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Volumn 14, Issue 6, 2015, Pages 1445-1453

TR4 nuclear receptor alters the prostate cancer CD133+ stem/progenitor cell invasion via modulating the EZH2-related metastasis gene expression

Author keywords

[No Author keywords available]

Indexed keywords

CD133 ANTIGEN; CELL NUCLEUS RECEPTOR; GELATINASE B; NOTCH1 RECEPTOR; TESTICULAR NUCLEAR RECEPTOR 4; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR SLUG; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; EZH2 PROTEIN, HUMAN; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; NR2C2 PROTEIN, HUMAN; PEPTIDE; POLYCOMB REPRESSIVE COMPLEX 2; PROM1 PROTEIN, HUMAN; PROM1 PROTEIN, MOUSE; PROTEIN BINDING; STEROID RECEPTOR; THYROID HORMONE RECEPTOR;

EID: 84930957605     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-14-0971     Document Type: Article
Times cited : (15)

References (50)
  • 2
    • 66449115904 scopus 로고    scopus 로고
    • Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells
    • Shyr C-R, Kang H-Y, Tsai M-Y, Liu N-C, Ku P-Y, Huang K-E, et al. Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells. Endocrinology 2009;150:2454-62.
    • (2009) Endocrinology , vol.150 , pp. 2454-2462
    • Shyr, C.-R.1    Kang, H.-Y.2    Tsai, M.-Y.3    Liu, N.-C.4    Ku, P.-Y.5    Huang, K.-E.6
  • 3
    • 80053900399 scopus 로고    scopus 로고
    • The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice
    • Collins LL, Lee Y-F, Ting H-J, Lin W-J, Liu N-C, Meshul CK, et al. The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice. Reprod Biol Endocrinol 2011;9:138.
    • (2011) Reprod Biol Endocrinol , vol.9 , pp. 138
    • Collins, L.L.1    Lee, Y.-F.2    Ting, H.-J.3    Lin, W.-J.4    Liu, N.-C.5    Meshul, C.K.6
  • 4
    • 84861911675 scopus 로고    scopus 로고
    • Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis
    • Lin S-J, Ho H-C, Lee Y-F, Liu N-C, Liu S, Li G, et al. Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis. Reprod Biol Endocrinol 2012;10:43.
    • (2012) Reprod Biol Endocrinol , vol.10 , pp. 43
    • Lin, S.-J.1    Ho, H.-C.2    Lee, Y.-F.3    Liu, N.-C.4    Liu, S.5    Li, G.6
  • 6
    • 84905393591 scopus 로고    scopus 로고
    • TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system
    • Lin S-J, Lee SO, Lee Y-F, Miyamoto H, Yang D-R, Li G, et al. TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system. Carcinogenesis 2014;35:1399-406.
    • (2014) Carcinogenesis , vol.35 , pp. 1399-1406
    • Lin, S.-J.1    Lee, S.O.2    Lee, Y.-F.3    Miyamoto, H.4    Yang, D.-R.5    Li, G.6
  • 7
    • 55949136562 scopus 로고    scopus 로고
    • Roles of the EZH2 histone methyltransferase in cancer epigenetics
    • Simon JA, Lange CA. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res 2008;647:21-9.
    • (2008) Mutat Res , vol.647 , pp. 21-29
    • Simon, J.A.1    Lange, C.A.2
  • 9
    • 84874299107 scopus 로고    scopus 로고
    • New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. Non-stem/progenitor cells
    • Lee SO, Ma Z, Yeh C-R, Luo J, Lin T-H, Lai K-P, et al. New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells. J Mol Cell Biol 2013;5:14-26.
    • (2013) J Mol Cell Biol , vol.5 , pp. 14-26
    • Lee, S.O.1    Ma, Z.2    Yeh, C.-R.3    Luo, J.4    Lin, T.-H.5    Lai, K.-P.6
  • 10
    • 34248140257 scopus 로고    scopus 로고
    • Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens
    • Miki J, Furusato B, Li H, Gu Y, Takahashi H, Egawa S, et al. Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens. Cancer Res 2007;67:3153-61.
    • (2007) Cancer Res , vol.67 , pp. 3153-3161
    • Miki, J.1    Furusato, B.2    Li, H.3    Gu, Y.4    Takahashi, H.5    Egawa, S.6
  • 11
    • 84878765030 scopus 로고    scopus 로고
    • Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer
    • Yang D-R, Ding X-F, Luo J, Shan Y-X, Wang R, Lin S-J, et al. Increased chemosensitivity via targeting testicular nuclear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in prostate cancer CD133+ stem/progenitor cells to battle prostate cancer. J Biol Chem 2013;288:16476-83.
