메뉴 건너뛰기




Volumn 4, Issue 6, 2015, Pages 615-624

Freshly thawed and continuously cultured human bone marrow-derived mesenchymal stromal cells comparably ameliorate allergic airways inflammation in immunocompetent mice

Author keywords

Asthma; Cryopreservation; Mesenchymal stromal cells; Mouse

Indexed keywords

BONE MARROW DERIVED MESENCHYMAL STEM CELL EXTRACT; CELL EXTRACT; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; RANTES; UNCLASSIFIED DRUG;

EID: 84930510460     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2014-0268     Document Type: Article
Times cited : (73)

References (48)
  • 1
    • 84860238652 scopus 로고    scopus 로고
    • Multipotentmesenchymal stromal cells and the innate immune system
    • Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol 2012;12: 383–396.
    • (2012) Nat Rev Immunol , vol.12 , pp. 383-396
    • Le Blanc, K.1    Mougiakakos, D.2
  • 2
    • 84862534451 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: New directions
    • Keating A. Mesenchymal stromal cells: New directions. Cell Stem Cell 2012;10:709–716.
    • (2012) Cell Stem Cell , vol.10 , pp. 716
    • Keating, A.1
  • 3
    • 84885099905 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Sensors and switchers of inflam
    • Bernardo ME, Fibbe WE. Mesenchymal stromal cells: Sensors and switchers of inflammation. Cell Stem Cell 2013;13:392–402.
    • (2013) Cell Stem Cell , vol.13 , pp. 392-402
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 4
    • 84872088799 scopus 로고    scopus 로고
    • The meaning, the sense and the significance: Translating the scienceofmesenchymal stem cells into medicine
    • Bianco P, Cao X, Frenette PS et al. The meaning, the sense and the significance: Translating the scienceofmesenchymal stem cells into medicine. Nat Med 2013;19:35–42.
    • (2013) Nat Med , vol.19 , pp. 35-42
    • Bianco, P.1    Cao, X.2    Frenette, P.S.3
  • 5
    • 84868091993 scopus 로고    scopus 로고
    • Safety of cell therapy with mesenchymal stro-mal cells (SafeCell): A systematic review and meta-analysis of clinical trials
    • Lalu MM, McIntyre L, Pugliese C et al. Safety of cell therapy with mesenchymal stro-mal cells (SafeCell): A systematic review and meta-analysis of clinical trials. PLoS One 2012; 7:e47559.
    • (2012) Plos One , vol.7
    • Lalu, M.M.1    McIntyre, L.2    Pugliese, C.3
  • 6
    • 84858080480 scopus 로고    scopus 로고
    • Long-term complications, immunologic effects, androleofpassage foroutcomeinmesenchymal stromal cell therapy
    • von Bahr L, Sundberg B, Lönnies L et al. Long-term complications, immunologic effects, androleofpassage foroutcomeinmesenchymal stromal cell therapy. Biol Blood Marrow Transplant 2012;18:557–564.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 557-564
    • Von Bahr, L.1    Sundberg, B.2    Lönnies, L.3
  • 7
    • 84883740641 scopus 로고    scopus 로고
    • Canada approves stem cell product
    • Cyranoski D. Canada approves stem cell product. Nat Biotechnol 2012;30:571.
    • (2012) Nat Biotechnol , vol.30 , pp. 571
    • Cyranoski, D.1
  • 8
    • 84881092225 scopus 로고    scopus 로고
    • Immu-nological characterization of multipotent mes-enchymal stromal cells–the International Society for Cellular Therapy (ISCT) working proposal
    • Krampera M, Galipeau J, Shi Y et al. Immu-nological characterization of multipotent mes-enchymal stromal cells–the International Society for Cellular Therapy (ISCT) working proposal. Cytotherapy 2013;15:1054–1061.
