Do our "big data" in genetic analysis need to get bigger?

Psychophysiology

Volumn 51, Issue 12, 2014, Pages 1321-1322

  Baker, Laura A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Missing heritability; Multivariate GWAS; RDoC

Indexed keywords

ENDOPHENOTYPE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; SINGLE NUCLEOTIDE POLYMORPHISM;

ENDOPHENOTYPES; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84930348238     PISSN: 00485772     EISSN: 14698986     Source Type: Journal    
DOI: 10.1111/psyp.12351     Document Type: Note

References (6)

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2. Medland, S. E., & Neale, M. C. (2009). An integrated phenomic approach to multivariate allelic association. European Journal of Human Genetics, 18, 233-239.
3. Tuvblad, C., Gao, Y., Isen, J., Botwick, T., Raine, A., & Baker, L. A. (2012). The heritability of the skin conductance orienting response: A longitudinal twin study. Biological Psychology, 89, 47-53. doi: 10.1016/j.biopsycho.2011.09.003
4. Visscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012). Five years of GWAS discovery. American Journal of Human Genetics, 90, 7-24. doi: 10.1016/j.ajhg.2011.11.029
5. Visscher, P. M., Hemani, G., Vinkhuyzen, A. A. E., Chen, G.-B., Lee, S. H., Wray, N. R., ... Yang, J. (2014). Statistical power to detect genetic (co) variance of complex traits using SNP data in unrelated samples. PLoS Genetics, 10, e1004269.
6. Vrieze, S. I., Malone, S. M., Pankratz, N., Vaidyanathan, U., Miller, M. B., Kang, H. M., ... Iacono, W. G. (2014). Genetic associations of nonsynonymous exonic variants with psychophysiological endophenotypes. Psychophysiology, 51, 1300-1308.