    • (2013) J Biol Chem , vol.288 , pp. 16476-16483
    • Yang, D.-R.1    Ding, X.-F.2    Luo, J.3    Shan, Y.-X.4    Wang, R.5    Lin, S.-J.6
  • 12
    • 32144457046 scopus 로고    scopus 로고
    • Using three-dimensional acinar structures for molecular and cell biological assays
    • Xiang B, Muthuswamy SK. Using three-dimensional acinar structures for molecular and cell biological assays. Methods Enzymol 2006;406:692-701.
    • (2006) Methods Enzymol , vol.406 , pp. 692-701
    • Xiang, B.1    Muthuswamy, S.K.2
  • 14
    • 45549091414 scopus 로고    scopus 로고
    • Prostate cancer stem cells: A new target for therapy
    • Maitland NJ, Collins AT. Prostate cancer stem cells: a new target for therapy. J Clin Oncol 2008;26:2862-70.
    • (2008) J Clin Oncol , vol.26 , pp. 2862-2870
    • Maitland, N.J.1    Collins, A.T.2
  • 15
    • 84901489826 scopus 로고    scopus 로고
    • Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling
    • Luo J, Ok Lee S, Liang L, Huang CK, Li L, Wen S, et al. Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling. Oncogene 2014;33:2768-78.
    • (2014) Oncogene , vol.33 , pp. 2768-2778
    • Luo, J.1    Ok Lee, S.2    Liang, L.3    Huang, C.K.4    Li, L.5    Wen, S.6
  • 16
    • 84918815694 scopus 로고    scopus 로고
    • TR4 nuclear receptor promotes prostate cancer metastasis via up-regulation of CCL2/CCR2 signaling
    • Ding X, Yang D-R, Lee SO, Chen Y-L, Xia L-Q, Lin S-J, et al. TR4 nuclear receptor promotes prostate cancer metastasis via up-regulation of CCL2/CCR2 signaling. Int J Cancer 2015;136:955-64.
    • (2015) Int J Cancer , vol.136 , pp. 955-964
    • Ding, X.1    Yang, D.-R.2    Lee, S.O.3    Chen, Y.-L.4    Xia, L.-Q.5    Lin, S.-J.6
  • 17
  • 19
    • 84898912555 scopus 로고    scopus 로고
    • Expression of CD133 correlates with tumor stage, lymph node metastasis and recurrence in oral squamous cell carcinoma
    • Reggiani Bonetti L, Migaldi M, Boninsegna A, Fanali C, Farina M. Expression of CD133 correlates with tumor stage, lymph node metastasis and recurrence in oral squamous cell carcinoma. J Cancer Sci Ther 2014;6:094-8.
    • (2014) J Cancer Sci Ther , vol.6 , pp. 094-098
    • Reggiani Bonetti, L.1    Migaldi, M.2    Boninsegna, A.3    Fanali, C.4    Farina, M.5
  • 20
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007;1:313-23.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6
  • 21
    • 33748375376 scopus 로고    scopus 로고
    • Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases
    • Mehra N, Penning M, Maas J, Beerepoot LV, Van Daal N, Van Gils CH, et al. Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases. Clin Cancer Res 2006;12:4859-66.
    • (2006) Clin Cancer Res , vol.12 , pp. 4859-4866
    • Mehra, N.1    Penning, M.2    Maas, J.3    Beerepoot, L.V.4    Van Daal, N.5    Van Gils, C.H.6
  • 22
    • 77952313391 scopus 로고    scopus 로고
    • Evaluation of the frequency of putative prostate cancer stem cells in primary and metastatic prostate cancer
    • Eaton CL, Colombel M, Van Der Pluijm G, Cecchini M, Wetterwald A, Lippitt J, et al. Evaluation of the frequency of putative prostate cancer stem cells in primary and metastatic prostate cancer. Prostate 2010;70:875-82.
    • (2010) Prostate , vol.70 , pp. 875-882
    • Eaton, C.L.1    Colombel, M.2    Van Der Pluijm, G.3    Cecchini, M.4    Wetterwald, A.5    Lippitt, J.6
  • 23
    • 4344561557 scopus 로고    scopus 로고
    • Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy
    • Yu YP, Landsittel D, Jing L, Nelson J, Ren B, Liu L, et al. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol 2004;22:2790-9.
    • (2004) J Clin Oncol , vol.22 , pp. 2790-2799
    • Yu, Y.P.1    Landsittel, D.2    Jing, L.3    Nelson, J.4    Ren, B.5    Liu, L.6
  • 25
    • 77956277833 scopus 로고    scopus 로고
    • EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-b1 and is a predictor of outcome in ovarian carcinoma patients
    • Rao Z-Y, Cai M-Y, Yang G-F, He L-R, Mai S-J, Hua W-F, et al. EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-b1 and is a predictor of outcome in ovarian carcinoma patients. Carcinogenesis 2010;31:1576-83.
