A teaching intervention in a contouring dummy run improved target volume delineation in locally advanced non-small cell lung cancer: Reducing the interobserver variability in multicentre clinical studies;Verbesserung der Zielvolumendefinition durch einen Dummy Run mit interventionellem Konturierungstraining beim lokal fortgeschrittenen nicht-kleinzelligen Lungenkarzinom: Reduktion der Interobserver-Variabilität in klinischen Multizenterstudien

Strahlentherapie und Onkologie

Volumn 191, Issue 6, 2015, Pages 525-533

  Schimek Jasch, Tanja ^a,d   Troost, Esther G C ^b   Rücker, Gerta ^a   Prokic, Vesna ^a,d   Avlar, Melanie ^d   Duncker Rohr, Viola ^c   Mix, Michael ^a,d   Doll, Christian ^a,d   Grosu, Anca Ligia ^a,d   Nestle, Ursula ^a,d  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c Klinikum Offenburg   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Dummy Run; nodal irradiation; Positron emission tomography; Radiochemotherapy; Target volume definition

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADVANCED CANCER; ARTICLE; CANCER RADIOTHERAPY; CANCER STAGING; CASE REPORT; CLINICAL EDUCATION; COMPUTED TOMOGRAPHY SCANNER; DUMMY RUN CONTOUR; FEMALE; HUMAN; LUNG ADENOCARCINOMA; MULTICENTER STUDY (TOPIC); PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIMARY TUMOR; PROTOCOL COMPLIANCE; RADIATION ONCOLOGIST; RADIOLOGICAL PARAMETERS; RADIOTHERAPY PLANNING SYSTEM; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; TARGET VOLUME DELINEATION; AUDIOVISUAL EQUIPMENT; CARCINOMA, NON-SMALL-CELL LUNG; CLINICAL COMPETENCE; CLINICAL TRIAL; COMPUTER ASSISTED RADIOTHERAPY; EDUCATION; GERMANY; LUNG NEOPLASMS; MULTICENTER STUDY; NETHERLANDS; OBSERVER VARIATION; ONCOLOGY; PATHOLOGY; PROCEDURES; RADIATION DOSE; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; TUMOR VOLUME;

CARCINOMA, NON-SMALL-CELL LUNG; CLINICAL COMPETENCE; GERMANY; HUMANS; LUNG NEOPLASMS; MANIKINS; NETHERLANDS; OBSERVER VARIATION; RADIATION ONCOLOGY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TUMOR BURDEN;

EID: 84930088926     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-015-0812-8     Document Type: Article

References (33)

