FOLLICLE; PARTICLE SIZE; PATHOLOGY; PHOTOCHEMOTHERAPY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; SKIN ABSORPTION; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ACNE VULGARIS; ADMINISTRATION, TOPICAL; ANIMALS; DISEASE MODELS, ANIMAL; FOLLOW-UP STUDIES; GOLD; HAIR FOLLICLE; HUMANS; PARTICLE SIZE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT; SEBACEOUS GLANDS; SKIN ABSORPTION; SWINE; TREATMENT OUTCOME;

EID: 84931057831     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.89     Document Type: Article

References (30)

1. Anderson RR (1999) Targeting of sebaceous follicles as a treatment of sebaceous gland disorders, US Patent 6183773
2. Anderson RR, Farinelli W, Laubach H, et al. (2006) Selective photothermolysis of lipid-rich tissues: a free electron laser study. Lasers Surg Med 38:913-9
3. Anderson RR, Parrish JA (1983) Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 220:524-7
4. Cotsarelis G, Sun TT, Lavker RM (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61:1329-37
5. De Soete D, Gijbels R, Hoste J (1972) Neutron Activation Analysis. Wiley-Interscience: London, New York, Sydney, Toronto
6. Elman M, Slatkine M, Harth Y (2003) The effective treatment of acne vulgaris by a high-intensity, narrow band 405-420 nm light source. J Cosmet Laser Ther 5:111-7
7. Gad SC, Sharp KL, Montgomery C, et al. (2012) Evaluation of the toxicity of intravenous delivery of auroshell particles (gold-silica nanoshells). Int J Toxicol 31:584-94
8. Jain PK, Lee KS, El-Sayed IH, et al. (2006) Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B 110: 7238-48
9. Hirsch LR, Gobin AM, Lowery AR, et al. (2006) Metal nanoshells. Ann Biomed Eng 34:15-22
10. Hongcharu W, Taylor CR, Chang Y, et al. (2000) Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol 115:183-92
11. Kligman AM (1974) An overview of acne. J Invest Dermatol 62:268-87
12. Kosaka S, Kawana S, Zouboulis CC, et al. (2006) Targeting of sebocytes by aminolevulinic acid-dependent photosensitization. Photochem Photobiol 82:453-7
13. Lademann J, Richter H, Teichmann A, et al. (2007) Nanoparticles-An efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm 66: 159-64
14. Lloyd JR, Mirkov M (2002) Selective photothermolysis of the sebaceous glands for acne treatment. Lasers Surg Med 31:115-20
15. Neumann RA, Knobler RM, Pieczkowski F, et al. (1991) Enzyme histochemical analysis of cell viability after argon laser-induced coagulation necrosis of the skin. J Am Acad Dermatol 25(6 Pt 1):991-8
16. Oldenburg SJ, Averitt RD, Westcott SL, et al. (1998) Nanoengineering of optical resonances. Chem Phys Lett 288:243-7
17. Omi T, Bjerring P, Sato S, et al. (2004) 420 nm intense continuous light therapy for acne. J Cosmet Laser Ther 6:156-62
18. Patzelt A, Richtera H, Knorra F, et al. (2011) Selective follicular targeting by modification of the particle sizes. J Control Release 150:45-8
19. Panteleyev AA, Rosenbach T, Paus R, et al. (2000) The bulge is the source of cellular renewal in the sebaceous gland of mouse skin. Arch Dermatol Res 292:573-6
20. Papakonstantinou E, Aletras AJ, Glass E, et al. (2005) Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. J Invest Dermatol 125:673-84
21. Peck GL, Olsen TG, Yoder FW, et al. (1979) Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. N Engl J Med 300: 329-33
22. Rolland A, Wagner N, Chatelus A, et al. (1993) Site-specific drug delivery to pilosebaceous structures using polymeric microspheres. Pharm Res 10: 1738-44
23. Sakamoto FH, Doukas AG, FarinelliWA, et al. (2012) Selective photothermolysis to target sebaceous glands: theoretical estimation of parameters and preliminary results using a free electron laser. Lasers Surg Med 44: 175-83
24. Sakamoto FH, Lopes JD, Anderson RR (2010) Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Acne vulgaris: when and why consider photodynamic therapy?. J Am Acad Dermatol 63:183-93
25. Sakamoto FH, Tannous Z, Doukas AG, et al. (2009) Porphyrin distribution after topical aminolevulinic acid in a novel porcine model of sebaceous skin. Lasers Surg Med 41:154-60
26. Solodyn NDA (2006) 50-808 as per US FDA/CDER Statistical Review, page 7. Approval Date: 02 August 2006 http://www.accessdata.fda.gov/drug satfda-docs/nda/2006/050808s000-StatR.pdf
27. Strauss JS, Stranieri AM, Farrell LN, et al. (1980) The effect of marked inhibition of sebum production with 13 cis-retinoic acid on skin surface lipid composition. J Invest Dermatol 74:66-7
28. Toll R, Jacobi U, Richter H, et al. (2004) Penetration profile of microspheres in follicular targeting of terminal hair follicles. J Invest Dermatol 123:168-76
29. Webster GF (2010) Light and laser therapy for acne: sham or science?. Facts and controversies. Clin Dermatol 28:31-3
30. Williams HC, Dellavalle RP, Garner S (2012) Acne vulgaris. Lancet 379:361-72