Resveratrol Inhibits Proliferation and Induces Apoptosis of Pathological Scar Fibroblasts Through the Mechanism Involving TGF-β1/Smads Signaling Pathway

Cell Biochemistry and Biophysics

Volumn 71, Issue 3, 2015, Pages 1267-1272

  Zhai, Xiao xiang ^a   Ding, Ji cun ^b   Tang, Zhi ming ^a  

^a Department of Radiology   (China)

^b XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

Fibroblasts; Pathological scar; Resveratrol; TGF 1 Smads signaling pathway

Indexed keywords

MESSENGER RNA; RESVERATROL; SMAD PROTEIN; STILBENE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; CELL PROLIFERATION; CICATRIX; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL PROLIFERATION; CICATRIX; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD PROTEINS; STILBENES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84930088048     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-014-0317-6     Document Type: Article

References (10)

1. Zhang, Z. F., Zhu, F., Xiao, L., Wang, M., Tian, R., Shi, C. J., et al. (2011). Side population cells in the human gallbladder cancer cell line GBC-SD are regulated by TGF-β-induced epithelial–mesenchymal transition. Journal of Huazhong University of Science and Technology,2011(31), 749–755.
2. Zhao, K. S. (2012). Biological features and effects of resveratrol. Chinese Journal of Pathophysiology,2012(28), 1709–1711.
3. Ma, S. T., Yang, D. C., Tang, B., Li, D., Li, G., & Yang, Y. J. (2012). Resveratrol resists alcoholic myocardial fibrosis by inhibiting the matrix metalloproteinases. Chinese Journal of Arteriosclerosis,2012(20), 21–24.
4. Vieira de Almeida, L. M., Pineiro, C. C., Brolese, G., Leal, R. B., Gottfried, C., & Goncalves, C. A. (2008). Protective effects of resveratrol on hydrogen peroxide-induced toxicity in primary cortical astrocyte culture. Neurochemical Research,2008(33), 8–15.
5. Ding, J. C., Zhai, X. X., Chen, X. H., Li, J. G., & Zhang, (2008). Effects of Wubeizi ointment solution on the proliferation of keloid-derived fibroblasts. Journal Hebei Medical University,2008(29), 829–833.
6. Wang, K., & Liu, G. (2012). Advances in the treatment of keloids. Chinese Journal of Integrated Traditional and Western Medicine,2012(11), 202–204.
7. Jiao, H. Q., Wang, R., Sun, H. M., Liu, Y., Guo, M., Su, H. X., et al. (2009). Effect of resveratrol on the growth of human skin cancer cell line A431 and its underlying mechanism. Journal of Capital Medical University,2009(30), 212–217.
8. Suzuki, H., Yagi, K., Kondo, M., Miyazono, K., & Miyazawa, K. (2008). C-Ski inhibits the TGF-beta signaling pathway through stabilization of the inactive Smad complexes on Smad binding elements. Oncogene,2008(23), 5068–5076.
9. Grady, W. M. (2008). Transforming growth factor-beta, Smads, and cancer. Clinical Cancer Research,2008(11), 3191–3197.
10. Sun, H. J., Meng, X. Y., & Hu, C. T. (2012). MicroRNA-200c inhibits cell proliferation and collagen synthesis in human keloid fibroblasts via TGF-β1/smad pathway. Chinese Journal of Aesthetic Medicine,2012(21), 1539–1542.