Association of CD209L tandem repeats polymorphism with susceptibility to human immunodeficiency virus-1 infection, disease progression, and treatment outcomes: A Moroccan cohort study

Clinical Microbiology and Infection

Volumn 21, Issue 5, 2015, Pages 513.e1-513.e5

  Fayssel, N ^a   Bensghir, R ^b   Ouladlahsen, A ^b   Abdelghaffar, H ^c   Sodqi, M ^b   Lahlou, K ^a   Benjelloun, S ^a   Marhoum El Filali, K ^b   Ezzikouri, S ^a   Wakrim, L ^a  

^a Institut Pasteur du Maroc   (Morocco)

^b Hassan II University of Casablanca   (Morocco)

^c IBN ROCHD UNIVERSITY HOSPITAL   (Morocco)

Author keywords

AIDS; CD4+; L SIGN; Tandem repeats; Viral load

Indexed keywords

CD209 ANTIGEN; ANTIRETROVIRUS AGENT; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; CLEC4M PROTEIN, HUMAN; LECTIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ALLELE; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FOLLOW UP; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; MOROCCAN; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; TANDEM REPEAT; TREATMENT OUTCOME; TREATMENT RESPONSE; VIRUS LOAD; AGED; DISEASE PREDISPOSITION; GENETIC PREDISPOSITION; GENETICS; GENOTYPING TECHNIQUE; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOLATION AND PURIFICATION; MIDDLE AGED; MOROCCO; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADULT; AGED; ANTI-RETROVIRAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CELL ADHESION MOLECULES; COHORT STUDIES; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GENOTYPING TECHNIQUES; HIV INFECTIONS; HIV-1; HUMANS; LECTINS, C-TYPE; MALE; MIDDLE AGED; MOROCCO; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE; TANDEM REPEAT SEQUENCES; TREATMENT OUTCOME; VIRAL LOAD;

EID: 84930519324     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2014.12.012     Document Type: Article

References (19)

1. UNAIDS: Global Report UNAIDS report on the global AIDS epidemic2013 2013, http://www.unaids.org/en/resources/campaigns/globalreport2013/globalreport.
2. Kouyoumjian S.P., Mumtaz G.R., Hilmi N., Zidouh A., El Rhilani H., Alami K., et al. The epidemiology of HIV infection in Morocco: systematic review and data synthesis. Int J STD AIDS 2013, 24(7):507-516.
3. Tomescu C., Abdulhaqq S., Montaner L.J. Evidence for the innate immune response as a correlate of protection in human immunodeficiency virus (HIV)-1 highly exposed seronegative subjects (HESN). Clin Exp Immunol 2011, 164(2):158-169.
4. Frodsham A.J., Hill A.V. Genetics of infectious diseases. Hum Mol Genet 2004, 13(Spec No. 2):R187-R194.
5. Bashirova A.A., Geijtenbeek T.B., van Duijnhoven G.C., van Vliet S.J., Eilering J.B., Martin M.P., et al. Adendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. JExp Med 2001, 193(6):671-678.
6. Pohlmann S., Soilleux E.J., Baribaud F., Leslie G.J., Morris L.S., Trowsdale J., et al. DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proc Natl Acad Sci USA 2001, 98(5):2670-2675.
7. Feinberg H., Guo Y., Mitchell D.A., Drickamer K., Weis W.I. Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR. JBiol Chem 2005, 280(2):1327-1335.
8. Liu H., Zhu T. Determination of DC-SIGN and DC-SIGNR repeat region variations. Methods Mol Biol 2005, 304:471-481.
9. Mitchell D.A., Fadden A.J., Drickamer K. Anovel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. JBiol Chem 2001, 276(31):28939-28945.
10. Boily-Larouche G., Iscache A.L., Zijenah L.S., Humphrey J.H., Mouland A.J., Ward B.J., et al. Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1. PloS One 2009, 4(10):e7211.
11. Lichterfeld M., Nischalke H.D., van Lunzen J., Sohne J., Schmeisser N., Woitas R., et al. The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDS. Clin Immunol 2003, 107(1):55-59.
12. Liu H., Carrington M., Wang C., Holte S., Lee J., Greene B., et al. Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility. JInfect Dis 2006, 193(5):698-702.
13. Barreiro L.B., Quintana-Murci L. DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: from population stratification to a possible advantage of the 7/5 heterozygous genotype. JInfect Dis 2006, 194(8):1184-1185. author reply 1185-1187.
14. Ezzikouri S., Rebbani K., Fakhir F.Z., Alaoui R., Nadir S., Diepolder H., et al. The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads. Clin Microbiol Infect 2014, 20(5):O325-O332.
15. Wichukchinda N., Kitamura Y., Rojanawiwat A., Nakayama E.E., Song H., Pathipvanich P., et al. The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection. AIDS Res Hum Retroviruses 2007, 23(5):686-692.
16. Leckband D.E., Menon S., Rosenberg K., Graham S.A., Taylor M.E., Drickamer K. Geometry and adhesion of extracellular domains of DC-SIGNR neck length variants analyzed by force-distance measurements. Biochemistry 2011, 50(27):6125-6132.
17. Xu L., Li Q., Ye H., Zhang Q., Chen H., Huang F., et al. The nine-repeat DC-SIGNR isoform is associated with increased HIV-RNA loads and HIV sexual transmission. JClin Immunol 2010, 30(3):402-407.
18. Moore D.M., Hogg R.S., Yip B., Wood E., Tyndall M., Braitstein P., et al. Discordant immunologic and virologic responses to highly active antiretroviral therapy are associated with increased mortality and poor adherence to therapy. JAcquir Immune Defic Syndr 2005, 40(3):288-293.
19. Snyder G.A., Ford J., Torabi-Parizi P., Arthos J.A., Schuck P., Colonna M., et al. Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor. JVirol 2005, 79(8):4589-4598.