Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 21, 2015, Pages 6712-6717

  Toda, Alyssa M A ^a   Huganir, Richard L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPA receptor phosphorylation; PACAP38; Synaptic transmission

Indexed keywords

AMPA RECEPTOR; DOPAMINE; GLUTAMATE RECEPTOR 1; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NORADRENALIN; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE;

ANIMAL CELL; ARTICLE; HIPPOCAMPAL CA1 REGION; IMMUNOPRECIPITATION; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NERVE STIMULATION; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SYNAPTIC TRANSMISSION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; METABOLISM; PHOSPHORYLATION;

ANIMALS; BINDING SITES; CA1 REGION, HIPPOCAMPAL; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EXCITATORY POSTSYNAPTIC POTENTIALS; MICE; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE, TYPE I; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE, TYPE II; SYNAPTIC TRANSMISSION;

EID: 84930221627     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507229112     Document Type: Article

References (31)

1. Anggono V, Huganir RL (2012) Regulation of AMPA receptor trafficking and synaptic plasticity. Curr Opin Neurobiol 22(3):461-469.
2. Huganir RL, Nicoll RA (2013) AMPARs and synaptic plasticity: The last 25 years. Neuron 80(3):704-717.
3. Kessels HW, Malinow R (2009) Synaptic AMPA receptor plasticity and behavior. Neuron 61(3):340-350.
4. Lu W, Roche KW (2012) Posttranslational regulation of AMPA receptor trafficking and function. Curr Opin Neurobiol 22(3):470-479.
5. Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL (1996) Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron 16(6):1179-1188.
6. Serulle Y, et al. (2007) A GluR1-cGKII interaction regulates AMPA receptor trafficking. Neuron 56(4):670-688.
7. Lee HK, Kameyama K, Huganir RL, Bear MF (1998) NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21(5):1151-1162.
8. Hu H, et al. (2007) Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell 131(1):160-173.
9. Seol GH, et al. (2007) Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity. Neuron 55(6):919-929.
10. Diering GH, Gustina AS, Huganir RL (2014) PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity. Neuron 84(4):790-805.
11. Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL (2000) Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405(6789):955-959.
12. Man HY, Sekine-Aizawa Y, Huganir RL (2007) Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit. Proc Natl Acad Sci USA 104(9):3579-3584.
13. Lee HK, et al. (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112(5):631-643.
14. Lee HK, Takamiya K, He K, Song L, Huganir RL (2010) Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. J Neurophysiol 103(1):479-489.
15. Lee HK, et al. (2007) Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Mol Cell Neurosci 36(1):86-94.
16. Delgado JY, et al. (2007) NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840. J Neurosci 27(48):13210-13221.
17. Gray EE, Guglietta R, Khakh BS, O'Dell TJ (2014) Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. J Biol Chem 289(21):14600-14611.
18. Jenkins MA, et al. (2014) Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840. Mol Pharmacol 85(4):618-629.
19. Roberto M, Brunelli M (2000) PACAP-38 enhances excitatory synaptic transmission in the rat hippocampal CA1 region. Learn Mem 7(5):303-311.
20. Roberto M, Scuri R, Brunelli M (2001) Differential effects of PACAP-38 on synaptic responses in rat hippocampal CA1 region. Learn Mem 8(5):265-271.
21. Kondo T, Tominaga T, Ichikawa M, Iijima T (1997) Differential alteration of hippocampal synaptic strength induced by pituitary adenylate cyclase activating polypeptide-38 (PACAP-38). Neurosci Lett 221(2-3):189-192.
22. Ciranna L, Cavallaro S (2003) Opposing effects by pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide on hippocampal synaptic transmission. Exp Neurol 184(2):778-784.
23. Dickson L, Finlayson K (2009) VPAC and PAC receptors: From ligands to function. Pharmacol Ther 121(3):294-316.
24. Costa L, Santangelo F, Li Volsi G, Ciranna L (2009) Modulation of AMPA receptor-mediated ion current by pituitary adenylate cyclase-activating polypeptide (PACAP) in CA1 pyramidal neurons from rat hippocampus. Hippocampus 19(1):99-109.
25. Gardoni F, et al. (2012) The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway. J Cell Sci 125(Pt 6):1401-1406.
26. Takuma K, et al. (2014) An enriched environment ameliorates memory impairments in PACAP-deficient mice. Behav Brain Res 272:269-278.
27. Otto C, et al. (2001) Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient mice. J Neurosci 21(15):5520-5527.
28. Tsutsumi M, et al. (2002) A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: A potential therapy for type 2 diabetes. Diabetes 51(5):1453-1460.
29. Ressler KJ, et al. (2011) Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature 470(7335):492-497.
30. Song I, Huganir RL (2002) Regulation of AMPA receptors during synaptic plasticity. Trends Neurosci 25(11):578-588.
31. Oh MC, Derkach VA, Guire ES, Soderling TR (2006) Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation. J Biol Chem 281(2):752-758.