-
3
-
-
84889817038
-
New insights into the dementia epidemic
-
4130738 1:CAS:528:DC%2BC3sXhvFKhtbzL 24283198
-
Larson EB, Yaffe K, Langa KM. New insights into the dementia epidemic. N Engl J Med. 2013;369(24):2275-7.
-
(2013)
N Engl J Med.
, vol.369
, Issue.24
, pp. 2275-2277
-
-
Larson, E.B.1
Yaffe, K.2
Langa, K.M.3
-
4
-
-
84903947419
-
Alzheimer's disease drug-development pipeline: Few candidates, frequent failures
-
4095696 25024750
-
Cummings JL, Morstorf T, Zhong K. Alzheimer's disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther. 2014;6(4):37.
-
(2014)
Alzheimers Res Ther.
, vol.6
, Issue.4
, pp. 37
-
-
Cummings, J.L.1
Morstorf, T.2
Zhong, K.3
-
5
-
-
70349103713
-
Memantine
-
1:CAS:528:DC%2BD1MXhsVOgtr%2FP 19739697
-
McKeage K. Memantine. CNS Drugs. 2009;23(10):881-97.
-
(2009)
CNS Drugs.
, vol.23
, Issue.10
, pp. 881-897
-
-
McKeage, K.1
-
7
-
-
0037417238
-
Memantine in moderate-to-severe Alzheimer's disease
-
1:CAS:528:DC%2BD3sXis1egt7k%3D 12672860
-
Reisberg B, Doody R, Stoffler A, et al. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med. 2003;348(14):1333-41.
-
(2003)
N Engl J Med.
, vol.348
, Issue.14
, pp. 1333-1341
-
-
Reisberg, B.1
Doody, R.2
Stoffler, A.3
-
8
-
-
34249873186
-
A 24-week randomized, controlled trial of memantine in patients with moderate-to-severe Alzheimer disease
-
17545739
-
van Dyck CH, Tariot PN, Meyers B, et al. A 24-week randomized, controlled trial of memantine in patients with moderate-to-severe Alzheimer disease. Alzheimer Dis Assoc Disord. 2007;21(2):136-43.
-
(2007)
Alzheimer Dis Assoc Disord.
, vol.21
, Issue.2
, pp. 136-143
-
-
Van Dyck, C.H.1
Tariot, P.N.2
Meyers, B.3
-
9
-
-
84863229484
-
Donepezil and memantine for moderate-to-severe Alzheimer's disease
-
1:CAS:528:DC%2BC38XktFOgtbs%3D 22397651
-
Howard R, McShane R, Lindesay J, et al. Donepezil and memantine for moderate-to-severe Alzheimer's disease. N Engl J Med. 2012;366(10):893-903.
-
(2012)
N Engl J Med.
, vol.366
, Issue.10
, pp. 893-903
-
-
Howard, R.1
McShane, R.2
Lindesay, J.3
-
10
-
-
0345872128
-
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
-
1:CAS:528:DC%2BD2cXmtlantA%3D%3D 14734594
-
Tariot PN, Farlow MR, Grossberg GT, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA. 2004;291(3):317-24.
-
(2004)
JAMA.
, vol.291
, Issue.3
, pp. 317-324
-
-
Tariot, P.N.1
Farlow, M.R.2
Grossberg, G.T.3
-
11
-
-
84872399089
-
Memantine in patients with Alzheimer's disease receiving donepezil: New analyses of efficacy and safety for combination therapy
-
3580327 1:CAS:528:DC%2BC3sXjs12msbk%3D 23336974
-
Atri A, Molinuevo JL, Lemming O, et al. Memantine in patients with Alzheimer's disease receiving donepezil: new analyses of efficacy and safety for combination therapy. Alzheimers Res Ther. 2013;5(1):6.
-
(2013)
Alzheimers Res Ther.
