Skin and self-injury: A possible link between peripheral innervation and immune function?

Developmental Medicine and Child Neurology

Volumn 57, Issue 7, 2015, Pages 677-680

  Symons, Frank J ^a,b   Gilles, Elizabeth ^c   Tervo, Raymond ^b   Wendelschafer Crabb, Gwen ^a   Panoutsopoulou, Ioanna ^a   Kennedy, William ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MAYO CLINIC   (United States)

^c CHILDREN S HOSPITALS AND CLINICS OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SUBSTANCE P;

ADOLESCENT; ARTICLE; AUTOMUTILATION; BITE; CASE REPORT; CHILD; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INNERVATION; INTELLECTUAL IMPAIRMENT; MALE; MAST CELL DEGRANULATION; MICROSCOPY; NERVE FIBER; NEUROLOGIC DISEASE; PEPTIDE ANALYSIS; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; SCHOOL CHILD; SEX DIFFERENCE; SKIN BIOPSY; SKIN DEFECT; SKIN INJURY; SKIN SCAR;

EID: 84930749876     PISSN: 00121622     EISSN: 14698749     Source Type: Journal    
DOI: 10.1111/dmcn.12580     Document Type: Article

References (10)

1. Schroeder SR, Oster-Granite ML, Berkson G, et al. Self-injurious behavior: gene-brain-behavior relationships. Ment Retard Dev Disabil Res Rev 2001; 7: 3-12.
2. Symons FJ, Wendelschafer-Crabb G, Kennedy W, Heeth W, Bodfish JW. Degranulated mast cells in the skin of adults with self-injurious behavior and neurodevelopmental disorders. Brain Behav Immun 2009; 23: 365-70.
3. Symons FJ, Wendelschafer-Crabb G, Kennedy W, et al. Evidence of altered epidermal nerve fiber morphology in adults with self-injurious behavior and neurodevelopmental disorders. Pain 2008; 134: 232-7.
4. Kennedy WR, Wendelschafer-Crabb G, Johnson T. Quantification of epidermal nerves in diabetic neuropathy. Neurology 1996; 47: 1042-8.
5. Kennedy WR, Wendelschafer-Crabb G, Polydefkis M, McArthur J. Pathology and quantitation of cutaneous nerves. In: Dyck PJ, Thomas PK, editors. Peripheral Neuropathy, 4th edn. Philadelphia, PA: Saunders, 2005: 869-96.
6. McCarthy BG, Hsieh ST, Stocks A, et al. Cutaneous innervation in sensory neuropathies: evaluation by skin biopsies. Neurology 1995; 45: 1848-55.
7. Rice FL, Albers KM, Davis BM, et al. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophics, trk receptors, and p75LNGFR. Dev Biol 1998; 198: 57-81.
8. Albers KM, Wright DE, Davis BM. Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system. J Neurosci 1994; 14: 1422-32.
9. Lewin GR, Mendell LM. Nerve growth factor and nociception. TINS 1993; 16: 353-9.
10. Moalem G, Tracey DJ. Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev 2006; 51: 240-64.