Prognostic significance of the concomitant existence of lymphovascular and perineural invasion in locally advanced gastric cancer patients who underwent curative gastrectomy and adjuvant chemotherapy

Japanese Journal of Clinical Oncology

Volumn 45, Issue 6, 2015, Pages 541-546

  Hwang, Jun Eul ^a   Hong, Ji Yun ^a   Kim, Ji Eun ^a   Shim, Hyun Jeong ^a   Bae, Woo Kyun ^a   Hwang, Eu Chang ^a   Jeong, Oh ^a   Park, Young Kyu ^a   Lee, Kyung Hwa ^a   Lee, Jae Hyuk ^a   Cho, Sang Hee ^a   Chung, Ik Joo ^a  

^a Chonnam National University Hwasun Hospital and Medical School   (South Korea)

Author keywords

Adjuvant chemotherapy; Gastrectomy; Gastric cancer; Lymphovascular invasion; Perineural invasion

Indexed keywords

CISPLATIN; FLUOROPYRIMIDINE; FLUOROURACIL; ANTINEOPLASTIC AGENT;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BODY SURFACE; CANCER ADJUVANT THERAPY; CANCER PATIENT; CANCER RECURRENCE; CANCER REGISTRY; CANCER STAGING; CANCER SURVIVAL; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GASTRECTOMY; HEMATOLOGIC MALIGNANCY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CANCER; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PERINEURAL INVASION; PROGNOSIS; STOMACH CANCER; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION; UNSPECIFIED SIDE EFFECT; VERY ELDERLY; ADJUVANT CHEMOTHERAPY; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; MIDDLE AGED; ODDS RATIO; PATHOLOGY; PERIPHERAL NERVE TUMOR; PREDICTIVE VALUE; RISK; RISK ASSESSMENT; RISK FACTOR; SECONDARY; STOMACH NEOPLASMS; TUMOR INVASION; VASCULAR TUMOR;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; CISPLATIN; DISEASE-FREE SURVIVAL; FEMALE; FLUOROURACIL; GASTRECTOMY; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; ODDS RATIO; PERIPHERAL NERVOUS SYSTEM NEOPLASMS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS; STOMACH NEOPLASMS; VASCULAR NEOPLASMS;

EID: 84930786899     PISSN: 03682811     EISSN: 14653621     Source Type: Journal    
DOI: 10.1093/jjco/hyv031     Document Type: Article

References (24)

