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Volumn 71, Issue 1, 2015, Pages 61-73

Inconclusive evidence for non-inferior immunogenicity of two- compared with three-dose HPV immunization schedules in preadolescent girls: A systematic review and meta-analysis

Author keywords

Antibodies; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus vaccine L1, type 16,18; Human papillomavirus vaccine L1, type 6,11,16,18; Immunization schedule; Non inferiority; Vaccination

Indexed keywords

WART VIRUS VACCINE; VIRUS ANTIBODY;

EID: 84930536912     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2015.02.005     Document Type: Review
Times cited : (31)

References (43)
  • 1
    • 63749101977 scopus 로고    scopus 로고
    • Report Available from:, (Date last accessed 11-11-2014)
    • International Agency for Research on Cancer World cancer report 2008, [Report] Available from:, (Date last accessed 11-11-2014). http://www.iarc.fr/en/publications/pdfs-online/wcr/2008/index.php.
    • (2008) World cancer report
  • 2
    • 0032840918 scopus 로고    scopus 로고
    • Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    • Walboomers J.M., Jacobs M.V., Manos M.M., Bosch X.F., Kummer J.A., Shah K.V., et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999, 189(1):12-19.
    • (1999) J Pathol , vol.189 , Issue.1 , pp. 12-19
    • Walboomers, J.M.1    Jacobs, M.V.2    Manos, M.M.3    Bosch, X.F.4    Kummer, J.A.5    Shah, K.V.6
  • 3
    • 0025275938 scopus 로고
    • Prevalence, incidence, and estimated life-time risk of cervical human papillomavirus infections in a nonselected finnish female population
    • Syrjanen K., Hakama M., Saarikoski S., Vayrynen M., Yliskoski M., Syrjanen S., et al. Prevalence, incidence, and estimated life-time risk of cervical human papillomavirus infections in a nonselected finnish female population. Sex Transm Dis 1990, 17(1):15-19.
    • (1990) Sex Transm Dis , vol.17 , Issue.1 , pp. 15-19
    • Syrjanen, K.1    Hakama, M.2    Saarikoski, S.3    Vayrynen, M.4    Yliskoski, M.5    Syrjanen, S.6
  • 4
    • 84879798247 scopus 로고    scopus 로고
    • Clinical trials of human papillomavirus vaccines and beyond
    • Lehtinen M., Dillner J. Clinical trials of human papillomavirus vaccines and beyond. Nat Rev Clin Oncol 2013, 10(7):400-410.
    • (2013) Nat Rev Clin Oncol , vol.10 , Issue.7 , pp. 400-410
    • Lehtinen, M.1    Dillner, J.2
  • 5
    • 84930538969 scopus 로고    scopus 로고
    • Report Available from:, (Date last accessed 24-8-2014)
    • European Medicines Agency Assessment report cervarix 2013, [Report] Available from:, (Date last accessed 24-8-2014). http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Assessment_Report_-Variation/human/000721/WC500160885.pdf.
    • (2013) Assessment report cervarix
  • 6
    • 84930538229 scopus 로고    scopus 로고
    • ReportAvailable from:, (Date last accessed 24-8-2014)
    • European Medicines Agency Assessment report gardasil 2014, [Report] Available from:, (Date last accessed 24-8-2014). http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Assessment_Report_-Variation/human/000703/WC500170695.pdf.
    • (2014) Assessment report gardasil
  • 8
    • 84900432256 scopus 로고    scopus 로고
    • Two-dose strategies for human papillomavirus vaccination: how well do they need to protect?
    • Jit M., Choi Y.H., Laprise J.F., Boily M.C., Drolet M., Brisson M. Two-dose strategies for human papillomavirus vaccination: how well do they need to protect?. Vaccine 2014, 32(26):3237-3242.
    • (2014) Vaccine , vol.32 , Issue.26 , pp. 3237-3242
    • Jit, M.1    Choi, Y.H.2    Laprise, J.F.3    Boily, M.C.4    Drolet, M.5    Brisson, M.6
  • 9
    • 84930541866 scopus 로고    scopus 로고
    • Zwei-Dosen-Schema für HPV-Impfstoffe.