, vol.5
, Issue.1
, pp. 6
-
-
Atri, A.1
Molinuevo, J.L.2
Lemming, O.3
-
12
-
-
84962078301
-
Evidence for an additive effect of memantine and donepezil: Consistent conclusions from DOMINO-AD study and memantine clinical trial program (poster)
-
Hendrix S, Ellison N, Stanworth S, et al. Evidence for an additive effect of memantine and donepezil: consistent conclusions from DOMINO-AD study and memantine clinical trial program (poster). In: 7th clinical trials conference on Alzheimer's disease; 2014.
-
(2014)
7th Clinical Trials Conference on Alzheimer's Disease
-
-
Hendrix, S.1
Ellison, N.2
Stanworth, S.3
-
14
-
-
84876272836
-
Once-daily memantine: A guide to its use in moderate to severe Alzheimer's disease in the EU
-
1:CAS:528:DC%2BC3sXhvVWlsr7L 23229767
-
Lyseng-Williamson KA, McKeage K. Once-daily memantine: a guide to its use in moderate to severe Alzheimer's disease in the EU. Drugs Aging. 2013;30(1):51-8.
-
(2013)
Drugs Aging.
, vol.30
, Issue.1
, pp. 51-58
-
-
Lyseng-Williamson, K.A.1
McKeage, K.2
-
15
-
-
79959657881
-
Memantine: A treatment for Alzheimers disease with a new formulation
-
1:CAS:528:DC%2BC3MXns12ksLc%3D
-
Makino KM, Porsteinsson AP. Memantine: a treatment for Alzheimers disease with a new formulation. Aging Health. 2011;7(3):349-62.
-
(2011)
Aging Health.
, vol.7
, Issue.3
, pp. 349-362
-
-
Makino, K.M.1
Porsteinsson, A.P.2
-
16
-
-
84878842182
-
Slow excitotoxicity in Alzheimer's disease
-
Ong WY, Tanaka K, Dawe GS, et al. Slow excitotoxicity in Alzheimer's disease. J Alzheimers Dis. 2013;35(4):643-68.
-
(2013)
J Alzheimers Dis.
, vol.35
, Issue.4
, pp. 643-668
-
-
Ong, W.Y.1
Tanaka, K.2
Dawe, G.S.3
-
17
-
-
34547672741
-
Agonist concentration dependency of blocking kinetics but not equilibrium block of N-methyl-d-aspartate receptors by memantine
-
1:CAS:528:DC%2BD2sXovFers7s%3D 17632186
-
Gilling KE, Jatzke C, Parsons CG. Agonist concentration dependency of blocking kinetics but not equilibrium block of N-methyl-d-aspartate receptors by memantine. Neuropharmacology. 2007;53(3):415-20.
-
(2007)
Neuropharmacology.
, vol.53
, Issue.3
, pp. 415-420
-
-
Gilling, K.E.1
Jatzke, C.2
Parsons, C.G.3
-
18
-
-
33744500234
-
Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity
-
16817864
-
Volbracht C, van Beek J, Zhu C, et al. Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity. Eur J Neurosci. 2006;23(10):2611-22.
-
(2006)
Eur J Neurosci.
, vol.23
, Issue.10
, pp. 2611-2622
-
-
Volbracht, C.1
Van Beek, J.2
Zhu, C.3
-
19
-
-
84883459353
-
Memantine and cholinesterase inhibitors: Complementary mechanisms in the treatment of Alzheimer's disease
-
3753463 1:CAS:528:DC%2BC3sXhtlGmur7F 23657927
-
Parsons CG, Danysz W, Dekundy A, et al. Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease. Neurotox Res. 2013;24(3):358-69.
-
(2013)
Neurotox Res.
