Citric acid cough reflex test: Establishing normative data

Speech, Language and Hearing

Volumn 17, Issue 4, 2014, Pages 216-224

  Monroe, Margaret Delia ^a,b   Manco, Kimberley ^a,b,c   Bennett, Rachel ^a,b   Huckabee, Maggie Lee ^a,b  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

^b NEW ZEALAND BRAIN RESEARCH INSTITUTE   (New Zealand)

^c MIDDLEMORE HOSPITAL   (New Zealand)

Author keywords

Aspiration; Assessment; Citric acid; Cough; Dysphagia; Norms

Indexed keywords

EID: 84930760719     PISSN: 2050571X     EISSN: 20505728     Source Type: Journal    
DOI: 10.1179/2050572814Y.0000000041     Document Type: Article

References (38)

1. Addington W. R., Stephens R. E., Gilliland K. A. 1999. Assessing the laryngeal cough reflex and the risk of developing pneumonia after stroke: an interhospital comparison. Stroke, 30:1203-1207.
2. Addington W. R., Stephens R. E., Widdicombe J. G., Rekab K. 2005. Effect of stroke location on the laryngeal cough reflex and pneumonia risk. Cough, 1:4-10.
3. Bevan S., Geppetti P. 1994. Protons: small stimulants of capsaicinsensitive sensory nerves. Trends in Neurosciences, 17:509-512.
4. Bickerman H. A., Barach A. L., Itkin S., Drimmer F. 1954. Experimental production of cough in human subjects induced by citric acid aerosols: preliminary studies on the evaluation of antitussive agents. The American Journal of the Medical Sciences, 228:156-163.
5. Chang A. B., Widdicombe J. G. 2007. Cough throughout life: children, adults and the senile. Pulmonary Pharmacology & Therapeutics, 20(4):371-382.
6. Dicpinigaitis P. V., Rauf K. 1998. The influence of gender on cough reflex sensitivity. Chest, 113:1319-1321.
7. Ebihara S., Ebihara T., Kanezaki M., Gui P., Yamasaki M., Arai H., et al. 2011. Aging deteriorated perception of urge to cough without changing cough reflex thresholds to citric acid in female never smokers. Cough, 7(3):1-6.
8. Gravenstein J. S., Devloo R. A., Beecher H. K. 1954. Effect of antitussive agents on experimental and pathological cough in man. Journal of Applied Physiology, 7:119-139.
9. Hutchings H. A., Morris S., Eccles R., Jawad M. S. 1993. Voluntary suppression of cough induced by inhalation of capsaicin in healthy volunteers. Respiratory Medicine, 87:379-382.
10. Imoto Y., Kojima A., Osawa Y., Sunaga H., Fujieda S. 2011. Cough reflex induced by capsaicin inhalation in patients with dysphagia. Acta Otolaryngol (Stockh), 131:96-100.
11. Kastelik J. A., Thompson R. H., Aziz I., Ojoo J. C., Redington A. E., Morice A. H. 2002. Sex-related differences in cough reflex sensitivity in patients with chronic cough. American Journal of Respiratory and Critical Care Medicine, 166(7):961-964.
12. Katsumata U., Sekizawa K., Ebihara T., Sasaki H. 1995. Aging effects on cough reflex. Chest, 107:290-291.
13. Kenia P., Houghton T., Beardsmore C. 2008. Does inhaling menthol affect nasal patency or cough? Pediatric Pulmonology, 43:532-537.
14. Kidd D., Lawson J., Nesbitt R., MacMahon J. 1993. Aspiration in acute stroke: a clinical study with videofluoroscopy. Quarterly Journal of Medicine, 86:825-829.
15. Lee P. L. C., Cotterrill-Jones C., Eccles R. 2002. Voluntary control of cough. Pulmonary Pharmacology and Therapeutics, 15:37-320.
16. Leow L., Huckabee M. L., Anderson T. 2006. Cough response to inhalation of citric acid in young healthy adults. Dysphagia, 21(4):302.
17. Miles A., Huckabee M. L. 2013. Intra- and Inter-rater reliability for judgement of cough following citric acid inhalation. International Journal of Speech and Language Pathology, 15(2):209-215.
