TeratoScore: Assessing the Differentiation Potential of Human Pluripotent Stem Cells by Quantitative Expression Analysis of Teratomas

Stem Cell Reports

Volumn 4, Issue 6, 2015, Pages 967-974

  Avior, Yishai ^a   Biancotti, Juan Carlos ^b,c   Benvenisty, Nissim ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; ANEUPLOIDY; ARTICLE; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; CHROMOSOME ABERRATION; CONTROLLED STUDY; DIPLOIDY; FETUS; GENE EXPRESSION; GERM LAYER; GOLD STANDARD; HUMAN; HUMAN CELL; HUMAN TISSUE; KARYOTYPE; MALIGNANT NEOPLASTIC DISEASE; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SCORING SYSTEM; TERATOMA; TERATOSCORE; CELL CULTURE; CELL LINEAGE; COMPUTER INTERFACE; CYTOLOGY; DNA MICROARRAY; GENETICS; INTERNET; METABOLISM; NEOPLASM; PATHOLOGY;

TRANSCRIPTOME;

ALGORITHMS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; CHROMOSOME ABERRATIONS; DIPLOIDY; HUMANS; INTERNET; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLURIPOTENT STEM CELLS; TERATOMA; TRANSCRIPTOME; USER-COMPUTER INTERFACE;

EID: 84930909420     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2015.05.006     Document Type: Article

References (27)