    • Available from:(Date last accessed 7-8-2014).
    • Apotheke Adhoc. Zwei-Dosen-Schema für HPV-Impfstoffe. Available from: (Date last accessed 7-8-2014). http://www.apotheke-adhoc.de/nachrichten/wissenschaft/nachricht-detail-wissenschaft/hpv-impfstoffe-zwei-dosen-schema-fuer-gardasil-und-cervarix/.
    • Apotheke Adhoc
  • 10
    • 84930538801 scopus 로고    scopus 로고
    • Two versus three doses of quadrivalent HPV vaccine: the immunogenicity study that could.
    • Presented on August 24, in HPV Conference 2014 Seattle.
    • Dobson S. Two versus three doses of quadrivalent HPV vaccine: the immunogenicity study that could. Presented on August 24, 2014 in HPV Conference 2014 Seattle.
    • (2014)
    • Dobson, S.1
  • 12
    • 84855184271 scopus 로고    scopus 로고
    • Immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine administered as a 2-dose schedule compared with the licensed 3-dose schedule: results from a randomized study
    • Romanowski B., Schwarz T.F., Ferguson L.M., Peters K., Dionne M., Schulze K., et al. Immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine administered as a 2-dose schedule compared with the licensed 3-dose schedule: results from a randomized study. Hum Vaccin 2011, 7(12):1374-1386.
    • (2011) Hum Vaccin , vol.7 , Issue.12 , pp. 1374-1386
    • Romanowski, B.1    Schwarz, T.F.2    Ferguson, L.M.3    Peters, K.4    Dionne, M.5    Schulze, K.6
  • 13
    • 78649803667 scopus 로고    scopus 로고
    • The current state of introduction of human papillomavirus vaccination into national immunisation schedules in Europe: first results of the VENICE2 2010 survey
    • Dorleans F., Giambi C., Dematte L., Cotter S., Stefanoff P., Mereckiene J., et al. The current state of introduction of human papillomavirus vaccination into national immunisation schedules in Europe: first results of the VENICE2 2010 survey. Euro Surveill 2010, 15(47).
    • (2010) Euro Surveill , vol.15 , Issue.47
    • Dorleans, F.1    Giambi, C.2    Dematte, L.3    Cotter, S.4    Stefanoff, P.5    Mereckiene, J.6
  • 14
    • 84907979711 scopus 로고    scopus 로고
    • Immunogenicity of bivalent HPV vaccine among partially vaccinated young adolescent girls in Uganda
    • EPub
    • LaMontagne D.S., Mugisha E., Pan E., Kumakech A., Ssemaganda A., Kemp T.J., et al. Immunogenicity of bivalent HPV vaccine among partially vaccinated young adolescent girls in Uganda. Vaccine 2014, 32(47):6306-6311. EPub. 10.1016/j.vaccine.2014.08.071.
    • (2014) Vaccine , vol.32 , Issue.47 , pp. 6306-6311
    • LaMontagne, D.S.1    Mugisha, E.2    Pan, E.3    Kumakech, A.4    Ssemaganda, A.5    Kemp, T.J.6
  • 15
    • 0037464808 scopus 로고    scopus 로고
    • Interaction revisited: the difference between two estimates
    • Altman D.G., Bland J.M. Interaction revisited: the difference between two estimates. BMJ 2003, 326(7382). p.219.
    • (2003) BMJ , vol.326 , Issue.7382 , pp. 219
    • Altman, D.G.1    Bland, J.M.2
  • 16
    • 84930539465 scopus 로고    scopus 로고
    • Cochrane Collaboration website.
  • 17
    • 84924519573 scopus 로고    scopus 로고
    • Comparing vaccines: A systematic review of the use of the non-inferiority margin in vaccine trials
    • Donken R., de Melker H.E., Rots N.Y., Berbers G.A., Knol M.J. Comparing vaccines: A systematic review of the use of the non-inferiority margin in vaccine trials. Vaccine 2015, 10.1016/j.vaccine.2015.01.072.
