The Cardioprotective Effects of Resveratrol in Rats with Simultaneous Type 2 Diabetes and Renal Hypertension

Natural Product Communications

Volumn 10, Issue 2, 2015, Pages 335-338

  Mozafari, Masoud ^a   Nekooeian, Ali Akbar ^a   Mashghoolozekr, Elaheh ^a   Panjeshahin, Mohammad Reza ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes; Oxidative stress; Rat; Renal hypertension; Resveratrol

Indexed keywords

CREATINE KINASE MB; GLUCOSE; GLUTATHIONE REDUCTASE; MALONALDEHYDE; RESVERATROL; SUPEROXIDE DISMUTASE; NONSTEROID ANTIINFLAMMATORY AGENT; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; CORONARY VASCULAR RESISTANCE; DRUG EFFICACY; DRUG MECHANISM; ENZYME BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HEART DISEASE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE PRESSURE; HEART PROTECTION; HEART RATE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; RAT; RENOVASCULAR HYPERTENSION; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; ANIMAL; CHEMICALLY INDUCED; COMPLICATION; DIABETES MELLITUS, EXPERIMENTAL; HEART DISEASES; HYPERTENSION, RENAL; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; HEART DISEASES; HYPERTENSION, RENAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; STILBENES;

EID: 84930975811     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1501000232     Document Type: Article

References (23)

1. Rush JW, Quadrilatero J, Levy AS, Ford RJ. (2007) Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats. Experimental Biology and Medicine, 232, 814-822.
2. Mokni M, Limam F, Elkahoui S, Amri M, Aouani E. (2007) Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury. Archives of Biochemistry and Biophysics, 457, 1-6.
3. Durham KK, Smith CS, Rush JW. (2011) Chronic resveratrol treatment alleviates myocardial ischemia injury in a hypertensive model. The Journal of the Federation of American Societies for Eeperimental Biology, 25, 611-639.
4. Dernek S, Ikizler M, Erkasap N, Ergun B, Koken T, Yilmaz K, Sevin B, Kaygisiz Z, Kural T. (2004) Cardioprotection with resveratrol pretreatment: Improved beneficial effects over standard treatment in rat hearts after global ischemia. Scandinavian Cardiovascular Journal, 38, 245-254.
5. Liu Z, Song Y, Zhang X, Liu Z, Zhang W, Mao W, Wang W, Cui W, Zhang X, Jia X. (2005) Effects of trans?resveratrol on hypertension?induced cardiac hypertrophy using the partially nephrectomized rat model. Clinical and Experimental Pharmacology and Physiology, 32, 1049-1054.
6. Palsamy P , Subramanian S. (2010) Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic cell dysfunction in streptozotocin?nicotinamide?induced diabetic rats. Journal of Cellular Physiology, 224, 423-432.
7. Su H-C, Hung L-M, Chen J-K. (2006) Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. American Journal of Physiology-Endocrinology and Metabolism, 290, E1339-E1346.
8. Ma H-j, Cao Y-k, Liu Y-x, Wang R, Wu Y-m. (2008) Microinjection of resveratrol into rostral ventrolateral medulla decreases sympathetic vasomotor tone through nitric oxide and intracellular Ca2 in anesthetized male rats. Acta Pharmacologica Sinica, 29, 906-912.
9. Szkudelski T, Szkudelska K. (2011) Antićdiabetic effects of resveratrol. Annals of the New York Academy of Sciences, 1215, 34-39.
10. Nekooeian AA, Khalili A, Khosravi MB. (2014) Effects of short-term renovascular hypertension and type 2 diabetes on cardiac functions in rats. Iranian Journal of Medical Sciences, 39, 51-59.
11. Thirunavukkarasu M, Penumathsa SV, Koneru S, Juhasz B, Zhan L, Otani H, Bagchi D, Das DK, Maulik N. (2007) Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase. Free Radical Biology and Medicine, 43, 720-729.
12. Nishio S, Teshima Y, Takahashi N, Thuc LC, Saito S, Fukui A, Kume O, Fukunaga N, Hara M, Nakagawa M. (2012) Activation of CaMKII as a key regulator of reactive oxygen species production in diabetic rat heart. Journal of Molecular and Cellular Cardiology, 52, 1103-1111.
13. Mazzanti L, Rabini RA, Faloia E, Fumelli P, Bertoli E, De Pirro R. (1990) Altered cellular Ca2+ and Na+ transport in diabetes mellitus. Diabetes, 39, 850-854.
14. Ceriello A, Quagliaro L, D'Amico M, Di Filippo C, Marfella R, Nappo F, Berrino L, Rossi F, Giugliano D. (2002) Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat. Diabetes, 51, 1076-1082.
15. Singh VP, Le B, Khode R, Baker KM, Kumar R. (2008) Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes, 57, 3297-3306.
16. Nekooeian AA, Khalili A, Khosravi MB. (2014) Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: A study of antihypertensive mechanisms. Journal of Asian Natural Products Research, 16, 1-10.
17. Das S, Das DK. (2007) Anti-inflammatory responses of resveratrol. Inflammation and Allergy Drug Targets (Formerly Current Drug Targets-Inflammation and Allergy), 6, 168-173.
18. Novakovic A, Bukarica LG, Kanjuh V, Heinle H. (2006) Potassium channels?mediated vasorelaxation of rat aorta induced by resveratrol. Basic and Clinical Pharmacology and Toxicology, 99, 360-364.
19. Chen C-J, Yu W, Fu Y-C, Wang X, Li J-L, Wang W. (2009) Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway. Biochemical and Biophysical Research Communications, 378, 389-393.
20. Li Y, Cao Z, Zhu H. (2006) Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacological Research, 53, 6-15.
21. Ungvari Z, Orosz Z, Rivera A, Labinskyy N, Xiangmin Z, Olson S, Podlutsky A, Csiszar A. (2007) Resveratrol increases vascular oxidative stress resistance. American Journal of Physiology-Heart and Circulatory Physiology, 292, H2417-H2424.
22. Mizutani K, Ikeda K, Kawai Y, Yamori Y. (2001) Protective effect of resveratrol on oxidative damage in male and female stroke?prone spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology, 28, 55-59.
23. Nekooeian AA, Khalili A, Khosravi MB. (2014) Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension. Indian Journal of Pharmacology, 46, 398-403.