Comparison of isotonic and hypotonic intravenous maintenance fluids: A randomized clinical trial

JAMA Pediatrics

Volumn 169, Issue 5, 2015, Pages 445-451

  Friedman, Jeremy N ^a   Beck, Carolyn E ^a   Degroot, Julie ^a   Geary, Denis F ^b   Sklansky, Daniel J ^c   Freedman, Stephen B ^d  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HYPOTONIC SOLUTION; ISOTONIC SOLUTION; SODIUM CHLORIDE;

ADOLESCENT; ARTICLE; BRADYCARDIA; CHILD; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EDEMA; FEMALE; HUMAN; HYPERNATREMIA; HYPERTENSION; HYPERVOLEMIA; HYPONATREMIA; INFANT; INTENSIVE CARE; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; PEDIATRIC WARD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SODIUM BLOOD LEVEL; WEIGHT GAIN; COMPARATIVE STUDY; DEVICES; FLUID THERAPY; INTRAVENOUS DRUG ADMINISTRATION; PRESCHOOL CHILD; PROCEDURES; TREATMENT OUTCOME;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; FLUID THERAPY; HUMANS; HYPERNATREMIA; HYPONATREMIA; HYPOTONIC SOLUTIONS; INFANT; INFUSIONS, INTRAVENOUS; ISOTONIC SOLUTIONS; MALE; TREATMENT OUTCOME;

EID: 84930730279     PISSN: 21686203     EISSN: 21686211     Source Type: Journal    
DOI: 10.1001/jamapediatrics.2014.3809     Document Type: Article

References (29)

1. Arieff AI, Ayus JC, Fraser CL. Hyponatraemia and death or permanent brain damage in healthy children. BMJ. 1992;304(6836):1218-1222.
2. Auroy Y, Benhamou D, Péquignot F, Jougla E, Lienhart A. Hyponatraemia-related death after paediatric surgery still exists in France. Br J Anaesth. 2008;101(5):741.
3. McRae RG, Weissburg AJ, Chang KW. Iatrogenic hyponatremia: a cause of death following pediatric tonsillectomy. Int J Pediatr Otorhinolaryngol. 1994;30(3):227-232.
4. Duke T, Kinney S, Waters K. Hyponatraemia and seizures in oncology patients associated with hypotonic intravenous fluids. J Paediatr Child Health. 2005;41(12):685-686.
5. ISMP Medical Safety Alert. Plain D5W or hypotonic saline solutions post-op could result in acute hyponatremia and death in healthy children. August 13, 2009. http://ismp.org/newsletters/acutecare/articles/20090813.asp. Accessed June 7, 2014.
6. Office of the Chief Coroner Province of Ontario. Report of the Paediatric Death Review Committee and Deaths Under Five Committee. June 19-20, 2007. https://www.childdeathreview.org/wpcontent/uploads/Publications/PDRCAnnualReport07.pdf. Accessed June 7, 2014.
7. Holliday MA, Segar WE. The maintenance need for water in parenteral fluid therapy. Pediatrics. 1957;19(5):823-832.
8. Armon K, Riordan A, Playfor S, Millman G, Khader A; Paediatric Research Society. Hyponatraemia and hypokalaemia during intravenous fluid administration. Arch Dis Child. 2008;93(4):285-287.
9. Freeman MA, Ayus JC, Moritz ML. Maintenance intravenous fluid prescribing practices among paediatric residents. Acta Paediatr. 2012;101(10):e465-e468.
10. Carandang F, Anglemyer A, Longhurst CA, et al. Association between maintenance fluid tonicity and hospital-acquired hyponatremia. J Pediatr. 2013;163(6):1646-1651.
11. Moritz ML, Ayus JC. Prevention of hospital-acquired hyponatremia: do we have the answers? Pediatrics. 2011;128(5):980-983.
12. Hoorn EJ, Geary D, Robb M, Halperin ML, Bohn D. Acute hyponatremia related to intravenous fluid administration in hospitalized children: an observational study. Pediatrics. 2004;113(5):1279-1284.
13. Moritz ML, Ayus JC. Intravenous fluid management for the acutely ill child. Curr Opin Pediatr. 2011;23(2):186-193.
14. Friedman JN; Canadian Paediatric Society, Acute Care Committee. Risk of acute hyponatremia in hospitalized children and youth receiving maintenance intravenous fluids. Paediatr Child Health. 2013;18(2):102-107.
15. Holliday MA. Isotonic saline expands extracellular fluid and is inappropriate for maintenance therapy. Pediatrics. 2005;115(1):193-194.
16. Holliday MA, Ray PE, Friedman AL. Fluid therapy for children: facts, fashions and questions. Arch Dis Child. 2007;92(6):546-550.
17. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114(2) (suppl 4th report):555-576.
18. Neville KA, Verge CF, Rosenberg AR, O'Meara MW, Walker JL. Isotonic is better than hypotonic saline for intravenous rehydration of children with gastroenteritis: a prospective randomised study. Arch Dis Child. 2006;91(3):226-232.
19. Kannan L, Lodha R, Vivekanandhan S, Bagga A, Kabra SK, Kabra M. Intravenous fluid regimen and hyponatraemia among children: a randomized controlled trial. Pediatr Nephrol. 2010;25(11):2303-2309.
20. Saba TG, Fairbairn J, Houghton F, Laforte D, Foster BJ. A randomized controlled trial of isotonic versus hypotonic maintenance intravenous fluids in hospitalized children. BMC Pediatr. 2011;11:82.
21. Beck CE. Hypotonic versus isotonic maintenance intravenous fluid therapy in hospitalized children: a systematic review. Clin Pediatr (Phila). 2007;46(9):764-770.
22. Choong K, Kho ME, Menon K, Bohn D. Hypotonic versus isotonic saline in hospitalised children: a systematic review. Arch Dis Child. 2006;91(10):828-835.
23. Montañana PA, Modesto I Alapont V, Ocón AP, López PO, López Prats JL, Toledo Parreño JD. The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study. Pediatr Crit Care Med. 2008;9(6):589-597.
24. Rey C, Los-Arcos M, Hernández A, Sánchez A, Díaz JJ, López-Herce J. Hypotonic versus isotonic maintenance fluids in critically ill children: a multicenter prospective randomized study. Acta Paediatr. 2011;100(8):1138-1143.
25. Yung M, Keeley S. Randomised controlled trial of intravenous maintenance fluids. J Paediatr Child Health. 2009;45(1-2):9-14.
26. Jorro Barón FAJ, Meregalli CN, Rombolá VA, et al. Hypotonic versus isotonic intravenous maintenance fluids in critically ill pediatric patients: a randomized controlled trial. Arch Argent Pediatr. 2013;111(4):281-287.
27. Choong K, Arora S, Cheng J, et al. Hypotonic versus isotonic maintenance fluids after surgery for children: a randomized controlled trial. Pediatrics. 2011;128(5):857-866.
28. Wang J, Xu E, Xiao Y. Isotonic versus hypotonic maintenance IV fluids in hospitalized children: ameta-analysis. Pediatrics. 2014;133(1):105-113.
29. Foster BA, Tom D, Hill V. Hypotonic versus isotonic fluids in hospitalized children: a systematic review and meta-analysis. J Pediatr. 2014;165(1):163-169.e2.