1. P.W. Andrews, N. Benvenisty, R. McKay, M.F. Pera, J. Rossant, H. Semb, G.N. Stacey Steering Committee of the International Stem Cell Initiative The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research Nat. Biotechnol. 23 2005 795 797
2. U. Ben-David, G. Arad, U. Weissbein, B. Mandefro, A. Maimon, T. Golan-Lev, K. Narwani, A.T. Clark, P.W. Andrews, N. Benvenisty, and J. Carlos Biancotti Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells Nat. Commun. 5 2014 4825
3. J.C. Biancotti, K. Narwani, N. Buehler, B. Mandefro, T. Golan-Lev, O. Yanuka, A. Clark, D. Hill, N. Benvenisty, and N. Lavon Human embryonic stem cells as models for aneuploid chromosomal syndromes Stem Cells 28 2010 1530 1540
4. C. Bock, E. Kiskinis, G. Verstappen, H. Gu, G. Boulting, Z.D. Smith, M. Ziller, G.F. Croft, M.W. Amoroso, and D.H. Oakley et al. Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines Cell 144 2011 439 452
5. G.L. Boulting, E. Kiskinis, G.F. Croft, M.W. Amoroso, D.H. Oakley, B.J. Wainger, D.J. Williams, D.J. Kahler, M. Yamaki, and L. Davidow et al. A functionally characterized test set of human induced pluripotent stem cells Nat. Biotechnol. 29 2011 279 286
6. P. Cahan, and G.Q. Daley Origins and implications of pluripotent stem cell variability and heterogeneity Nat. Rev. Mol. Cell Biol. 14 2013 357 368
7. P. Cahan, H. Li, S.A. Morris, E. Lummertz da Rocha, G.Q. Daley, and J.J. Collins CellNet: network biology applied to stem cell engineering Cell 158 2014 903 915
8. R.S. Chapman, and L.J. Hesketh Behavioral phenotype of individuals with Down syndrome Ment. Retard. Dev. Disabil. Res. Rev. 6 2000 84 95
9. M.H. Chin, M.J. Mason, W. Xie, S. Volinia, M. Singer, C. Peterson, G. Ambartsumyan, O. Aimiuwu, L. Richter, and J. Zhang et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures Cell Stem Cell 5 2009 111 123
10. B. Cisterna, M. Costanzo, E. Scherini, C. Zancanaro, and M. Malatesta Ultrastructural features of skeletal muscle in adult and aging Ts65Dn mice, a murine model of Down syndrome Muscles Ligaments Tendons J. 3 2013 287 294
11. J. Itskovitz-Eldor, M. Schuldiner, D. Karsenti, A. Eden, O. Yanuka, M. Amit, H. Soreq, and N. Benvenisty Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers Mol. Med. 6 2000 88 95
12. O. Kopper, O. Giladi, T. Golan-Lev, and N. Benvenisty Characterization of gastrulation-stage progenitor cells and their inhibitory crosstalk in human embryoid bodies Stem Cells 28 2010 75 83
13. A. Kostanecka, L.B. Close, K. Izumi, I.D. Krantz, and M. Pipan Developmental and behavioral characteristics of individuals with Pallister-Killian syndrome Am. J. Med. Genet. A. 158A 2012 3018 3025
14. N. Lavon, K. Narwani, T. Golan-Lev, N. Buehler, D. Hill, and N. Benvenisty Derivation of euploid human embryonic stem cells from aneuploid embryos Stem Cells 26 2008 1874 1882
15. T. Le Carrour, S. Assou, S. Tondeur, L. Lhermitte, N. Lamb, T. Rème, V. Pantesco, S. Hamamah, B. Klein, and J. De Vos Amazonia!: An Online Resource to Google and Visualize Public Human whole Genome Expression Data Open Bioinformatics J. 4 2010 5 10
16. F.J. Müller, J. Goldmann, P. Löser, and J.F. Loring A call to standardize teratoma assays used to define human pluripotent cell lines Cell Stem Cell 6 2010 412 414
17. F.J. Müller, B.M. Schuldt, R. Williams, D. Mason, G. Altun, E.P. Papapetrou, S. Danner, J.E. Goldmann, A. Herbst, and N.O. Schmidt et al. A bioinformatic assay for pluripotency in human cells Nat. Methods 8 2011 315 317
18. F.J. Müller, B. Brandl, and J.F. Loring Assessment of human pluripotent stem cells with PluriTest The Stem Cell Research Community StemBook 2012 Harvard Stem Cell Institute Cambridge, MA
19. K. Narwani, J.C. Biancotti, T. Golan-Lev, N. Buehler, D. Hill, S. Shifman, N. Benvenisty, and N. Lavon Human embryonic stem cells from aneuploid blastocysts identified by pre-implantation genetic screening In Vitro Cell. Dev. Biol. Anim. 46 2010 309 316
20. K. Osafune, L. Caron, M. Borowiak, R.J. Martinez, C.S. Fitz-Gerald, Y. Sato, C.A. Cowan, K.R. Chien, and D.A. Melton Marked differences in differentiation propensity among human embryonic stem cell lines Nat. Biotechnol. 26 2008 313 315
21. J.A. Ozolek, and C.A. Castro Teratomas derived from embryonic stem cells as models for embryonic development, disease, and tumorigenesis M. Kallos, ed. Embryonic Stem Cells-Basic Biology to Bioengineering 2011 InTech
22. D. Patterson Molecular genetic analysis of Down syndrome Hum. Genet. 126 2009 195 214
23. M. Schuldiner, and N. Benvenisty Factors controlling human embryonic stem cell differentiation Methods Enzymol. 365 2003 446 461
24. R. Segel, I. Peter, L.A. Demmer, J.M. Cowan, J.D. Hoffman, and D.W. Bianchi The natural history of trisomy 12p Am. J. Med. Genet. A. 140 2006 695 703
25. F. Speleman, J.G. Leroy, N. Van Roy, A. De Paepe, R. Suijkerbuijk, H. Brunner, L. Looijenga, M.R. Verschraegen-Spae, and E. Orye Pallister-Killian syndrome: characterization of the isochromosome 12p by fluorescent in situ hybridization Am. J. Med. Genet. 41 1991 381 387
26. V. Tabar, and L. Studer Pluripotent stem cells in regenerative medicine: challenges and recent progress Nat. Rev. Genet. 15 2014 82 92
27. J.A. Thomson, J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, and J.M. Jones Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147