Preparation of mucoadhesive patches for buccal administration of metoprolol succinate: In vitro and in vivo drug release and bioadhesion

Tropical Journal of Pharmaceutical Research

Volumn 11, Issue 1, 2012, Pages 9-17

  Verma, Navneet ^a,b   Chattopadhyay, Pronobesh ^c  

^a IFTM UNIVERSITY   (India)

^b Department of Electronics and Communication Engineering GovtEngineering College   (India)

^c Defence R D Organization   (India)

Author keywords

Bioavailability; Buccal patches; Chitosan; Metoprolol succinate; Mucoadhesive; Sodium carboxymethylcellulose

Indexed keywords

CARBOXYMETHYLCELLULOSE; CHITOSAN; METOPROLOL SUCCINATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BUCCAL PATCH; CHEEK MUCOSA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MOISTURE; MUCOADHESION; NONHUMAN; RABBIT; SWINE; TENSILE STRENGTH; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84930480570     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v11i1.2     Document Type: Article

References (21)

1. Cilurzo F, Cupone I, Selmin F. Fast dissolving films made of maltodextrins. Eur J Pharm Biopharm 2008; 70: 895-900.
2. Mashru RC, Sutariya MG. Development and evaluation of fast dissolving film of salbutamol sulphate. Drug Dev Ind Pharm 2005; 1: 25-34.
3. Asha S, Sathesh BP, Divakar G, Purohit KP. Development and evaluation of buccoadhesive drug delivery system for atorvastatin calcium. J Current Pharm Res 2010; 1: 31-38.
4. Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery: A promising option for orally less efficient drugs. J Control Rel 2006; 114: 15-40.
5. Nafee NA, Ismail FA, Boraje NA. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Acta Pharm 2003; 53: 199-212.
6. Morales JO, McConville JT. Manufacture and characterization of mucoadhesive buccal films. Eur J Pharm Biopharm 2011; 77: 187-199.
7. Andrew GP, Laverty TP, Jones DS. Mucoadhesive polymeric platform for controlled drug delivery. Eur J Pharm Biopharm 2009; 71: 505-518.
8. Gandhi RB, Roninson JR. Bioadhesion in drug Delivery. Indian J Pharm Sci 1988; 50: 145-152.
9. Hao J, Heng PWS. Buccal Delivery System, Drug Dev Ind Pharm 2003; 29: 821-832.
10. Shojaei AH, Li X. Determination of transport route of acyclovir across buccal mucosa. Proc Int Symp Control Release Bioact Mater 1997; 24: 427-428.
11. Randhawa MA, Malik SA, Javed M. Buccal absorption of weak acidic drugs is not related to their degree of ionization as estimated from the Henderson-Hasselbalch equation. Pak J Med Research 2003; 42: 116-119.
12. Riikka L, Eera S, Kaisa T, Mikko B. Intraorally fast dissolving particles of a poorly soluble drug: Preparation and in vitro characterization. Eur J Pharm Biopharm 2009; 71: 271-281.
13. Ellen H, Marianne H, Arne S. Mucoadhesive and drug permeation of free mixed films of pectin and Chitosan: An in vivo study. Eur J Pharm Biopharm 2009; 71: 325-331.
14. Aleksandra M, Ewa K, Tomasz C. Electro-osmotic flow as a result of Buccal iontophoresis- Buccal mucosa properties, Eur J Pharm Biopharm 2009; 72: 595-599.
15. Ana F, Juliane H, Andreas BS. In-vitro evaluation of natural and methylated cyclodextrin as Buccal permeation enhancing system for omeprazole delivery. Eur J Pharm Biopharm 2009; 71: 339-345.
16. Khairnar A, Parridhi J, Dheeraj B. Development of mucoadhesive buccal patch containing aceclofenac: In vitro evaluation. Int J Pharm Tech Research 2009; 1: 978-981.
17. Perioli L, Ambrogi V. Development of mucoadhesive patches for buccal administration of Ibuprofen. J Control Rel 2004; 99: 73-82.
18. Henrihsen I, Green LK Bioadhesion of hydrated chitosan: an in vitro and in vivo study. Int J Pharm 1996; 145: 231-240.
19. Lehr CM, Bouwstra JA. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymer. Int J Pharm 1992; 78: 43-48.
20. Nafee NA, Ismail FA. Mucoadhesive delivery system. II. Formulation and In-vitro/In-vivo evaluation of buccal mucoadhesive tablets containing water soluble drugs. Drug Dev Ind Pharm 2004; 30: 995-1004.
21. Panigrahy RN, Mahale AM, Dhaked PS. Formulation and invitro evaluation of combined floating mucoadhesive tablet of Metoprolol succinate. Int J Pharm Sci 2011; 3: 221-226.