    • (2010) Carcinogenesis , vol.31 , pp. 1576-1583
    • Rao, Z.-Y.1    Cai, M.-Y.2    Yang, G.-F.3    He, L.-R.4    Mai, S.-J.5    Hua, W.-F.6
  • 26
    • 84855862051 scopus 로고    scopus 로고
    • The role of EZH2 in the regulation of the activity ofmatrix metalloproteinases in prostate cancer cells
    • Shin YJ, Kim J-H. The role of EZH2 in the regulation of the activity ofmatrix metalloproteinases in prostate cancer cells. PLoS ONE 2012;7:e30393.
    • (2012) PLoS ONE , vol.7 , pp. e30393
    • Shin, Y.J.1    Kim, J.-H.2
  • 28
    • 69449098426 scopus 로고    scopus 로고
    • TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation
    • Xie S, Lee Y-F, Kim E, Chen L-M, Ni J, Fang L-Y, et al. TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. Proc Natl Acad Sci 2009;106:13353-8.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 13353-13358
    • Xie, S.1    Lee, Y.-F.2    Kim, E.3    Chen, L.-M.4    Ni, J.5    Fang, L.-Y.6
  • 29
    • 77953472807 scopus 로고    scopus 로고
    • CD133, Trop-2 and alpha 2 beta 1 integrin surface receptors as markers of putative human prostate cancer stem cells
    • Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, et al. CD133, Trop-2 and alpha 2 beta 1 integrin surface receptors as markers of putative human prostate cancer stem cells. Am J Transl Res 2010;2:135-44.
    • (2010) Am J Transl Res , vol.2 , pp. 135-144
    • Trerotola, M.1    Rathore, S.2    Goel, H.L.3    Li, J.4    Alberti, S.5    Piantelli, M.6
  • 30
    • 84888341755 scopus 로고    scopus 로고
    • Nuclear receptors as regulators of stem cell and cancer stem cell metabolism
    • Simandi Z, Cuaranta-Monroy I, Nagy L. Nuclear receptors as regulators of stem cell and cancer stem cell metabolism. Semin Cell Dev Biol 2013;24:716-23.
    • (2013) Semin Cell Dev Biol , vol.24 , pp. 716-723
    • Simandi, Z.1    Cuaranta-Monroy, I.2    Nagy, L.3
  • 31
    • 84864344679 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis
    • Au SL, Wong CC, Lee JM, Fan DN, Tsang FH, Ng IO, et al. Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis. Hepatology 2012;56:622-31.
    • (2012) Hepatology , vol.56 , pp. 622-631
    • Au, S.L.1    Wong, C.C.2    Lee, J.M.3    Fan, D.N.4    Tsang, F.H.5    Ng, I.O.6
  • 32
    • 78651506355 scopus 로고    scopus 로고
    • High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients
    • Cai MY, Hou JH, Rao HL, Luo RZ, Li M, Pei XQ, et al. High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients. Mol Med 2011;17:12-20.
    • (2011) Mol Med , vol.17 , pp. 12-20
    • Cai, M.Y.1    Hou, J.H.2    Rao, H.L.3    Luo, R.Z.4    Li, M.5    Pei, X.Q.6
  • 34
    • 78049307003 scopus 로고    scopus 로고
    • Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo
    • Hu S, Yu L, Li Z, Shen Y, Wang J, Cai J, et al. Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo. Cancer Biol Ther 2010;10:788-95.
    • (2010) Cancer Biol Ther , vol.10 , pp. 788-795
    • Hu, S.1    Yu, L.2    Li, Z.3    Shen, Y.4    Wang, J.5    Cai, J.6
  • 36
    • 79955513100 scopus 로고    scopus 로고
    • Aberrations of EZH2 in cancer
    • Chase A, Cross NC. Aberrations of EZH2 in cancer. Clin Cancer Res 2011;17:2613-8.
    • (2011) Clin Cancer Res , vol.17 , pp. 2613-2618
    • Chase, A.1    Cross, N.C.2
  • 37
    • 84871841675 scopus 로고    scopus 로고
    • Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
    • Qi W, Chan H, Teng L, Li L, Chuai S, Zhang R, et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci 2012;109:21360-5.
    • (2012) Proc Natl Acad Sci , vol.109 , pp. 21360-21365
    • Qi, W.1    Chan, H.2    Teng, L.3    Li, L.4    Chuai, S.5    Zhang, R.6
  • 38
    • 62549111693 scopus 로고    scopus 로고
    • The epithelial-to-mesenchymal transition and cancer stem cells: A coalition against cancer therapies
    • Hollier BG, Evans K, Mani SA. The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies. J Mammary Gland Biol Neoplasia 2009;14:29-43.
    • (2009) J Mammary Gland Biol Neoplasia , vol.14 , pp. 29-43
    • Hollier, B.G.1    Evans, K.2    Mani, S.A.3
  • 39