    • (2013) Cytotherapy , vol.15 , pp. 1054-1061
    • Krampera, M.1    Galipeau, J.2    Shi, Y.3
  • 9
    • 84877938781 scopus 로고    scopus 로고
    • Clinical-grade mesenchymal stromal cells produced under various good manufacturing practice processes differ in their immunomodulatory properties: Standardization of immune quality controls
    • Menard C, Pacelli L, Bassi G et al. Clinical-grade mesenchymal stromal cells produced under various good manufacturing practice processes differ in their immunomodulatory properties: Standardization of immune quality controls. Stem Cells Dev 2013;22:1789–1801.
    • (2013) Stem Cells Dev , vol.22 , pp. 1789-1801
    • Menard, C.1    Pacelli, L.2    Bassi, G.3
  • 10
    • 84901368359 scopus 로고    scopus 로고
    • Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation
    • Viswanathan S, Keating A, Deans R et al. Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation. Stem Cells Dev 2014;23:1157–1167.
    • (2014) Stem Cells Dev , vol.23 , pp. 1157-1167
    • Viswanathan, S.1    Keating, A.2    Deans, R.3
  • 11
    • 77957855505 scopus 로고    scopus 로고
    • Derivation efficiency, cell proliferation, freeze-thaw survival, stem-cell properties and differentiation of human Wharton’s jelly stem cells
    • Fong CY, Subramanian A, Biswas A et al. Derivation efficiency, cell proliferation, freeze-thaw survival, stem-cell properties and differentiation of human Wharton’s jelly stem cells. Reprod Biomed Online 2010;21: 391–401.
    • (2010) Reprod Biomed Online , vol.21 , pp. 391-401
    • Fong, C.Y.1    Subramanian, A.2    Biswas, A.3
  • 12
    • 84870594362 scopus 로고    scopus 로고
    • The effects of freeze/thawing process on cryopre-served equine umbilical cord blood-derived mesenchymal stem cells
    • Eini F, Foroutan T, Bidadkosh A. The effects of freeze/thawing process on cryopre-served equine umbilical cord blood-derived mesenchymal stem cells. Comp Clin Pathol 2012;21:1713–1718.
    • (2012) Comp Clin Pathol , vol.21 , pp. 1713-1718
    • Eini, F.1    Foroutan, T.2    Bidadkosh, A.3
  • 13
    • 84864805619 scopus 로고    scopus 로고
    • Effect of different freezing rates during cryopreservation of rat mesenchymal stem cells using combinations of hydroxyethyl starch and dimethylsulfoxide
    • Naaldijk Y, Staude M, Fedorova V et al. Effect of different freezing rates during cryopreservation of rat mesenchymal stem cells using combinations of hydroxyethyl starch and dimethylsulfoxide. BMC Biotechnol 2012;12:49.
    • (2012) BMC Biotechnol , vol.12 , pp. 49
    • Naaldijk, Y.1    Staude, M.2    Fedorova, V.3
  • 14
    • 84861795594 scopus 로고    scopus 로고
    • Evaluation of bone marrow-derived mesenchymal stem cells after cryopreservation and hypother-mic storageinclinicallysafe medium
    • Ginis I, Grinblat B, Shirvan MH. Evaluation of bone marrow-derived mesenchymal stem cells after cryopreservation and hypother-mic storageinclinicallysafe medium. TissueEng Part C Methods 2012;18:453–463.
    • (2012) Tissueeng , vol.18 , pp. 453-463
    • Ginis, I.1    Grinblat, B.2    Shirvan, M.H.3
  • 15
    • 84855890176 scopus 로고    scopus 로고
    • Cry-opreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-g licensing
    • François M, Copland IB, Yuan S et al. Cry-opreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-g licensing. Cytotherapy 2012;14: 147–152.
    • (2012) Cytotherapy , vol.14 , pp. 147-152
    • François, M.1    Copland, I.B.2    Yuan, S.3
  • 16
    • 84906275192 scopus 로고    scopus 로고
    • Do cryo-preserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?