    • (2015) Vaccine
    • Donken, R.1    de Melker, H.E.2    Rots, N.Y.3    Berbers, G.A.4    Knol, M.J.5
  • 18
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyse
    • Higgins J.P., Thompson S.G., Deeks J.J., Altman D.G. Measuring inconsistency in meta-analyse. BMJ 2003, 327(7414):557-560.
    • (2003) BMJ , vol.327 , Issue.7414 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3    Altman, D.G.4
  • 19
    • 84886032410 scopus 로고    scopus 로고
    • Durable antibody responses following one dose of the bivalent human papillomavirus L1 virus-like particle vaccine in the Costa Rica Vaccine Trial
    • Safaeian M., Porras C., Pan Y., Kreimer A., Schiller J.T., Gonzalez P., et al. Durable antibody responses following one dose of the bivalent human papillomavirus L1 virus-like particle vaccine in the Costa Rica Vaccine Trial. Cancer Prev Res (Phila) 2013, 6(11):1242-1250.
    • (2013) Cancer Prev Res (Phila) , vol.6 , Issue.11 , pp. 1242-1250
    • Safaeian, M.1    Porras, C.2    Pan, Y.3    Kreimer, A.4    Schiller, J.T.5    Gonzalez, P.6
  • 20
    • 84877118332 scopus 로고    scopus 로고
    • Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial
    • Dobson S.R., McNeil S., Dionne M., Dawar M., Ogilvie G., Krajdenn M., et al. Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial. JAMA 2013, 309(17):1793-1802.
    • (2013) JAMA , vol.309 , Issue.17 , pp. 1793-1802
    • Dobson, S.R.1    McNeil, S.2    Dionne, M.3    Dawar, M.4    Ogilvie, G.5    Krajdenn, M.6
  • 21
    • 84893009653 scopus 로고    scopus 로고
    • Overcoming barriers to HPV vaccination: non-inferiority of antibody response to human papillomavirus 16/18 vaccine in adolescents vaccinated with a two-dose vs. a three-dose schedule at 21 months
    • Lazcano-Ponce E., Stanley M., Munoz N., Torres L., Cruz-Valdez A., Salmeron J., et al. Overcoming barriers to HPV vaccination: non-inferiority of antibody response to human papillomavirus 16/18 vaccine in adolescents vaccinated with a two-dose vs. a three-dose schedule at 21 months. Vaccine 2014, 32(6):725-732.
    • (2014) Vaccine , vol.32 , Issue.6 , pp. 725-732
    • Lazcano-Ponce, E.1    Stanley, M.2    Munoz, N.3    Torres, L.4    Cruz-Valdez, A.5    Salmeron, J.6
  • 22
    • 84901396246 scopus 로고    scopus 로고
    • Immune response to the HPV-16/18 AS04-adjuvanted vaccine administered as a 2-dose or 3-dose schedule up to 4 years after vaccination: results from a randomized study
    • Romanowski B., Schwarz T.F., Ferguson L.M., Ferguson M., Peters K., Dionne M., et al. Immune response to the HPV-16/18 AS04-adjuvanted vaccine administered as a 2-dose or 3-dose schedule up to 4 years after vaccination: results from a randomized study. Hum Vaccin Immunother 2014, 10(5).
    • (2014) Hum Vaccin Immunother , vol.10 , Issue.5
    • Romanowski, B.1    Schwarz, T.F.2    Ferguson, L.M.3    Ferguson, M.4    Peters, K.5    Dionne, M.6
  • 24
    • 84884920436 scopus 로고    scopus 로고
    • Clinical progression of high-grade cervical intraepithelial neoplasia: estimating the time to preclinical cervical cancer from doubly censored national registry data
    • Vink M.A., Bogaards J.A., van Kemenade F.J., de Melker H.E., Meijer C.J.L.M., Berkhof J. Clinical progression of high-grade cervical intraepithelial neoplasia: estimating the time to preclinical cervical cancer from doubly censored national registry data. Am J Epidemiol 2013, 178(7):1161-1169.