1. WHO (2014) World Health Organization. World cancer factsheet January 2014: world cancer burden (2012). Accessed 6 Nov. 2014
2. Auperin A, Le Pechoux C, Rolland E, Curran WJ, Furuse K, Fournel P, Belderbos J, Clamon G, Ulutin HC, Paulus R, Yamanaka T, Bozonnat MC, Uitterhoeve A, Wang X, Stewart L, Arriagada R, Burdett S, Pignon JP (2010) Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol 28:2181–2190. doi:10.1200/JCO.2009.26.2543
3. Goeckenjan G, Sitter H, Thomas M, Branscheid D, Flentje M, Griesinger F, Niederle N, Stuschke M, Blum T, Deppermann KM, Ficker JH, Freitag L, Lubbe AS, Reinhold T, Spath-Schwalbe E, Ukena D, Wickert M, Wolf M, Andreas S, Auberger T, Baum RP, Baysal B, Beuth J, Bickeboller H, Bocking A, Bohle RM, Bruske I, Burghuber O, Dickgreber N, Diederich S, Dienemann H, Eberhardt W, Eggeling S, Fink T, Fischer B, Franke M, Friedel G, Gauler T, Gutz S, Hautmann H, Hellmann A, Hellwig D, Herth F, Heussel CP, Hilbe W, Hoffmeyer F, Horneber M, Huber RM, Hubner J, Kauczor HU, Kirchbacher K, Kirsten D, Kraus T, Lang SM, Martens U, Mohn-Staudner A, Muller KM, Muller-Nordhorn J, Nowak D, Ochmann U, Passlick B, Petersen I, Pirker R, Pokrajac B, Reck M, Riha S, Rube C, Schmittel A, Schonfeld N, Schutte W, Serke M, Stamatis G, Steingraber M, Steins M, Stoelben E, Swoboda L, Teschler H, Tessen HW, Weber M, Werner A, Wichmann HE, Irlinger Wimmer E, Witt C, Worth H, German Respiratory S, German Cancer S (2011) Prevention, diagnosis, therapy, and follow-up of lung cancer: interdisciplinary guideline of the German Respiratory Society and the German Cancer Society. Pneumologie 65:39–59. doi:10.1055/s-0030-1255961
4. Fleckenstein J, Hellwig D, Kremp S, Grgic A, Groschel A, Kirsch CM, Nestle U, Rube C (2011) F-18-FDG-PET confined radiotherapy of locally advanced NSCLC with concomitant chemotherapy: results of the PET-PLAN pilot trial. International journal of radiation oncology, biology, physics. 81:e283–e289. doi:10.1016/j.ijrobp.2011.01.020
5. van Baardwijk A, Wanders S, Boersma L, Borger J, Ollers M, Dingemans AM, Bootsma G, Geraedts W, Pitz C, Lunde R, Lambin P, De Ruysscher D (2010) Mature results of an individualized radiation dose prescription study based on normal tissue constraints in stages I to III non-small-cell lung cancer. J Clin Oncol 28:1380–1386. doi:10.1200/JCO.2009.24.7221
6. Hoffmann AL, Troost EG, Huizenga H, Kaanders JH, Bussink J (2012) Individualized dose prescription for hypofractionation in advanced non-small-cell lung cancer radiotherapy: an in silico trial. International journal of radiation oncology, biology, physics. Int J Radiat Oncol Biol Phys 83:1596–1602. doi:10.1016/j.ijrobp.2011.10.032
7. van Elmpt W, De Ruysscher D, van der Salm A, Lakeman A, van der Stoep J, Emans D, Damen E, Ollers M, Sonke JJ, Belderbos J (2012) The PET-boost randomised phase II dose-escalation trial in non-small cell lung cancer. Radiother Oncol 104:67–71. doi:10.1016/j.radonc.2012.03.005
8. Nestle U, Kremp S, Grosu AL (2006) Practical integration of [18F]-FDG-PET and PET-CT in the planning of radiotherapy for non-small cell lung cancer (NSCLC): the technical basis, ICRU-target volumes, problems, perspectives. Radiother Oncol 81:209–225. doi:10.1016/j.radonc.2006.09.011
9. MacManus M, Nestle U, Rosenzweig KE, Carrio I, Messa C, Belohlavek O, Danna M, Inoue T, Deniaud-Alexandre E, Schipani S, Watanabe N, Dondi M, Jeremic B (2009) Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006–2007. Radiother Oncol 91:85–94. doi:10.1016/j.radonc.2008.11.008
