메뉴 건너뛰기




Volumn 9, Issue 3, 2015, Pages 121-129

Nintedanib in the treatment of idiopathic pulmonary fibrosis

Author keywords

disease progression; forced vital capacity; interstitial lung disease; safety; treatment outcome; tyrosine kinase

Indexed keywords

NINTEDANIB; PIRFENIDONE; PLACEBO; ENZYME INHIBITOR; INDOLE DERIVATIVE; PROTEIN TYROSINE KINASE;

EID: 84930694331     PISSN: 17534658     EISSN: 17534666     Source Type: Journal    
DOI: 10.1177/1753465815579365     Document Type: Review
Times cited : (55)

References (32)
  • 1
    • 84916231955 scopus 로고    scopus 로고
    • New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound healing responses
    • Ahluwalia N. Shea B. Tager A. (2014) New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound healing responses. Am J Respir Crit Care Med 190: 867–878.
    • (2014) Am J Respir Crit Care Med , vol.190 , pp. 867-878
    • Ahluwalia, N.1    Shea, B.2    Tager, A.3
  • 2
    • 84993761704 scopus 로고    scopus 로고
    • OFEV™ (nintedanib) prescribing information
    • Ridgefield, CT,. Available at:, accessed 30 October 2014
    • Boehringer Ingelheim Pharmaceuticals, Inc. (2014) OFEV™ (nintedanib) prescribing information. Ridgefield, CT. Available at: http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Ofev/ofev.pdf ( accessed 30 October 2014).
    • (2014)
  • 3
    • 84963991419 scopus 로고    scopus 로고
    • Summary of product characteristics
    • OFEV (nintedanib)., Boehringer Ingelheim Pharmaceuticals, Inc., RE Available at:, accessed 20 March 2015
    • Boehringer Ingelheim Pharmaceuticals, Inc. (2015) OFEV (nintedanib). Summary of product characteristics. Boehringer Ingelheim Pharmaceuticals, Inc., RE Available at: http://www.ema.europa.eu/ema ( accessed 20 March 2015).
    • (2015)
  • 5
    • 84993836241 scopus 로고    scopus 로고
    • Pre-specified subgroup analyses of pooled data from the INPULSIS™ trials of nintedanib in idiopathic pulmonary fibrosis
    • The International Colloquium on Lung and Airway Fibrosis, Mont Tremblant, Canada, 20–24, September, 2014,. Available at:, accessed 3 November 2014
    • Costabel U. Richeldi L. Azuma A. Inoue Y. Collard H. Tschoepe I. (2014) Pre-specified subgroup analyses of pooled data from the INPULSIS™ trials of nintedanib in idiopathic pulmonary fibrosis. The International Colloquium on Lung and Airway Fibrosis, Mont Tremblant, Canada, 20–24 September 2014. Available at: http://www.iclaf.com/conference/index.php/2014/ICLAF/paper/view/106 ( accessed 3 November 2014).
    • (2014)
    • Costabel, U.1    Richeldi, L.2    Azuma, A.3    Inoue, Y.4    Collard, H.5    Tschoepe, I.6
  • 6
    • 84993818021 scopus 로고    scopus 로고
    • Effect of baseline emphysema on reduction in FVC decline with nintedanib in the INPULSIS™ trials
    • The International Colloquium on Lung and Airway Fibrosis, Mont Tremblant, Canada, 20–24, September, 2014,. Available at:, accessed 3 November 2014
    • Cottin V. Taniguchi H. Richeldi L. Collard H. Kaye M. Hansell D. (2014) Effect of baseline emphysema on reduction in FVC decline with nintedanib in the INPULSIS™ trials. The International Colloquium on Lung and Airway Fibrosis, Mont Tremblant, Canada, 20–24 September 2014. Available at: http://www.iclaf.com/conference/index.php/2014/ICLAF/paper/view/151 ( accessed 3 November 2014).
    • (2014)
    • Cottin, V.1    Taniguchi, H.2    Richeldi, L.3    Collard, H.4    Kaye, M.5    Hansell, D.6
  • 7
    • 84865113809 scopus 로고    scopus 로고
    • New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis
    • Fernandez I. Eickelberg O. (2012) New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis. Lancet 380: 680–688.
    • (2012) Lancet , vol.380 , pp. 680-688
    • Fernandez, I.1    Eickelberg, O.2
  • 8
    • 84878686854 scopus 로고    scopus 로고
    • Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
    • Fingerlin T. Murphy E. Zhang W. Peljto A. Brown K. Steele M. (2013) Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet 45: 613–620.
    • (2013) Nat Genet , vol.45 , pp. 613-620
    • Fingerlin, T.1    Murphy, E.2    Zhang, W.3    Peljto, A.4    Brown, K.5    Steele, M.6
  • 9
    • 80051720737 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: update on genetic discoveries
    • Garcia C. (2011) Idiopathic pulmonary fibrosis: update on genetic discoveries. Proc Am Thorac Soc 8: 158–162.
    • (2011) Proc Am Thorac Soc , vol.8 , pp. 158-162
    • Garcia, C.1