1. Sakuramoto S, Sasako M, Yamaguchi T, Kinoshita T, Fujii M, Nashimoto A, et al. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 2007;357:1810-20.
2. Bang YJ, KimYW, Yang HK, Chung HC, Park YK, Lee KH, et al. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC):a phase 3 open-label, randomised controlled trial. Lancet 2012;379:315-21.
3. Sasako M, Sakuramoto S, Katai H, Kinoshita T, Furukawa H, Yamaguchi T, et al. Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. J Clin Oncol 2011;29:4387-93.
4. Hasegawa H, Fujitani K, Kurokawa Y, Hirao M, Nakazuru S, Mita E, et al. Effect of S-1 adjuvant chemotherapy on survival following recurrence and efficacy of first-line treatment in recurrent gastric cancer. Chemotherapy 2010;56:436-43.
5. Deng J, You Q, Gao Y, Yu Q, Zhao P, Zheng Y, et al. Prognostic value of perineural invasion in gastric cancer: a systematic review and meta-analysis. PLoS ONE 2014;9:e88907.
6. Dicken BJ, Graham K, Hamilton SM, Andrews S, Lai R, Listgarten J, et al. Lymphovascular invasion is associated with poor survival in gastric cancer:an application of gene-expression and tissue array techniques. Ann Surg 2006;243:64-73.
7. Talamonti MS, Kim SP, Yao KA, Wayne JD, Feinglass J, Bennett CL, et al. Surgical outcomes of patients with gastric carcinoma: the importance of primary tumor location and microvessel invasion. Surgery 2003;134:720-7; discussion 727-9.
8. Wada T, Kunisaki C, Hasegawa S, Takagawa R, Momiyama M, Kosaka T, et al. Factors predictive of recurrence after surgery for gastric cancer followed by adjuvant S-1 chemotherapy. Anticancer Res 2013;33:1747-51.
9. Lim SB, Yu CS, Jang SJ, Kim TW, Kim JH, Kim JC. Prognostic significance of lymphovascular invasion in sporadic colorectal cancer. Dis Colon Rectum 2010;53:377-84.
10. Huh JW, Kim HR, Kim YJ. Prognostic value of perineural invasion in patients with stage II colorectal cancer. Ann Surg Oncol 2010;17:2066-72.
11. Wang XL, Fang JP, Tang RY, Chen XM. Different significance between intratumoral and peritumoral lymphatic vessel density in gastric cancer: a retrospective study of 123 cases. BMC Cancer 2010;10:299.
12. Maehara Y, Kabashima A, Koga T, Tokunaga E, Takeuchi H, Kakeji Y, et al. Vascular invasion and potential for tumor angiogenesis and metastasis in gastric carcinoma. Surgery 2000;128:408-16.
13. Gotoda T, Yanagisawa A, Sasako M, Ono H, Nakanishi Y, Shimoda T, et al. Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers. Gastric Cancer 2000;3:219-25.
14. Fujimoto A, Ishikawa Y, Akishima-Fukasawa Y, Ito K, Akasaka Y, Tamai S, et al. Significance of lymphatic invasion on regional lymph node metastasis in early gastric cancer using LYVE-1 immunohistochemical analysis. Am J Clin Pathol 2007;127:82-8.
15. Borie F,Millat B, Fingerhut A, Hay JM, Fagniez PL, De Saxce B. Lymphatic involvement in early gastric cancer: prevalence and prognosis in France. Arch Surg 2000;135:1218-23.
16. Rubin MA, Mucci NR, Manley S, Sanda M, Cushenberry E, Strawderman M, et al. Predictors of Gleason pattern 4/5 prostate cancer on prostatectomy specimens:can high grade tumor be predicted preoperatively? JUrol 2001;165:114-8.
17. de la Taille A, Katz A, Bagiella E, Olsson CA, O'Toole KM, Rubin MA. Perineural invasion on prostate needle biopsy: an independent predictor of final pathologic stage. Urology 1999;54:1039-43.
18. Beard CJ, Chen MH, Cote K, Loffredo M, Renshaw AA, Hurwitz M, et al. Perineural invasion is associated with increased relapse after external beam radiotherapy for men with low-risk prostate cancer and may be a marker for occult, high-grade cancer. Int J Radiat Oncol Biol Phys 2004;58:19-24.
19. O'Brien CJ, Lahr CJ, Soong SJ, Gandour MJ, Jones JM, Urist MM, et al. Surgical treatment of early-stage carcinoma of the oral tongue-wound adjuvant treatment be beneficial? Head Neck Surg 1986;8:401-8.
20. Fagan JJ, Collins B, Barnes L, D'Amico F,Myers EN, Johnson JT. Perineural invasion in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 1998;124:637-40.
21. Liebig C, Ayala G,Wilks J, Verstovsek G, Liu H, Agarwal N, et al. Perineural invasion is an independent predictor of outcome in colorectal cancer. J Clin Oncol 2009;27:5131-7.
22. Fujita S, Nakanisi Y, Taniguchi H, Yamamoto S, Akasu T, Moriya Y, et al. Cancer invasion to Auerbach's plexus is an important prognostic factor in patients with pT3-pT4 colorectal cancer. Dis Colon Rectum 2007;50:1860-6.
23. Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol 2008;9:215-21.
24. Compton CC. Colorectal carcinoma: diagnostic, prognostic, and molecular features. Mod Pathol 2003;16:376-88.