Use of belimumab throughout pregnancy to treat active systemic lupus erythematosus-A case report

Seminars in Arthritis and Rheumatism

Volumn 44, Issue 2, 2014, Pages 195-197

  Danve, Abhijeet ^a   Perry, Lisa ^a   Deodhar, Atul ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Belimumab; Lupus; Lupus nephritis; Pregnancy; Systemic lupus erythematosus

Indexed keywords

ANTINUCLEAR ANTIBODY; AZATHIOPRINE; BELIMUMAB; DOUBLE STRANDED DNA; ENOXAPARIN; GRANULOCYTE ANTIBODY; HYDROXYCHLOROQUINE; LISINOPRIL; LOW MOLECULAR WEIGHT HEPARIN; MYCOPHENOLIC ACID; PHOSPHOLIPID ANTIBODY; PREDNISONE; RITUXIMAB; RO ANTIBODY; THIOPURINE METHYLTRANSFERASE; WARFARIN; IMMUNOSUPPRESSIVE AGENT; MONOCLONAL ANTIBODY;

ADULT; ANGIONEUROTIC EDEMA; ANTIPHOSPHOLIPID SYNDROME; APGAR SCORE; ARTHRALGIA; ARTICLE; BREAST FEEDING; BREECH PRESENTATION; CASE REPORT; CAUCASIAN; CESAREAN SECTION; COMPLEMENT BLOOD LEVEL; DEEP VEIN THROMBOSIS; DISCOID LUPUS ERYTHEMATOSUS; DRUG CONTRAINDICATION; DRUG DOSE REDUCTION; DRUG ERUPTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EBSTEIN ANOMALY; ECHOCARDIOGRAPHY; FAMILY HISTORY; FEMALE; FETUS MONITORING; FEVER; FOLLOW UP; HIGH RISK PREGNANCY; HUMAN; HYPOCOMPLEMENTEMIA; KIDNEY BIOPSY; LEUKOPENIA; LOW DRUG DOSE; LUPUS ERYTHEMATOSUS NEPHRITIS; POLYARTICULAR ARTHRALGIA; PREECLAMPSIA; PREGNANCY OUTCOME; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; PROTEINURIA; REMISSION; SERUM SICKNESS; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT RESPONSE; INCIDENCE; LUPUS ERYTHEMATOSUS, SYSTEMIC; NEWBORN; PREGNANCY; PREGNANCY COMPLICATIONS; TREATMENT OUTCOME;

ADULT; ANTIBODIES, MONOCLONAL, HUMANIZED; EBSTEIN ANOMALY; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; INFANT, NEWBORN; LUPUS ERYTHEMATOSUS, SYSTEMIC; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; TREATMENT OUTCOME;

EID: 84930680545     PISSN: 00490172     EISSN: 1532866X     Source Type: Journal    
DOI: 10.1016/j.semarthrit.2014.05.006     Document Type: Article

References (14)

1. Chakravarty E.F., Bush T.M., Manzi S., Clarke A.E., Ward M.M. Prevalence of adult systemic lupus erythematosus in California and Pennsylvania in 2000: estimates obtained using hospitalization data. Arthritis Rheum 2007, 56:2092.
2. Auyeung-Kim D.J., Devalaraia M.N., Migone T.S., Cai W., Chellman G.J. Developmental and peri-postnatal study in cynomolgus monkeys with belimumab, a monoclonal antibody directed against B-lymphocyte stimulator. Reprod Toxicol 2009, 28:443-455.
3. Use of intravenous (IV) benlysta in pregnant patients with systemic lupus erythematosus (SLE). GlaxoSmithKline Data on File.
4. Molad Y., Borkowski T., Monselise A., Ben-Haroush A., Sulkes J., Hod M., et al. Maternal and fetal outcome of lupus pregnancy: a prospective study of 29 pregnancies. Lupus 2005, 14:145-151.
5. Clowse M.E., Jamison M., Myers E., James A.H. A national study of the complications of lupus in pregnancy. Am J Obstet Gynecol 2008, 199:127.e1-127.e6.
6. Lateef A., Petri M. Management of pregnancy in systemic lupus erythematosus. Nat Rev Rheumatol 2012, 8:710-718.
7. Lima F., Buchanan N.M., Khamashta M.A., Kerslake S., Hughes G.R. Obstetric outcome in systemic lupus erythematosus. Semin Arthritis Rheum 1995, 25:184-192.
8. Boumpas D.T., Fessler B.J., Austin H.A., Balow J.E., Klippel J.H., Lockshin M.D. Systemic lupus erythematosus: emerging concepts. Part 2: dermatologic and joint disease, the antiphospholipid antibody syndrome, pregnancy and hormonal therapy, morbidity and mortality, and pathogenesis. Ann Intern Med 1995, 123:42-53.
9. Lockshin M.D., Harpel P.C., Druzin M.L., Becker C.G., Klein R.F., Watson R.M., et al. Lupus pregnancy. II. Unusual pattern of hypocomplementemia and thrombocytopenia in the pregnant patient. Arthritis Rheum 1985, 28:58-66.
10. Clowse M.E., Magder L.S., Witter F., et al. Azathioprine use in lupus pregnancy. Arthritis Rheum 2005, 52(Suppl. 9):S386-S387.
11. Fine L., Barnett E.V., Danovitch G.M., Nissenson A.R., Conolly M.E., Lied S.M., et al. Systemic lupus erythematosus in pregnancy. Ann Intern Med 1981, 94:667-677.
12. Baer A.N., Witter F.R., Petri M. Lupus and pregnancy. Obstet Gynecol Surv 2011, 66:639-653.
13. Correa-Villaseñor A., Ferencz C., Neill C.A., Wilson P.D., Boughman J.A. Ebstein's malformation of the tricuspid valve: genetic and environmental factors. The Baltimore-Washington Infant Study Group. Teratology 1994, 50:137-147.
14. Allan L.D., Desai G., Tynan M.J. Prenatal echocardiographic screening for Ebstein's anomaly for mothers on lithium therapy. Lancet 1982, 2:875.