, vol.24
, Issue.3
, pp. 358-369
-
-
Parsons, C.G.1
Danysz, W.2
Dekundy, A.3
-
20
-
-
84863600343
-
A study of potential pharmacokinetic and pharmacodynamic interactions between dextromethorphan/quinidine and memantine in healthy volunteers
-
22712629
-
Pope LE, Schoedel KA, Bartlett C, et al. A study of potential pharmacokinetic and pharmacodynamic interactions between dextromethorphan/quinidine and memantine in healthy volunteers. Clin Drug Investig. 2012;32(8):e1-15.
-
(2012)
Clin Drug Investig.
, vol.32
, Issue.8
, pp. 1-e15
-
-
Pope, L.E.1
Schoedel, K.A.2
Bartlett, C.3
-
21
-
-
84879297248
-
The safety, tolerability, and efficacy of once-daily memantine (28 mg): A multinational, randomized, double-blind, placebo-controlled trial in patients with moderate-to-severe Alzheimer's disease taking cholinesterase inhibitors
-
3680656 1:CAS:528:DC%2BC3sXhvVSmtrvI 23733403
-
Grossberg GT, Manes F, Allegri RF, et al. The safety, tolerability, and efficacy of once-daily memantine (28 mg): a multinational, randomized, double-blind, placebo-controlled trial in patients with moderate-to-severe Alzheimer's disease taking cholinesterase inhibitors. CNS Drugs. 2013;27(6):469-78.
-
(2013)
CNS Drugs.
, vol.27
, Issue.6
, pp. 469-478
-
-
Grossberg, G.T.1
Manes, F.2
Allegri, R.F.3
-
22
-
-
84962080435
-
Clinical benefits of extended-release memantine (28 mg, once daily) as a function of disease severity in people with moderate to severe Alzheimer's disease: Post hoc analysis from a randomized trial (abstract no. P3-271 plus poster)
-
Tocco M, Hendrix S, Miller M, et al. Clinical benefits of extended-release memantine (28 mg, once daily) as a function of disease severity in people with moderate to severe Alzheimer's disease: post hoc analysis from a randomized trial (abstract no. P3-271 plus poster). Alzheimers Dement. 2013;9(4 Suppl.):P655.
-
(2013)
Alzheimers Dement.
, vol.9
, Issue.4
, pp. 655
-
-
Tocco, M.1
Hendrix, S.2
Miller, M.3
-
23
-
-
84991621533
-
Response across multiple outcome measures in a randomized trial of extended-release memantine (28 mg once daily) in patients with moderate-to-severe Alzheimer's disease (abstract no. P3-386 plus poster)
-
Graham S, Hendrix S, Miller M, et al. Response across multiple outcome measures in a randomized trial of extended-release memantine (28 mg once daily) in patients with moderate-to-severe Alzheimer's disease (abstract no. P3-386 plus poster). Alzheimers Dement. 2012;8(4 Suppl.):P591.
-
(2012)
Alzheimers Dement.
, vol.8
, Issue.4
, pp. 591
-
-
Graham, S.1
Hendrix, S.2
Miller, M.3
-
24
-
-
84962121032
-
Cumulative benefits of extended-release memantine (28 mg, once daily) across clinical domains in patients with moderate to severe alzheimer's disease: An area under the curve analysis (abstract no. NR 16 plus poster)
-
Atri A, Tocco M, Hendrix S, et al. Cumulative benefits of extended-release memantine (28 mg, once daily) across clinical domains in patients with moderate to severe alzheimer's disease: an area under the curve analysis (abstract no. NR 16 plus poster). Am J Geriatr Psychiatry. 2014;22(3, Suppl.):S120-S1.
-
(2014)
Am J Geriatr Psychiatry
, vol.22
, Issue.3
, pp. S120-S1
-
-
Atri, A.1
Tocco, M.2
Hendrix, S.3
-
25
-
-
84962121210
-
Effects of extended-release memantine (28 mg, once daily) on cognitive domains in patients with moderate to severe Alzheimer's disease: Post hoc analysis of a randomized trial (abstract no. 26 plus poster)
-
Tocco M, Hendrix S, Miller M, et al. Effects of extended-release memantine (28 mg, once daily) on cognitive domains in patients with moderate to severe Alzheimer's disease: post hoc analysis of a randomized trial (abstract no. 26 plus poster). Consult Pharm. 2011;26(10):750.