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao M-J, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008;133:704-15.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.-J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 40
    • 66149131111 scopus 로고    scopus 로고
    • Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
    • Santisteban M, Reiman JM, Asiedu MK, Behrens MD, Nassar A, Kalli KR, et al. Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res 2009;69:2887-95.
    • (2009) Cancer Res , vol.69 , pp. 2887-2895
    • Santisteban, M.1    Reiman, J.M.2    Asiedu, M.K.3    Behrens, M.D.4    Nassar, A.5    Kalli, K.R.6
  • 41
    • 79953689605 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-tomesenchymal transition (EMT)-phenotypic cells: Are they cousins or twins?
    • Kong D, Li Y, Wang Z, Sarkar FH. Cancer stem cells and epithelial-tomesenchymal transition (EMT)-phenotypic cells: are they cousins or twins? Cancers 2011;3:716-29.
    • (2011) Cancers , vol.3 , pp. 716-729
    • Kong, D.1    Li, Y.2    Wang, Z.3    Sarkar, F.H.4
  • 42
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009;9:265-73.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 43
    • 77954674441 scopus 로고    scopus 로고
    • Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells
    • Ouyang G, Wang Z, Fang X, Liu J, Yang CJ. Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells. Cell Mol Life Sci 2010;67:2605-18.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 2605-2618
    • Ouyang, G.1    Wang, Z.2    Fang, X.3    Liu, J.4    Yang, C.J.5
  • 45
    • 0032507879 scopus 로고    scopus 로고
    • BRCA1 as a potential human prostate tumor suppressor: Modulation of proliferation, damage responses and expression of cell regulatory proteins
    • Fan S, Wang J-A, Yuan R, Ma YX, Meng Q, Erdos MR, et al. BRCA1 as a potential human prostate tumor suppressor: modulation of proliferation, damage responses and expression of cell regulatory proteins. Oncogene 1998;16:3069-82.
    • (1998) Oncogene , vol.16 , pp. 3069-3082
    • Fan, S.1    Wang, J.-A.2    Yuan, R.3    Ma, Y.X.4    Meng, Q.5    Erdos, M.R.6
  • 46
    • 78651468714 scopus 로고    scopus 로고
    • miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors
    • Moskwa P, Buffa FM, Pan Y, Panchakshari R, Gottipati P, Muschel RJ, et al. miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell 2011;41:210-20.
    • (2011) Mol Cell , vol.41 , pp. 210-220
    • Moskwa, P.1    Buffa, F.M.2    Pan, Y.3    Panchakshari, R.4    Gottipati, P.5    Muschel, R.J.6
  • 47
    • 79959459359 scopus 로고    scopus 로고
    • Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity
    • Kim E, Liu N-C, Yu I-C, Lin H-Y, Lee Y-F, Sparks JD, et al. Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity. Diabetes 2011;60:1493-503.
    • (2011) Diabetes , vol.60 , pp. 1493-1503
    • Kim, E.1    Liu, N.-C.2    Yu, I.-C.3    Lin, H.-Y.4    Lee, Y.-F.5    Sparks, J.D.6
  • 48
    • 77950191479 scopus 로고    scopus 로고
    • Targeting cancer cell metabolism: The combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
    • Sahra IB, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, et al. Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res 2010;70:2465-75.
    • (2010) Cancer Res , vol.70 , pp. 2465-2475
    • Sahra, I.B.1    Laurent, K.2    Giuliano, S.3    Larbret, F.4    Ponzio, G.5    Gounon, P.6
  • 49
    • 80053504259 scopus 로고    scopus 로고
    • Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients
    • He X-X, Tu S, Lee M-H, Yeung S-C. Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients. Ann Oncol 2011;22:2640-5.
    • (2011) Ann Oncol , vol.22 , pp. 2640-2645
    • He, X.-X.1    Tu, S.2    Lee, M.-H.3    Yeung, S.-C.4
  • 50
    • 77955458963 scopus 로고    scopus 로고
    • The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
    • Ben Sahra I, Tanti JF, Bost F. The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells. Autophagy 2010;6:670-1.
    • (2010) Autophagy , vol.6 , pp. 670-671
    • Ben Sahra, I.1    Tanti, J.F.2    Bost, F.3


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