Practical considerations for using functional uniform prior distributions for dose-response estimation in clinical trials

Biometrical Journal

Volumn 56, Issue 6, 2014, Pages 947-962

  Bornkamp, Björn ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Bayesian statistics; Dose finding; Emax model; Functional uniform prior; Jeffreys prior

Indexed keywords

MAXIMUM LIKELIHOOD ESTIMATION;

BAYESIAN STATISTICS; CLINICAL TRIAL; DOSE FINDING; DOSE RESPONSE; DOSE RESPONSE RELATIONSHIPS; EMAX MODEL; FUNCTIONAL UNIFORM PRIOR; INFERENCE PROBLEM; JEFFREYS'S PRIORS; PRIOR DISTRIBUTION;

BAYESIAN NETWORKS;

BAYES THEOREM; BIOMETRY; CLINICAL TRIAL (TOPIC); COMPUTER PROGRAM; DOSE RESPONSE; HUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROCEDURES;

BAYES THEOREM; BIOMETRY; CLINICAL TRIALS AS TOPIC; CLINICAL TRIALS, PHASE I AS TOPIC; CLINICAL TRIALS, PHASE II AS TOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; SOFTWARE;

EID: 84931043153     PISSN: 03233847     EISSN: 15214036     Source Type: Journal    
DOI: 10.1002/bimj.201300138     Document Type: Article

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