-
(2011)
Consult Pharm.
, vol.26
, Issue.10
, pp. 750
-
-
Tocco, M.1
Hendrix, S.2
Miller, M.3
-
26
-
-
84962048063
-
Sustained cognitive improvement with extended-release memantine (28 mg, once daily) in moderate to severe Alzheimer's disease (abstract no. M1116 plus poster)
-
Tocco M, Hendrix S, Miller ML, et al. Sustained cognitive improvement with extended-release memantine (28 mg, once daily) in moderate to severe Alzheimer's disease (abstract no. M1116 plus poster). Ann Neurol. 2012;72(Suppl. 16):S42.
-
(2012)
Ann Neurol.
, vol.72
, pp. 42
-
-
Tocco, M.1
Hendrix, S.2
Miller, M.L.3
-
27
-
-
84962048060
-
Extended-release memantine (28 mg, once daily) provides behavioral benefits across a wide range of disease severity in patients with moderate to severe Alzheimer's disease: Post hoc analysis from a randomized trial (abstract no. NR 16 plus poster)
-
Graham SM, Hendrix S, Miller ML, et al. Extended-release memantine (28 mg, once daily) provides behavioral benefits across a wide range of disease severity in patients with moderate to severe Alzheimer's disease: post hoc analysis from a randomized trial (abstract no. NR 16 plus poster). Am J Geriatr Psychiatry. 2013;21(3):S139.
-
(2013)
Am J Geriatr Psychiatry.
, vol.21
, Issue.3
, pp. 139
-
-
Graham, S.M.1
Hendrix, S.2
Miller, M.L.3
-
28
-
-
84962075541
-
Extended-release memantine (28 mg, once daily) and sustained behavioral improvement: Post hoc responder analysis from a randomized trial in patients with moderate to severe Alzheimer's disease (abstract no. P04.197 plus poster)
-
Cummings J, Hendrix S, Miller M, et al. Extended-release memantine (28 mg, once daily) and sustained behavioral improvement: post hoc responder analysis from a randomized trial in patients with moderate to severe Alzheimer's disease (abstract no. P04.197 plus poster). Neurology. 2012;78.
-
(2012)
Neurology
, pp. 78
-
-
Cummings, J.1
Hendrix, S.2
Miller, M.3
-
29
-
-
84962104916
-
Effects of extended-release memantine (28 mg, once daily) on language and communication abilities in patients with moderate to severe Alzheimer's disease (abstract no. M1156 plus poster)
-
Tocco M, Hendrix S, Miller ML, et al. Effects of extended-release memantine (28 mg, once daily) on language and communication abilities in patients with moderate to severe Alzheimer's disease (abstract no. M1156 plus poster). Ann Neurol. 2012;72(Suppl. 16):S52-3.
-
(2012)
Ann Neurol.
, vol.72
, pp. 52-S53
-
-
Tocco, M.1
Hendrix, S.2
Miller, M.L.3
-
30
-
-
84962118392
-
Efficacy of extended-release memantine (28 mg, once daily): Post hoc responder analysis from a randomized trial in patients with moderate to severe Alzheimer's disease (abstract no. 27 plus poster)
-
Graham SM, Hendrix S, Miller ML, et al. Efficacy of extended-release memantine (28 mg, once daily): post hoc responder analysis from a randomized trial in patients with moderate to severe Alzheimer's disease (abstract no. 27 plus poster). Consult Pharm. 2011;26(10):750.
-
(2011)
Consult Pharm.
