Timing is everything: Coordinated control of host shutoff by influenza a virus NS1 and PA-X proteins

Journal of Virology

Volumn 89, Issue 13, 2015, Pages 6528-6531

  Khaperskyy, Denys A ^a   McCormick, Craig ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 30; ENDONUCLEASE; MESSENGER RNA; NONSTRUCTURAL PROTEIN 1; PA X PROTEIN; POLYADENYLIC ACID BINDING PROTEIN; POLYMERASE ACIDIC PROTEIN; POLYMERASE BASIC PROTEIN 1; POLYMERASE BASIC PROTEIN 2; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; INS1 PROTEIN, INFLUENZA VIRUS; PA-X PROTEIN, INFLUENZA A VIRUS; REPRESSOR PROTEIN; VIRAL PROTEIN;

ARTICLE; CELLULAR DISTRIBUTION; FRAMESHIFT MUTATION; HUMAN; INFLUENZA A; INFLUENZA VIRUS A; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; RIBOSOMAL FRAMESHIFTING; RNA DEGRADATION; VIRUS GENOME; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSCRIPTION; VIRUS VIRULENCE; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; INFLUENZA A VIRUS; METABOLISM; PHYSIOLOGY; TIME;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

HOST-PATHOGEN INTERACTIONS; INFLUENZA A VIRUS; REPRESSOR PROTEINS; TIME; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84930892539     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00386-15     Document Type: Article

References (20)

1. Eisfeld AJ, Neumann G, Kawaoka Y. 2015. At the centre: influenza A virus ribonucleoproteins. Nat Rev Microbiol 13:28-41. http://dx.doi.org /10.1038/nrmicro3367.
2. Ventoso I, MacMillan SE, Hershey JW, Carrasco L. 1998. Poliovirus 2A proteinase cleaves directly the eIF-4G subunit of eIF-4F complex. FEBS Lett 435:79-83. http://dx.doi.org/10.1016/S0014-5793(98)01027-8.
3. Joachims M, Van Breugel PC, Lloyd RE. 1999. Cleavage of poly(A)- binding protein by enterovirus proteases concurrent with inhibition of translation in vitro. J Virol 73:718-727.
4. Kuyumcu-Martinez NM, Joachims M, Lloyd RE. 2002. Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease. J Virol 76:2062-2074. http://dx.doi.org/10.1128/jvi.76.5.2062-2074.2002.
5. Kuyumcu-Martinez NM, Van Eden ME, Younan P, Lloyd RE. 2004. Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: a novel mechanism for host translation shutoff. Mol Cell Biol 24:1779-1790. http://dx.doi.org/10.1128/MCB.24.4.1779-1790.2004.
6. Elgadi MM, Hayes CE, Smiley JR. 1999. The herpes simplex virus vhs protein induces endoribonucleolytic cleavage of target RNAs in cell extracts. J Virol 73:7153-7164.
7. Jagger BW, Wise HM, Kash JC, Walters KA, Wills NM, Xiao YL, Dunfee RL, Schwartzman LM, Ozinsky A, Bell GL, Dalton RM, Lo A, Efstathiou S, Atkins JF, Firth AE, Taubenberger JK, Digard P. 2012. An overlapping protein-coding region in influenza A virus segment 3 modulates the host response. Science 337:199-204. http://dx.doi.org/10.1126/science.1222213.
8. Gao H, Sun Y, Hu J, Qi L, Wang J, Xiong X, Wang Y, He Q, Lin Y, Kong W, Seng LG, Sun H, Pu J, Chang KC, Liu X, Liu J. 2015. The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses. Sci Rep 5:8262. http://dx.doi .org/10.1038/srep08262.
9. Khaperskyy DA, Emara MM, Johnston BP, Anderson P, Hatchette TF, McCormick C. 2014. Influenza A virus host shutoff disables antiviral stress-induced translation arrest. PLoS Pathog 10:e1004217. http://dx.doi .org/10.1371/journal.ppat.1004217.
10. Plotch SJ, Bouloy M, Krug RM. 1979. Transfer of 5'-terminal cap of globin mRNA to influenza viral complementary RNA during transcription in vitro. Proc Natl Acad Sci USA 76:1618-1622. http://dx.doi.org/10.1073/pnas.76.4.1618.
11. Plotch SJ, Bouloy M, Ulmanen I, Krug RM. 1981. A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viralRNAtranscription. Cell 23:847-858. http://dx.doi.org/10.1016/0092-8674(81)90449-9.
12. Desmet EA, Bussey KA, Stone R, Takimoto T. 2013. Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis. J Virol 87:3108-3118. http://dx.doi.org/10.1128/JVI.02826-12.
13. Feng P, Everly DNJ, Read GS. 2001. mRNA decay during herpesvirus infections: interaction between a putative viral nuclease and a cellular translation factor. J Virol 75:10272-10280. http://dx.doi.org/10.1128/JVI .75.21.10272-10280.2001.
14. Kumar GR, Glaunsinger BA. 2010. Nuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNA. Mol Cell Biol 30:4996-5008. http://dx .doi.org/10.1128/MCB.00600-10.
15. Covarrubias S, Gaglia MM, Kumar GR, Wong W, Jackson AO, Glaunsinger BA. 2011. Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1. PLoS Pathog 7:e1002339. http://dx.doi .org/10.1371/journal.ppat.1002339.
16. Gaglia MM, Covarrubias S, Wong W, Glaunsinger BA. 2012. A common strategy for host RNA degradation by divergent viruses. J Virol 86:9527-9530. http://dx.doi.org/10.1128/JVI.01230-12.
17. Nemeroff ME, Barabino SM, Li Y, Keller W, Krug RM. 1998. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell 1:991-1000. http://dx.doi.org/10.1016/S1097-2765(00)80099-4.
18. Lu Y, Wambach M, Katze MG, Krug RM. 1995. Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor. Virology 214:222-228. http://dx.doi.org/10.1006/viro.1995.9937.
19. Tan SL, Katze MG. 1998. Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferoninduced PKR protein kinase. J Interferon Cytokine Res 18:757-766. http: //dx.doi.org/10.1089/jir.1998.18.757.
20. Yángüez E, Nieto A. 2011. So similar, yet so different: selective translation of capped and polyadenylated viral mRNAs in the influenza virus infected cell. Virus Res 156:1-12. http://dx.doi.org/10.1016/j.virusres.2010.12.016.