메뉴 건너뛰기




Volumn 10, Issue 5, 2015, Pages

Quantifying the tendency of therapeutic target proteins to bind promiscuous or selective compounds

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2C ADRENERGIC RECEPTOR; CHEMOKINE RECEPTOR; DIHYDROOROTATE DEHYDROGENASE; FIBROBLAST GROWTH FACTOR RECEPTOR 3; G PROTEIN COUPLED RECEPTOR; LIGAND; PROTEIN SERINE THREONINE KINASE; PURINERGIC P2Y12 RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; PROTEIN BINDING;

EID: 84930616579     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126838     Document Type: Article
Times cited : (14)

References (12)
  • 2
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • PMID: 18936753
    • Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol. 2008; 4: 682-690. doi: 10.1038/nchembio.118 PMID: 18936753
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 3
    • 84889262928 scopus 로고    scopus 로고
    • Polypharmacology - Foe or friend?
    • PMID: 23919353
    • Peters JU. Polypharmacology - foe or friend? J. Med. Chem. 2013; 56: 8955-8971. doi: 10.1021/jm400856t PMID: 23919353
    • (2013) J. Med. Chem. , vol.56 , pp. 8955-8971
    • Peters, J.U.1
  • 4
    • 84907943686 scopus 로고    scopus 로고
    • Polypharmacology: Challenges and opportunities in drug discovery
    • PMID: 24946140
    • Anighoro A, Bajorath J, Rastelli G. Polypharmacology: challenges and opportunities in drug discovery. J. Med. Chem. 2014; 57: 7874-7887. doi: 10.1021/jm5006463 PMID: 24946140
    • (2014) J. Med. Chem. , vol.57 , pp. 7874-7887
    • Anighoro, A.1    Bajorath, J.2    Rastelli, G.3
  • 5
    • 84871812725 scopus 로고    scopus 로고
    • On the origins of drug polypharmacology
    • Jalencas X, Mestres J. On the origins of drug polypharmacology. Med. Chem. Comm. 2013; 4: 80-87.
    • (2013) Med. Chem. Comm. , vol.4 , pp. 80-87
    • Jalencas, X.1    Mestres, J.2
  • 6
    • 84879892154 scopus 로고    scopus 로고
    • Compound promiscuity: What can we learn from current data?
    • PMID: 23524195
    • Hu Y, Bajorath J. Compound promiscuity: What can we learn from current data? Drug Discov. Today 2013; 18: 644-650. doi: 10.1016/j.drudis.2013.03.002 PMID: 23524195
    • (2013) Drug Discov. Today , vol.18 , pp. 644-650
    • Hu, Y.1    Bajorath, J.2
  • 7
    • 84872002166 scopus 로고    scopus 로고
    • How promiscuous are pharmaceutically relevant compounds? A data-driven assessment
    • PMID: 23090085
    • Hu Y, Bajorath J. How promiscuous are pharmaceutically relevant compounds? A data-driven assessment. AAPS J. 2013; 15: 104-111. doi: 10.1208/s12248-012-9421-y PMID: 23090085
    • (2013) AAPS J , vol.15 , pp. 104-111
    • Hu, Y.1    Bajorath, J.2
  • 8
    • 79955027927 scopus 로고    scopus 로고
    • Global assessment of scaffold hopping potential for current pharmaceutical targets
    • Hu Y, Bajorath J. Global assessment of scaffold hopping potential for current pharmaceutical targets. Med. Chem. Comm. 2010; 1: 339-344.
    • (2010) Med. Chem. Comm. , vol.1 , pp. 339-344
    • Hu, Y.1    Bajorath, J.2
  • 10
    • 84860833500 scopus 로고    scopus 로고
    • Reorganizing the protein space at the Universal Protein Resource (UniProt)
    • UniProtConsortium. Reorganizing the protein space at the Universal Protein Resource (UniProt). Nucleic Acids Res. 2012; 40: D142-D148.
    • (2012) Nucleic Acids Res. , vol.40 , pp. D142-D148
  • 11
    • 0029894013 scopus 로고    scopus 로고
    • The properties of known drugs. 1. Molecular frameworks
    • PMID: 8709122
    • Bemis GW, Murcko MA. The properties of known drugs. 1. Molecular frameworks. J. Med. Chem. 1996; 39: 2887-2893. PMID: 8709122
    • (1996) J. Med. Chem. , vol.39 , pp. 2887-2893
    • Bemis, G.W.1    Murcko, M.A.2
  • 12
    • 0036662353 scopus 로고    scopus 로고
    • Using molecular equivalence numbers to visually explore structural features that distinguish chemical libraries
    • PMID: 12132893
    • Xu YJ, Johnson M. Using molecular equivalence numbers to visually explore structural features that distinguish chemical libraries. J. Chem. Inf. Comput. Sci. 2002; 42: 912-926. PMID: 12132893
    • (2002) J. Chem. Inf. Comput. Sci. , vol.42 , pp. 912-926
    • Xu, Y.J.1    Johnson, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.