    • Moll G, Alm JJ, Davies LC et al. Do cryo-preserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties? Stem Cells 2014;32:2430–2442.
    • (2014) Stem Cells , vol.32 , pp. 2430-2442
    • Moll, G.1    Alm, J.J.2    Davies, L.C.3
  • 17
    • 59849120888 scopus 로고    scopus 로고
    • IFATS collection: Immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model
    • Cho KS, Park HK, Park HY et al. IFATS collection: Immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model. Stem Cells 2009;27:259–265.
    • (2009) Stem Cells , vol.27 , pp. 259-265
    • Cho, K.S.1    Park, H.K.2    Park, H.Y.3
  • 18
    • 77954075079 scopus 로고    scopus 로고
    • Immunomodulatory effects of adipose-derived stem cells in airway allergic diseases
    • Cho KS, Roh HJ. Immunomodulatory effects of adipose-derived stem cells in airway allergic diseases. Curr Stem Cell Res Ther 2010; 5:111–115.
    • (2010) Curr Stem Cell Res Ther , vol.5 , pp. 111-115
    • Cho, K.S.1    Roh, H.J.2
  • 19
    • 78649809743 scopus 로고    scopus 로고
    • Human mesenchymal stem cells suppress chronic airway inflammation in the murine ov-albumin asthma model
    • Bonfield TL, Koloze M, Lennon DP et al. Human mesenchymal stem cells suppress chronic airway inflammation in the murine ov-albumin asthma model. Am J Physiol Lung Cell Mol Physiol 2010;299:L760–L770.
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299 , pp. L760-L770
    • Bonfield, T.L.1    Koloze, M.2    Lennon, D.P.3
  • 20
    • 77956261268 scopus 로고    scopus 로고
    • Adipose-derived stromal cells inhibit allergic airway inflammation in mice
    • Park HK, Cho KS, Park HY et al. Adipose-derived stromal cells inhibit allergic airway inflammation in mice. Stem Cells Dev 2010;19: 1811–1818.
    • (2010) Stem Cells Dev , vol.19 , pp. 1811-1818
    • Park, H.K.1    Cho, K.S.2    Park, H.Y.3
  • 21
    • 77950377767 scopus 로고    scopus 로고
    • Bone marrow stromal cells use TGF-beta to suppress allergic responsesinamouse model of ragweed-induced asthma
    • Nemeth K, Keane-Myers A, Brown JM et al. Bone marrow stromal cells use TGF-beta to suppress allergic responsesinamouse model of ragweed-induced asthma. Proc Natl Acad Sci USA 2010;107:5652–5657.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5652-5657
    • Nemeth, K.1    Keane-Myers, A.2    Brown, J.M.3
  • 22
    • 84860412104 scopus 로고    scopus 로고
    • Mes-enchymal stem cells ameliorate the histopatho-logical changes in a murine model of chronic asthma
    • Firinci F, Karaman M, Baran Y et al. Mes-enchymal stem cells ameliorate the histopatho-logical changes in a murine model of chronic asthma. Int Immunopharmacol 2011;11:1120–1126.
    • (2011) Int Immunopharmacol , vol.11 , pp. 1126
    • Firinci, F.1    Karaman, M.2    Baran, Y.3
  • 23
    • 79960081138 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice
    • Goodwin M, Sueblinvong V, Eisenhauer P et al. Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice. Stem Cells 2011;29:1137–1148.
    • (2011) Stem Cells , vol.29 , pp. 1137-1148
    • Goodwin, M.1    Sueblinvong, V.2    Eisenhauer, P.3
  • 24
    • 79952042164 scopus 로고    scopus 로고
    • Allogeneic mes-enchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells
    • Kavanagh H, Mahon BP. Allogeneic mes-enchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy 2011;66:523–531.