10. Belderbos JS, Heemsbergen WD, De Jaeger K, Baas P, Lebesque JV (2006) Final results of a Phase I/II dose escalation trial in non-small-cell lung cancer using three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 66:126–134. doi:10.1016/j.ijrobp.2006.04.034
11. De Ruysscher D, Wanders S, van Haren E, Hochstenbag M, Geeraedts W, Utama I, Simons J, Dohmen J, Rhami A, Buell U, Thimister P, Snoep G, Boersma L, Verschueren T, van Baardwijk A, Minken A, Bentzen SM, Lambin P (2005) Selective mediastinal node irradiation based on FDG-PET scan data in patients with non-small-cell lung cancer: a prospective clinical study. Int J Radiat Oncol Biol Phys 62:988–994. doi:10.1016/j.ijrobp.2004.12.019
12. Caldwell CB, Mah K, Ung YC, Danjoux CE, Balogh JM, Ganguli SN, Ehrlich LE (2001) Observer variation in contouring gross tumor volume in patients with poorly defined non-small-cell lung tumors on CT: the impact of 18FDG-hybrid PET fusion. Int J Radiat Oncol Biol Phys 51:923–931
13. Nestle U, Weber W, Hentschel M, Grosu AL (2009) Biological imaging in radiation therapy: role of positron emission tomography. Phys Med Biol 54:R1–R25. doi:10.1088/0031-9155/54/1/R01
14. Steenbakkers RJ, Duppen JC, Fitton I, Deurloo KE, Zijp LJ, Comans EF, Uitterhoeve AL, Rodrigus PT, Kramer GW, Bussink J, De Jaeger K, Belderbos JS, Nowak PJ, van Herk M, Rasch CR (2006) Reduction of observer variation using matched CT-PET for lung cancer delineation: a three-dimensional analysis. Int J Radiat Oncol Biol Phys 64:435–448. doi:10.1016/j.ijrobp.2005.06.034
15. Nestle U, Mix M, Weber W, Grosu AL (2011) Klinische Studien zum Einsatz der PET in der Bestrahlungsplanung in Deutschland: Ein Update. Nuklearmediziner 34:130–132. doi:10.1055/s-0031-1280790
16. Schimek-Jasch T, Küsters A, Hoffmans H, Nestle U (2014) Optimierung der Strahlentherapieplanung bei lokal fortgeschrittenen NSCLC durch 18F-FDG PET-CT: Stand der PET-Plan-Studie. Nuklearmediziner 37:175–180. doi:10.1055/s-0034-1376972
17. Djarv E, Nyman J, Baumann P, Ekberg L, Hoyer M, Lax I, Lewensohn R, Levin N, Lund JA, Morhed E, Ericsson SR, Traberg A, Wittgren L, Johansson KA (2006) Dummy run for a phase II study of stereotactic body radiotherapy of T1-T2 N0M0 medical inoperable non-small cell lung cancer. Acta Oncol 45:973–977. doi:10.1080/02841860600919241
18. Foppiano F, Fiorino C, Frezza G, Greco C, Valdagni R, Radiotherapy ANWGoP (2003) The impact of contouring uncertainty on rectal 3D dose-volume data: results of a dummy run in a multicenter trial (AIROPROS01-02). Int J Radiat Oncol Biol Phys 57:573–579
19. Giraud P, Elles S, Helfre S, De Rycke Y, Servois V, Carette MF, Alzieu C, Bondiau PY, Dubray B, Touboul E, Housset M, Rosenwald JC, Cosset JM (2002) Conformal radiotherapy for lung cancer: different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologists. Radiother Oncol 62:27–36
20. Matzinger O, Poortmans P, Giraud JY, Maingon P, Budiharto T, van den Bergh AC, Davis JB, Musat E, Ataman F, Huyskens DP, Gulyban A, Bolla M, Group ERO (2009) Quality assurance in the 22991 EORTC ROG trial in localized prostate cancer: dummy run and individual case review. Radiother Oncol 90:285–290. doi:10.1016/j.radonc.2008.10.022
21. Poortmans PM, Venselaar JL, Struikmans H, Hurkmans CW, Davis JB, Huyskens D, van Tienhoven G, Vlaun V, Lagendijk JJ, Mijnheer BJ, De Winter KA, Van der Hulst MH, Van den Bogaert WF (2001) The potential impact of treatment variations on the results of radiotherapy of the internal mammary lymph node chain: a quality-assurance report on the dummy run of EORTC Phase III randomized trial 22922/10925 in Stage I-III breast cancer(1). Int J Radiat Oncol Biol Phys 49:1399–1408