    • (2013) Am J Epidemiol , vol.178 , Issue.7 , pp. 1161-1169
    • Vink, M.A.1    Bogaards, J.A.2    van Kemenade, F.J.3    de Melker, H.E.4    Meijer, C.J.L.M.5    Berkhof, J.6
  • 25
    • 84893666624 scopus 로고    scopus 로고
    • Association of varying number of doses of quadrivalent human papillomavirus vaccine with incidence of condyloma
    • Herweijer E., Leval A., Ploner A., Eloranta S., Simard J.F., Dillner J., et al. Association of varying number of doses of quadrivalent human papillomavirus vaccine with incidence of condyloma. JAMA 2014, 311(6):597-603.
    • (2014) JAMA , vol.311 , Issue.6 , pp. 597-603
    • Herweijer, E.1    Leval, A.2    Ploner, A.3    Eloranta, S.4    Simard, J.F.5    Dillner, J.6
  • 26
    • 80054087108 scopus 로고    scopus 로고
    • Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine
    • Kreimer A.R., Rodriguez A.C., Hildesheim A., Herrero R., Porras C., Schiffman M., et al. Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine. J Natl Cancer Inst 2011, 103(19):1444-1451.
    • (2011) J Natl Cancer Inst , vol.103 , Issue.19 , pp. 1444-1451
    • Kreimer, A.R.1    Rodriguez, A.C.2    Hildesheim, A.3    Herrero, R.4    Porras, C.5    Schiffman, M.6
  • 27
    • 84930540358 scopus 로고    scopus 로고
    • HPV immunization of Québec pre-adolescents: Two or three doses?
    • Available from: (date last accessed 16-12).
    • Institut National De Santé Publique de Québec. HPV immunization of Québec pre-adolescents: Two or three doses? Available from: (date last accessed 16-12-2014). http://www.inspq.qc.ca/pdf/publications/1837_HPV_Immunization_PreAdolescents.pdf.
    • (2014)
  • 28
    • 34248631118 scopus 로고    scopus 로고
    • Immunization of early adolescent females with human papillomavirus type 16 and 18 L1 virus-like particle vaccine containing AS04 adjuvant
    • Pedersen C., Petaja T., Strauss G., Rumke H.C., Poder A., Richardus J.H., et al. Immunization of early adolescent females with human papillomavirus type 16 and 18 L1 virus-like particle vaccine containing AS04 adjuvant. J Adolesc Health 2007 Jun, 40(6):564-571.
    • (2007) J Adolesc Health , vol.40 , Issue.6 , pp. 564-571
    • Pedersen, C.1    Petaja, T.2    Strauss, G.3    Rumke, H.C.4    Poder, A.5    Richardus, J.H.6
  • 29
    • 33750938518 scopus 로고    scopus 로고
    • Comparison of the immunogenicity and reactogenicity of a prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in male and female adolescents and young adult women
    • Block S.L., Nolan T., Sattler C., Barr E., Giacoletti K.E., Marchant C.D., et al. Comparison of the immunogenicity and reactogenicity of a prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in male and female adolescents and young adult women. Pediatrics 2006 Nov, 118(5):2135-2145.
    • (2006) Pediatrics , vol.118 , Issue.5 , pp. 2135-2145
    • Block, S.L.1    Nolan, T.2    Sattler, C.3    Barr, E.4    Giacoletti, K.E.5    Marchant, C.D.6
  • 30
    • 84908371999 scopus 로고    scopus 로고
    • Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine: final analysis of a long-term follow-up study up to 9.4 years post-vaccination
    • Naud P.S., Roteli-Martins C.M., De Carvalho N.S., Teixeira J.C., de Borba P.C., Sanchez N., et al. Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine: final analysis of a long-term follow-up study up to 9.4 years post-vaccination. Hum Vaccin Immunother 2014, 10(8).
    • (2014) Hum Vaccin Immunother , vol.10 , Issue.8
    • Naud, P.S.1    Roteli-Martins, C.M.2    De Carvalho, N.S.3    Teixeira, J.C.4    de Borba, P.C.5    Sanchez, N.6
  • 31
    • 84904322244 scopus 로고    scopus 로고
    • Alternative dosage schedules with HPV virus-like particle vaccines
    • Stanley M.A., Sudenga S.L., Giuliano A.R. Alternative dosage schedules with HPV virus-like particle vaccines. Expert Rev Vaccin 2014, 13(8):1027-1038.
