MiRNA-15a mediates cell cycle arrest and potentiates apoptosis in breast cancer cells by targeting synuclein-γ

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 16, 2014, Pages 6949-6954

  Li, Ping ^a,b   Xie, Xiao Bing ^b   Chen, Qian ^c   Pang, Guo Lian ^d   Luo, Wan ^a   Tu, Jian Cheng ^a   Zheng, Fang ^a   Liu, Song Mei ^a   Han, Lu ^a   Zhang, Jian Kun ^d   Luo, Xian Yong ^d   Zhou, Xin ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Department of Internal Medicine First People's Hospital of Qujing   (China)

Author keywords

Apoptosis; Breast cancer; Cell cycle; MicroRNA 15a; SNCG

Indexed keywords

3' UNTRANSLATED REGION; GAMMA SYNUCLEIN; MICRORNA; MIRN15 MICRORNA, HUMAN; SNCG PROTEIN, HUMAN; TUMOR PROTEIN;

3' UNTRANSLATED REGION; APOPTOSIS; BIOSYNTHESIS; BREAST TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; GAMMA-SYNUCLEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEOPLASM PROTEINS;

EID: 84931052950     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.16.6949     Document Type: Article

References (27)

1. Ambros V (2001). MicroRNAs: tiny regulators with great potential. Cell, 107, 823-6.
2. Bartel DP (2004). MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell, 116, 281-97.
3. Cai CK, Zhao GY, Tian LY, et al (2012). miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma. Oncol Rep, 28, 1764-70.
4. Chen C, Ridzon DA, Broomer AJ, et al (2005). Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res, 33, 179.
5. Chen Q, Xia HW, Ge XJ, et al (2013). Serum miR-19a predicts resistance to FOLFOX chemotherapy in advanced colorectal cancer cases. Asian Pac J Cancer Prev, 14, 7421-6.
6. Cortez MA, Welsh JW, Calin GA (2012). Circulating microRNAs as noninvasive biomarkers in breast cancer. Recent Results Cancer Res, 195, 151-61.
7. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917.
8. Garzon R, Heaphy CE, Havelange V, et al (2009). MicroRNA 29b functions in acute myeloid leukemia. Blood, 114, 5331-41.
9. Guo J, Shou C, Meng L, et al (2007). Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer. Int J Cancer, 121, 1296-305.
10. Harquail J, Benzina S, Robichaud GA (2012). MicroRNAs and breast cancer malignancy: an overview of miRNA-regulated cancer processes leading to metastasis. Cancer Epidemiol Biomarkers Prev, 11, 269-80.
11. Huang F, Liu C, Shi YH, et al (2013). MicroRNA-101 inhibits cell proliferation, invasion, and promotes apoptosis by regulating cyclooxygenase-2 in Hela cervical carcinoma cells. Asian Pac J Cancer Prev, 14, 5915-20.
12. Jiang Y, Liu YE, Goldberg ID, et al (2004). A novel heat-shock protein-associated chaperone, stimulates ligand-dependent estrogen receptor a signaling and mammary tumorigenesis. Cancer Res, 64, 4539-46.
13. Jiang Y, Liu YE, Lu A, et al (2003). Stimulation of estrogen receptor signaling by gamma synuclein. Cancer Res, 63, 3899-903.
14. Lian J, Zhang X, Tian H, et al (2009). Altered microRNA expression in patients with non-obstructive zoospermia. Reprod Biol Endocrinol, 7, 13.
15. Liu YE, Pu W, Jiang Y, et al (2007). Chaperoning of estrogen receptor and induction of mammary gland proliferation by neuronal protein synuclein gamma. Oncogene, 26, 2115-25.
16. Luo Q, Li X, Li J, et al (2013). MiR-15a is underexpressed and inhibits the cell cycle by targeting CCNE1 in breast cancer. Int J Oncol, 43, 1212-8.
17. Ng SB, Yan J, Huang G, et al (2011). Dysregulated microRNAs affect pathways and targets of biologic relevance in nasaltype natural killer/T-cell lymphoma. Blood, 118, 4919-29.
18. Paik JH, Jang JY, Jeon YK, et al (2011). MicroRNA-146a Downregulates NFκB Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma. Clin Cancer Res, 17, 4761-71.
19. Qin XJ, Ling BX (2012). Proteomic studies in breast cancer (Review). Oncol Lett, 3, 735-43.
20. Shenouda SK, Alahari SK (2009). MicroRNA function in cancer: oncogene or a tumor suppressor? Cancer Metastasis Rev, 28, 369-78.
21. Thorsen SB, Obad S, Jensen NF, et al (2012). The therapeutic potential of microRNAs in cancer. Cancer J, 18, 275-84.
22. Valencia-Sanchez MA, Liu J, Hannon GJ, et al (2006). Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev, 20, 515-24.
23. Wang H, Tan G, Dong L, et al (2012). Circulating MiR-125b as a marker predicting chemoresistance in breast cancer. PLoS One, 7, 34210.
24. Wei F, Xu J, Tang L, et al (2012). p27 (Kip1) V109G polymorphism and cancer risk: a systematic review and meta-analysis. Cancer Biother Radiopharm, 27, 665-71.
25. Wu K, Quan Z, Weng Z, et al (2007). Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis. Breast Cancer Res Treatment, 101, 259-67.
26. Yamanaka Y, Tagawa H, Takahashi N, et al (2009). Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia. Blood, 114, 3265-75.
27. Yu Q, Liu SL, Wang H, et al (2013). miR-126 Suppresses the proliferation of cervical cancer cells and alters cell sensitivity to the chemotherapeutic drug bleomycin. Asian Pac J Cancer Prev, 14, 6569-72.