    • (2011) Allergy , vol.66 , pp. 523-531
    • Kavanagh, H.1    Mahon, B.P.2
  • 25
    • 79960141710 scopus 로고    scopus 로고
    • Mesen-chymal stem cell transfer suppresses airway remodeling in a toluene diisocyanate-induced murineasthmamodel
    • Lee SH, Jang AS, Kwon JH et al. Mesen-chymal stem cell transfer suppresses airway remodeling in a toluene diisocyanate-induced murineasthmamodel. AllergyAsthmaImmunol Res 2011;3:205–211.
    • (2011) Allergyasthmaimmunolres , vol.3 , pp. 205-211
    • Lee, S.H.1    Jang, A.S.2    Kwon, J.H.3
  • 26
    • 82755177356 scopus 로고    scopus 로고
    • Sup
    • Ou-Yang HF, Huang Y, Hu XB et al. Suppression of allergic airway inflammation in a mouse model of asthma by exogenous mesen-chymal stem cells. Exp Biol Med (Maywood) 2011;236:1461–1467.
    • (2011) Exp Biol Med (Maywood) , vol.236 , pp. 1461-1467
    • Ou-Yang, H.F.1    Huang, Y.2    Hu, X.B.3
  • 27
    • 84856631196 scopus 로고    scopus 로고
    • Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma
    • Ionescu LI, Alphonse RS, Arizmendi N et al. Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma. Am J Respir Cell Mol Biol 2012;46:207–216.
    • (2012) Am J Respir Cell Mol Biol , vol.46 , pp. 207-216
    • Ionescu, L.I.1    Alphonse, R.S.2    Arizmendi, N.3
  • 28
    • 84894048356 scopus 로고    scopus 로고
    • Mesenchymal stromal cells mediate As- pergillus hyphal extract-induced allergic airway inflammationbyinhibitionoftheTh17 signaling pathway
    • 28 Lathrop MJ, Brooks EM, Bonenfant NR et al. Mesenchymal stromal cells mediate As- pergillus hyphal extract-induced allergic airway inflammation by inhibitionoftheTh17 signaling pathway. Stem Cells Translational Medicine 2014;3:194–205.
    • (2014) Stem Cells Translational Medicine , vol.3 , pp. 194-205
    • Lathrop, M.J.1    Brooks, E.M.2    Bonenfant, N.R.3
  • 29
    • 33749532124 scopus 로고    scopus 로고
    • As-pergillus fumigatus generates an enhanced Th2-biasedimmuneresponseinmicewithdefec-tive cystic fibrosis transmembrane conductance regulator
    • Allard JB, Poynter ME, Marr KA et al. As-pergillus fumigatus generates an enhanced Th2-biasedimmuneresponseinmicewithdefec-tive cystic fibrosis transmembrane conductance regulator. J Immunol 2006;177:5186–5194.
    • (2006) J Immunol , vol.177 , pp. 5186-5194
    • Allard, J.B.1    Poynter, M.E.2    Marr, K.A.3
  • 30
    • 64049104440 scopus 로고    scopus 로고
    • Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
    • Allard JB, Rinaldi L, Wargo MJ et al. Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products. Eur J Immunol 2009;39: 776–788.
    • (2009) Eur J Immunol , vol.39 , pp. 776-788
    • Allard, J.B.1    Rinaldi, L.2    Wargo, M.J.3
  • 31
    • 80051599870 scopus 로고    scopus 로고
    • Intratra-cheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice
    • Kim ES, Chang YS, Choi SJ et al. Intratra-cheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice. Respir Res 2011;12:108.