    • (2014) Expert Rev Vaccin , vol.13 , Issue.8 , pp. 1027-1038
    • Stanley, M.A.1    Sudenga, S.L.2    Giuliano, A.R.3
  • 32
    • 84861009178 scopus 로고    scopus 로고
    • Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination
    • Smolen K.K., Gelinas L., Franzen L., Dobson S., Dawar M., Ogilvie G., et al. Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination. Vaccine 2012, 30(24):3572-3579.
    • (2012) Vaccine , vol.30 , Issue.24 , pp. 3572-3579
    • Smolen, K.K.1    Gelinas, L.2    Franzen, L.3    Dobson, S.4    Dawar, M.5    Ogilvie, G.6
  • 33
    • 84900447648 scopus 로고    scopus 로고
    • Antibody avidity measurements in recipients of Cervarix vaccine following a two-dose schedule or a three-dose schedule
    • Boxus M., Lockman L., Fochesato M., Lorin C., Thomas F., Giannini S.L. Antibody avidity measurements in recipients of Cervarix vaccine following a two-dose schedule or a three-dose schedule. Vaccine 2014, 32(26):3232-3236.
    • (2014) Vaccine , vol.32 , Issue.26 , pp. 3232-3236
    • Boxus, M.1    Lockman, L.2    Fochesato, M.3    Lorin, C.4    Thomas, F.5    Giannini, S.L.6
  • 35
    • 69749112025 scopus 로고    scopus 로고
    • Second national serum bank for population-based seroprevalence studies in the Netherlands
    • van der Klis F.R., Mollema L., Berbers G.A., de Melker H.E., Coutinho R.A. Second national serum bank for population-based seroprevalence studies in the Netherlands. Neth J Med 2009, 67(7):301-308.
    • (2009) Neth J Med , vol.67 , Issue.7 , pp. 301-308
    • van der Klis, F.R.1    Mollema, L.2    Berbers, G.A.3    de Melker, H.E.4    Coutinho, R.A.5
  • 36
    • 84869057659 scopus 로고    scopus 로고
    • Changes in antibody seroprevalence of seven high-risk HPV types between nationwide surveillance studies from 1995-96 and 2006-07 in The Netherlands
    • p. e48807
    • Scherpenisse M., Mollers M., Schepp R.M., Boot H.J., Meijer C.J.L.M., Berbers G.A., et al. Changes in antibody seroprevalence of seven high-risk HPV types between nationwide surveillance studies from 1995-96 and 2006-07 in The Netherlands. PLoS One 2012, 7(11). p. e48807.
    • (2012) PLoS One , vol.7 , Issue.11
    • Scherpenisse, M.1    Mollers, M.2    Schepp, R.M.3    Boot, H.J.4    Meijer, C.J.L.M.5    Berbers, G.A.6
  • 37
    • 79958128068 scopus 로고    scopus 로고
    • Reported adverse events in girls aged 13-16 years after vaccination with the human papillomavirus (HPV)-16/18 vaccine in the Netherlands
    • van Klooster T.M., Kemmeren J.A., van der Maas N.A., de Melker H.E. Reported adverse events in girls aged 13-16 years after vaccination with the human papillomavirus (HPV)-16/18 vaccine in the Netherlands. Vaccine 2011, 29(28):4601-4607.
    • (2011) Vaccine , vol.29 , Issue.28 , pp. 4601-4607
    • van Klooster, T.M.1    Kemmeren, J.A.2    van der Maas, N.A.3    de Melker, H.E.4
  • 38
    • 84904581436 scopus 로고    scopus 로고
    • Human papillomavirus vaccination coverage among adolescents, 2007-2013, and postlicensure vaccine safety monitoring, 2006-2014-United States
    • Stokley S., Jeyarajah J., Yankey D., Cano M., Gee J., Roark J., et al. Human papillomavirus vaccination coverage among adolescents, 2007-2013, and postlicensure vaccine safety monitoring, 2006-2014-United States. MMWR Morb Mortal Wkly Rep 2014, 63(29):620-624.
