Effect of intravenous lignocaine on perioperative stress response and post-surgical ileus in elective open abdominal surgeries: A double-blind randomized controlled trial

ANZ Journal of Surgery

Volumn 85, Issue 6, 2015, Pages 425-429

  Sridhar, Parnandi ^a   Sistla, Sarath Chandra ^a   Ali, Sheik Manwar ^a   Karthikeyan, Vilvapathy Senguttuvan ^a   Badhe, Ashok Shankar ^a   Ananthanarayanan, Palghat Hariharan ^a  

^a JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Abdominal surgery; Ileus; Intravenous lignocaine; Post operative pain; Stress response

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER; C REACTIVE PROTEIN; IL6 PROTEIN, HUMAN; INTERLEUKIN 6; LIDOCAINE;

ADOLESCENT; ADULT; AGED; BLOOD; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ADMINISTRATION; DRUG EFFECTS; ELECTIVE SURGERY; FEMALE; HUMAN; ILEUS; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE COUNT; MALE; METABOLISM; MIDDLE AGED; PAIN, POSTOPERATIVE; PHYSIOLOGICAL STRESS; PHYSIOLOGY; POSTOPERATIVE COMPLICATIONS; POSTOPERATIVE NAUSEA AND VOMITING; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANALGESICS; ANTI-INFLAMMATORY AGENTS; BIOMARKERS; C-REACTIVE PROTEIN; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ELECTIVE SURGICAL PROCEDURES; FEMALE; HUMANS; ILEUS; INFUSIONS, INTRAVENOUS; INTERLEUKIN-6; LEUKOCYTE COUNT; LIDOCAINE; MALE; MIDDLE AGED; PAIN, POSTOPERATIVE; POSTOPERATIVE COMPLICATIONS; POSTOPERATIVE NAUSEA AND VOMITING; STRESS, PHYSIOLOGICAL; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84930181702     PISSN: 14451433     EISSN: 14452197     Source Type: Journal    
DOI: 10.1111/ans.12783     Document Type: Article

References (17)

1. Herroeder S, Pecher S, Schönherr ME etal. Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann. Surg. 2007; 246: 192-200.
2. Yeager MP, Colacchio TA, Yu CT etal. Morphine inhibits spontaneous and cytokine-enhanced natural killer cell cytotoxicity in volunteers. Anesthesiology 1995; 83: 500-508.
3. Moore CM, Desborough JP, Powell H, Burrin JM, Hall GM. Effects of extradural anaesthesia on interleukin-6 and acute phase response to surgery. Br. J. Anaesth. 1994; 72: 272-279.
4. Kücükakin B, Lykkesfeldt J, Nielsen HJ, Reiter RJ, Rosenberg J, Gögenur I. Utility of melatonin to treat surgical stress after major vascular surgery - a safety study. J. Pineal Res. 2008; 44: 426-431.
5. Bisgaard T, Klarskov B, Kehlet H, Rosenberg J. Preoperative dexamethasone improves surgical outcome after laparoscopic cholecystectomy: a randomized double-blind placebo-controlled trial. Ann. Surg. 2003; 238: 651-660.
6. Kuo CP, Jao SW, Chen KM etal. Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br. J. Anaesth. 2006; 97: 640-646.
7. Koppert W, Weigand M, Neumann F etal. Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery. Anesth. Analg. 2004; 98: 1050-1055.
8. Rimbäck G, Cassuto J, Tollesson PO. Treatment of postoperative paralytic ileus by intravenous lidocaine infusion. Anesth. Analg. 1990; 70: 414-419.
9. Groudine SB, Fisher HA, Kaufman RP Jr etal. Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy. Anesth. Analg. 1998; 86: 235-239.
10. Harvey KP, Adair JD, Isho M, Robinson R. Can intravenous lidocaine decrease postsurgical ileus and shorten hospital stay in elective bowel surgery? A pilot study and literature review. Am. J. Surg. 2009; 198: 231-236.
11. Cassuto J, Wallin G, Högström S, Faxén A, Rimbäck G. Inhibition of postoperative pain by continuous low-dose intravenous infusion of lidocaine. Anesth. Analg. 1985; 64: 971-974.
12. Desborough JP. The stress response to trauma and surgery. Br. J. Anaesth. 2000; 85: 109-117.
13. Kaba A, Laurent SR, Detroz BJ etal. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology 2007; 106: 11-18.
14. Yardeni IZ, Beilin B, Mayburd E, Levinson Y, Bessler H. The effect of perioperative intravenous lidocaine on postoperative pain and immune function. Anesth. Analg. 2009; 109: 1464-1469.
15. Wu C-T, Borel CO, Lee M-S etal. The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy. Anesth. Analg. 2005; 100: 448-453.
16. Wuethrich PY, Romero J, Burkhard FC, Curatolo M. No benefit from perioperative intravenous lidocaine in laparoscopic renal surgery: a randomised, placebo-controlled study. Eur. J. Anaesthesiol. 2012; 29: 537-543.
17. Grady MV, Mascha E, Sessler DI, Kurz A. The effect of perioperative intravenous lidocaine and ketamine on recovery after abdominal hysterectomy. Anesth. Analg. 2012; 115: 1078-1084.