  • 10
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F. Roth G. Krssak M. Kautschitsch S. Sommergruber W. Tontsch-Grunt U. (2008) BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 68: 4774–4782.
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.2    Krssak, M.3    Kautschitsch, S.4    Sommergruber, W.5    Tontsch-Grunt, U.6
  • 11
    • 84928655120 scopus 로고    scopus 로고
    • Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis
    • Hostettler K. Zhong J. Papakonstantinou E. Karakiulakis G. Tamm M. Seidel P. (2014) Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis. Respir Res 15: 157.
    • (2014) Respir Res , vol.15 , pp. 157
    • Hostettler, K.1    Zhong, J.2    Papakonstantinou, E.3    Karakiulakis, G.4    Tamm, M.5    Seidel, P.6
  • 12
    • 84930713121 scopus 로고    scopus 로고
    • InterMune, Inc., Brisbane, CA,. Available at:, accessed 3 November 2014
    • InterMune, Inc. (2014) ESBRIET® (pirfenidone) prescribing information. InterMune, Inc., Brisbane, CA. Available at: www.esbriet.com ( accessed 3 November 2014).
    • (2014) ESBRIET® (pirfenidone) prescribing information
  • 13
    • 84894029673 scopus 로고    scopus 로고
    • Staging of acute exacerbation in patients with idiopathic pulmonary fibrosis
    • Kishaba T. Tamaki H. Shimaoka Y. Fukuyama H. Yamashiro S. (2014) Staging of acute exacerbation in patients with idiopathic pulmonary fibrosis. Lung 192: 141–149.
    • (2014) Lung , vol.192 , pp. 141-149
    • Kishaba, T.1    Tamaki, H.2    Shimaoka, Y.3    Fukuyama, H.4    Yamashiro, S.5
  • 14
    • 84993829608 scopus 로고    scopus 로고
    • Effect of FEV1/FVC ratio on reduction in FVC decline with nintedanib in the INPULSIS™ trials
    • The International Colloquium on Lung and Airway Fibrosis, Mont Tremblant, Canada, 20–24, September, 2014,. Available at:, accessed 3 November 2014
    • Kolb M. Inoue Y. Costabel U. Hernandez P. Bailes Z. Schlenker-Herceg R. (2014) Effect of FEV1/FVC ratio on reduction in FVC decline with nintedanib in the INPULSIS™ trials. The International Colloquium on Lung and Airway Fibrosis, Mont Tremblant, Canada, 20–24 September 2014. Available at: http://www.iclaf.com/conference/index.php/2014/ICLAF/paper/view/149 ( accessed 3 November 2014).
    • (2014)
    • Kolb, M.1    Inoue, Y.2    Costabel, U.3    Hernandez, P.4    Bailes, Z.5    Schlenker-Herceg, R.6
  • 15
    • 80051795063 scopus 로고    scopus 로고
    • Comprehensive care of the patient with idiopathic pulmonary fibrosis
    • Lee J. McLaughlin S. Collard H. (2011) Comprehensive care of the patient with idiopathic pulmonary fibrosis. Curr Opin Pulm Med 17: 348–354.
    • (2011) Curr Opin Pulm Med , vol.17 , pp. 348-354
    • Lee, J.1    McLaughlin, S.2    Collard, H.3
  • 16
    • 84888399697 scopus 로고    scopus 로고
    • Epidemiology of idiopathic pulmonary fibrosis
    • Ley B. Collard H. (2013) Epidemiology of idiopathic pulmonary fibrosis. Clin Epidemiol 5: 483–492.
    • (2013) Clin Epidemiol , vol.5 , pp. 483-492
    • Ley, B.1    Collard, H.2
  • 17
    • 79951844263 scopus 로고    scopus 로고
    • Clinical course and prediction of survival in idiopathic pulmonary fibrosis
    • Ley B. Collard H. King T. Jr (2011) Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 183: 431–440.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 431-440
    • Ley, B.1    Collard, H.2    King, T.3
  • 18
    • 84924419413 scopus 로고    scopus 로고
    • Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences
    • Natsuizaka M. Chiba H. Kuronuma K. Otsuka M. Kudo K. Mori M. (2014) Epidemiologic survey of Japanese patients with idiopathic pulmonary fibrosis and investigation of ethnic differences. Am J Respir Crit Care Med 190: 773–779.
    • (2014) Am J Respir Crit Care Med , vol.190 , pp. 773-779
    • Natsuizaka, M.1    Chiba, H.2    Kuronuma, K.3    Otsuka, M.4    Kudo, K.5    Mori, M.6
  • 19
    • 84928618282 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of nintedanib and pirfenidone in idiopathic pulmonary fibrosis
    • 10, December, (epub ahead of print)
    • Ogura T. Taniguchi H. Azuma A. Inoue Y. Kondoh Y. Hasegawa Y. (2014). Safety and pharmacokinetics of nintedanib and pirfenidone in idiopathic pulmonary fibrosis. Eur Respir J 10 December (epub ahead of print).
    • (2014) Eur Respir J
    • Ogura, T.1    Taniguchi, H.2    Azuma, A.3    Inoue, Y.4    Kondoh, Y.5    Hasegawa, Y.6
  • 20