, vol.26
, Issue.10
, pp. 750
-
-
Graham, S.M.1
Hendrix, S.2
Miller, M.L.3
-
31
-
-
84962100151
-
Effects of extended-release memantine (28 mg, once daily) on individual activities of daily living in patients with moderate to severe Alzheimer's disease: Post hoc factor analysis of a randomized trial (abstract no. 20 plus poster)
-
Tocco M, Hendrix S, Miller ML, et al. Effects of extended-release memantine (28 mg, once daily) on individual activities of daily living in patients with moderate to severe Alzheimer's disease: post hoc factor analysis of a randomized trial (abstract no. 20 plus poster). Consult Pharm. 2011;26(10):747.
-
(2011)
Consult Pharm.
, vol.26
, Issue.10
, pp. 747
-
-
Tocco, M.1
Hendrix, S.2
Miller, M.L.3
-
32
-
-
84962121211
-
Efficacy and tolerability of memantine extended release added to stable donepezil regimen in individuals with moderate to severe Alzheimer's disease: Subset analysis of a randomized clinical trial (abstract no. P1-370 plus poster)
-
Grossberg G, Alva G, Hendrix S, et al. Efficacy and tolerability of memantine extended release added to stable donepezil regimen in individuals with moderate to severe Alzheimer's disease: subset analysis of a randomized clinical trial (abstract no. P1-370 plus poster). Alzheimers Dement. 2014;10(4):P450.
-
(2014)
Alzheimers Dement.
, vol.10
, Issue.4
, pp. 450
-
-
Grossberg, G.1
Alva, G.2
Hendrix, S.3
-
33
-
-
84962098111
-
Adding memantine to cholinesterase inhibitor treatment stabilizes or improves low to moderate agitation in patients with moderate to severe Alzheimer's disease: Post hoc analysis of five randomized trials (poster no. LB 54)
-
Hendrix S, Ellison N, Pejovic V, et al. Adding memantine to cholinesterase inhibitor treatment stabilizes or improves low to moderate agitation in patients with moderate to severe Alzheimer's disease: post hoc analysis of five randomized trials (poster no. LB 54). In: Annual meeting of the American Association for Geriatric Psychiatry. 2015.
-
(2015)
Annual Meeting of the American Association for Geriatric Psychiatry
-
-
Hendrix, S.1
Ellison, N.2
Pejovic, V.3
-
34
-
-
84962129888
-
Adding memantine to stable cholinesterase inhibitor therapy in patients with moderate to severe Alzheimer's disease is associated with improvement in various neuropsychiatric symptoms: A pooled analysis (poster no. LB 55)
-
Hendrix S, Ellison N, Pejovic V, et al. Adding memantine to stable cholinesterase inhibitor therapy in patients with moderate to severe Alzheimer's disease is associated with improvement in various neuropsychiatric symptoms: a pooled analysis (poster no. LB 55). In: Annual meeting of the American Association for Geriatric Psychiatry. 2015.
-
(2015)
Annual Meeting of the American Association for Geriatric Psychiatry
-
-
Hendrix, S.1
Ellison, N.2
Pejovic, V.3
-
35
-
-
84962071573
-
Effects of add-on memantine on daily functioning in patients with moderate to severe Alzheimer's disease receiving stable donepezil treatment (poster)
-
Hendrix S, Ellison N, Pejovic V, et al. Effects of add-on memantine on daily functioning in patients with moderate to severe Alzheimer's disease receiving stable donepezil treatment (poster). In: 12th international conference on Alzheimer's and Parkinson's Diseases. 2015.
-
(2015)
12th International Conference on Alzheimer's and Parkinson's Diseases
-
-
Hendrix, S.1
Ellison, N.2
Pejovic, V.3
-
36
-
-
41049104686
-
Current pharmacologic treatment of dementia: A clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians
-
18316755
-
Qaseem A, Snow V, Cross JT Jr, et al. Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Ann Intern Med. 2008;148(5):370-8.
-
(2008)
Ann Intern Med.