    • (2011) Respir Res , vol.12 , pp. 108
    • Kim, E.S.1    Chang, Y.S.2    Choi, S.J.3
  • 32
    • 79959461779 scopus 로고    scopus 로고
    • Intrapulmo-nary delivery of human umbilical cord mesen-chymal stem cells attenuates acute lung injury by expanding CD4+CD25+ Forkhead Boxp3 (FOXP3)+ regulatory T cells and balancing anti-and pro-inflammatory factors
    • Sun J, Han ZB, Liao W et al. Intrapulmo-nary delivery of human umbilical cord mesen-chymal stem cells attenuates acute lung injury by expanding CD4+CD25+ Forkhead Boxp3 (FOXP3)+ regulatory T cells and balancing anti-and pro-inflammatory factors. Cell Physiol Bio-chem 2011;27:587–596.
    • (2011) Cell Physiol Bio-Chem , vol.27 , pp. 587-596
    • Sun, J.1    Han, Z.B.2    Liao, W.3
  • 33
    • 84863012337 scopus 로고    scopus 로고
    • Intratra-cheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats
    • Chang YS, Choi SJ, Sung DK et al. Intratra-cheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats. Cell Transplant 2011;20:1843–1854.
    • (2011) Cell Transplant , vol.20 , pp. 1843-1854
    • Chang, Y.S.1    Choi, S.J.2    Sung, D.K.3
  • 34
    • 84876286103 scopus 로고    scopus 로고
    • Short-term, long-term and paracrine effect of human umbilical cord-derived stem cellsinlung injury prevention and repair in experimental bronchopulmonary dysplasia
    • Pierro M, Ionescu L, Montemurro T et al. Short-term, long-term and paracrine effect of human umbilical cord-derived stem cellsinlung injury prevention and repair in experimental bronchopulmonary dysplasia. Thorax 2013;68: 475–484.
    • (2013) Thorax , vol.68 , pp. 475-484
    • Pierro, M.1    Ionescu, L.2    Montemurro, T.3
  • 35
    • 80053282797 scopus 로고    scopus 로고
    • Bone marrowderived mesenchymalstem cellsinhibit inflammationandpreservevascularendothelial integrity in the lungs after hemorrhagic shock
    • Pati S, Gerber M, Menge TD et al. Bone marrowderived mesenchymalstem cellsinhibit inflammationandpreservevascularendothelial integrity in the lungs after hemorrhagic shock. PLoS One 2011;6:e25171.
    • (2011) Plos One , vol.6
    • Pati, S.1    Gerber, M.2    Menge, T.D.3
  • 36
    • 1442332442 scopus 로고    scopus 로고
    • Adult
    • Peister A, Mellad JA, Larson BL et al. Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood 2004;103: 1662–1668.
    • (2004) Blood , vol.103 , pp. 1662-1668
    • Peister, A.1    Mellad, J.A.2    Larson, B.L.3
  • 37
    • 84930533928 scopus 로고    scopus 로고
    • AboutPACT, Accessed January , 14, 2015
    • About PACT. Available at https://secure.emmes.com/pactweb/Facilities. Accessed January 14, 2015.
  • 38
    • 62949170977 scopus 로고    scopus 로고
    • Production Assistance for Cellular Therapies (PACT): Four-year experience from the United States National Heart, Lung, and Blood Institute (NHLBI) contract research program in celland tissue therapies
    • Reed W, Noga SJ, Gee AP et al. Production Assistance for Cellular Therapies (PACT): Four-year experience from the United States National Heart, Lung, and Blood Institute (NHLBI) contract research program in cell and tissue therapies. Transfusion 2009;49: 786–796.
    • (2009) Transfusion , vol.49 , pp. 786-796
    • Reed, W.1    Noga, S.J.2    Gee, A.P.3
  • 39
    • 0029085275 scopus 로고
    • A computer-
    • Schuessler TF, Bates JH. A computer-controlledresearchventilator for smallanimals: Design and evaluation. IEEE Trans Biomed Eng 1995;42:860–866.
    • (1995) IEEE Trans Biomed Eng , vol.42 , pp. 860-866
    • Schuessler, T.F.1    Bates, J.H.2
  • 40
    • 0035064478 scopus 로고    scopus 로고
    • Respiratory mechanics and lung development in the rat from early age to adulthood
    • 1985
    • Gomes RF, Shardonofsky F, Eidelman DH et al. Respiratory mechanics and lung development in the rat from early age to adulthood. J Appl Physiol (1985) 2001;90:1631–1638.