    • 84904006129 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001–11
    • Raghu G. Chen S. Yeh W. Maroni B. Li Q. Lee Y. (2014) Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001–11. Lancet Respir Med 2: 566–572.
    • (2014) Lancet Respir Med , vol.2 , pp. 566-572
    • Raghu, G.1    Chen, S.2    Yeh, W.3    Maroni, B.4    Li, Q.5    Lee, Y.6
  • 21
    • 79952717349 scopus 로고    scopus 로고
    • An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management
    • Raghu G. Collard H. Egan J. Martinez F. Behr J. Brown K. (2011) An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 183: 788–824.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 788-824
    • Raghu, G.1    Collard, H.2    Egan, J.3    Martinez, F.4    Behr, J.5    Brown, K.6
  • 23
    • 84902369532 scopus 로고    scopus 로고
    • Design of the INPULSIS trials: two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis
    • Richeldi L. Cottin V. Flaherty K. Kolb M. Inoue Y. Raghu G. (2014a) Design of the INPULSIS trials: two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis. Respir Med 108: 1023–1030.
    • (2014) Respir Med , vol.108 , pp. 1023-1030
    • Richeldi, L.1    Cottin, V.2    Flaherty, K.3    Kolb, M.4    Inoue, Y.5    Raghu, G.6
  • 25
    • 84993729074 scopus 로고    scopus 로고
    • Pooled analysis of mortality data from the TOMORROW and INPULSIS™ trials of nintedanib in idiopathic pulmonary fibrosis (IPF)
    • The International Colloquium on Lung and Airway Fibrosis, Mont Tremblant, Canada, 20–24, September, 2014,. Available at:, accessed 3 November 2014
    • Richeldi L. Kirsten A. Roman J. Le Maulf F. Hallmann C. Stowasser S. (2014c) Pooled analysis of mortality data from the TOMORROW and INPULSIS™ trials of nintedanib in idiopathic pulmonary fibrosis (IPF). The International Colloquium on Lung and Airway Fibrosis, Mont Tremblant, Canada, 20–24 September 2014. Available at: http://www.iclaf.com/conference/index.php/2014/ICLAF/paper/view/202 ( accessed 3 November 2014).
    • (2014)
    • Richeldi, L.1    Kirsten, A.2    Roman, J.3    Le Maulf, F.4    Hallmann, C.5    Stowasser, S.6
  • 26
    • 84906064819 scopus 로고    scopus 로고
    • Acute exacerbations complicating interstitial lung disease
    • Ryerson C. Collard H. (2014) Acute exacerbations complicating interstitial lung disease. Curr Opin Pulm Med 20: 436–441.
    • (2014) Curr Opin Pulm Med , vol.20 , pp. 436-441
    • Ryerson, C.1    Collard, H.2
  • 27
    • 79953652811 scopus 로고    scopus 로고
    • Acute exacerbation of idiopathic pulmonary fibrosis: incidence, risk factors and outcome
    • Song J. Hong S. Lim C. Koh Y. Kim D. (2011) Acute exacerbation of idiopathic pulmonary fibrosis: incidence, risk factors and outcome. Eur Respir J 37: 356–363.
    • (2011) Eur Respir J , vol.37 , pp. 356-363
    • Song, J.1    Hong, S.2    Lim, C.3    Koh, Y.4    Kim, D.5
  • 28
    • 79952943038 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers
    • Stopfer P. Rathgen K. Bischoff D. Lüdtke S. Marzin K. Kaiser R. (2011) Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica 41: 297–311.
    • (2011) Xenobiotica , vol.41 , pp. 297-311
    • Stopfer, P.1    Rathgen, K.2    Bischoff, D.3    Lüdtke, S.4    Marzin, K.5    Kaiser, R.6
  • 29
    • 84898792564 scopus 로고    scopus 로고
    • Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis
    • Wollin L. Maillet I. Quesniaux V. Holweg A. Ryffel B. (2014) Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis. J Pharmacol Exp Ther 349: 209–220.
    • (2014) J Pharmacol Exp Ther , vol.349 , pp. 209-220
    • Wollin, L.1    Maillet, I.2    Quesniaux, V.3    Holweg, A.4    Ryffel, B.5
  • 30
    • 84928995543 scopus 로고    scopus 로고
    • Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
    • 5, March, (epub ahead of print)
    • Wollin L. Wex E. Pautsch A. Schnapp G. Hostettler K. Stowasser S. (2015) Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis. Eur Respir J 5 March (epub ahead of print).
    • (2015) Eur Respir J
    • Wollin, L.1    Wex, E.2    Pautsch, A.3    Schnapp, G.4    Hostettler, K.5    Stowasser, S.6
  • 31
    • 84891161727 scopus 로고    scopus 로고
    • Pathogenesis of idiopathic pulmonary fibrosis
    • Wolters P. Collard H. Jones K. (2014) Pathogenesis of idiopathic pulmonary fibrosis. Annu Rev Pathol 9: 157–179.
    • (2014) Annu Rev Pathol , vol.9 , pp. 157-179
    • Wolters, P.1    Collard, H.2    Jones, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.