, vol.148
, Issue.5
, pp. 370-378
-
-
Qaseem, A.1
Snow, V.2
Cross, Jr.J.T.3
-
37
-
-
84864302966
-
High-dose donepezil or memantine: Next step for Alzheimer's disease?
-
Singh I, Grossberg GT. High-dose donepezil or memantine: next step for Alzheimer's disease? Current Psychiatry. 2012;11(6):20.
-
(2012)
Current Psychiatry.
, vol.11
, Issue.6
, pp. 20
-
-
Singh, I.1
Grossberg, G.T.2
-
40
-
-
84863669083
-
Memantine and cholinesterase inhibitor combination therapy for Alzheimer's disease: A systematic review
-
3378937 22689908
-
Farrimond LE, Roberts E, McShane R. Memantine and cholinesterase inhibitor combination therapy for Alzheimer's disease: a systematic review. BMJ Open. 2012;2(3):e000917.
-
(2012)
BMJ Open.
, vol.2
, Issue.3
, pp. 000917
-
-
Farrimond, L.E.1
Roberts, E.2
McShane, R.3
-
41
-
-
84962114349
-
Cost-effectiveness of memantine extended release for treatment of moderate-to-severe Alzheimer's disease in the United States (abstract no. P2-320 plus poster)
-
Thibault CSL, Stillman IO, Chen S, et al. Cost-effectiveness of memantine extended release for treatment of moderate-to-severe Alzheimer's disease in the United States (abstract no. P2-320 plus poster). Alzheimers Dement. 2014;10(4 Suppl.):P596-P7.
-
(2014)
Alzheimers Dement.
, vol.10
, Issue.4
, pp. P596-P7
-
-
Thibault, C.S.L.1
Stillman, I.O.2
Chen, S.3
-
42
-
-
84887489111
-
Long-term associations between cholinesterase inhibitors and memantine use and health outcomes among patients with Alzheimer's disease
-
23332671
-
Zhu CW, Livote EE, Scarmeas N, et al. Long-term associations between cholinesterase inhibitors and memantine use and health outcomes among patients with Alzheimer's disease. Alzheimers Dement. 2013;9(6):733-40.
-
(2013)
Alzheimers Dement.
, vol.9
, Issue.6
, pp. 733-740
-
-
Zhu, C.W.1
Livote, E.E.2
Scarmeas, N.3
-
43
-
-
52649127458
-
Long-term course and effectiveness of combination therapy in Alzheimer disease
-
2718545 1:CAS:528:DC%2BD1cXhtVOiu7%2FE 18580597
-
Atri A, Shaughnessy LW, Locascio JJ, et al. Long-term course and effectiveness of combination therapy in Alzheimer disease. Alzheimer Dis Assoc Disord. 2008;22(3):209-21.
-
(2008)
Alzheimer Dis Assoc Disord.
, vol.22
, Issue.3
, pp. 209-221
-
-
Atri, A.1
Shaughnessy, L.W.2
Locascio, J.J.3
-
44
-
-
66149095869
-
Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
-
2823571 1:STN:280:DC%2BD1Mzksl2ksg%3D%3D 19204022
-
Lopez OL, Becker JT, Wahed AS, et al. Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease. J Neurol Neurosurg Psychiatry. 2009;80(6):600-7.
-
(2009)
J Neurol Neurosurg Psychiatry.
, vol.80
, Issue.6
, pp. 600-607
-
-
Lopez, O.L.1
Becker, J.T.2
Wahed, A.S.3
-
45
-
-
77951874698
-
Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease
-
2874259 19845950
-
Rountree SD, Chan W, Pavlik VN, et al. Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease. Alzheimers Res Ther. 2009;1(2):7.
-
(2009)
Alzheimers Res Ther.
, vol.1
, Issue.2
, pp. 7
-
-
Rountree, S.D.1
Chan, W.2
Pavlik, V.N.3
|