    • (2001) J Appl Physiol , vol.90 , pp. 1631-1638
    • Gomes, R.F.1    Shardonofsky, F.2    Eidelman, D.H.3
  • 41
    • 84905983559 scopus 로고    scopus 로고
    • Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia
    • Asmussen S, Ito H, Traber DL et al. Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Thorax 2014;69:819–825.
    • (2014) Thorax , vol.69 , pp. 819-825
    • Asmussen, S.1    Ito, H.2    Traber, D.L.3
  • 42
    • 77953831397 scopus 로고    scopus 로고
    • Human adipose-derived stromal cells accelerate diabetic wound healing: Impact of cell formulation and delivery
    • Amos PJ, Kapur SK, Stapor PC et al. Human adipose-derived stromal cells accelerate diabetic wound healing: Impact of cell formulation and delivery. Tissue Eng Part A 2010;16: 1595–1606.
    • (2010) Tissue Eng Part A , vol.16 , pp. 1595-1606
    • Amos, P.J.1    Kapur, S.K.2    Stapor, P.C.3
  • 43
    • 84862900149 scopus 로고    scopus 로고
    • Are therapeutic human mesenchymal stromal cells compatible with human blood?
    • Moll G, Rasmusson-Duprez I, von Bahr L et al. Are therapeutic human mesenchymal stromal cells compatible with human blood? Stem Cells 2012;30:1565–1574.
    • (2012) Stem Cells , vol.30 , pp. 1565-1574
    • Moll, G.1    Rasmusson-Duprez, I.2    Von Bahr, L.3
  • 44
    • 84883375670 scopus 로고    scopus 로고
    • Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation
    • Jitschin R, Mougiakakos D, Von Bahr L et al. Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation. Stem Cells 2013;31:1715–1725.
    • (2013) Stem Cells , vol.31 , pp. 1715-1725
    • Jitschin, R.1    Mougiakakos, D.2    Von Bahr, L.3
  • 45
    • 84856960632 scopus 로고    scopus 로고
    • Human MSC suppression correlates with cyto-kine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation
    • François M, Romieu-Mourez R, Li M et al. Human MSC suppression correlates with cyto-kine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. Mol Ther 2012;20:187–195.
    • (2012) Mol Ther , vol.20 , pp. 187-195
    • François, M.1    Romieu-Mourez, R.2    Li, M.3
  • 46
    • 84876138850 scopus 로고    scopus 로고
    • Human mesenchymal stem cells reduce lung injury in immunocompromised mice but not in immunocompetent mice
    • Lim R, Milton P, Murphy SV et al. Human mesenchymal stem cells reduce lung injury in immunocompromised mice but not in immunocompetent mice. Respiration 2013; 85:332–341.
    • (2013) Respiration , vol.85 , pp. 332-341
    • Lim, R.1    Milton, P.2    Murphy, S.V.3
  • 47
    • 0023726937 scopus 로고
    • Anti-proliferative
    • Gajewski TF, Fitch FW. Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but notTh1 murine helperTlymphocyte clones. J Immunol 1988;140:4245–4252.
    • (1988) J Immunol , vol.140 , pp. 4245-4252
    • Gajewski, T.F.1    Fitch, F.W.2
  • 48
    • 0026700113 scopus 로고
    • IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cyto-lytic potentialbyTh1orTh2humanTcellclones
    • Parronchi P, De Carli M, Manetti R et al. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cyto-lytic potentialbyTh1orTh2humanTcellclones. J Immunol 1992;149:2977–2983.
    • (1992) J Immunol , vol.149 , pp. 2977-2983
    • Parronchi, P.1    De Carli, M.2    Manetti, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.