18. Miles A., Moore S., McFarlane M., Lee F., Allen J., Huckabee M. L. 2013b. Comparison of cough reflex test against instrumental assessment of aspiration. Physiology and Behaviour, 118:25-31.
19. Miles A., Zeng I. S., McLauchlan H., Huckabee M. L. 2013a. Cough reflex testing in Dysphagia following stroke: a randomized controlled trial. Journal of Clinical Medicine and Research, 5(3):222-233.
20. Moreaux B., Nemmar A., Beerens D., Gustin P. 2000. Inhibiting effect of ammonia on citric acid-induced cough in pigs: a possible involvement of substance P. Pharmacology and Toxicology, 87(6):279-285.
21. Morice A. H. 1996. Inhalation cough challenge in the investigation of the cough reflex and antitussives. Pulmonary Pharmacology, 9:281-284.
22. Morice A. H., Fonatana G. A., Belvisi M. G., Birring S. S., Chung K. F., Dicpinigaitis F., et al. 2007. ERS Guidelines on the assessment of cough. European Respiratory Journal, 29(6):1256-1276.
23. Morice A. H., Kastelik J. A., Thompson R. 2001. Cough challenge in the assessment of cough reflex. British Journal of Clinical Pharmacology, 52:365-375.
24. Newnham D. M., Hamilton S. J. C. 1997. Sensitivity of the cough reflex in young and elderly subjects. Age and Ageing, 26(3):185-188.
25. Pantaleo T., Bongianni F., Mutolo D. 2002. Central nervous system mechanisms of cough. Pulmonary Pharmacology and Therapeutics, 15:227-233.
26. Pinto A., Yanai M., Sezikawa K., Aikawa T., Sasaki H. 1995. Conditioned enhancement of cough response in awake guninea-pigs. International Archives of Allergy and Immunology, 108:95-98.
27. Ramsay D., Smithard D., Kalra L. 1999. Silent aspiration: what do we know? Dysphagia, 20:218-225.
28. Ramsay J., Wright C., Thompson R., Hull D., Morice A. H. 2008. Assessment of antitussive efficacy of dextromethorphan in smoking related cough: objective vs. subjective measures. British Journal of Clinical Pharmacology, 65(5):737-741.
29. Ricciardolo F. L. M. 2001. Mechanisms of citric acid-induced bronchoconstriction. American Journal of Medicine, 111:18-24.
30. Rostami-Hodjegan A., Abdul-Manap R., Wright C. E., Tucker G. T., Morice A. H. 2001. The placebo response to citric acid induced cough: pharmacodynamics and gender differences. Pulmonary Pharmacology and Therapeutics, 14(4):315-319.
31. Sams D. A., Truncale T., Brooks S. M. 2005. The effects of aging on the human cough reflex. Chest, 128(4):p294S.
32. Stephens R. E., Addington W. R., Widdicombe J. G. 2003. Effect of acute unilateral middle cerebral artery infarcts on voluntary cough and the laryngeal cough reflex. American Journal of Physical Medicine and Rehabilitation, 82:379-383.
33. Teramoto S., Ishii T., Yamamoto H., Yamaguchi Y., Namba R., Hanaoka Y., et al. 2005. Significance of chronic cough as a defence mechanism or a symptom in elderly patients with aspiration and aspiration pneumonia. European Respiratory Journal, 25(1):210-211.
34. Thompson R. H., Wright C., Morice A. H. 1999. Female gender and enhanced citric acid induced cough response. Thorax, 54:A75.
35. Wakasugi Y., Tohara H., Hattori F., Motohashi Y., Nakana A., Goto S., et al. 2008. Screening test for silent aspiration at the bedside. Dysphagia, 23(4):364-370.
36. Wheeler-Hegland K., Pitts T., Bolser D., Davenport P. W. 2011. Urge to cough with voluntary suppression following mechanical pharyngeal stimulation. Bratslavia Medical Journal, 112(3):109-114.
37. Widdicombe J., Eccles R., Fontana G. 2006. Supramedullary influences on cough. Respiratory Physiology and Neurobiology, 152:320-328.
38. Zaugg M., Lucchinetti E. 2000. Respiratory function in the elderly. Anesthesiology Clinics of North America, 18(1):47-58.