    • (2014) MMWR Morb Mortal Wkly Rep , vol.63 , Issue.29 , pp. 620-624
    • Stokley, S.1    Jeyarajah, J.2    Yankey, D.3    Cano, M.4    Gee, J.5    Roark, J.6
  • 39
    • 84855732950 scopus 로고    scopus 로고
    • Safety and tolerability of bivalent HPV vaccine: an Italianpost-licensure study
    • Gasparini R., Bonanni P., Levi M., Bechini A., Boccalini S., Tiscione E., et al. Safety and tolerability of bivalent HPV vaccine: an Italianpost-licensure study. Hum Vaccin 2011, 7 Suppl: p. 136-146.
    • (2011) Hum Vaccin , vol.7 , Issue.SUPPL , pp. 136-146
    • Gasparini, R.1    Bonanni, P.2    Levi, M.3    Bechini, A.4    Boccalini, S.5    Tiscione, E.6
  • 40
    • 71649091113 scopus 로고    scopus 로고
    • Comparison of the immunogenicity and safety of Cervarix and Gardasil human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 years
    • Einstein M.H., Baron M., Levin M.J., Chatterjee A., Edwards R.P., Zepp F., et al. Comparison of the immunogenicity and safety of Cervarix and Gardasil human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 years. Hum Vaccin 2009, 5(10):705-719.
    • (2009) Hum Vaccin , vol.5 , Issue.10 , pp. 705-719
    • Einstein, M.H.1    Baron, M.2    Levin, M.J.3    Chatterjee, A.4    Edwards, R.P.5    Zepp, F.6
  • 41
    • 84880876639 scopus 로고    scopus 로고
    • Comparison of different assays to assess human papillomavirus (HPV) type 16- and 18-specific antibodies after HPV infection and vaccination
    • Scherpenisse M., Schepp R.M., Mollers M., Mooij S.H., Meijer C.J.L.M., Berbers G.A., et al. Comparison of different assays to assess human papillomavirus (HPV) type 16- and 18-specific antibodies after HPV infection and vaccination. Clin Vaccine Immunol 2013, 20(8):1329-1332.
    • (2013) Clin Vaccine Immunol , vol.20 , Issue.8 , pp. 1329-1332
    • Scherpenisse, M.1    Schepp, R.M.2    Mollers, M.3    Mooij, S.H.4    Meijer, C.J.L.M.5    Berbers, G.A.6
  • 42
    • 84879151548 scopus 로고    scopus 로고
    • Review: current knowledge on the role of HPV antibodies after natural infection and vaccination: implications for monitoring an HPV vaccination programme
    • Mollers M., Vossen J.M., Scherpenisse M., van der Klis F.R.M., Meijer C.J.L.M., de Melker H.E. Review: current knowledge on the role of HPV antibodies after natural infection and vaccination: implications for monitoring an HPV vaccination programme. J Med Virol 2013, 85(8):1379-1385.
    • (2013) J Med Virol , vol.85 , Issue.8 , pp. 1379-1385
    • Mollers, M.1    Vossen, J.M.2    Scherpenisse, M.3    van der Klis, F.R.M.4    Meijer, C.J.L.M.5    de Melker, H.E.6
  • 43
    • 84930541367 scopus 로고    scopus 로고
    • GlaxoSmithKline
    • Available from: (Date last accessed 24-8).
    • GlaxoSmithKline. Clinical study register. Study ID 115411. Available from: (Date last accessed 24-8-2014). http://www.gsk-clinicalstudyregister.com/study/115411%3Fcsrf_token=1398861437.11%23%2312fb16077d858694ad3b4fdad9fc54c849a8fbe5%26search_terms=hpv%26titles=%26study_ids=%26study_type=%26document_type=%26recruitment=%26conditions=%26compounds=%26lead=%26collaborators=%26gender=%26patient_level_data=%26age_from=%26age_from_type=%26age_to=%26age_to_type=%26first_receive_from=%26first_receive_to=%26last_updated_from=%26last_updated_to=%26country=%26state=%26search=Search#ps.
    • (2014) Clinical study register. Study ID 115411


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