High-level quinolone resistance is associated with the overexpression of smeVWX in Stenotrophomonas maltophilia clinical isolates

Clinical Microbiology and Infection

Volumn 21, Issue 5, 2015, Pages 464-467

  Garcia Leon G ^a   Ruiz de Alegria Puig C ^b   Garcia de la Fuente C ^b   Martinez Martinez L ^b,c   Martinez J L ^a   Sanchez M B ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^c UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

Multidrug efflux pump; Quinolone resistance; S.maltophilia; SmeDEF; SmeVWX

Indexed keywords

AMINO ACID; ASPARTIC ACID; CHLORAMPHENICOL; CIPROFLOXACIN; DNA TOPOISOMERASE; NALIDIXIC ACID; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN SMEDEF; OUTER MEMBRANE PROTEIN SMEF; QUINOLONE; RNA 16S; TETRACYCLINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; MUTANT PROTEIN; QUINOLONE DERIVATIVE; REPRESSOR PROTEIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMEVWX GENE; STENOTROPHOMONAS MALTOPHILIA; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; HUMAN; MICROBIAL SENSITIVITY TEST; MISSENSE MUTATION;

BACTERIA (MICROORGANISMS); STENOTROPHOMONAS MALTOPHILIA;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTANT PROTEINS; MUTATION, MISSENSE; QUINOLONES; REPRESSOR PROTEINS; STENOTROPHOMONAS MALTOPHILIA;

EID: 84930514929     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2015.01.007     Document Type: Article

References (22)

1. Brooke J.S. Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. Clin Microbiol Rev 2012, 25:2-41.
2. Looney W.J., Narita M., Muhlemann K. Stenotrophomonas maltophilia: an emerging opportunist human pathogen. Lancet Infect Dis 2009, 9:312-323.
3. Sanchez M.B., Hernandez A., Martinez J.L. Stenotrophomonas maltophilia drug resistance. Future Microbiol 2009, 4:655-660.
4. Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A., Sebaihia M., et al. The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Genome Biol 2008, 9:R74.
5. Okazaki A., Avison M.B. Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. Antimicrob Agents Chemother 2007, 51:359-360.
6. Gould V.C., Okazaki A., Avison M.B. Beta-lactam resistance and beta-lactamase expression in clinical Stenotrophomonas maltophilia isolates having defined phylogenetic relationships. JAntimicrob Chemother 2006, 57:199-203.
7. Alonso A., Martinez J.L. Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia. Antimicrob Agents Chemother 2000, 44:3079-3086.
8. Sanchez M.B., Hernandez A., Rodriguez-Martinez J.M., Martinez-Martinez L., Martinez J.L. Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants. BMC Microbiol 2008, 8:148.
9. Ribera A., Domenech-Sanchez A., Ruiz J., Benedi V.J., Jimenez de Anta M.T., Vila J. Mutations in gyrA and parC QRDRs are not relevant for quinolone resistance in epidemiological unrelated Stenotrophomonas maltophilia clinical isolates. Microb Drug Resist 2002, 8:245-251.
10. Valdezate S., Vindel A., Saez-Nieto J.A., Baquero F., Canton R. Preservation of topoisomerase genetic sequences during invivo and invitro development of high-level resistance to ciprofloxacin in isogenic Stenotrophomonas maltophilia strains. JAntimicrob Chemother 2005, 56:220-223.
11. Garcia-Leon G., Salgado F., Oliveros J.C., Sanchez M.B., Martinez J.L. Interplay between intrinsic and acquired resistance to quinolones in Stenotrophomonas maltophilia. Environ Microbiol 2014, 16:1282-1296.
12. Gould V.C., Avison M.B. SmeDEF-mediated antimicrobial drug resistance in Stenotrophomonas maltophilia clinical isolates having defined phylogenetic relationships. JAntimicrob Chemother 2006, 57:1070-1076.
13. Sanchez P., Alonso A., Martinez J.L. Regulatory regions of smeDEF in Stenotrophomonas maltophilia strains expressing different amounts of the multidrug efflux pump SmeDEF. Antimicrob Agents Chemother 2004, 48:2274-2276.
14. Chang L.L., Chen H.F., Chang C.Y., Lee T.M., Wu W.J. Contribution of integrons, and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrophomonas maltophilia. JAntimicrob Chemother 2004, 53:518-521.
15. Alonso A., Martinez J.L. Expression of multidrug efflux pump SmeDEF by clinical isolates of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 2001, 45:1879-1881.
16. Whitby P.W., Carter K.B., Burns J.L., Royall J.A., LiPuma J.J., Stull T.L. Identification and detection of Stenotrophomonas maltophilia by rRNA-directed PCR. JClin Microbiol 2000, 38:4305-4309.
17. James G. PCR for clinical microbiology. Universal bacterial identification by PCR and DNA sequencing of 16S rRNA gene 2010, 209-214. Springer, New York. M. Schuller, T.P. Sloots, G.S. James, C.L. Halliday, I.W.J. Carter (Eds.).
18. Vila J., Marcos M.A., Jimenez de Anta M.T. Acomparative study of different PCR-based DNA fingerprinting techniques for typing of the Acinetobacter calcoaceticus-A. baumannii complex. JMed Microbiol 1996, 44:482-489.
19. Alonso A., Martinez J.L. Multiple antibiotic resistance in Stenotrophomonas maltophilia. Antimicrob Agents Chemother 1997, 41:1140-1142.
20. Garcia-Leon G., Hernandez A., Hernando-Amado S., Alavi P., Berg G., Martinez J.L. Afunction of SmeDEF, the major quinolone resistance determinant of Stenotrophomonas maltophilia, is the colonization of plant roots. Appl Environ Microbiol 2014, 80:4559-4565.
21. Valdezate S., Vindel A., Echeita A., Baquero F., Canton R. Topoisomerase II and IV quinolone resistance-determining regions in Stenotrophomonas maltophilia clinical isolates with different levels of quinolone susceptibility. Antimicrob Agents Chemother 2002, 46:665-671.
22. Sanchez M.B., Martinez J.L. SmQnr contributes to intrinsic resistance to quinolones in Stenotrophomonas maltophilia. Antimicrob Agents Chemother 2010, 54:580-581.