Microarray-based genotyping and detection of drug-resistant HBV mutations from 620 Chinese patients with chronic HBV infection

Brazilian Journal of Infectious Diseases

Volumn 19, Issue 3, 2015, Pages 291-295

  Hua, Wenhao ^a   Zhang, Guanbin ^b   Guo, Shujun ^c   Li, Weijie ^a   Sun, Lanhua ^b   Xiang, Guangxin ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b NATIONAL ENGINEERING RESEARCH CENTER FOR BEIJING BIOCHIP TECHNOLOGY   (China)

^c Department of Infectious Disease Pingdingshan General Hospital Medical Group   (China)

Author keywords

Chronic HBV; Drug resistance mutations; Genotyping; Microarray

Indexed keywords

ADEFOVIR; ANTIVIRUS AGENT; ENTECAVIR; LAMIVUDINE; TELBIVUDINE; VIRUS DNA; ADENINE; GUANINE; PHOSPHONIC ACID DERIVATIVE; THYMIDINE;

AGED; ANTIVIRAL RESISTANCE; ARTICLE; BLOOD LEVEL; CHINESE; CHRONIC HEPATITIS B; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENOTYPE; GENOTYPING TECHNIQUE; HEPATITIS B VIRUS; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MUTATIONAL ANALYSIS; NONHUMAN; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; STOP CODON; VERY ELDERLY; VIRUS IDENTIFICATION; VIRUS MUTATION; ADULT; ANALOGS AND DERIVATIVES; ASIAN CONTINENTAL ANCESTRY GROUP; DRUG EFFECTS; GENETICS; HEPATITIS B, CHRONIC; MUTATION; PROGNOSIS; VIROLOGY;

ADENINE; ADULT; ANTIVIRAL AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; DNA, VIRAL; DRUG RESISTANCE, VIRAL; FEMALE; GENOTYPE; GUANINE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LAMIVUDINE; MALE; MICROARRAY ANALYSIS; MUTATION; ORGANOPHOSPHONATES; PROGNOSIS; SEQUENCE ANALYSIS, DNA; THYMIDINE;

EID: 84930087989     PISSN: 14138670     EISSN: 16784391     Source Type: Journal    
DOI: 10.1016/j.bjid.2015.03.012     Document Type: Article

References (20)

1. World Health Organization Hepatitis B fact sheets 2012, Available from: http://www.who.int/mediacentre/factsheets/fs204/en/ [updated July 2014].
2. Bartholomeusz A., Schaefer S. Hepatitis B virus genotypes: comparison of genotyping methods. Rev Med Virol 2004, 14:3-16.
3. Miyakawa Y., Mizokami M. Classifying hepatitis B virus genotypes. Intervirology 2003, 46:329-338.
4. Chu C.J., Hussain M., Lok A.S. Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology 2002, 122:1756-1762.
5. Wai C.T., Chu C.J., Hussain M., et al. HBV genotype B is associated with better response to interferon therapy in HBeAg (+) chronic hepatitis than genotype C. Hepatology 2002, 36:1425-1430.
6. Nebbia G., Peppa D., Maini M.K. Hepatitis B infection: current concepts and future challenges. Q J Med 2012, 105:109-113.
7. Lok A.S., Zoulim F., Locarnini S., et al. Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management. Hepatology 2007, 46:254-265.
8. Wang F., Wang H., Shen H., et al. Evolution of hepatitis B virus polymerase mutations in a patient with HBeAg-positive chronic hepatitis B virus treated with sequential monotherapy and add-on nucleoside/nucleotide analogues. Clin Ther 2009, 31:360-366.
9. Lok A.S., McMahon B.J. Chronic hepatitis B: update 2009. Hepatology 2009, 50:661-662.
10. Tillmann H.L., McHutchison J.G. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med 2008, 358:1517-1518.
11. Yuen L.K., Locarnini S.A. Genetic variability of hepatitis B virus and response to antiviral treatments: searching for a bigger picture. J Hepatol 2009, 50:445-448.
12. Borroto-Esoda K., Miller M.D., Arterburn S. Pooled analysis of amino acid changes in the HBV polymerase in patients from four major adefovir dipivoxil clinical trials. J Hepatol 2007, 47:492-498.
13. Nie H., Evans A.A., London W.T., et al. Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion. J Hepatol 2012, 56:795-802.
14. Yuan J., Zhou B., Tanaka Y., et al. Hepatitis B virus (HBV) genotypes/subgenotypes in China: mutations in core promoter and precore/core ad their clinical implications. J Clin Virol 2007, 39:87-93.
15. Han Y., Huang L.H., Liu C.M., et al. Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients. J Gastroenterol Hepatol 2009, 24:1417-1423.
16. Zoulim F., Locarnini S. Hepatitis B virus resistance to nucleos(t)ide analogues. Gastroenterology 2009, 137:1593-1608.
17. Wang Z., Huang Y., Wen S., et al. Hepatitis B virus genotypes and subgenotypes in China. Hepatol Res 2007, 37:S36-S41.
18. Zeng G., Wang Z., Wen S., et al. Geographic distribution, virologic and clinical characteristics of hepatitis B virus genotypes in China. J Viral Hepat 2005, 12:609-617.
19. Li X., Liu Y., Zhao P., et al. Investigation into drug-resistant mutations of HBV from 845 nucleoside analogue-naïve Chinese patients with chronic HBV infection. Antivir Ther 2015, 20(2):141-147.
20. Song Z.L., Cui Y.J., Zheng W.P., et al. Diagnostic and therapeutic progress of multi-drug resistance with anti-HBV nucleotide analogues. World J Gastroenterol 2012, 18:7149-7157.