22. Spoelstra FO, Senan S, Le Pechoux C, Ishikura S, Casas F, Ball D, Price A, De Ruysscher D, van Sornsen de Koste JR, Lung Adjuvant Radiotherapy Trial Investigators G (2010) Variations in target volume definition for postoperative radiotherapy in stage III non-small-cell lung cancer: analysis of an international contouring study. Int J Radiat Oncol Biol Phys 76:1106–1113. doi:10.1016/j.ijrobp.2009.02.072
23. Senan S, van Sornsen de Koste J, Samson M, Tankink H, Jansen P, Nowak PJ, Krol AD, Schmitz P, Lagerwaard FJ (1999) Evaluation of a target contouring protocol for 3D conformal radiotherapy in non-small cell lung cancer. Radiother Oncol 53:247–255
24. Senan S, Le Pechoux C, Spoelstra FO, Ishikura S, Casas F, Ball D, Price A, De Ruysscher D, van Sörnsen de Koste JR (2007) A need to standardize post-operative radiotherapy (PORT) fields used for non-small cell lung cancer (NSCLC): analysis of an international dummy-run study: A1–02. J Thorac Oncol 2:S308–S309
25. Valley JF, Bernier J, Tercier PA, Fogliata-Cozzi A, Rosset A, Garavaglia G, Mirimanoff RO (1998) Quality assurance of the EORTC radiotherapy trial 22931 for head and neck carcinomas: the dummy run. Radiother Oncol 47:37–44
26. Van de Steene J, Linthout N, de Mey J, Vinh-Hung V, Claassens C, Noppen M, Bel A, Storme G (2002) Definition of gross tumor volume in lung cancer: inter-observer variability. Radiother Oncol 62:37–49
27. Vorwerk H, Beckmann G, Bremer M, Degen M, Dietl B, Fietkau R, Gsanger T, Hermann RM, Alfred Herrmann MK, Holler U, van Kampen M, Korber W, Maier B, Martin T, Metz M, Richter R, Siekmeyer B, Steder M, Wagner D, Hess CF, Weiss E, Christiansen H (2009) The delineation of target volumes for radiotherapy of lung cancer patients. Radiother Oncol 91:455–460. doi:10.1016/j.radonc.2009.03.014
28. Schaefer A, Nestle U, Kremp S, Hellwig D, Grgic A, Buchholz HG, Mischke W, Gromoll C, Dennert P, Plotkin M, Senftleben S, Thorwarth D, Tosch M, Wahl A, Wengenmair H, Rube C, Kirsch CM (2012) Multi-centre calibration of an adaptive thresholding method for PET-based delineation of tumour volumes in radiotherapy planning of lung cancer. Nuklearmedizin 51:101–110. doi:10.3413/Nukmed-0452-11-12
29. Schaefer A, Kremp S, Hellwig D, Rube C, Kirsch CM, Nestle U (2008) A contrast-oriented algorithm for FDG-PET-based delineation of tumour volumes for the radiotherapy of lung cancer: derivation from phantom measurements and validation in patient data. Eur J Nucl Med Mol Imaging 35:1989–1999. doi:10.1007/s00259-008-0875-1
30. Chapet O, Kong FM, Quint LE, Chang AC, Ten Haken RK, Eisbruch A, Hayman JA (2005) CT-based definition of thoracic lymph node stations: an atlas from the University of Michigan. Int J Radiat Oncol Biol Phys 63:170–178. doi:10.1016/j.ijrobp.2004.12.060
31. Giraud P, De Rycke Y, Lavole A, Milleron B, Cosset JM, Rosenzweig KE (2006) Probability of mediastinal involvement in non-small-cell lung cancer: a statistical definition of the clinical target volume for 3-dimensional conformal radiotherapy? Int J Radiat Oncol Biol Phys 64:127–135. doi:10.1016/j.ijrobp.2005.06.043
32. Rucker G, Schimek-Jasch T, Nestle U (2012) Measuring inter-observer agreement in contour delineation of medical imaging in a dummy run using Fleissʼ kappa. Methods Inf Med 51:489–494. doi:10.3414/ME12-01-0005
33. Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174